联系方式
Email:wuchangsheng@sdu.edu.cn
办公地址：N1楼309室


教育背景
2011.09-2015.08，荷兰莱顿大学，分子生物技术，博士；
2008.09-2011.06，山东大学，天然产物化学，硕士；
2004.09-2008.06，山东大学，药学专业，本科。


工作经历
2018.7至今，山东大学微生物技术研究院，教授
2017.04-2018.07，美国洛克菲勒大学，宏基因组学，博士后；
2015.09-2017.02，荷兰莱顿大学，分子生物技术，博士后；


研究方向
1.微生物来源的新颖天然产物的发现
2.新颖天然产物的生物合成及合成生物学改造


主持或参加科研项目:
1. 山东大学“齐鲁青年****”学科建设经费， 2018.08-2023.07，在研，主持。
2. 荷兰科学研究组织Rubicon基金项目，2017.04-2019.03，已结题，主持。


所获奖励
1.2015年莱顿大学优秀博士毕业奖
2. 2017年莱顿大学科学学院c.j.kok jury award


发表论文
1.Zhang, P.; Zhang, Z.; Li, Z. F.; Chen, Q.; Li, Y. Y.; Gong, Y.; Yue, X. J.; Sheng, D. H.; Zhang, Y. M.;Wu,C.*; Li, Y. Z.* Phylogeny-guided Characterization of Glycosyltransferases for Epothilone Glycosylation.Microbiol. Biotech.2019, doi.org/10.1111/1751-7915.13421. (*共同通讯)
2.Wu, C.^#; ShangZ.^#; Lemetre C.; Ternei M. A. ;Brady S. F.;Cadasides, calcium-dependent acidic lipopeptides from the soil metagenome that are active against multidrug resistant bacteria.J. Am. Chem. Soc.2019,141, 3910-3919. (#共同一作)
3.Machushynets N.;Wu, C. *; Elsayed S. S.; Hankemeier T.; van Wezel G. P. * Discovery of novel glycerolated quinazolinones fromStreptomyces sp. MBT27.J. Ind. Microbiol. Biotechnol. 2019.46, 483-492. (*共同通讯)
4.Wu, C.; van der Heul, H.U.; Melnik, A. V.; Luebben, J.; Pannu, N.; Dorrestein, P. C.; Choi, Y. H.; van Wezel, G. P. Lugdunomycin, an angucycline-derived molecule with unprecedented chemical architecture.Angew. Chem. Int. Ed.2019,58,2809 –2814.
5. Wu, C.; Du, C.; Ichinose, K.;Choi, Y. H.; van Wezel, G. P. Discovery ofC-glycosylpyranonaphthoquinones inStreptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow. J. Nat. Prod. 2017, 80, 269–277.
6. Gubbens, J.; Wu, C.;Zhu, H.;Filippov,D. V.;Florea, B. L.;Rigali, S.;Overkleeft, H. S.; van Wezel, G. P. Intertwined Precursor Supply during Biosynthesis of the Catecholate–Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.ACS Chem. Biol.2017,12, 2756–2766.
7. Wu, C.; Ichinose, K.;Choi, Y. H.; van Wezel, G. P. Aromatic Polyketide GTRI-02 is a previously unidentified product of the act gene cluster inStreptomyces coelicolor A3(2).ChemBioChem.2017, 18, 1428–1434.
8.Wu, C.; Medema, M. H.; L?kamp, R. M.; Zhang, L.; Dorrestein, P. C.; Choi, Y. H.; van Wezel, G. P. Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes inKitasatospora sp. MBT66.ACS Chem. Biol. 2016,11, 478–490.
9.Wu, C.^#; Zhu, H.^#; van Wezel, G. P.; Choi, Y. H. Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids.Metabolomics 2016, 12:90. (#共同一作)
10. Wu, C.; Choi, Y. H.; van Wezel, G. P. Metabolic profiling as a tool for prioritizing antimicrobial compounds.J. Ind. Microbiol. Biotechnol.2016,43, 299–312.
11.Wu, C.; Du, C.; Gubbens, J.; Choi, Y. H.; van Wezel, G. P. Metabolomics-Driven Discovery of a Prenylated Isatin Antibiotic Produced byStreptomyces Species MBT28.J. Nat. Prod.2015,78, 2355–2363.
12. Wu, C.; Kim, H. K.; van Wezel, G. P.; Choi, Y. H. Metabolomics in the natural products field – a gateway to novel antibiotics.Drug Discov. Today Technol.2015,13, 11–17.
13. Wu, C.; Zacchetti, B.; Ram, A. F. J.; van Wezel, G. P.; Claessen, D.; Choi, Y. H. Expanding the chemical space for natural products byAspergillus-Streptomyces co-cultivation and biotransformation.Sci. Rep.2015,5, 10868.
14.Wu, C.; van Wezel, G. P.; Choi, Y. H. Identification of novel endophenaside antibiotics produced byKitasatospora sp. MBT66.J. Antibiot. (Tokyo).2015,68, 445–452.
15. Zheng, L.; Wang, M.; Ibarra-Estrada, E.; Wu, C.; Wilson, E.; Verpoorte, R.; Klinkhamer, P.; Choi, Y. H. Investigation of Chemomarkers of Astragali Radix of Different Ages and Geographical Origin by NMR Profiling. Molecules2015,20, 3389–3405.
16. Yuan, C.; Li, G.;Wu, C.; Wang, H.; Zhao, Z.; Lou, H. A New Fatty Acid from the Endolichenic FungusMassarina sp.Chem. Nat. Compd.2015,51, 415–417.
17. Zhu, H.; Swierstra, J.;Wu, C.; Girard, G.; Choi, Y. H.; Van Wamel, W.; Sandiford, S. K.; van Wezel, G. P. Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils. Microbiology2014,160, 1714–1726.
18. Yuan, C.; Wang, H.;Wu, C.; Jiao, Y.; Li, M.Wang, Y.; Wang, S.; Zhao, Z.; Lou, H.Austdiol, fulvic acid and citromycetin derivatives from an endolichenic fungus,Myxotrichum sp.Phytochem. Lett.2013,6, 662–666.
19.Wu, C.; Lin, Z.; Wang, L.; Guo, D. Phenolic Compounds with NF-κB Inhibitory Effects from the FungusPhellinus baumii.Bioorg. Med. Chem. Lett. 2011,21, 3261–3267.
20. Wang, L.; Guo, D.; Wang, S.; Wu, C.; Rehman, M. U.; Lou, H. Phenolic Glycosides from the Chinese LiverwortReboulia hemisphaerica.Helv. Chim. Acta 2011,94, 1146–1152.



专利
Wu, C.; Choi, Y. H.; van Wezel, G. P. Methods of preparation and use of novel polyketides. EuropeanPatentApplication.WO