所属部门：食品科学与工程学院
姓名：刘茜
性别：女
学历学位：博士
职称：讲师，研究生导师
政治面貌：中共党员
社会兼职：健康管理师
营养指导员
陕西省营养学会会员
学习工作经历：
2017年12月-至今，西北大学食品科学与工程学院，讲师
2017年7月-2017年12月，西北大学化工学院食品工程系，讲师
2012年9月-2017年6月，西北农林科技大学食品科学与工程学院，食品科学，博士
2008年9月-2012年6月，西北农林科技大学食品科学与工程学院，食品质量与安全，学士
研究方向：
主要从事食品功能化学与营养方向研究，研究内容具体包括：膳食营养组分对神经退行性疾病及代谢综合征的干预作用；天然食品因子脑神经细胞保护作用的营养功能性评价与分子机制研究；天然多糖生物活性及构效关系研究。承担本科生《食品营养学》、《食品添加剂》等课程讲授。
联系方式：
通讯地址：陕西省西安市碑林区太白北路229号食品科学与工程学院
邮编：710069
电子邮件：qianliu_edu@163.com liuqian2017@nwu.edu.cn


博士，讲师。主要从事食品功能化学与营养方向研究，研究内容具体包括：膳食营养组分对神经退行性疾病及代谢综合征的干预作用；天然食品因子脑神经细胞保护作用的营养功能性评价与分子机制研究；天然多糖生物活性及构效关系研究。目前已在The FASEB Journal、Molecular Nutrition & Food Research、Journal of Agricultural and Food Chemistry、Journal of Functional Foods、Food & Function等发表 SCI 论文 20 余篇。主持国家自然科学基金等科研项目5项。目前任Frontiers in Aging Neuroscience评审编辑。


研究成果：
[1] Qian Liu, Yuwei Chen, Chun Shen, Yating Xiao, Yutang Wang, Zhigang Liu^*, Xuebo Liu^*. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. The FASEB Journal. 2017, 31(4):1494-1507. （IF₂₀₁₇=5.595，2区，TOP 期刊）
该成果被《中国科学报》、Science Daily、Nutrition Insight等国内外媒体广泛报道。
[2] Qian Liu, Yaya Hu, Youfang Cao, Ge Song, Zhigang Liu^*, Xuebo Liu^*. Chicoric Acid ameliorates lipopolysaccharide induced oxidative stress via promoting Keap1/Nrf2 transcriptional signaling pathway in BV-2 microglial cells and mice brain. Journal of Agricultural and Food Chemistry. 2017, 65(2):338-347.
（IF₂₀₁₇=3.412，1区，TOP 期刊，入选当年ESI前1%高被引论文）
[3] Qian Liu, Jie Fang, PanPan Chen, Yun Die, Jing Wang, Zhigang Liu, Xuebo Liu^*. Chicoric acid improves neuron survival against inflammation through promoting mitochondrial function and energy metabolism. Food & Function. 2019, 10(9), 6157-6169.
(IF₂₀₁₉= 4.171, 1区，TOP 期刊）
[4] Qian Liu^#, Yutang Wang^#, ChunXia Xiao, Wanqiang Wu, Xuebo Liu^*. Metabolism of chicoric acid by rat liver microsomes and bioactivity comparisons of chicoric acid and its metabolites. Food & Function. 2015, 6(6):1928-1935.
(IF₂₀₁₅=2.686, 1区，TOP 期刊）
[5] Qian Liu, Fan Liu, Liling Zhang, Yajie Niu, Zhigang Liu, Xuebo Liu^*. Comparison of chicoric acid, and its metabolites caffeic acid and caftaric acid: in vitro protection of biological macromolecules and inflammatory responses in BV2 microglial cells. Food Science and Human Wellness. 2017, 6(4):155-166.
