职称：教授
所属学科：植物科学
研究方向：1）植物（真菌）生物技术；2）药用植物（真菌）资源及功能基因的开发利用。
电话/传真：
电子信箱：xuanweizhou@sjtu.edu.cn
联系地址：上海市东川路800号，上海交大农业与生物学院B311

个人简介：
周选围，男，1962年生，博士，陕西咸阳人。上海交通大学农业与生物学院教授/博士生导师。1984毕业于现陕西理工大学并参加工作，分别在汉中师范学院、陕西理工学院、陕西理工大学工作至2004年，历任助教、讲师、副教授、教授。工作期间在华东师范大学学习硕士学位课程，在上海师范大学学习获得博士学位。2004年11月至今在上海交通大学农业与生物学院植物科学系工作，2011.5~2012.5在美国马里兰大学（University of Maryland College Park, MD）访问****。曾任陕西省食品学会理事、汉中市食品与生物工程学会秘书长，现为中国菌物学会、上海市生物工程学会等会员。担任《Journal of Plant Science and Pathology》主编、《Chinese Traditional Medicine Journal》编委。
主要成果：
主编《生物技术概论》（高等教育出版社，2010）获上海交通大学优秀教材二等奖，并入选“十二五”普通高等教育本科国家级规划教材”（2014），2019以新形态教材形式再版；“生物技术教育课程建设与应用”获得上海交通大学2015年度教学成果奖、校长教学奖二等奖；2019年获得上海交通大学“教书育人奖”个人奖（提名奖）。主讲《生物技术概论》、《生物技术与人类》等课程；《生物技术概论》作为大规模在线开放课程（MOOC）在“爱课程”网“中国大学MOOC”平台上线运行。
曾主持或参加国家重点研发计划、国家高技术研究发展计划（863计划）重点项目、国家自然基金面上项目、上海市科委、企事业单位委托项目等各级各类科研项目10余项。运用DNA改组技术对FIPs基因改组，为其体外生产合成和改善蛋白的生物学活性奠定基础；初步揭示了该家族蛋白的抗肿瘤作用及其作用机制。在Journal of Agriculture and Food Chemistry、Applied Microbiology and Biotechnology、Journal of Cellular Physiology、Food and Agricultural Immunology、Critical Reviews in Biotechnology、Drug discovery Today、中国科学、应用环境与生物学报等国内外专业期刊上发表各类学术论文100余篇，其中SCI收录50余篇；获得国家授权发明专利10项。
近期代表性论文：（第一或通讯）
[1] Li QZ, Zheng YZ, and Zhou XW*.Fungal immunomodulatory proteins: characteristic, potential anti-tumor activities and their molecular mechanisms. Drug Discovery Today, 2019, 24(1): 307-314.
[2]Xia F, Zhou X, Liu Y, Li YL, Bai XH, & Zhou XW*. Composition and predictive functional analysis of bacterial communities inhabiting Chinese Cordyceps insight into conserved core microbiome. BMC Microbiology, 2019, 19(1), 105.
[3] Li QZ, Chang YZ, He ZM, Chen L, Zhou XW*.Immunomodulatory activity of Ganoderma lucidum immunomodulatoryprotein via PI3K/Akt and MAPK signaling athways in RAW264.7 cells.Journal of Cellular Physiology. 2019, 234:23337–23348.
[4] Zheng YZ, Li QZ, Shao KD, Mao PW, Liu Y, Zhou XW*. Expression of Ganoderma lucidumfungal immunomodulatory protein(FIP-glu) in Saccharomyces cerevisiaeand its Immunoreactivity. International Journal of Agriculture and Biology. 2019,22(2): 369-374.
[5]Shao KD, Mao PW, Li QZ, Li LDJ, Wang YL,Zhou XW*. Characterization of a novel fungal immunomodulatory protein, FIP-SJ75 shuffled from Ganoderma lucidum, Flammulina velutipes and Volvariella volvacea. Food and Agricultural Immunology. 2019, 30(1): 1253–1270.
[6]Liu Y, Mao PW, Jin MY, Bai XH,Zhou XW*.Breaking the sporoderm of Ganoderma lucidum spores by combining enzymatic hydrolysis reaction with physical actuation.Biocell.2019, 43(7-1): 458-465.
[7]Li LDJ, Mao PW, Shao KD, Bai XH, Zhou XW*.Ganoderma proteins and their potential applications in cosmetics. Applied Microbiology and Biotechnology. 2019, 103:9239–9250
[8] Li QZ, Chang YZ, Su KQ, Wang XL, Bai XH, Zhou XW*. Cloning and characterization of the promoters of fungal immunomodulatory proteins gene from Ganoderma spp.andtheir response to methyl jasmonate and salicylic acid. International Journal of Medicinal Mushrooms. 2018, 20(2): 177-189.
