从天然产物中寻找生物活性化合物是新药研发的重要途径之一，临床应用的许多药物是由天然的动物、植物及微生物经提取分离或结构改造得到的，但天然资源是有限的，并且大多数活性化合物在天然界是微量或极微量的，无法满足研究和药用的需要，因此，通过合成的手段获得天然化合物及其衍生物是十分必要的。本课程讲授各类天然产物（醌类、黄酮类、生物碱类、木质素类、萜类、皂甙类、甾体类、等）的结构特征、生合成途径、全合成及半合成方法，结构简化及修饰等，使学生掌握各类天然化合物的合成策略和方法。

Natural products as one of the most important sources for biologically active materials play key role in drug research. Many drugs used in clinics are extracted and separated from natural resources, such as animal, plants and microorganisms or their structure modified derivatives. The scarceness of natural resources and relatively low quantity of active components contained in natural materials has made it impossible to meet the growing demand of natural products for pharmaceutical research and clinical use. It is necessary to develop new synthetic methods to obtain natural products and their derivatives. This course covers the most important areas of natural products, such as structural characteristics, bio-synthesis, semi and total synthesis, structural simplification and modification. Students of this course will have knowledge of designing strategy and methods for organic synthesis of different natural products.