[6] Guiping Gong, Tiantian Dang, Jie Fang, Yangni Deng, Qian Liu, Wei Dai, Jing Sun，Langhong Wang，Yuxia Liu, Tingting Sun, Shuang Song, Luodi Fan, Linjuan Huang*, Zhongfu Wang*. Preparation, Structural Characterization and Bioactivity of PHPD-IV-4 derived from Porphyra haitanensis. Food Chemistry, 2020, 329, 127042. (IF₂₀₁₉=6.306, 2区，TOP 期刊）
[7] Guiping Gong, Qian Liu, Yangni Deng, Tiantian Dang, Wei Dai, Tingting Liu, Yang Liu, Jing Sun, Langhong Wang, Yuxia Liu, Tingting Sun, Shuang Song, Zhongfu Wang^*, Linjuan Huang^*. Arabinogalactan derived from Lycium barbarum fruit inhibits cancer cell growth via cell cycle arrest and apoptosis. International Journal of Biological Macromolecules, 2020, 149(15): 639-650. （IF₂₀₁₉= 5.162，2区）
[8] Tingting Sun, Hong Zhang, Ye Li, Yang Liu, Wei Dai, Jie Fang, Cui Cao, Yun Die, Qian Liu, Chunliu Wang, Lintao Zhao, Guiping Gong, Zhongfu Wang*, Linjuan Huang*. Physicochemical properties and immunological activities of polysaccharides from both crude and wine-processed Polygonatum sibiricum. International Journal of Biological Macromolecules, 2020, 143(15), 255-264. （IF₂₀₁₉= 5.162，2区）
[9] Yangni Deng, Qian Liu, Tiantian Dang, Guiping Gong, Xiaoyi Chen, Rui Tang, JingSun, Shuang Song, Linjuan Huang*, Zhongfu Wang*.Preparation, Structural Characterization and Bioactivity of 4-O-Methylglucuronoxylan from Artemisia sphaerocephala Krasch. Carbohydrate Polymers (2019): 115009. (IF₂₀₁₉= 7.182, 2区，TOP 期刊）
[10] Rui Tang, Xiaoyi Chen, Tiantian Dang, Yangni Deng, Zihua Zou, Qian Liu, Guiping Gong, Shuang Song, Fangli Ma, Linjuan Huang* and Zhongfu Wang^*. Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. Food & Function. 2019. 2019, 10(7), 4231-4241. (IF₂₀₁₉= 4.171, 1区，TOP 期刊）
[11] Xiaoyi Chen, Rui Tang, Tingting Liu, Wei Dai, Qian Liu, Guiping Gong, Shuang Song, Minghua Hu, Linjuan Huang^*, Zhongfu Wang^*. Physicochemical properties, antioxidant activity and immunological effects in vitro of polysaccharides from Schisandra sphenanthera and Schisandra chinensis. International Journal of Biological Macromolecules. 2019, 131:744-751. （IF₂₀₁₉= 5.162，2区）
[12] Zihua Zou^#, Ming Wei^#, Jie Fang, Wei Dai, Tingting Sun, Qian Liu, Guiping Gong,Yuxia Liu, Shuang Song, Fangli Ma, Langhong Wang, Linjuan Huang, Zhongfu Wang^*. Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities. International Journal of Biological Macromolecules, 2019. (DOI: 10.1016/j.ijbiomac.2019.10.192) （IF₂₀₁₉= 5.162，2区）
[13] Jing Wang, Qian Liu, Haifang Xiao, Xingxing Luo, Xuebo Liu^*. Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways. Toxicology in Vitro. 2019,56:75-83. （IF₂₀₁₉= 2.959，3区）
[14] Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu^*, Xuebo Liu^*. Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress. The Journal of Nutritional Biochemistry. 2018, 56: 16-25. （IF₂₀₁₈=4.49，2区）
[15] Guiping Gong, Tiantian Dang, Yangni Deng, Jianli Han, Zihua Zou, Sun Jing, Ying Zhang, Qian Liu, Linjuan Huang, Zhongfu Wang^*. Physicochemical properties and biological activities of polysaccharides from Lycium barbarum prepared by fractional precipitation. International Journal of Biological Macromolecules. 2018, 109: 611-618. （IF₂₀₁₈=4.784，2区）
