Donghua Wang ——Associate Professor
Nationality:
CHINA

Phone:


Email:
wdh022@tju.edu.cn

Office:
Room 446, Building 11, Tianjin University

School:
School of Pharmaceutical Science and Technology

ResearcherID:
K-1098-2015

Group weblink








Education Experience
2006 Ph. D. Tianjin University, CN

Professional Experience
1998-2004 lecturer Tianjin University
1996-1998 assistant Tianjin University
2004-2015 associate professor Tianjin University

Research Area
The research in the group of Wang involves the design, synthesis, and biological activity evaluation of new compounds, with focus on industrialization of generic drugs, intermediates, and fine chemicals. Specific areas include 1) Design and synthesis of the Rho kinase inhibitor, 2) Design and synthesis of the PDE4 inhibitor, and 3) Design and synthesis of antihistamine drugs



Honors and Awards

Patents

Highlighted Publications
Lin,Y.; Wang, Y.; Sima, L-F.; Wang, D.-H.; Cao, X.-H.; Chen, L.-G.; Chen, B. Design, synthesis and biological activity evaluation of desloratadine analogues as H-1 receptor antagonists. Bioorgan. Med. Chem. 2013, 21, 4178.
Lin,Y.; Huang, P.; Liu, S.; Sima, L.; Chen, L.; Wang, D.A convenient method for the synthesis of roflumilast. Res. Chem. Intermed. 2013, 39, 2107.
Chen, M.; Liu, S.; Wang, X.; Luo, H.; Chen, L.; Wang, D. Synthesis of 1-Isoquinolinol and Hydroxyfasudil. Chin. J. Org. Chem. 2012, 32, 404.
Wang, Y.; Wang, J.; Lin, Y.; Si-Ma, L.-F.; Wang, D.-H. Chen, L.-G.; Deng-Ke, L. Synthesis and Antihistamine Evaluations of Novel Loratadine Analogues. Bioorgan. Med. Chem. 2011, 21, 4454.
Wang, D.; Qu, W.; Shi, L.; Wei, J. Molecular Docking and Pharmacophore Model Studies of Rho Kinase Inhibitors. Mol. Simulat. 2011, 37, 488.

ResearcherID Publications
Year Title Author(s) Source Volume
2015 Design, Synthesis, and Biological Evaluations of Several Y-26732 Analogues Wang, Xinran; Chen, Ligong; Li, Hang; et al. Journal of Heterocyclic Chemistry 52
2015 Synthesis and structure confirmation of the impurity in crude roflumilast product Sun, Chang-hai; Lin, Yan; Sun, Meng; et al. Research on Chemical Intermediates 41
2014 Design, synthesis and evaluation of biological activity of novel fasudil analogues Li, Hang; Wang, Donghua; Liu, Shuai; et al. Pharmazie 69
2014 Synthesis of an impurity in crude roflumilast Zhang, Hankang; Lin, Yan; Li, Yan; et al. Journal of Chemical Research
2013 A convenient method for the synthesis of roflumilast Lin, Yan; Huang, Peijun; Liu, Shuai; et al. Research on Chemical Intermediates 39
2013 Design, synthesis and biological activity evaluation of desloratadine analogues as H-1 receptor antagonists Lin, Yan; Wang, Yue; Sima, Li-Feng; et al. Bioorganic & Medicinal Chemistry 21
2013 Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product Lin, Yan; Huang, Peijun; Qi, Haofei; et al. Research on Chemical Intermediates 39
2012 Design, Synthesis and Antihistamine Evaluations of Several N-hydroxyalkyl Desloratadine Analogues Lin, Yan; Wang, Yue; Sima, Li-feng; et al. Medicinal Chemistry 8
2012 Highly Selective Amination of o- and p-Alkyl Phenols over Pd/Al2O3-BaO Ma, Jianchao; Wang, Huabang; Sun, Meng; et al. Bulletin of the Korean Chemical Society 33
2012 Synthesis of 1-Isoquinolinol and Hydroxyfasudil Chen Meizhu; Liu Shuai; Wang Xinran; et al. Chinese Journal of Organic Chemistry 32