[9]Xu H, Guo MY, Gao YH, Bai XH，Zhou XW*.Expression and characteristics of manganese peroxidase from Ganoderma lucidumin Pichia pastorisand its application in the degradation of four dyes and phenol. BMC Biotechnology. 2017, 17:19.
[10] Guo MY, Liu Y, Gao YH, Jin T, Zhang HB, Zhou XW*. Identification and Bioactive Potential of Endogenetic Fungi Isolated from Medicinal Caterpillar Fungus Ophiocordyceps sinensis from Tibetan Plateau. International Journal of Agriculture & Biology. 2017, 19(2):307-313.
[11] Xia F, Chen X, Guo MY, Bai XH, Liu Y, Shen GR, Li YL, Lin J, Zhou XW*.High-throughputsequencing-based analysisof endogeneticfungalcommunitiesinhabitingthe ChineseCordycepsrevealsunexpectedly high fungaldiversity.Scientific Reports.2016, 6:33437.
[12] Xu H,Kong YY, Chen X, Guo MY, Bai XH, Lu YJ, Li W，Zhou XW*.Recombinant FIP-gat, a fungal immunomodulatory protein from Ganoderma atrum, induces growth inhibition and cell death in breast cancer cells. Journal of Agricultural and Food Chemistry. 2016, 64(13):2690-2698.
[13] Xia F, Liu Y, Guo MY, Shen GR, Lin J, Zhou XW*. Pyrosequencinganalysisrevealedcomplexendogenetic microorganism community from natural DongChong XiaCao and its microhabitat.BMC Microbiology. 2016, 6(1):196.
[14] Zhou XW*, Liu Yan, Su KQ, Zhang YM. Species clarification of the widely cultivated Ganoderma in China based on rDNA and FIP gene sequence analysis. International Journal of Agriculture & Biology. 2016, 18(5):932- 938.
[15]Xia F, Liu Y, Shen GR, Lin J, Zhou XW^*. Investigation and analysis of microbiological communities in natural Ophiocordyceps sinensis. Canadian Journal of Microbiology.2015, 61(2): 104-111
[16]Zhou XW^*,Su KQ, Zhang YM. Phylogenetic analysis of widely cultivated Ganodermain China based on the mitochondrial V4-V6 region of SSU rDNA. Genetics and Molecular Research.2015,14(1): 886-897.
[17] Zhou XW*, Li LJ, Tian EW. Advances in research of artificial cultivation of Ophiocordyceps sinensisin China. Critical Review in Biotechnology. 2014, 34(3): 233-43.
[18] Cong WR, Xu H, Liu Y, Li QZ, Li W, Zhou XW*.Production and functional characterization of a novel fungal immunomodulatory protein FIP-SN shuffled from two genes of Ganoderma species. Applied Microbiology and Biotechnology. 2014, 98(13):5967-75.
[19] Cong WR, Liu Y, Li QZ, Zhou XW*.Cloning and analysis of a functional promoter of fungal immunomodulatory protein fromFlammulina velutipes. Molecular Biology Reports. 2014, 41(7):4381-7.
[20] Cong WR, Gong ZH, Shi DD, Zhou XW*.Cloning and analysis of mating-type gene MAT1-1-1 from Cordyceps militaris. International Journal of Medicinal Mushrooms.2014, 16(5) : 449-462.
[21] Liu Y, Yuan WN, Zhou XW^*.Optimization of submerged culture conditions for the mycelial biomass and bioactive metabolites production by Cordyceps militaris.Journal of Pure and Applied Microbiololgy. 2014, 8(6): 4245-4254.
[22] Wang XF,Li QZ, Bao TW, Cong WR, Zhou XW*. In vitrorapid evolution of fungal immunomodulatory proteins by DNA family shuffling.Applied Microbiology and Biotechnology. 2013, 97(6): 2455-2465.
[23]Zhou XW*,Cong WR, Su KQ, Zhang YM. Ligninolytic enzymes from Ganoderma spp.-Current status and potential applications.Critical Review in Microbiology.2013, 39(4):416-26
[24] Zhou XW*, Su KQ, Zhang YM. Applied modern biotechnology for cultivation of Ganoderma and development of their products. Applied Microbiology and Biotechnology. 2012, 93(3):941-963.
[25]Zhou XW*, Wang XF, Li QZ. Expression and characteristic of the Cu/Zn superoxide dismutase gene from the insect parasitizing fungusCordyceps militaris. Molecular Biology Reports.2012, 39(12):10303-10311.
[26]Wang XF, Su KQ, Bao TW, Cong WR, Chen YF, Li QZ, Zhou XW*.Immunomodulatory effects of fungal proteins. Current Topics in Nutraceutical Research. 2012,10 (1): 1-11.
