杨兴斌
职称/职务：教授/院长全面负责学院行政工作/财务
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电子信箱：xbyang@snnu.edu.cn
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杨兴斌，男，1969年10月19日生，博士，现为陕西师范大学食品工程与营养科学学院教授、博士导师，教育部“药用资源与天然药物化学”重点实验室和“西北濒危药材资源开发”国家工程实验室学术带头人。1997年毕业于北京化工大学，获应用化学硕士学位，同年分配在第四军医大学工作。2004年获第四军医大学医学（药理学）博士学位。先后在西安东盛科技有限责任公司、西安德施普生物制品有限责任公司、江苏天琦生物科技有限责任公司等企业工作或开展保健食品、新药的合作研究。2008.10-2010.02及其后3次在澳大利亚西澳大学（UniversityofWesternAustralia）做访问学者、访问教授及合作研究。

目前主持国家自然科学基金面上项目2项，作为副组长承担全军“十五”医学重点课题1项，“十五”和“十一五”国家重大科技专项基金项目各1项，以及中央高校基金特别支持项目等多项。主编《水苏糖与健康》（第二版）著作1部，编写《临床新药手册》等著作4部，申请发明专利3项。2002年获军队科技进步三等奖（参加），2007年获陕西省科技进步一等奖（参加）和2013年获陕西高等学校科技进步一等奖（主持）。先后发表学术论文80余篇，其中在Antioxidants&RedoxSignaling(IF8.5),AmericanJournalofClinicalNutrition(IF6.7),FreeRadicalBiology&Medicine(IF5.8),PLoSONE,JournalofAgriculturalandFoodChemistry,FoodChemistry等极具影响力的SCI杂志发表论文40余篇，并被SCI源期刊论文引用300余次。现担任JournalofAgriculturalandFoodChemistry,FoodChemistry等农业食品领域SCI一、二区专业杂志的审稿人。也担任国家自然科学基金食品科学学科申请代码设置细化专家及评审专家，国家科学技术奖励及教育部科学技术奖励评审专家。2011年获中国食品产业产学研创新发展杰出科研人才奖。

熟悉保健食品的申报注册工作，具备丰富的生物制品产、学、研一体化与产业战略发展管理经验。与企业合作，相继开发了爽QQ牌水苏糖口香糖（企业标准：Q/DSP010-2007）、肠内美人牌水珍唯美食品、水苏冲剂（国食健字：G**）和德施普粉（国食健字：G**）等系列保健食品（市场化商品），并且参与驰名产品“白加黑”药物新剂型的研发，参加完成了Genistein等国家Ⅰ、Ⅱ、Ⅲ类新药的临床前安全评价研究多项。现已成功构建地笋、地黄天然水苏糖工业制备技术，实现以水苏糖为基础组方的系列保健食品产业技术升级。同时，利用先进的生物化妆品纳米包裹与渗透技术，开发出新一代引领世界先进水平的细胞护理生物化妆品（抗皱赋弹、祛痘护肤品与生发特殊用途化妆品），进入产业化与市场启动阶段。目前，主要从事天然产物工程、蛋白质工程、食品分子营养及保健食品方面的产学研应用基础研究与健康产品研发工作。

研究领域与研究生培养方向：

①功能糖、类黄酮、多肽等食品功能因子的分离纯化、工业制备、质量控制、化学修饰与结构鉴定，以及保健食品的申报注册。

②主要通过生化和分子生物学方法，在细胞和动物水平研究营养失衡与调节在血管疾病、2型糖尿病、肿瘤和脂肪肝等代谢疾病发生发展过程中的分子机制，探索食品功能因子及天然产物靶向干预的新机制和新方法，筛选并发现新型食品功能因子。

③饮食硝酸盐/亚硝酸盐在维持血管内皮功能稳态中的分子营养机制，以及类黄酮、磺化与糖苷化类黄酮、脂肪酸、甲基供体食物等营养素的血管生物学与营养药学，为心血管疾病的预防性营养干预和膳食指导提供理论基础，寻找潜在的营养干预靶点与新型健康产品。

④研究生课题涉及食品科学、生物学、医学（药学）、化学等学科基础，以食品加工制备与质量控制（分析）为基本技能，重点开展食品功能因子及天然产物的功能评价、分子营养机制阐释等研究工作，瞄准与引领国际食品营养科学前沿，全面培养研究生的专业科学研究水平。

代表性SCI学术论文（JCR分区）：

1.,XiaolongShi,YanZhao,YadongJiao,TengruiShi,XingbinYang*.ROS-DependentMitochondriaMolecularMechanismsUnderlyingAntitumorActivityofPleurotusabalonusAcidicPolysaccharidesinHumanBreastCancerMCF-7Cells.PloSONE,2013(SCI二区,IF4.092,inpress).

