昆明理工大学灵长类转化医学研究院导师教师师资介绍简介-

本站小编 Free考研考试/2021-11-07

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E-mail: wangzb@lpbr.cn






一、教育与工作经历 Education and working experiences



教育经历
1997.9-2001.6：湖北农学院动物科学系，农学学士
2001.9-2004.6：甘肃农业大学动物医学院，基础兽医学，获得农学硕士学位
2004.9-2007.6：甘肃农业大学动物医学院，基础兽医学，获得农学博士学位
1997.09-2001.06: Department of Animal Science, Hubei Agricultural College, B.S. in agriculture
2001.09-2004.06: College of Veterinary Medicine, Gansu Agricultural University, M.A. in agriculture
2004.09-2007.06: College of Veterinary Medicine, Gansu Agricultural University, Ph.D in agriculture
工作经历
2018.8至今：昆明理工大学灵长类转化医学研究院，副教授
2017.1-2018.8：中科院昆明动物研究所，副研究员
2010.10-2016.12：中科院昆明动物研究所，助理研究员
2007.8-2010.9：中国科学院动物模型与人类疾病机理重点实验室，博士后，神经生物学，合作导师：胡新天研究员


2007.08-2010.08: Post-doctoral, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province (AMHD), Chinese Academy of Sciences
2010.10-2016.12: Assistant professor, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province (AMHD), Chinese Academy of Sciences
2017.01-2018.12: Associate professor, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province (AMHD), Chinese Academy of Sciences
2018.12-Now: Associate Professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology
2018.12-Now: Yunnan Key Laboratory of Primate Biomedical Research, Professor



二、主要研究方向 Research Interests



神经退行性疾病猕猴模型的构建
基于猴模型的神经退行性疾病治疗研究
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Modeling neurodegeneration diseases in monkey
Treatment of neurodegeneration diseases based on NHP models



三、科研领域描述 RESEARCH FILEDS



老年痴呆和帕金森病是排名前两位的神经退行性疾病，目前对这些疾病的发病机理不清，也没有有效的治疗手段。当前临床上的一些药物主要是基于啮齿类等低等动物的实验数据，所以很多药物在这些动物模型效果显著，但是临床上效果不佳或者根本效果，这可能是由于这些实验动物在生理结构和行为表型上与人存在巨大差异造成的。因此选择与人类有十分相似的脑结构与功能系统、且与人类基因相似度高达97.5％，具有推理、分析、决策、记忆等人类高级脑功能的非人灵长类动物作为实验动物，建立退行性模型，在此基础上开展疾病发病机理和治疗研究。
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Alzheimer's disease (AD) and Parkinson's disease (PD) are the top two neurodegenerative diseases. The cause and precise pathological mechanism of AD and PD remains unclear. Most of the current clinical drugs are mainly based on experimental data of experimental animals such as rodents. Due to the dramatic differences in physiological structures and behavioral phenotypes between the animals and human beings, these drugs are effective in the animal models, but most are failed in clinical trials. Compared to rodents that are inbred,nonhuman primates(NHPs are outbred. Behavioral outcome measures such as finemotor skills, which are affected in PD, can be easily tested inNHPs but not in other large species, like pigs.Clinically relevantbehavioral outcome measures are critical to determinethe efficacy of the strategy.TheNHPs, whose brain morphology and function like human beings, are used to develop new models that may be more suitable for preclinical therapeuticdevelopment.