[27]Li QZ, Huang L, Wang XF, Li XS, Wu SQ, Zhou XW*. Fungal immunomodulatory protein from Flammulina velutipes induces cytokine gene xpression in mouse spleen cells. Current Topics in Nutraceutical Research. 2011, 9(3): 111-118.
[28] Li QZ, Wang XF, Zhou XW*. Recent status and prospects of the fungal immunomodulatory protein family. Critical Reviews in Biotechnology. 2011, 31(4): 365-375.
[29]Li QZ, Zheng SB, Wang XF, Bao TW, Zhou XW*.Preparation of rabbit anti-Ganoderma sinensisimmunomodulatory protein polyclonal antibody. African Journal of Microbiology Research. 2011, 5(12): 1562-1564.
[30] Li QZ, Wang XF, Bao TW, Ran L, Lin J, Zhou XW*. In vitro synthesis of a recombinant fungal immunomodulatory protein from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt.:Fr.) P.Karst. (Aphyllophoromycetideae) and analysis of its immunomodulatory activity. International Journal of Medicinal Mushrooms, 2010, 12(4):347–358.
[31]Li QZ, Wang XF, Chen YY, Lin J, Zhou XW*. Cytokines expression induced byGanoderma sinensisfungal immunomodulatory proteins (FIP-gsi) in mouse spleen cells.Applied Biochemistry and Biotechnology. 2010, 162(5):1403-1413.
[32]Zhou XW*,Zhu HF, Liu L, Lin J. Recent advances and prospect on taxol-producing endophytic fungi. Applied Microbiology and Biotechnology. 2010, 86(6): 1707-1717.
[33]Zhou XW*, Xie MQ, Hong F, Li QZ, Lin J.Genomic clones andcharacterization of a FIP-gsi gene encoding a fungal immunomodulatory protein from Ganoderma sinensis. International Journal of Medicinal Mushrooms. 2009, 11(1):77-86.
[34]Zhou XW*, Zheng WL, Zhu HF, Tang KX. Identification of a taxol-producing endophytic fungus EFY-36. African Journal of Biotechnology. 2009, 2009, 8(11): 2623-2625.
[35]Gong ZH, Su Y, Huang L, Lin J, Tang KX, Zhou XW*. Cloning and analysis of glyceraldehyde-3- phosphate dehydrogenase gene from Cordyceps militaris. African Journal of Agricultural Research. 2009, 4(4): 402-408.
[36]Huang L, Li QZ, Chen YY, Wang XF, Zhou XW*. Determination and analysis ofcordycepin and adenosine in the products of Cordyceps spp. African Journal of Microbiology Research. 2009, 3(12): 957-961.
[37]Zhou XW, Gong ZH, Su Y, Lin J, Tang KX.Cordycepsfungi: natural products, pharmacological functions and developmental products. Journal of Pharmacy and Pharmacology. 2009, 61(3):279-291.
[38]Zhou XW, Li QZ, Yin YZ, Chen YY, Lin J. Identification of medicinal Ganoderma species based on PCR with specific primers and PCR-RFLP. Planta Medica.2008, 74(2): 197-200.
[39]Zhou XW, Wei YM, Zhu HF, Wang ZN, Lin J, Liu L, Tang KX. Protoplast formation, regeneration and transformation from the taxol-producing fungus Ozonium sp. African Journal of Biotechnology. 2008, 7 (12): 2017-2024.
[40]Zhou XW,Lin J, Yin YZ, Zhao JY, Sun XF, Tang KX. Ganodermataceae: natural products and their related pharmacological functions.American Journal of Chinese Medicine. 2007, 35(4): 559-574.
[41]Zhou XW, Lin J, Yin YZ, Sun XF, Tang KX. Participation in Research Program: a novel course in undergraduate education of life science.Biochemistry and Molecular Biology Education. 2007, 35(5):322-327
[42]Zhou XW, Lin J, Yin YZ, Li QZ, Zhao JY, Tang KX. Comparison of rapid DNA extraction methods applied to PCR identification of medicinal mushroomGanodermaspp. Preparative Biochemistry & Biotechnology. 2007, 37(4): 369- 380.
[43]Zhou XW,Jiang H, Lin J,Tang KX. Cytotoxic activities of Coriolus versicolor(Yunzhi) extracts on human liver cancer and breast cancer cell line. African Journal of Biotechnology. 2007, 6(15):1740-1743.
[44]Zhou XW, Wang ZN, Jiang KJ, Wei YM, Lin J, Sun XF, Tang KX. Screening of taxol-producing endophytic fungi from Taxus chinensisvar. mairei.Applied Biochemistry and Microbiology. 2007, 43(4):439-443.