2.TingLi,JiaoZhu,LingGuo,XiaolongShi,YafeiLiu,XingbinYang*.Differentialeffectsofpolyphenols-enrichedextractsfromhawthornfruitpeelsandfleshesoncellcycleandapoptosisinhumanMCF-7breastcarcinomacells.FoodChemistry,2013(SCI二区,IF3.655,inpress).

3.YanfeiSun,XingbinYang*,XinshanLu,DongyingWang,YanZhao*.ProtectiveeffectsofKeemblackteapolysaccharidesonacutecarbon-causedoxidativehepatotoxicityinmice.FoodandChemicalToxicology,2013(Correspondingauthor,SCI二区,IF=2.999,inpress)

4.XingbinYang,CatherinePBondonno,AdelineIndrawan,JonathanMHodgson,KevinDCroft*.AnimprovedmassspectrometrybasedmeasurementofNOmetabolitesinbiologicalfluids.FreeRadicalBiology&Medicine,2013,56,1-8(SCI二区,IF5.769)

5.NianwuHe,XiaolongShi,YanZhao,LingminTian,DongyingWang,XingbinYang*.Inhibitoryeffectsandmolecularmechanismsofselenium-containingteapolysaccharidesonhumanbreastcancerMCF-7cells.JournalofAgriculturalandFoodChemistry,2013,61(3),579-588(Correspondingauthor,SCI一区,IF2.823)

6.XingbinYang,SuYang,YurongGuo,YadongJiao,YanZhao*.Compositionalcharacterizationofsolubleapplepolysaccharides,andtheirantioxidantandhepatoprotectiveeffectsonacuteCCl4-causedliverdamageinmice.FoodChemistry,2013,138,1256-1264(SCI二区,IF3.655)

7.LingminTian,XiaolongShi,LinhongYu,JiaoZhu,RuiMa,XingbinYang*.Chemicalcompositionandhepatoprotectiveeffectsofpolyphenol-richextractfromHouttuyniacordatatea.JournalofAgriculturalandFoodChemistry,2012,60,4641-4648(Correspondingauthor,SCI一区,IF2.823)

8.XingbinYang*,YanZhao.Absorptionandmetabolismofredwindpolyphenolsandtheirpotentialhealthbenefitsincardiovascularfunction.AmericanJournalofClinicalNutrition,2012,95,1496-1497(Correspondingauthor,SCI一区,IF6.669)

9.CatherinePBondonno*,KevinDCroft,IanBPuddey,MichaelJConsidine,XingbinYang,NatalieCWard,JonathanMHodgson.Nitratecausesadose-dependentaugmentationofnitricoxidestatusinhealthywomen.Food&Function,2012,3,522-527(SCI,IF1.179)

10.XingbinYang*.Commentsfor“Cancer:Solvinganage-oldproblem”.Nature,2012,483,S2-S6(SCI,IF36.1)

11.XingbinYang*.Commentsfor“Prevention:Nippedinthebud”.Nature,2012,485,S18-S19(SCI,IF36.1)

12.DongyingWang,YanZhao,YadongJiao,LinhongYu,SuYang,XingbinYang*.AntioxidativeandhepatoprotectiveeffectsofthepolysaccharidesfromZizyphusjujubecv.Shaanbeitanzao.CarbohydratePolymers,2012,88,1453-1459(Correspondingauthor,SCI,IF3.628)

13.HaishengZhang,MinZhang,LinhongYu,YanZhao,NianwuHe,XingbinYang*.Antitumoractivitiesofquercetinandquercetin-5",8-disulfonateinhumancolonandbreastcancercelllines.FoodandChemicalToxicology,2012,50,1589-1599(Correspondingauthor,SCI二区,IF=2.999)

14.NianwuHe,XingbinYang*,YadongJiao,LingminTian,YanZhao*.CharacterizationofantioxidantandantiproliferativeacidicpolysaccharidesfromChinesewolfberryfruits.FoodChemistry,2012,133,978-989(Correspondingauthor,SCI二区,IF3.655)

