E-mail: zhangrr@lpbr.cn






一、教育及工作经历?( Education and Research Experience )



2014年2月-2019年 7月 瑞士巴塞尔大学生物医学系 博士后
2007年9月-2013年12月 中国科学院上海生物化学与细胞生物学研究所 博士
2003年9月-2007年7月 云南大学生命科学学院 学士
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02/2014-07/2019 Department of Biomedicine, University of Basel, Switzerland, Postdoc
09/2007-12/2013 Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China, Ph.D.
09/2003 - 07/2007 School of Life Sciences, Yunnan University, China, B.S.



二、主要研究方向 (Research Interest)



调控神经干细胞命运的信号通路和表观遗传机制
灵长类神经发生和神经再生的调控机制和功能研究
Genetic and epigenetic regulations of neural stem cell fate
Neurogenesis and neural regeneration in primates




三、科研领域简介 (Research Introduction)



神经干细胞是神经发生的基础。神经干细胞库的维持不但对大脑的早期发育有着至关重要的作用，而且与成年阶段大脑功能的正常行使密切相关。神经干细胞的命运受到多种机制的精密调节，包括遗传和表观遗传因子。本研究将以啮齿类和灵长类动物为模型，运用遗传、细胞和分子生物学等手段进一步探索调控其神经干细胞命运和神经发生的广谱和物种特异性机制，为促进成年哺乳动物（尤其是灵长类）的神经发生和损伤修复提供线索。
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Neural stem cells (NSCs) are the source of neurogenesis. The maintenance of NSC pool is not only critical for brain development, but also for adult brain functions. The fate of NSC requires very precise regulations, involving both genetic and epigenetic factors. Using genetics, cell biology and molecular biology techniques in rodent and primate models, we aim to investigate the general and species-specific mechanisms in the regulation of NSC fate and adult neurogenesis. Our study will provide clues and potential strategies to improve adult neurogenesis and brain repair in mammals, especially in primates.



四、承担科研项目情况 (Research Funding)



2018年1月-2019年 7月 瑞士巴塞尔大学优秀青年****项目 主持
2014年2月-2019年 07月 瑞士国家自然科学基金项目 主要参与
2007年9月-2013年 12月 中国国家自然科学基金项目和科技部专项 主要参与
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01/2018-07/2019 Excellent Junior Researcher Fund from the University of Basel, PI
02/2014-07/2019 Swiss National Science Foundation, main member.
09/2007-12/2013 National Science Foundation of China, Ministry of Sciences and Technology of China, main member.



五、代表性论文 (Publications)



Runrui Zhang, Marcelo Boareto, Anna Engler, Angeliki Louvi, Claudio Giachino, Dagmar Iberand Verdon Taylor. Id4 downstream of Notch2 maintains neural stem cell quiescence in the adult hippocampus.Cell Reports. (2019)28 (6):1485-1498 (Cover story).
Runrui Zhang*,Anna Engler*, VerdonTaylor.Notch:Aninteractive player inneurogenesisanddisease.Cell Tissue Res.(2018) 371(1):73-89.
Anna Engler*,Runrui Zhang*, Verdon Taylor. Notch and neurogenesis. Adv Exp Med Biol.(2018) 1066:223-234.
Anna Engler, Chiara Rolando, Claudio Giachino, Ichiko Saotome , Andrea Erni, Callum Brien, Runrui Zhang, Ursula Zimber-Strobl, Freddy Radtke, Angeliki Louvi and Verdon Taylor. Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone. Cell Reports.(2017) 22(4), 992-1002.
Xiao Hu,LeiZhang,Shi-QingMao,Zheng Li,Jiekai Chen,Run-RuiZhang, Hai-PingWu, Juan Gao,Fan Guo,WeiLiu,YufeiXu,YujiangGeno Shi, Duanqing Pei,andGuo-LiangXu.TetandTDG mediateDNAdemethylationessentialforsomatic cellreprogramming.CellStemCell.(2014) 14:512-22.
Runrui Zhang*,Qing-YanCui*, KiyohitoMurai*,YenChing Lim,ZacharyD.Smith,ShengnanJin,PengYe,LuisRosa,YewKokLee,Hai-PingWu,WeiLiu,Zhi-MeiXu,LuYang,Yu-QiangDing, FuchouTang,AlexanderMeissner, ChunmingDing, YanhongShi,Guo-LiangXu.Tet1regulatesadulthippocampalneurogenesisandcognition.CellStemCell.(2013) 13:237-245. (Highlighted and previewed in the same issue).
Jialei Hu,BoO.Zhou,Run-RuiZhang,KanglingZhang,Jinqiu Zhou,GuoliangXu.The N-terminusofhistoneH3is requiredfor denovo DNAmethylationinchromatin.Proc NatlAcadSciUSA.(2009) 106, 22187-192.



六、招生招聘



实验室招聘实验助理和硕士研究生。欢迎大专及以上学历，有发育和分子生物学基础，并具备动物工作和细胞培养经验的人员加盟。有意者请发送简历至zhangrr@lpbr.cn。