姓 名
陈洁
性别
女


出生年份
1977年7月
职称
副教授/硕士生导师

固定电话

E-mail
77chenjie@sdu.edu.cn




个人简介
陈洁，博士，副教授，妇幼保健专业硕士生导师，现任社会医学与妇幼保健学系副主任。近年来承担国家级课题2项，省部级课题2项。以第一作者或通讯作者在国内外发表论文10余篇，其中SCI收录8篇。主要从事妇科肿瘤防治以及孕产妇遗传咨询、产前诊断、生殖内分泌疾病的研究。
教育经历
2015.08-2016.08: 斯坦福大学，访问****
2014.07-2015.09：山东大学，博士后
2000.09-2005.07：山东大学，博士，妇产科
1995.09-2000.07：山东大学，本科，临床医学
工作经历
2013.07至今 山东大学公共卫生学院 副教授/硕士生导师
2005.07-2013.07 山东大学公共卫生学院 讲师
研究领域
1.妇科肿瘤防治，肿瘤分子标志物鉴定与早期筛查，恶性肿瘤发生转移的分子监测及机制研究。
2.孕产妇遗传咨询、产前诊断、生殖内分泌疾病的研究。
承担的主要研究课题
1. STEAP1 在卵巢癌发生发展和血管生成中作用机制的研究 山东省自然科学基金2017.08-2020.06 负责人
2. EFEMP1对卵巢癌细胞侵袭转移和血管生成作用的研究 国家自然科学基金项目2013.01-2015.12 负责人
3. fibulin-4在卵巢癌发生发展中作用机制的研究 中国博士后科学基金项目2014.06-2016.06 负责人
4. HMGB1促进卵巢癌细胞侵袭转移分子机制的研究 山东大学自主创新项目2012.01-2014.12 负责人
主要学术论文
1.Chen J, Wang M, Xi B, Xue J, He D, Zhang J, Zhao Y. SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. PLoS One. 2012;7(8):e42413. Epub 2012 Aug 3. （SCI）
2.Chen J, Shi D, Liu X, Fang S, Zhang J, Zhao Y. Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis. BMC Cancer. 2012 Oct 10;12(1):464.（SCI）
3.Chen J, Zhang J, Zhao Y, Li J, Fu M. Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones. J Cancer Res Clin Oncol. 2009; 135(7): 909-917. （SCI）
4.Chen J, Wei D, Zhao Y, Liu X, Zhang J. Overexpression of EFEMP1 Correlates with Tumor Progression and Poor Prognosis in Human Ovarian Carcinoma. PLoS One. 2013 Nov 13;8(11):e78783. （SCI）
5.Chen J, Zhang J, Liu X, Fang R, Zhao Y, Ma D. Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncol Rep. 2014 Jun;31(6):2601-10. （SCI）
6.Chen J, Liu Z, Fang S, Fang R, Liu X, Zhao Y, Li X, Huang L, Zhang J. Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas. BMC Cancer. 2015 Mar 4;15:91. （SCI）
7.Yin X, Fang S, Wang M, Wang Q, Fang R, Chen J（Corresponding author）. EFEMP1 promotes ovarian cancer cell growth, invasion and metastasis via activated the AKT pathway. Oncotarget. 2016 Jul 26;7(30):47938-47953.（SCI）
8.Wang T, Wang M, Fang S, Wang Q, Fang R, Chen J（Corresponding author）. Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway. Oncotarget. 2017 Mar 21;8(12):18991-19012.（SCI）

Curriculum Vitae
Family name: Jie
First names: Chen
Year of birth: July 24, 1977
Gender: Female
Working institution: Institute of Maternal and Child Health,
School of Public Health, Shandong University
Working experiences /Present position: Associate Professor
2013-to date Associate Professor, School of Public Health, Shandong University.
2005-2013 Lecturer, School of Public Health, Shandong University.
Education:
Institution
(Date from - Date to)
Degree(s) or Diploma(s) obtained:

Stanford University,
USA（2015.08-2016.08）
Visiting scholar, OBGYN

Shandong University, P.R. China
(2000.09-2005.07)
Ph.D (direct PhD program), School of Medicine

Shandong University, P.R. China
(1995.09-2000.07)
M.B., School of Medicine

Expertise/Research issues:
1) Study on genetic counseling, prenatal diagnosis and reproductive endocrine diseases in pregnant women.
2) Molecular identification and early screening of tumor markers; mechanism of carcinogenesis and metastasis of malignant maternal tumors.
Selected Research Projects as PIs:
1) Study on the mechanism of STEAP1 in carcinogenesis, development and angiogenesis of ovarian cancer
Agency: Shandong Natural Science Foundation of China
Funding period: August 1, 2017- June 30, 2020
2) The research about the role of EFEMP1 in ovarian cancer invasion, metastasis and angiogenesis
Agency: National Nature Science Foundation of China
Funding period: January 1, 2013- December 30, 2015
3) The role of fibulin-4 in the pathogenesis and development of ovarian cancer
Agency: China Postdoctoral Science Foundation
Funding period: January 1, 2013- December 30, 2014
Selected Publications：
1) Chen J, Wang M, Xi B, Xue J, He D, Zhang J, Zhao Y. SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. PLoS One. 2012;7(8):e42413. Epub 2012 Aug 3. IF：3.534
2) Chen J, Shi D, Liu X, Fang S, Zhang J, Zhao Y. Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis. BMC Cancer. 2012 Oct 10;12(1):464. IF：3.319
3) Chen J, Zhang J, Zhao Y, Li J, Fu M. Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones. J Cancer Res Clin Oncol. 2009; 135(7): 909-917. IF：3.009
4) Chen J, Wei D, Zhao Y, Liu X, Zhang J. Overexpression of EFEMP1 Correlates with Tumor Progression and Poor Prognosis in Human Ovarian Carcinoma. PLoS One. 2013 Nov 13;8(11):e78783. IF：3.534
5) Chen J, Zhang J, Liu X, Fang R, Zhao Y, Ma D. Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncol Rep. 2014 Jun;31(6):2601-10. IF：2.191
6) Chen J, Liu Z, Fang S, Fang R, Liu X, Zhao Y, Li X, Huang L, Zhang J. Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas. BMC Cancer. 2015 Mar 4;15:91. IF：3.319
7) Yin X, Fang S, Wang M, Wang Q, Fang R, Chen J (Corresponding author). EFEMP1 promotes ovarian cancer cell growth, invasion and metastasis via activated the AKT pathway. Oncotarget. 2016 Jul 26;7(30):47938-47953.
8) Wang T, Wang M, Fang S, Wang Q, Fang R, Chen J (Corresponding author). Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway. Oncotarget. 2017 Mar 21;8(12):18991-19012.