15.Nian-WuHe,YanZhao,LingGuo,JunShang,Xing-BinYang*.Antioxidant,antiproliferativeandpro-apoptoticactivitiesofasaponinextractderivedfromtherootsofPanaxnotoginseng(Burk.)FH.Chen.JournalofMedicinalFood,201215,350-359(Correspondingauthor,SCI,IF1.408)

16.TongWang,XingbinYang,DongyingWang,YadongJiao,YuWang,YanZhao*.SeparationandquantificationofcompositionalreducingcarbohydratesinpolysaccharidesandfoodsbycapillaryzoneelectrophoresiswithprecolumnPMPderivatization.CarbohydratePolymers,2012,88,754-762(SCI,IF3.628)

17.CatherineP.Bondonno,XingbinYang,KevinD.Croft,MichaelJ.Considine,NatalieC.Ward,LisaRich,IanB.Puddey,EwaldSwinny,AidillaMubarak,JonathanMHodgson*.Flavonoid-richapplesandnitrate-richspinachaugmentnitricoxidestatusandimproveendothelialfunctioninhealthymenandwomen:arandomisedcontrolledtrial.FreeRadicalBiology&Medicine,2012,52,95-102(SCI二区,IF5.769)

18.LingminTian,YanZhao,ChaoGuo,XingbinYang*.AcomparativestudyontheantioxidantactivitiesofanacidicpolysaccharideandvarioussolventextractsderivedfromherbalHouttuyniacordata.CarbohydratePolymers,2011,83,537-544(Correspondingauthor,SCI,IF3.463)

19.XingbinYang,KevinDCroft,YaPLee,TrevorAMori,IanBPuddey,SofiaSipsas,AnneBarden,EwaldSwinny,JonathanMHodgson*.Theeffectsofalupin-enricheddietonoxidativestressandfactorsinfluencingvascularfunctioninoverweightsubjects.AntioxidantsandRedoxSignaling,2010,13,1517-1524(SCI,IF8.209)

20.XingbinYang,YanZhao,NianwuHe,KevinD.Croft*.Isolation,characterization,andimmunologicaleffectsofα-galacto-oligosaccharidesfromanewsource,theherbLycopuslucidusTurcz.JournalofAgriculturalandFoodChemistry,2010,58,8253-8258(SCI一区，IF2.816)

21.XingbinYang,YouLv,LingminTian,YanZhao*.Compositionandsystemicimmuneactivityofthepolysaccharidesfromanherbaltea(LycopuslucidusTurcz).JournalofAgriculturalandFoodChemistry,2010,58,6075-6080（SCI一区,IF2.816）

22.YouLv,XingbinYang*,YanZhao,YunRuan,YingYang,ZhezhiWang.SeparationandquantificationofcomponentmonosaccharidesoftheteapolysaccharidesfromGynostemmapentaphyllumbyHPLCwithindirectUVdetection.FoodChemistry,2009,112,742-746(Correspondingauthor,SCI二区,IF3.146)

23.XingbinYang*,YanZhao,YingYang,YunRuan.Isolationandcharacterizationofimmunostimulatorypolysaccharidefromanherbtea,GynostemmapentaphyllumMakino.JournalofAgriculturalandFoodChemistry,2008,56(16),6905-6909（SCI一区,IF2.562）

24.XingbinYang*,YanZhao,GuoliLi,ZhezhiWang,YouLv.Chemicalcompositionandimmuno-stimulatingpropertiesofpolysaccharidebiologicalresponsemodifierisolatedfromRadixA.sinensis.FoodChemistry,2008,106,269-276(SCI二区,IF3.052)

25.XingbinYang*,YanZhao,YunRuan,YingYang.DevelopmentandapplicationofacapillaryelectrophoreticmethodforthecompositionanalysisofatypicalheteropolysaccharidefromCodonopsispilosulaNannf.Biological&PharmaceuticalBulletin,2008,31(10),1860-1865(SCI,IF1.765)

26.XingbinYang*,YanZhao,YouLv.InvivomacrophageactivationandphysicochemicalpropertyofthedifferentpolysaccharidefractionspurifiedfromAngelicasinensis.CarbohydratePolymers,2008,71,372-379(SCI,IF2.644)

27.XingbinYang*,YanZhao,YouLv.ChemicalcompositionandantioxidantactivityofanacidicpolysaccharideextractedfromCucurbitamoschataDuchesneexPoiret.JournalofAgriculturalandFoodChemistry,2007,55(12),4684-4690（SCI一区,IF2.532）