四、承担科研项目情况 Fundings



国家重点研发计划项目：发育代谢复杂疾病灵长类动物模型的创制与临床前研究，2018YFA**，2019-2024，224.1万元，子课题组长
国家自然科学基金地区基金项目，**，基于非人灵长类猕猴PD模型神经干细胞黑质原位移植治疗研究，2020.1-2023.12，40万，主持
云南省自然科学基金面上项目，猕猴黑质神经干细胞移植存活、分化及投射研究，2018.1-2021.12，10万，主持
973项目，2015CB755605，灵长类模型神经回路成像研究，2015.1-2019.8，349.4万，子课题组长
国家自然科学基金面上项目，**，阿尔兹海默病（AD）猕猴自发模型的筛选鉴定，2018/01-2021/12，80万，参加
国家自然科学基金面上项目，**，建立阿尔茨海默病（AD）转基因猴模型，2015/01-2018/12，150万元，参加
中国科学院战略性先导科技专项（B类），XDB**，学习与记忆相关脑区之间的神经网络活动规律，2012/01-2016/12，866万，课题骨干
973项目，2007CB947703，猕猴神经干细胞转化为神经元过程中，功能性回路形成的特征研究，2007.1-2010.8，538.95万，课题骨干
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National Key Research and Development Project （2018YFA**）, 2019-2024，2，241，000，Co-PI
Natural Science Foundation of China (**, 2017-2020, ￥400,000, PI.
2018-2021: “Study of Survival, differentiation and projection of macaque substantia nigra neural stem cell transplantation”, Project on Yunnan Natural Science Foundation,(Grant No. 2018FB052) , 100，000，PI
2015-2018: “Imaging study of primate model neural circuit”, 973 Project,(Grant No.2015CB755605),3，494，000 Sub-PI
2018-2021: “Screening and Identification of Spontaneous Model of Alzheimer's Disease in Macaque”, NSFC, (Grant No. **), 80,000；principal member



