教育背景
1999.9-2003.7，山东大学，生物技术学士
2003.9-2008.7，中科院上海药物研究所，药物设计博士


工作经历
2008.8-2011.7，美国加州大学戴维斯分校，博士后
2011.8-2016.8，美国桑福德伯纳姆医学研究所，博士后
2016.9-至今，山东大学微生物技术研究院，教授


研究方向
本课题组专注于研究重大疾病相关的靶标蛋白，如人体内的转录因子蛋白和病原微生物中的关键酶类及毒力因子等。
一方面利用结构生物学和分子药理学等方法，研究这些蛋白的结构和功能，并揭示蛋白和配体的相互作用，以及配体调控蛋白活性的分子机理；另一方面通过设计和搭建多种化合物筛选体系，发现新的靶向小分子，并进一步通过计算模拟和结构改造等手段，获得活性更好的新药先导化合物。

目前重点研究“类核受体”转录因子蛋白——bHLH-PAS（basic helix-loop-helix-PER-ARNT-SIM）家族，它们与很多人类疾病密切相关，而且普遍含有小分子配体结合口袋，因此是继核受体之后第二个可作为潜在药物靶标的转录因子家族。相关研究成果先后以第一或共同通讯作者发表在Nature、Nature Chemical Biology、Nature Communications、eLife、MCB、ATVB等国际学术期刊上。迄今共发表SCI论文32篇，谷歌学术h-index为21。