28.XingbinYang*,YanZhao,YanjuanZhou,YouLv,JieliMao,PingZhao.ComponentandantioxidantpropertiesofpolysaccharidefractionsisolatedfromAngelicasinensis(Oliv.)Diels.Biological&PharmaceuticalBulletin,2007,30(10),1884-1890(SCI,IF1.614)

29.XingbinYang*,YanZhao,HaifangWang,QibinMei*.MacrophageactivationbyanacidicpolysaccharideisolatedfromAngelicasinensis(Oliv.)Diels.BMBReports(JournalofBiochemistryandMolecularBiology),2007,40(5),636-643(SCI,IF2.141)

30.XingbinYang*,YanZhao,YouLv,YingYang,YunRuan.ProtectiveeffectofpolysaccharidefractionsfromRadixA.sinensisagainsttert-butylhydroperoxideinducedoxidativeinjuryinmurineperitonealmacrophages.BMBReports(JournalofBiochemistryandMolecularBiology),2007,40(6),928-935(SCI,IF2.141)

31.XingbinYang,YanZhao,QinweiWang,HaifangWang,QibingMei*.Analysisofthemonosaccharidecomponentsofangelicapolysaccharidesbyhighperformanceliquidchromatography.AnalyticalSciences,2005,21,1177-1180(SCI,IF1.735)

32.YanZhao,XingbinYang,QiaofengWang,PengjuanNan,YingJin,ShengyongZhang*.Determinationofenantiomericexcessfor2,3-dihydroxy-3-phenylpropionatecompoundsbycapillaryelectrophoresisusinghydroxypropyl-β-cyclodextrinaschiralselector.Chirality,2007,19,380-385（SCI-IF2.436）

33.YanZhao,XingbinYang,QiaofengWang,XiaoliSun,RuJiang,ShengyongZhang*.Determinationenantiomericexcessofaromatic1,2-diolswithHP-β-cyclodextrinaschiralselectorbycapillaryelectrophoresis.Chromatographia,2007,66,601-605（SCI,IF1.145）

34.YanZhao,XingbinYang,XiaoLiSun,RuJiang,ShengyongZhang*.Enantiomericseparationofsynthetic2,3-dihydroxy-3-phenylpropionatecompoundsbyβ-cyclodextrin-modifiedcapillaryelectrophoresis.JournalofChromatographyA,2006,1108,258-262(SCI二区,IF3.554)

35.YanZhao,XingbinYang,RuJiang,XiaoliSun,XiaoyeLi,WenminLiu,ShengyongZhang*.AnalysisofopticalpurityandimpurityofsyntheticD-phenylalanineproductsusingsulphatedβ-cyclodextrinaschiralselectorbythereversed-polaritycapillaryelectrophoresis.Chirality,2006,18,84-90（SCI,IF2.165）

36.YanZhao,XingbinYang,RuJiang,XiaoliSun,WenminLiu,ShengyongZhang*.Chiralseparationofsyntheticvicinaldiolcompoundsbycapillaryzoneelectrophoresiswithboratebufferandβ-cyclodextrinaschiralselector.AnalyticalSciences,2006,22,747-751(SCI,IF1.589)

37．XingbinYang,YanZhao,SiyuanZhou,LiLiu,HaifangWang,QibinMei*.AnalysisofmonosaccharidecompositioninAngelicapolysaccharidesbyprecolumnderivatizationhighperformanceliquidchromatography.ChineseJournalofAnalyticalChemistry,2005,33(9),1287-1290(SCIE,IF0.798).

38.YanZhao,LiLiu,XingbinYang,XiaoyeLi,WengminLiu,ShengyongZhang*.AnalysisofthemonosaccharidesinRheumtanguticumpolysaccharidesbycapillaryzoneelectroresis.ChineseJournalofAnalyticalChemistry,2006,34(2),255-258(SCIE,IF0.798)

39.YanZhao,XiaoliSun,XingbinYang,PengjuanNan,YingJin,ShengyongZhang*.Enantiomericseparationandopticalpurityanalysisofthreearylethanedioldbycapillaryzoneelectroresis.ChineseJournalofAnalyticalChemistry,2006,34(3),293-297(SCIE,IF0.798)

40.JingHe,XingbinYang,D.G.Evans,XueDuan.Newmethodstoremoveorganictemplatesfromporousmaterials.MaterialsChemistryandPhysics,2002,77,270-275

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