五、代表性论文和专著



Kaiyu Xu, Dong Chen, Zhengbo Wang, Jian Ma, Jian Zhou, Nanhui Chen, Longbao Lv, Yongtang Zheng, Xintian Hu, Yi Zhang & Jiali Li. Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging. Cell Discov. 2018 Sep 18;4:48. doi: 10.1038/s41421-018-0050-1. eCollection 2018.
Zhai, Rongwei; Rizak, Joshua; Zheng, Na; He, Xiaping; Li, Zhenhui; Yin, Yong; Su, Tao; He, Yingge; He, Rongqiao; Ma, Yuanye; Yang, Meifeng; Wang, Zhengbo; Hu, Xintian. Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Nonhuman Primates. Curr Alzheimer Res. 2018 Sep 4. doi: 10.2174/**66**8. [Epub ahead of print]
Baihui Huang, Shihao Wu, Zhengbo Wang, Longjiao Ge, Joshua D Rizak, Jing Wu, Jiali Li, Lin Xu, Longbao Lv, Yong Yin, Xintian Hu, Hao Li. Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP. Neuroscience. 2018 May 21;379:302-315.
Siling Liu, Zheng-Bo Wang, Dong Chen, Bowen Zhang, Ren-Rong Tian, Jing Wu, Ying Zhang, Kaiyu Xu, Liu-Meng Yang, Chao Cheng, Jian Ma, Longbao Lv, Yong-Tang Zheng, Xintian Hu, Yi Zhang, Xiangting Wang, Jiali Li. Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain. Genome Res. 2017 Sep;27(9):1608-1620.
Zheng-Bo Wang, Dong-Dong Qin, and Xin-Tian Hu. Engrafted newborn neurons could functionally integrate into the host neuronal network. Zool Res. 2017 Jan 18;38(1):5-6.
Tanzeel Huma, Xintian Hu, Yuanye Ma, Andrew Willden, Joshua Rizak, Muhammad Shahab, Zhengbo Wang. Kisspeptin-10 treatment generated specific GnRH expression in cells differentiated from rhesus monkey derived Lyon NSCs. Neuroscience. 2017 May 4;349:318-329.
Jing-Kuan Wei, Wen-Chao Wang, Rong-Wei Zhai, Yu-Hua Zhang, Shang-Chuan Yang, Joshua Rizak, Ling Li, Li-Qi Xu, Li Liu, Ming-Ke Pan, Ying-Zhou Hu, Abdelaziz Ghanemi, Jing Wu, Li-Chuan Yang, Hao Li, Long-Bao Lv, Jia-Li Li, Yong-Gang Yao, Lin Xu, Xiao-Li Feng, Yong Yin, Dong-Dong Qin, Xin-Tian Hu,Zheng-Bo Wang. Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Cell Rep. 2016 Jul 26;16(4):1016-1025.
Hao Li, Xiaoguang Lei, Ting Yan, Hongwei Li, Baihui Huang, Ling Li, Liqi Xu, Li Liu, Nanhui Chen, Longbao Lü, Yuanye Ma, Lin Xu, Jiali Li, Zhengbo Wang, Baorong Zhang, Xintian Hu. The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson's disease monkeys，Sci Rep，2015，5：12178.
Li-Yun Guo, Jing-Kuan Wei, Shang-Chuan Yang, Zheng-Bo Wang. Glaucoma model for stem cell transplantation research in New Zealand white rabbits.Dongwuxue Yanjiu. 2012 Apr;33(2):225-30. doi: 10.3724/SP.J.1141.2012.02225. Chinese.
Jin-Run Dong, Li-Yun Guo, Jia-Gui Qu, Ren-Li Qi, Wen-Chao Wang, Chun-Jie Xiao, Zheng-Bo Wang. Rhesus monkey embryonic stem cells differentiation, proliferation and allotransplantation. Dongwuxue Yanjiu. 2012 Feb;33(1):43-8. doi: 10.3724/SP.J.1141.2012.01043. Chinese.
Shang-Chuan Yang 1, Jin-Run Dong, Jia-Gui Qu, Xin-Tian Hu, Zheng-Bo Wang. A traumatic brain injury model for distinguishing between transplanted neural cells and host cells in vivo. Dongwuxue Yanjiu. 2011 Aug;32(4):421-7. doi: 10.3724/SP.J.1141.2011.04421. Chinese.
Ming-Li Li, Shi-Hao Wu, Jin-Jin Zhang, Hang-Yu Tian, Yong Shao, Zheng-Bo Wang, David M Irwin, Jia-Li Li, Xin-Tian Hu, Dong-Dong Wu. 547 Transcriptomes From 44 Brain Areas Reveal Features of the Aging Brain in Non-Human Primates. Genome Biol. 2020 Feb 24;21(1):46. doi: 10.1186/s13059-020-01962-z.
Dongdong Qin, Zhifei Li, Zhaoxia Li, Limin Wang, Zhengfei Hu, Longbao Lü, Zhengbo Wang, Yun Liu, Yong Yin, Zhaofu Li, Xintian Hu. Chronic Glucocorticoid Exposure Induces Depression-Like Phenotype in Rhesus Macaque (Macaca Mulatta). Front Neurosci. 2019 Mar 8;13:188. doi: 10.3389/fnins.2019.00188. eCollection 2019.
Ling-QunYe, HuiZhao, He-JiangZhou, Xiao-DieRen, Lin-LinLiu, Newton O.Otecko, Zheng-Bo Wang, Min-MinYang, LinZeng, Xin-TianHu, Yong-GangYao, Ya-PingZhang, Dong-DongWu. The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria. Science Bulletin Volume 62, Issue 12, 30 June 2017, Pages 820-830
Xiaping He, Zhenhui Li, Joshua D Rizak, Shihao Wu, Zhengbo Wang, Rongqiao He, Min Su, Dongdong Qin, Jingkun Wang, Xintian Hu. Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells. Front Neurosci. 2017 Jan 31;10:598.
Li-Juan Ye, Hui Bian, Yao-Dong Fan, Zheng-Bo Wang, Hua-Lin Yu, Yuan-Ye Ma, Feng Chen. Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions. Neural Regen Res. 2016 Sep;11(9):1464-1470.
Weili Yang, Guohao Wang, Chuan-En Wang, Xiangyu Guo, Peng Yin, Jinquan Gao, Zhuchi Tu, Zhengbo Wang, Jing Wu, Xintian Hu, Shihua Li and Xiao-Jiang Li. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015 May 27;35(21):8345-58.
Xiaoguang Lei, Hao Li, Baihui Huang, Joshua Rizak, Ling Li, Liqi Xu, Tianzhuang Huang, Li Liu, Jing Wu, Longbao Lü, Zhengbo Wang, Yingzhou Hu, Weidong Le, Xingli Deng, Jiali Li, Yonggang Yao, Lin Xu, Xintian Hu, Baorong Zhang. 1-methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque. PLoS One. 2015 May 26;10(5):e**.
Hao Li, Xiaoguang Lei, Baihui Huang, Joshua D Rizak, Lichuan Yang, Shangchuan Yang, Jing Wu, Longbao Lü, Jianhong Wang, Ting Yan, Hongwei Li, Zhengbo Wang, Yingzhou Hu, Weidong Le, Xingli Deng, Jiali Li, Lin Xu, Baorong Zhang, Xintian Hu. A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections. J Neurosci Methods. 2015 Aug 15;251:99-107.
Meifeng Yang, Junye Miao, Joshua Rizak, Rongwei Zhai, Zhengbo Wang, Tanzeel Huma, Ting Li, Na Zheng, Shihao Wu, Yingwei Zheng, Xiaona Fan, Jianzhen Yang, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Longbao Lü, Rongqiao He, Xintian Hu. Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. J Alzheimers Dis. 2014;41(4):1131-47.
Tanzeel Huma, Zhengbo Wang, Joshua Rizak, Fiaz Ahmad, Muhammad Shahab, Yuanye Ma, Shangchuan Yang, Xintian Hu. Kisspeptin-10 modulates the proliferation and differentiation of the rhesus monkey derived stem cell line: r366.4. Scientific World Journal. 2013 Nov 28;2013:135470
Jing Wu 1, Wenchao Wang, Joshua Dominic Rizak, Zhengbo Wang, Jianhong Wang, Xiaoli Feng, Jinrun Dong, Lin Li, Li Liu, Liqi Xu, Shangchuan Yang, Xintian Hu. A new method for piercing the tentorium cerebelli for implanting fragile electrodes into the brain stem in the rhesus monkey (Macaca mulatta). J Neurophysiol. 2013 Dec 11
Yongchang Chen, Zhengbo Wang, Yunhua Xie, Xiangyu Guo, Xianghui Tang, Shufen Wang, Shihua Yang, Kai Chen, Yuyu Niu, Weizhi Ji. Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells. J Neurosci Res. 2012 Jul;90(7):1382-91. doi: 10.1002/jnr.23030. Epub 2012 Mar 13.
Jianguang Ni, Huihui Jiang, Yixiang Jin, Nanhui Chen, Jianhong Wang, Zhengbo Wang, Yuejia Luo, Yuanye Ma, Xintian Hu. Dissociable modulation of overt visual attention in valence and arousal revealed by topology of scan path. PLoS One. 2011 Apr 6;6(4):e18262. doi: 10.1371/journal.pone.**.
王正波 余四九 崔燕 成年牦牛松果体的光镜和电镜观察 解剖学报 2007年4期 470-475
王正波 余四九 谭娟 崔燕 幼年牦牛松果体的光镜和电镜观察 中国兽医科学 2007, 37(9)