科研项目
6. 山东省泰山****青年专家计划，2020/1-2024/12，主持
5. 致病微生物III型分泌系统结构与功能的研究，国家重点研发计划（政府间国际科技创新合作重点专项），2019/11-2022/10，参与
4. 中德合作项目-亥姆霍兹国际实验室经费，2019/1-2023/12，参与
3. 介导微生物和宿主间信号传递的芳香烃受体AHR的结构和功能研究，国家自然科学基金青年基金，2018/1-2020/12，主持
2. 神经转录因子NPAS4的结构和功能研究，江苏省基础研究计划青年基金（山东大学苏州研究院），2017/7-2020/6，主持
1. 山东大学齐鲁青年****学科建设经费，2016/9-2021/9，主持
发表论文
回国工作后：
32. Xu M, Xu HH, Lin Y, Sun X, Wang LJ, Fang ZP, Su XH, Liang XJ, Hu Y, Liu ZM, Cheng Y, Wei Y, Li J, Li L, Liu HJ, Cheng Z, Tang N, Peng C, Li T, Liu T, Qiao L, Wu D, Ding YQ, Zhou WJ. LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis. Cell. 2019, 178: 1478-1492.
31. Wu D*, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim Y, Khorasanizadeh S, Rastinejad F*. Bidirectional modulation of HIF-2 activity through chemical ligands.Nat Chem Biol.2019, 15: 367-376. （*共同通讯作者）[获得F1000Prime推荐]
30. Chandra V#,Wu D#, Li S, Potluri N, Kim Y, Rastinejad F. The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission.Nat Commun. 2017, 8: 868.（#共同第一作者）
29. Wu D, Rastinejad F. Structural characterization of mammalian bHLH-PAS transcription factors.Curr Opin Struct Biol. 2017, 43: 1-9.
在美博后期间：
28. Smith SH, Jayawickreme C, Rickard DJ, Nicodeme E, Bui T, Simmons C, Coquery CM, Neil J, Pryor WM, Mayhew D, Rajpal DK, Creech K, Furst S, Lee J,Wu D, Rastinejad F, Willson TM, Viviani F, Morris DC, Moore JT, Cote-Sierra J. Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.J Invest Dermatol. 2017, 137: 2110-2119.
27. Wu D, Su X, Potluri N, Kim Y, Rastinejad F. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.eLife.2016, 5: e18790.
26. Vogel CF, Charrier JG,Wu D, McFall AS, Li W, Abid A, Kennedy IM, Anastasio C. Physicochemical properties of iron oxide nanoparticles that contribute to cellular ROS-dependent signaling and acellular production of hydroxyl radical.Free Radic Res. 2016, 50: 1153-1164.
25. Vogel CF, Chang WL, Kado S, McCulloh K, Vogel H,Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F, Gershwin ME. Transgenic overexpression of aryl hydrocarbon receptor repressor (AhRR) and AhR-mediated induction of CYP1A1, cytokines, and acute toxicity.Environ Health Perspect. 2016, 124: 1071-1083.
24. Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors.Nature. 2015, 524: 303-308.[在Nature同期News&Views栏目中被特别介绍，并获得F1000Prime推荐]
23. Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL,Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB.J Biol Chem. 2014, 289: 1866-1875.
22. Wu D, Potluri N, Kim Y, Rastinejad F. Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.Mol Cell Biol. 2013, 33: 4346-4356. [被编辑选为当期“意义显著”论文之一]
21. Chandra V, Huang P, Potluri N,Wu D, Kim Y, Rastinejad F. Multidomain integration in the structure of the HNF-4α nuclear receptor complex.Nature. 2013, 495: 394-398.
20. Vogel CF,Wu D, Goth SR, Baek J, Lollies A, Domhardt R, Grindel A, Pessah IN. Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation.Immunol Cell Biol. 2013, 91: 568-575.
19. Vogel CF, Garcia J,Wu D, Mitchell DC, Zhang Y, Kado NY, Wong P, Trujillo DA, Lollies A, Bennet D, Schenker MB, Mitloehner FM. Activation of inflammatory responses in human U937 macrophages by particulate matter collected from dairy farms: an in vitro expression analysis of pro-inflammatory markers.Environ Health. 2012, 11: 17.
18. Wu D#, Nishimura N#, Kuo V, Fiehn O, Shahbaz S, Van Winkle L, Matsumura F, Vogel CF. Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice.Arterioscler Thromb Vasc Biol. 2011, 31: 1260-1267. （#共同第一作者）[被编辑在同期社论中推荐]
17. Wu D, Wong P, Li W, Vogel CF, Matsumura F. Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.Toxicology. 2011, 285: 97-103.
16. Wu D, Li W, Lok P, Matsumura F, Vogel CF. AhR deficiency impairs expression of LPS-induced inflammatory genes in mice.Biochem Biophys Res Commun. 2011, 410: 358-363.
15. Fujisawa Y, Li W,Wu D, Wong P, Vogel C, Dong B, Kung HJ, Matsumura F. Ligand-independent activation of the aryl hydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment.Biol Chem. 2011, 392: 897-908.
14. Vogel CF, Li W,Wu D, Miller JK, Sweeney C, Lazennec G, Fujisawa Y, Matsumura F. Interaction of aryl hydrocarbon receptor and NF-κB subunit RelB in breast cancer is associated with interleukin-8 overexpression.Arch Biochem Biophys. 2011, 512: 78-86.
13. Dong B, Cheng W, Li W, Zheng J,Wu D, Matsumura F, Vogel CF. FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl hydrocarbon receptor.Biochim Biophys Acta. 2011, 1810: 427-431.
12. Sciullo EM, Vogel CF,Wu D, Murakami A, Ohigashi H, Matsumura F. Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages.Arch Toxicol. 2010, 84: 957-966.
11. Li W, Vogel CF,Wu D, Matsumura F. Non-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL/6J mice.Biol Chem. 2010, 391: 1205-1219.
在沪读博期间：
10. Han C, Hu T,Wu D, Qu S, Zhou J, Ding J, Shen X, Qu D, Jiang H. X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis.FEBS J. 2009, 276: 1125-1139.
9. Wu D, Kong Y, Han C, Chen J, Hu L, Jiang H, Shen X. D-Alanine-D-alanine ligase as a new target for the flavonoids quercetin and apigenin.Int J Antimicrob Agents. 2008, 32: 421-426.
8. Wu D, Zhang L, Kong Y, Du J, Chen S, Chen J, Ding J, Jiang H, Shen X. Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori.Proteins. 2008, 72: 1148-1160.
7. Wu D, Hu T, Zhang L, Chen J, Du J, Ding J, Jiang H, Shen X. Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis.Protein Sci. 2008, 17: 1066-1076.
6. Hu T#,Wu D#, Chen J, Ding J, Jiang H, Shen X. The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis.J Biol Chem. 2008, 283: 21284-21293.（#共同第一作者）
5. Kong Y#,Wu D#, Bai H, Han C, Chen J, Chen L, Hu L, Jiang H, Shen X. Enzymatic characterization and inhibitor discovery of a new cystathionine γ-synthase from Helicobacter pylori.J Biochem. 2008, 143: 59-68.（#共同第一作者）
4. Zhang L#, Kong Y#,Wu D#, Zhang H, Wu J, Chen J, Ding J, Hu L, Jiang H, Shen X. Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay.Protein Sci. 2008, 17: 1971-1978.（#共同第一作者）
3. Kong D, Zhu W,Wu D, Shen X, Jiang H. Comparison of three 3D-QSAR methods using a novel class of MURF inhibitors.J Theor Comput Chem. 2007, 6: 63-80.
2. Cai J, Han C, Hu T, Zhang J,Wu D, Wang F, Liu Y, Ding J, Chen K, Yue J, Shen X, Jiang H. Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.Protein Sci. 2006, 15: 2071-2081.
1. Luo H,Wu D, Shen C, Chen K, Shen X, Jiang H. Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction.Int J Biochem Cell Biol. 2006, 38: 589-599.
（下划线标注的为代表论文）

获奖情况
2018年全国海洋药物药理学术大会优秀青年报告奖