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上海交通大学药学院博士课程内容介绍《分子与临床药理学》

上海交通大学 免费考研网/2012-12-28


《分子与临床药理学》

课程代码C170741学分/学时3.0/54开课时间
课程名称分子与临床药理学
开课学院药学院
任课教师王永祥
面向专业药学专业
预修课程基础药理学
课程讨论时数12 (小时)课程实验数0 (小时)
课程内容简介

药理学研究导论主要以讲座的形式讲授药理学基本理论、新概念和研究进展,包括分子药理学如受体分类和功能、细胞信号转导、神经药理学如慢性疼痛药物和阿尔茨海默病药物治疗等、心血管代谢性疾病药理如血管紧张素转化酶抑制剂和抗2型糖尿病新型药物和临床药理学等领域。并且学生分组报告模拟研究计划,充分讨论。本课程即时反映国际研究动态前沿,着重国内外新药研发实践和转化药理学,结合授课教师药理和新药研究经验和成果,鼓励学生报告和讨论。

课程内容简介(英文)

The course of Pharmacology Guide focuses on Translational Pharmacology, covering research progresses of certain fields of Pharmacology including Molecular Pharmacology, Neuropharmacology, Cardiovascular Pharmacology, and Clinical Pharmacology. The course, in the format of lectures, will be given by teachers from the school as well as invited domestic and international scholars with expertise in their fields. After lectures, students are expected to give presentations of research proposals in group, marked by student representatives (directed by lecturers).

教学大纲

1)药物发现:靶向分子和高通量筛选(Drug discovery: target molecule and high throughput screening)王永祥2)药效动力学和药代动力学(Pharmacodynamics and pharmacokinetics)叶德全3)受体分类,功能及研究方法学(Receptor classification, function and research methodology) 叶德全4)分子信号转导(Molecular signal transduction) 叶德全5)基于寡核苷酸技术的新药开发(New drug development based on oligonucleotides)王永祥/马爱妞6)聚乙二醇化技术及相关药物(PEGylation technology and PEGylated drugs 王永祥7)可诱导分化干细胞研究进展及临床应用(Progress and clinical application of iPS)王永祥/guest speaker8)D-型氨基酸氧化酶生物学(Biology of D-amino acid oxidase)王永祥9)慢性疼痛的药物治疗(Chronic pain and drug treatment) 王永祥10) 针对炎症疾病的药物治疗(Drugs for the treatment of inflammatory diseases) 叶德全11)抗阿尔茨海默病药物治疗(Drug treatment of Alzheimer disease) 于洋12)针对肾脏和小肠的2型糖尿病治疗药物(Novel drugs targeting kidney and intestine for the treatment of type 2 diabetes mellitus)王永祥13)基于阻断血管紧张素的药物(Drugs derived from blockade of the angiotensin system)王永祥14)转化药理学:临床前候选药物的评价(Translational pharmacology: evaluation of preclinical development candidates)王永祥15)分组讨论研究报告(Group presentation of research proposals)王永祥/叶德全

课程进度计划

1)药物发现:靶向分子和高通量筛选(Drug discovery: target molecule and high throughput screening)王永祥2)药效动力学和药代动力学(Pharmacodynamics and pharmacokinetics)叶德全3)受体分类,功能及研究方法学(Receptor classification, function and research methodology) 叶德全4)分子信号转导(Molecular signal transduction) 叶德全5)基于寡核苷酸技术的新药开发(New drug development based on oligonucleotides)王永祥/马爱妞6)聚乙二醇化技术及相关药物(PEGylation technology and PEGylated drugs 王永祥7)可诱导分化干细胞研究进展及临床应用(Progress and clinical application of iPS)王永祥/guest speaker8)D-型氨基酸氧化酶生物学(Biology of D-amino acid oxidase)王永祥9)慢性疼痛的药物治疗(Chronic pain and drug treatment) 王永祥10) 针对炎症疾病的药物治疗(Drugs for the treatment of inflammatory diseases) 叶德全11)抗阿尔茨海默病药物治疗(Drug treatment of Alzheimer disease) 于洋12)针对肾脏和小肠的2型糖尿病治疗药物(Novel drugs targeting kidney and intestine for the treatment of type 2 diabetes mellitus)王永祥13)基于阻断血管紧张素的药物(Drugs derived from blockade of the angiotensin system)王永祥14)转化药理学:临床前候选药物的评价(Translational pharmacology: evaluation of preclinical development candidates)王永祥15)分组讨论研究报告(Group presentation of research proposals)王永祥/叶德全

课程考核要求

课程考核方式为分组报告研究计划,由学生代表评分(directed by lecturers)。

参 考 文 献
  • Goodman and Gilman's The Pharmacological Basis of Therapeutics, 12th Edition. McGraw Hill, 2011;Updated papers in the field of biomedicine.
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