六、授权发明专利 Patents



杨上川，张玉华，胡新天，王正波，胡英周，用于磁共振的大动物头部固定装置（申请号: 0.7），中国， ZL 0.7。
杨上川，胡新天，王正波，吴晶，双向微电极推进器及微电极（申请号:2.X），中国， ZL 2.X。
杨上川，胡新天，王正波，胡英周，用于大动物立体定位仪的耳杆高度可调耳杆座（申请号:1.8），中国， ZL 1.8.
杨上川，胡新天，王正波，王文超，马原野脑微量组织取样器（申请号:9.8），中国， ZL 9.8。
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ZL 0.7,Head Fixation Device for Magnetic Resonance Imaging in Large Animals. (Utility model patent)
ZL 2.X, Bidirectional microelectrode thruster and microelectrode. (Utility model patent)
ZL 1.8, Adjustable ear rod height for stereotaxic locator of large animals. (Utility model patent)
ZL 9.8, Sampler of the microcomponent of brain. (Patent for invention)



七、招聘招生



科研助理：要求获得硕士及以上学历，畜牧或兽医专业优先，有动物工作经验；具有独立工作能力和合作精神，善于交流，有良好的文字表达能力和协调沟通能力。
博士后：神经生物学、细胞生物学等专业博士毕业3年以内，以第一作者发表过SCI论文。
硕士研究生：欢迎优秀的本科生报考或调剂神经生物学专业硕士研究生。
有意者请发送简历至wangzb@lpbr.cn。