姓 名:
　刘爱骅 性 别:
　男
职 称:
　研究员 学 历:
　博士
电 话:
　** 传 真:
　**
电子邮件:
　liuah (AT) qibebt.ac.cn 个人主页:
　http://biosensor.qibebt.ac.cn
通讯地址:
　青岛市松岭路189号36号信箱　266101

简历：
2004年3月获日本东北大学博士学位, 主攻生物电化学及功能性自组装膜在生物传感上的应用。2004年至2006年，作为日本学术振兴会(JSPS)特别研究员，在日本产业综合技术研究所从事纳米管的功能化及其在生物传感上的应用研究。2006年5月至2010年5月先后在美国Michigan State University, University of Oklahoma及University of Texas做博士后研究, 分别从事基于高性能搀硼金钢石的生物器件、基于噬菌体的可控自组装、基于纳米技术的基因芯片、蛋白质纳米孔的DNA测序等方面的研究工作。2009年起任Frontiers in Bioscience責任编辑。已在Angewandte Chemie International Edition, Advanced Materials, Advanced Functional Materials, Analytical Chemistry和Biosensors & Bioelectronics等国外著名期刊上发表SCI论文50余篇。论文被他人总引用1600余次。受邀撰写英文专著章节共3部，已在美国出版。现主持国家自然科学基金重大研究计划项目、国家自然科学基金面上项目、中科院知识创新工程重要方向项目、中科院"百人计划"项目等。主要研究兴趣为：微生物(细菌、酵母或噬菌体)表面高效展示；生物纳米结构的可控自组装及其功能化；研发适用于生物能源过程监测和评价、工业控制、环境检测和食品安全的分析仪器、生物芯片和传感装置；生物燃料电池技术。

研究方向：
（1）生物纳米结构的可控自组装及其功能化；（2）生物芯片；（3）电化学生物传感器；（4）生物燃料电池。

专家类别：
研究员，百人计划

职务：
团队负责人

社会任职：


获奖及荣誉：
美国Sigma Xi科学研究协会杰出会员(2008)

日本学术振兴会(JSPS)Fellowship (2004)

日本国际教育协会赏(2003)




承担科研项目情况：


代表论著：
　　1. Fei Wang, Pei Liu, Lin Sun, Cuncheng Li*, Valery A. Petrenko*, and Aihua Liu*, Bio-mimetic Nanostructure Self-assembled from Au@Ag Heterogeneous Nanorods and Phage Fusion Proteins for Targeted Tumor Optical Detection and Photothermal Therapy, Scientific Reports 2014, 4, 6808.

　　2. Huan Qi, Fei Wang, Valery A. Petrenko, and Aihua Liu*, Peptide Microarray with Ligands at High Density Based on Symmetrical Carrier Landscape Phage for Detection of Cellulase, Analytical Chemistry 2014, 86, 5844–5850.

　　3. Chuantao Hou, Dapeng Yang, Bo Liang, and Aihua Liu*, Enhanced Performance of Glucose/O₂ Biofuel Cell Assembled with Laccase-Covalently Immobilized Three-Dimensional Macroporous Gold Film Based Biocathode, Analytical Chemistry 2014, 86, 6057–6063.

　　4. Xiangjiang Tang, Tingting Zhang, Bo Liang, Dongfei Han, Lingxing Zeng, Cheng Zheng, Tie Li, Mingdeng Wei, and Aihua Liu*, Sensitive electrochemical microbial biosensor for p-nitrophenylorganophosphates based on electrode modified with cell surface-displayed organophosphorus hydrolase and ordered mesopore carbons, Biosensors and Bioelectronics 2014, 60, 137-142.

　　5. Tingting Zhang, Lingxing Zeng, Lei Han, Tie Li*, Cheng Zheng, Mingdeng Wei, and Aihua Liu*, Ultrasensitive Electrochemical Sensor for p-Nitrophenyl Organophosphates Based on Ordered Mesoporous Carbons at Low Potential without Deoxygenization, Analytica Chimica Acta 2014, 822, 23–29.

　　6. Qiaolin Lang, Fei Wang, Long Yin, Mingjun Liu, Valery A. Petrenko, and Aihua Liu*, Specific probe selection from landscape phage display library and its application in enzyme-linked immunosorbent assay of free prostate-specific antigen, Analytical Chemistry 2014, 86, 2767-2774.

　　7. Xiangjiang Tang, Bo Liang, Tuyong Yi *, Giuseppe Manco, Ilaria Palchetti, and Aihua Liu*, Cell surface display of organophosphorus hydrolase for sensitive spectrophotometric detection of p-nitrophenol substituted organophosphates, Enzyme and Microbial Technology 2014, 55, 107-112.

　　8. Tingting Zhang, Qiaolin Lang, Lingxing Zeng, Tie Li, Mingdeng Wei*, and Aihua Liu*, Substituent effect on the oxidation peak potentials of phenol derivatives at ordered mesoporous carbons modified electrode and its application in determination of acidity coefficients (pKa), Electrochimica Acta 2014, 115, 283–289.

　　9. Qiaolin Lang, Long Yin, Jianguo Shi, Liang Li, Lin Xia, and Aihua Liu*, Co-immobilization of glucoamylase and glucose oxidase for electrochemical sequential enzyme electrode for starch biosensor and biofuel cell, Biosensors and Bioelectronics 2014, 51, 158-163.

　　10. Bo Liang, Qiaolin Lang, Xiangjiang Tang, and Aihua Liu*, Simultaneously improving stability and specificity of cell surface displayed glucose dehydrogenase mutants to construct whole-cell biocatalyst for glucose biosensor application, Bioresource Technology 2013, 147, 492–498.