[16] Zhijun Diao, Jing Li, Qian Liu, Yutang Wang^*. In-vivo metabolite profiling of chicoric acid in rat plasma, urine and feces after oral administration using liquid chromatography quadrupole time of flight mass spectrometry. Journal of Chromatography B. 2018, 8-14:1081-1082. （IF₂₀₁₈=2.813，3区）
[17] Zhigang Liu^#, Yuwei Chen^#, Qinglian Qiao, Yali Sun, Qian Liu, Bo Ren, Xuebo Liu^*. Sesamol supplementation prevents systemic inflammation-induced memory amyloidogenesis via inhibition of nuclear factor kappaB. Molecular Nutrition & Food Research. 2017, 61(5):**. （IF₂₀₁₇=5.151，2区，TOP期刊，入选当年ESI前1%高被引论文）
[18] Zhigang Liu^#, Yali Sun^#, Qinglian Qiao, Tong Zhao, Wentong Zhang, Bo Ren, Qian Liu, Xuebo Liu^*. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system. Food & Function. 2017, 8(2):710-719. （IF₂₀₁₇=3.289，1区，TOP期刊）
[19] Ge Song, Zhigang Liu, Qian Liu, Xuebo Liu^*. Lipoic acid prevents acrylamide-induced neurotoxicity in CD-1 mice and BV2 microglial cells via maintaining redox homeostasis. Journal of Functional Foods. 2017, 35:363–375. （IF₂₀₁₇=3.47，2区）
[20] Yutang Wang^#, Zhijun Diao^#, Jing Li, Bo Ren, Di Zhu, Qian Liu, Zhigang Liu, Xuebo Liu^*. Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system. RSC Advances. 2017, 7(57):36149-36162. （IF₂₀₁₇=2.936，3区）
[21] Yuting Cui, Peiran Lu, Ge Song, Qian Liu, Di Zhu, Xuebo Liu*. Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodinmediated extrinsic and intrinsic human hepatoblastoma cell apoptosis. Food and Chemical Toxicology. 2016, 92: 26-37. （IF₂₀₁₆=3.778，2区，TOP期刊）
[22] Li Yuan, Jing Wang, Wanqiang Wu, Qian Liu, Xuebo Liu*. Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines. Biomedicine & Pharmacotherapy. 2016, 81, 356-362. （IF₂₀₁₆=2.759，3区）
[23] Yutang Wang^#, Guo Xie^#, Qian Liu, Xiang Duan, Zhigang Liu, Xuebo Liu^*. Pharmacokinetics, tissue distribution, and plasma protein binding study of chicoric acid by HPLC-MS/MS. Journal of Chromatography B. 2016, 1031 (15): 139–145. （IF₂₀₁₆=2.603，3区）
[24] Yutang Wang, Laping Liu, Chunxia Xiao, Lin Chen, Peng Yang, Qian Liu, Jianlong Wang, Xuebo Liu*. Rapid determination of trace sulfonamides in milk by graphene oxide based magnetic solid phase extraction coupled with HPLC–MS/MS. Food Analytical Methods. 2016, 9(9): 2521-2530. （IF₂₀₁₆=2.038，2区）
[25] Li Yuan, Yuchen Wu, Xiaomeng Ren, Qian Liu, Jing Wang, Xuebo Liu*. Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia. Molecular and Cellular Biochemistry. 2014, 386:153-165. （IF₂₀₁₄=2.393，3区）
[26] Qisen Xiang, Qian Liu, Li Xu, Yan Qiao, Yutang Wang, Xuebo Liu*. Carnosic acid protects biomolecules from free radical-mediated oxidative damage in vitro. Food Science and Biotechnology. 2013, 22(5): 1381-1388. （IF₂₀₁₃=0.656，4区）
[27] 张月, 刘茜, 肖春霞. 辣椒碱对生物大分子氧化损伤的保护作用. 现代食品科技. 2017, 33(2):41-47.
[28] 张亦凡, 刘功关, 刘茜, 刘学波. 圣草酚抑制自由基诱导的生物大分子损伤及对肝癌细胞HepG2毒性的作用. 食品科学. 2013, 34(17): 126-130.
[29] 齐国源,马旻,刘茜,高楠,吴海云,杜双奎. 不同添加剂对蕨根淀粉凝沉性的影响. 粮食加工. 2011, 36(1): 34-36.

基金项目：
[1] 国家自然科学基金-青年科学基金项目，**，主持
[2] 中国博士后基金面上项目（二等）资助，2020M683542，主持
[3] 陕西省科技厅自然科学基础研究计划一般项目（青年）, 2019JQ-721, 主持
[4] 陕西省教育厅一般专项项目，20JK0936，主持
[5] 西安市科学技术局“农业技术研发项目”，20NYYF0023，主持
[6] 西北大学科研启动基金，，主持；
[7] 陕西省科技厅重点研发计划一般项目-农业领域, 2020NY-201，主要参与。


获奖情况：
[1] 2018年度陕西省科学技术奖二等奖（特色食物组分营养健康功能发掘与作用机制研究）（6/7）
[2] 参与指导学生获得“陕西省第一届营养食品创新创意大赛”一等奖，2019
[3] 首届青年教师讲课比赛，食品科学与工程学院，二等奖，2019
[4] 参与指导学生获得“建行杯”第六届中国国际 “互联网+” 大学生创新创业大赛陕西赛区省级复赛（高教主赛道），铜奖，2020
[5] 第二届青年教师讲课比赛，食品科学与工程学院，二等奖，2020
[6] “2019年度陕西省营养与健康领域先进工作者”，2020
[7] “陕西省第一期营养指导员培训班优秀学员”，2021