教授

张同存，男，博士，教授，博士生导师。天津市政协委员。兼任工业生物技术教育部重点实验室（江南大学）学术委员会委员，天津市蛋白质科学重点实验室（南开大学）学术委员会委员，中国发酵工业协会多元醇分会理事，中国生化与分子生物学会理事，天津市微生物学会理事，天津市细胞生物学学会理事，美国癌症学会高级会员，美国心脏病学会会员，中国保健品学会专家。
科研领域及方向
[1]心血管疾病和肿瘤等重大疾病转录调节异常的分子机制和相关新药开发等研究
[2]益生菌及工业微生物的功能基因与转录调控机制研究
[3]肠道微生态与健康调控及机制研究
科研情况
[1]国家自然科学基金：Stat3抑制myocardin诱导心肌肥厚的机制研究，80万，2013-2016
[2]863计划：食品微生物基因组改造（益生菌功能基因分析及安全性、功能评价），215万，2012-2015
[3]863计划：天然多糖的制备与功能多糖的研制，58万，2012-2015
[4]天津市应用基础与前沿技术研究计划：L.caseiHZ1新型降压肽的鉴定及其分子育种研究，2014-2017
[5]国家自然科学基金：Myocardin与雌激素受体协同诱导血管平滑肌细胞分化及机制研究，2009-2012
[6]国家自然科学基金：Myocarin诱导心肌肥厚及其机制的研究，2007-2009
[7]863计划：益生菌定向筛选与功能开发关键技术的研究，2008-2010
[8]973计划：表观遗传学的结构机理研究（课题4-表观遗传调控过程中重要蛋白的结构与功能研究），2009-2014
[9]高等学校博士学科点专项科研基金：MRTF-A促进雌激素代谢及机制研究，2012-2014
[10]天津市科委应用基础及前沿技术研究计划项目：Myocardin家族相关转录因子和SRC-1相互作用及在药物代谢中的作用，2007-2009
[11]天津市东丽区科技创新专项：重组猪转移因子rTF的研究及产业化，2011-2012
[12]天津科技大学海河****启动基金：Myocardin在动脉硬化发病中的作用及机制研究，2008-2010
[13]横向项目：D-塔格糖乳酸菌生物转化生产体系的建立，2013-2014
[14]横向项目：谷氨酸棒杆菌生产核苷酸发酵条件优化，2012-2013
主要学术成果
先后发表各类科研论文110余篇，其中SCI或EI收录论文70余篇，参编教材或专著6部，授权或申请发明专利9项。发表的主要学术论文有：
[1]XingWJ,LiaoXH,WangN,ZhaoDW,ZhengL,ZhengL,DongJ,ZhangTC*.MRTF-AandSTAT3promoteMDA-MB-231cellmigrationviahypermethylatingBRSM1.IUBMBLife.2015Apr9.（IF2.755）
[2]LiXM,LuoXG,WangN,ZhouH,SiCL,LiK,MaN,ZhangTC*.TheextractofHypericumascyronL.inducesbacterialcelldeaththroughapoptosispathway.JEthnopharmacol.2015May26;166:205-210.(IF2.939)
[3]LiXM,LuoXG,ZhangCZ,WangN,ZhangTC*.QualityevaluationofHypericumascyronextractbytwo-dimensionalhigh-performanceliquidchromatographycoupledwiththecolorimetric3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromidemethod.JSepSci.2015,38(4):576-584.(IF2.594)
[4]RuiZhang,NanWang,ManZhang,Li-NanZhang,Zhi-XiaGuo,Xue-GangLuo,HaoZhou,Hong-PengHe,ZhangTC*.Rho/MRTF-A-InducedIntegrinExpressionRegulatesAngiogenesisinDifferentiatedMultipotentMesenchymalStemCells.StemCellsInternational.2015.(IF2.806)
[5]LiM,WangN,GongHQ,LiWZ,LiaoXH,YangXL,HeHP,CaoDS,ZhangTC*.Ca2?signal-inducedcardiomyocytehypertrophythroughactivationofmyocardin.GENE.2015.15;557(1):43-51.(IF2.082)
[6]LiXM*,LuoXG*#,SiCL,WangN,ZhouH,HeJF,ZhangTC#.AntibacterialactivecompoundsfromHypericumascyronL.inducebacterialcelldeaththroughapoptosispathway.EurJMedChem.2015,96:436-444.(*Co-firstauthorwithstudent;#Co-correspondingauthors)（IF3.432）
[7]Xiang-ZhuShu,Li-NanZhang,RuiZhang,Cai-JiaoZhang,Hong-PengHe,HaoZhou,NanWang,ZhangTC*.Histoneacetyltransferasep300promotesMRTF-A-mediatestransactivationofVE-cadheringeneinhumanumbilicalveinendothelialcells.GENE.2015May25;563(1):17-23.(IF2.082)
[8]Ruo-LeiJian,Li-BinMao,YaoXu,Xiao-FanLi,Feng-PoWang,Xue-GangLuo,HaoZhou,Hong-PengHe,NanWang,ZhangTC*.Generationofinsulin-producingcellsfromC3H10T1/2mesenchymalprogenitorcells.GENE.2015May10;562(1):107-16.(IF2.082)
