摘要/Abstract

摘要： Hippo信号通路存在于果蝇和哺乳动物中，主要由上游调节分子、核心成分及下游调节分子组成，具有调控细胞增殖、分化及细胞周期等生理作用。近年来已有研究表明，Hippo信号通路单独或协同AMP活化蛋白激酶（AMP-activated protein kinase，AMPK）信号通路、哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）信号通路参与三大物质代谢，包括葡萄糖代谢、甲羟戊酸代谢和谷氨酰胺代谢。Hippo信号通路与卵巢物质代谢的关系是近几年兴起的研究热点。该文就Hippo信号通路通过单独或协同AMPK信号通路、mTOR信号通路调节卵巢的三大物质代谢过程，参与卵泡的生长、成熟及多囊卵巢综合征、卵巢癌的发生等的研究进展作一综述。
关键词: Hippo信号通路, 卵巢功能, 物质代谢, AMP活化蛋白激酶信号通路, 哺乳动物雷帕霉素靶蛋白信号通路
Abstract:
Hippo signaling pathway exists in drosophila and mammals, which is mainly composed of upstream modulators, core components and downstream modulators and has physiological functions such as cell proliferation, differentiation and cell cycle. In recent years, some research has shown that the Hippo signaling pathway can participate in three major substances, including glucose metabolism, mevalonate metabolism and glutamine metabolism, either alone or in combination with the AMP-activated protein kinase (AMPK) signaling pathway and the mammalian target of rapamycin (mTOR) signaling pathway. The relationship between Hippo signaling pathway and ovarian material metabolism is a research hotspot that has emerged in recent years. In this review, we summarize research progress that the Hippo signaling pathway regulates the maturation of follicles, polycystic ovary syndrome and ovarian cancer, through either alone or in combination with the AMPK signaling pathway and the mTOR signaling pathway.
Key words: Hippo signaling pathway, ovary function, material metabolism, AMPK signaling pathway, mTOR signaling pathway


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