　　11. Hongwei Wang, Qiaolin Lang, Liang Li, Bo Liang, Xiangjiang Tang, Lingrang Kong, Marco Mascini, and Aihua Liu*, Yeast surface displaying glucose oxidase as whole-cell biocatalyst: Construction, characterization and its electrochemical glucose sensing application, Analytical Chemistry 2013, 85, 6107–6112.

　　 12. Bo Liang, Liang Li, XiangJiang Tang, Qiaolin Lang, Hongwei Wang, Feng Li, Jianguo Shi, Wei Shen, Ilaria Palchetti, Marco Mascini, and Aihua Liu*, Microbial surface display of glucose dehydrogenase for amperometric D-glucose biosensor, Biosensors and Bioelectronics 2013, 45, 19-24.

　　8. Lin Xia, Bo Liang, Liang Li, Xiangjiang Tang, Ilaria Palchetti, Marco Mascini,and Aihua Liu*, Direct energy conversion from xylose using xylose dehydrogenase surface displayed bacteria based enzymatic biofuel cell, Biosensors & Bioelectronics 2013, 44, 160-163.

　　13. Liang Li, Bo Liang, Feng Li*, Jianguo Shi, Marco Mascini, Qiaolin Lang, and Aihua Liu*, Co-immobilization of glucose oxidase and xylose dehydrogenase displayed whole cell on multiwalled carbon nanotube nanocomposite films modified electrode for simultaneous voltammetric detection of D-glucose and D-xylose, Biosensors & Bioelectronics 2013, 42, 156-162.

　　14. Huan Qi, Haiqin Lu, Hua-ji Qiu, Valery A. Petrenko*, and Aihua Liu*, Phagemid vectors for phage display: Properties, characteristics and construction, Journal of Molecular Biology 2012, 417, 129-143.

　　15. Liang Li, Bo Liang, Jianguo Shi, Feng Li, Marco Mascini*, and Aihua Liu*, A selective and sensitive D-xylose electrochemical biosensor based on xylose dehydrogenase displayed on the surface of bacteria and multi-walled carbon nanotubes modified electrode, Biosensors and Bioelectronics 2012, 33, 100-105.

　　16. Bo Liang, Liang Li, Marco Mascin*, and Aihua Liu*, Construction of xylose dehydrogenase displayed on the surface of bacteria using ice nucleation protein for sensitive D-xylose detection, Analytical Chemistry 2012, 84, 275-282.

　　17. Aihua Liu, Qitao Zhao, D. M. Milan Krishantha, and Xiyun Guan, Unzipping of double-stranded DNA in engineered α-hemolysin pores, The Journal of Physical Chemistry Letters 2011, 2, 1372-1376.

　　18. Aihua Liu*, Liyou Wu, Zhili He, and Jizhong Zhou*, Development of highly fluorescent silica nanoparticles chemically doped with organic dye for sensitive DNA microarray detection, Analytical and Bioanalytical Chemistry 2011, 401, 2003-2011.

　　19. Aihua Liu, Gopal Abbineni, and Chuanbin Mao, Nanocomposite films layer-by-layer assembled from genetically engineered filamentous viruses and gold nanoparticles: nanoarchitecture- and humidity-tunable surface plasmon resonance spectra, Advanced Materials 2009, 21, 1001-1005.

　　20. Chuanbin Mao, Aihua Liu, and Binrui Cao, Virus-based chemical and biological sensing, Angewandte Chemie International Edition 2009, 48, 6790-6810.

　　21. Aihua Liu*, Towards development of chemosensors and biosensors with metal-oxide based nanowires or nanotubes, Biosensors & Bioelectronics 2008, 24, 167-177.

　　22. Aihua Liu*, Haoshen Zhou*, Masaki Ichihara, and Itaru Honma, Switchable titanate-nanotube electrode sensitive to nitrate, Applied Physics Letters 2007, 90, 253112.

　　23. Aihua Liu, Masaki Ichihara, Itaru Honma, and Haoshen Zhou, Vanadium-oxide nanotubes: synthesis and template-related electrochemical properties, Electrochemistry Communications 2007, 9, 1766-1771.

　　24. Aihua Liu, Itaru Honma, and Haoshen Zhou, Simultaneous voltammetric detection of dopamine and uric acid at their physiological level in the presence of ascorbic acid using poly(acrylic acid)- multiwalled carbon-nanotube composite-covered glassy-carbon electrode, Biosensors & Bioelectronics 2007, 23, 74-80.

　　25. Aihua Liu, Mingdeng Wei, Itaru Honma, and Haoshen Zhou, Biosensing properties of titanate-nanotube film: selective detection of dopamine in the presence of ascorbate and uric acid, Advanced Functional Materials 2006, 16, 371-376.

　　26. Aihua Liu, Mindeng Wei, Itaru Honma, and Haoshen Zhou, Direct electrochemistry of myoglobin in titanate nanotubes film, Analytical Chemistry 2005, 77, 8068-8074.

　　27. Aihua Liu, Itaru Honma, and Haoshen Zhou, Amperometric biosensor based on tyrosinase-conjugated polysaccharide hybrid film: selective determination of nanomolar neurotransmitters metabolite of 3,4-dihydroxyphenylacetic acid (DOPAC) in biological fluid, Biosensors & Bioelectronics 2005, 21, 809-816.

　　28. Aihua Liu and Jun-ichi Anzai, Use of polymeric indicator for electrochemical DNA sensor: poly(4-vinylpyridine) derivative bearing [Os(5,6 dimethyl-1,10-phenanthroline)₂Cl]²⁺, Analytical Chemistry 2004, 76, 2975-2980.