[9]Xing-HuaLiao,NanWang,Dong-WeiZhao,De-LiangZheng,LiZheng,Wen-JingXing,HaoZhou,Dong-SunCao,ZhangTC*.NF-κB(p65)negativelyregulatesmyocardin-inducedcardiomyocytehypertrophythroughmultiplemechanisms.CellularSignalling.2014,26(12),2738-2748.(IF4.471)
[10]HeH,LiuX,WangD,WangY,LiuL,ZhouH,LuoX,WangN,JiB,LuoY,ZhangTC*.SAHAinhibitsthetranscriptioninitiationofHPV18E6/E7genesinHeLacervicalcancercells.GENE.2014,553(2):98-104.(IF2.19)
[11]Xing-HuaLiao,NanWang,Long-YueLiu,LiZheng,Wen-JingXing,Dong-WeiZhao,Xue-GuangSun,PengHu,JianDong,ZhangTC*.MRTF-AandSTAT3synergisticallypromotebreastcancercellmigration.CellularSignalling.2014,26(11):2370-2380.(IF4.471)
[12]Xing-HuaLiao,Yan-QiLi,NanWang,LiZheng,Wen-JingXing,Dong-WeiZhao,Ting-BaoYan,YueWang,Long-YueLiu,Xue-GuangSun,PengHu,HaoZhou,ZhangTC*.Re-expressionandepigeneticmodificationofmaspininducedapoptosisinMCF-7cellsmediatedbymyocardin.CellularSignalling.2014,26(6):1335-1346.(IF4.304)
[13]GuXC,LuoXG,WangCX,MaDY,WangY,HeYY,LiW,ZhouH,ZhangTC*.CloningandanalysisofBileSaltHydrolaseGenesfromLactobacillusplantarumTH1CGMCCNo.8198.BiotechnolLett.2014,36(5):975-983.(IF1.853)
[14]Xing-HuaLiao,YueWang,NanWang,Ting-BaoYan,Wen-JingXing,LiZheng,Dong-WeiZhao,Yan-QiLi,Long-YueLiu,Xue-GuangSun,PengHu,ZhangTC*.Humanchorionicgonadotropin(hCG)decreaseshumanbreastcancercellproliferationandpromotesdifferentiation.IUBMBLife.2014,66(5):352-360.(IF2.789)
[15]LuoXG,ZhangCL,ZhaoWW,LiuZP,LiuL,MuA,GuoS,WangN,ZhouH,ZhangTC*.HistonemethyltransferaseSMYD3promotesMRTF-A-mediatedtransactivationofMYL9andmigrationofMCF-7breastcancercells.CancerLett.2014,344(1):129-137.(IF4.238)
[16]LiXM,LuoXG,MaN,LiK,LiW,MaDY,ZhangTC*.QualityandantitumouractivityevaluationofextractofHypericumascyron.BiomedChromatogr.2014,36(5):975-984.(IF1.966)
[17]Xing–HuaLiao,Da–LinLu,NanWang,Long–YueLiu,YueWang,Yan–QiLi,Ting–BaoYan,Xue–GuangSun,PengHuandZhangTC*.EstrogenreceptoramediatesproliferationofbreastcancerMCF–7cellsviaap21/PCNA/E2F1-dependentpathway.TheFEBSjournal.2014,281(3):927-42.(IF4.25)
[18]ZhipengLiu,XuegangLuo,LeiLiu,WenwenZhao,ShuGuo,YuGuo,NanWang,HongpengHe,XinghuaLiao,WenjianMa,HaoZhou,ZhangTC*.Histoneacetyltransferasep300promotesMegakaryoblasticleukemia1-mediatedtransactivationofcatechol-O-methyltransferase.ActaBiochBiophSin.2013,45(12):1002-1010.(IF1.807)
[19]ChunlingZhang,XuegangLuo,LeiLiu,ShuGuo,WenwenZhao,AiMu,HaoZhou,NanWang,ZhangTC*.MRTF-Aisupregulatedby17β-estradiolandpromotesmigrationofMCF-7breastcancercellsviatransactivationofMYL9andCYR61.ActaBiochBiophSin.2013,45(11):921-927.(IF1.807)
[20]NanWang,RuiZhang,Shui-JingWang,Chun-LingZhang,Li-BinMao,Chun-YuZhuang,Yan-YangTang,Xue-GangLuo,HaoZhou,ZhangTC*.VascularendothelialgrowthfactorstimulatesendothelialdifferentiationrommesenchymalstemcellsviaRho/myocardin-relatedtranscriptionactor-Asignalingpathway.TheInternationalJournalofBiochemistry&CellBiology.2013,45(7):1447-1456.(IF4.634)
