教育背景
博士 2012.10-2017.3 德国萨尔大学/亥姆霍兹药物研究所 药物生物技术
2008.9-2012.10湖南师范大学 微生物学
学士 2004.10-2008.6湖南科技大学 生物技术


工作经历
起止时间 单位名称 专业技术职务
2019.9-至今 山东大学 微生物技术研究院/国家重点实验室 教授
2019.5-2019.8山东大学微生物技术研究院/国家重点实验室 副研究员
2017.1-2019.3德国萨尔州亥姆霍兹药物研究所 博士后

研究方向
1.微生物活性代谢产物的挖掘
2. 微生物次级代谢产物的生物合成机制研究（基因组编辑、基因簇克隆、异源表达、功能酶的催化机理）
3.活性天然产物的合成生物学改造

科研项目
1.国家重点研发计划子课题（2019YFA**），2020-2024，主持
2. 山东省泰山****青年专家计划，2020-2024，主持
3. 山东大学齐鲁青年****启动经费，2019-2024, 主持

代表性论文
Yan Fu and Müller Rolf*.Class I methyltransferase VioH catalyzes unusual SAM cyclization leading to 4-methylazetidinecarboxylic acid formation in vioprolide biosynthesis.ACS Chemical Biology, 2019, 14(1), 99–105.
Yan Fu,# Auerbach David,# Chai Yi, Keller Lena, Tu Qiang, Hüttel Stephan, Glemser Ameli, Grab A. Hanusch, Bach Thorsten, Zhang Youming,* Müller Rolf*. Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation.Angewandt Chemie International Edition, 2018, 57(28):8754-8759.
Yan Fu,# Burgard Christian,# Popoff Alexander, Zaburannyi Nestor, Zipf Gregor, Maier Josef, Bernauer S. Hubert, Wenzel C. Silke, Müller Rolf*.Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production.Chemical Science, 2018, 9, 7510-7519.
Auerbach David,#Yan Fu,# Zhang Youming and Müller Rolf*. Characterization of an unusual glycerate esterification process in vioprolide biosynthesis.ACS Chemical Biology, 2018, 13(11), 3123–3130 .
Bian Xiaoying, Plaza Alberto,Yan Fu, Zhang Youming, Müller Rolf*. Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide.Biotechnology and bioengineering, 2015, 112(7):1343-1353.
Yin Jia, Hoffmann Michael, Bian Xiaoying, Tu Qiang,Yan Fu, Xia Liqiu, Ding Xuezhi, Stewart A. Francis, Müller Rolf, Fu Jun, Zhang Youming*. Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster fromStreptomyces albus DSM41398 inStreptomyces coelicolor A3(2).Scientific reports, 2015, 5, 15081.
Yan Fu, Cheng Xing, Ding Xuezhi, Yao Ting, Chen Hanna, Li Wenping, Hu Shengbiao, Yu Ziquan, Sun Yunjun, Zhang Youming, Xia Liqiu*. Improved insecticidal toxicity by fusing Cry1Ac ofBacillus thuringiensis with Av3 ofAnemonia viridis.Current Microbiology, 2014, 68(5):604-609.
Zhang Yunlei, Zhang Youming, Xia Liqiu,* Zhang Xiangli, Ding Xuezhi,Yan Fu, Wu Feng.E.coli Nissle 1917 targets and cures the primary tumors through expressing azurin protein.Applied Environmental Microbiology, 2012, 78(21):7603-7610.
Li Wenping, Xia Liqiu,* Ding Xuezhi, Lv Yuan, Luo Yushuang, Hu Shengbiao, Yin Jia,Yan Fu. Expression and characterization of a recombinant Cry1Ac crystal protein fused with an insect-specific neurotoxin ω-ACTX-Hv1a inBacillus thuringiensis.Gene, 2012, 498(2):323-327.