摘要/Abstract
摘要： 目的 ·阐明孕妇体内传统污染物（铅、汞、有机磷农药）和新型污染物（全氟化合物和三氯生）的暴露水平并分析各污染物间的相关性。方法 ·于 2010年 9月至 2013年 12月间在山东莱州湾地区建立出生队列，收集孕妇的生物样本进行污染物检测。将 149例同时完成问卷调查及以下指标检测的孕妇纳入研究：血铅、血汞、尿有机磷农药代谢产物 [包括磷酸二甲酯（ dimethylphosphate，DMP）、二甲基硫代磷酸酯（ dimethylthiophosphate，DMTP）、磷酸二乙酯（ diethylphosphate，DEP）、二乙基硫代磷酸酯（ diethylthiophosphate， DETP）等]、血清全氟化合物 [全氟辛酸（ perfluorooctanoic acid，PFOA）和全氟辛烷磺酸（ perfluorooctane sulfonate，PFOS）]、尿三氯生。描述各污染物的暴露水平，采用 Spearman相关分析及余弦聚类分析研究污染物之间的相关性。结果 ·铅、DMP、PFOA和 PFOS的检出率均为 100.0%；汞、 DMTP、DEP、DETP和三氯生的检出率分别为 89.3%、81.2%、97.3%、96.6%、59.1%。铅、汞、 PFOA、 PFOS、三氯生的浓度中位数（范围）分别为 28.40（11.30～ 65.70）μg/L、0.85（
关键词: 孕妇, 重金属, 有机磷农药, 全氟化合物, 三氯生, 相关性分析
Abstract:
Objective · To evaluate the levels of environmental pollutants including lead, mercury, organophosphorus pesticides (OPs), perfluoroalkyl and polyfluoroalkyl substances (PFASs) and triclosan (TCS) and further analyze the correlation between these pollutants in pregnant women. Methods · Pregnant women were recruited the Laizhou Wan Birth Cohort (LWBC) in Shandong September 2010 to December 2013. A total of 149 pregnant women were finally enrolled who completed questionnaires and provided sufficient biological samples for pollutants measurement including blood lead, blood mercury, urinary metabolites of OPs[dimethylphosphate (DMP), dimethylthiophosphate (DMTP), diethylphosphate (DEP), diethylthiophosphate (DETP), etc.], serum perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), as well as urinary TCS. Spearman correlation analysis and cosine cluster analysis were used to explore the correlation between pollutants. Results · The detection rates of lead, DMP, PFOA and PFOS were all 100.0%. And the detection rates of mercury, DMTP, DEP, DETP and TCS were 89.3%, 81.2%, 97.3%, 96.6% and 59.1%, respectively. The median and range of concentrations for lead, mercury, PFOA, PFOS and TCS were 28.40 (11.30–65.70) μg/L, 0.85 (
Key words: pregnant woman, heavy metal, organophosphorus pesticides (OPs), perfluoroalkyl and polyfluoroalkyl substances (PFASs), triclosan, correlation analysis
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