[21]NanWang,YaoXu,TaoQin,Feng-PoWang,Lin-LinMa,Xue-GangLuo,ZhangTC*.Myocardin-relatedtranscriptionfactor-Aisakeyregulatorinretinoicacid-inducedneural-likedifferentiationofadultbonemarrow-derivedmesenchymalstemcells.Gene.2013,523(2):178-186.(IF2.341)
[22]FengLin,NanWang,ZhangTC*.Theroleofendothelial-mesenchymaltransitionindevelopmentandpathologicalprocess.IUBMBLife.2012,64(9):717-723.(IF4.514)
[23]NanWang,Guang-DaRen,ZhenZhou,YaoXu,TaoQin,Ru-FaYu,ZhangTC*.CooperationofMyocardinandSmad2inInducingDifferentiationofMesenchymalStemCellsintoSmoothMuscleCells.IUBMBLife.2012,64(4):331-339.(IF3.514)
[24]JiaoLu,JinleiTang,YiLiu,XinnaZhu,ZhangTC*,XueliZhang.CombinatorialmodulationofgalPandglkgeneexpressionforimprovedalternativeglucoseutilization.ApplMicrobiolBiotechnol.2012,93(6):2455-2462.(IF3.425)
[25]LuoXG,TianWJ,NiM,JingXL,LvLH,WangN,JiangY,ZhangTC*.Solubleexpressionofactiverecombinanthumantissueplasminogenactivatorderivative(K2S)inEscherichiacoli.PharmBiol.2011,49(6):653-657.(IF0.878)
[26]LiaoXH,WangN,LiuQX,QinT,CaoB,CaoDS,ZhangTC*.Myocardin-RelatedTranscriptionFactor-AInducesCardiomyocyteHypertrophy.IUBMBLife.2011,63(1):54-61.(IF3.514)
[27]J.Wang,ZhangTC*andX.Liu.PreliminarycrystallographicanalysisoftheN-terminaldomainofFILIA,aproteinessentialforembryogenesis.crystallizationcommunications.2010,66(9):1111-1114.(IF0.563)
[28]Xiao-LanJing,Xue-GangLuo,Wen-JingTian,Li-HuiLv,YongJiang,NanWang,ZhangTC*.High-LevelExpressionoftheAntimicrobialPeptidePlectasininEscherichiacoli.CurrMicrobiol.2010,61(3):197-202.(IF1.51)
[29]Xue-GangLuo,TaoXi,ShuGuo,Zhi-PengLiu,NanWang,YongJiangandZhangTC*.EffectsofSMYD3overexpressionontransformation,serumdependence,andapoptosissensitivityinNIH3T3cells.IUBMBLife.2009,61(6):679-684.(IF3.578)
[30]NanWang,ZhenZhou,XinghuaLiaoandZhangTC*.RoleofmicroRNAsincardiachypertrophyandheartfailure.IUBMBLife.2009,61(6):566-571.(IF3.578)
[31]XinW*,ZhangTC*,CaoD,WangZ,AntosCL,LiS,WangY,OlsonEN,WangDZ.,Myocardininducescardiachypertrophy.CircRes.2006Apr28;98(8):1089-97(IF9.8)(*Co-firstauthor).
[32]FaucetteS*,ZhangTC*,MooreR，SueyoshiT，OmiecinskiC，LecluyseE，NegishiM，WangH，RelativeActivationofHumanPregnaneXReceptorversusConstitutiveAndrostaneReceptorDefinesDistinctClassesofCYP2B6andCYP3A4Inducers.JPharmacolExpTher.2006Oct13(IF4.908)(*Co-firstauthor).
[33]WangH，FaucetteS,ZhangTC，etal，ValidationofahumanCARvariant(hCAR3)astheinvitropredictorforPXRindependentCYP2B6/CYP3A4inductionDugMetaRev.38:115,179,2006.(IF5.135).
获奖情况
先后荣获天津市科协2012年度先进学会工作者、2012年天津科技大学优秀硕士论文、2013年天津市优秀硕士论文、2014年天津科技大学优秀硕士论文等奖励。
联系方式
办公地点：天津经济技术开发区第十三大街29号天津科技大学生物工程学院
邮政编码：300457
办公电话：,**
传真：
Email：tony@tust.edu.cn