[45]Zhou XW, Lin J, Zhang L, Chen ZH, Yin YZ, Guo BH, Sun XF and Tang KX. The development of biotechnology education in China.Biochemistry and Molecular Biology Education.2006, 34(2): 141-147.
[46]高秀莲,毛培文,黎刘定吉,周选围*.不同粒色青稞及其生物处理样品中脂肪含量和脂肪酸组成分析.上海交通大学学报(农业科学版).2019,37(6): 50-56.
[47]刘玲，李奇璋，周选围*，王玉亮. 重组黑芝免疫调节蛋白对小鼠巨噬细胞RAW264.7向M1型分化的影响. 食品科学. 2019,40 (23):170~175.
[48]刘栋，王萍，周智伟，周选围*.红曲霉发酵青稞中添加辅料对γ-氨基丁酸含量的影响.粮油食品科技. 2018,26(1): 95-100.
[49]张四维, 岑凯, 刘艳, 周选围*，王成树. 青藏高原野生冬虫夏草子实体发育时期的宏转录组研究. 中国科学:生命科学, 2018, 48: 1–9.
[50]高艳华, 李奇璋, 刘玲, 郑雨璋, 周选围*. 重组真菌免疫调节蛋白对巨噬细胞RAW 264.7激活应答的研究. 上海交通大学学报（农业科学版），2018，36, 53-58, 65.
[51]沈娜，黄楠楠，周选围*.发芽青稞面包加工工艺优化.粮油食品科技. 2017, 25(1):11-14.
[52]郭梦圆, 高艳华, 郑雨璋, 王萍, 夏 飞, 周选围*.冬虫夏草内生菌NS2-B1发酵培养基的筛选.应用生物与环境学报.2017,23 ( 5 ): 0939-0944
[53]徐慧, 郭梦圆, 靳通, 高艳华, 路慧丽, 李伟，周选围*.灵芝锰过氧化物酶毕赤酵母工程菌培养条件的优化. 第二军医大学学报. 2016,37(8):955-962.
[54]许燕, 胡明慧, 高蓓蓉, 周选围*.灵芝真菌免疫调节蛋白在体外对不同胃癌细胞的抑制作用. 药学实践杂志, 2016, 34(3): 223-226.
[55]张伊迪,周选围*.青稞籽粒中β-葡聚糖在发芽过程中的变化.中国农学通报. 2014, 30(24): 294-298.
[56]苏恺琪, 王雪飞, 周选围. 黑灵芝免疫调节蛋白基因的克隆和生物信息学分析. 上海交通大学学报（农业科学版）. 2012, 30(1): 65-71.
[57]郑文龙，朱慧芳，刘璐，叶巍，周选围*,尹京苑.产紫杉醇内生真菌EFY- 21 的鉴定与生物学特性研究.菌物研究. 2010, 8(1): 35-40.
[58]朱慧芳，郑文龙，王玉亮，冯小路，周选围*. 三种红豆杉属植物中紫杉烷类化合物含量的检测与分析. 上海交通大学学报（农学版）, 2010, 28(1): 9-13.
[59]李奇璋, 王雪飞, 黄蕾, 周选围*.紫芝免疫调节蛋白基因的原核表达与功能分析. 西北植物学报, 2010 ,30 (1) :0035-0040.
[60]苏颖,周选围*.改进苯酚-硫酸法快速测定虫草多糖含量. 食品研究与开发. 2008, 29(3):118-211.
[61]黄蕾,许滨竑,苏颖,龚振华,王玉亮,周选围*. 虫草属真菌中主要活性成分含量的比较. 上海交通大学学报（农学版）. 2008,26(1): 74-77.
[62]苏颖, 宋艳, 黄蕾, 邹豪, 周选围*复方虫草多糖含片质量控制方法的研究,药学实践杂志. 2008, 26(3):191-193,221.
[63]周选围,林娟,李奇璋,尹燡周,孙小芬,唐克轩. 灵芝蛋白类活性成分的研究进展. 天然产物开发与研究. 2007, 19(5):917-924.
[64]周选围,林娟,孙小芬,唐克轩. 中药指纹图谱与灵芝质量标准研究方法.中草药2006,37(8): 1121-1125.
[65]周选围,王子楠,魏雅敏,林娟,孙小芬,谈峰, 苗志奇,唐克轩. 红豆杉内生真菌发酵培养基和原生质体制备酶系统的筛选.应用与环境生物学报.2006,12 (2):176-181.
[66]周选围, 陈文强,邓百万,王智,彭浩,林娟. 生物技术在药用真菌资源开发与保护中的应用.中草药. 2005, 36(3):451-455.
代表性授权发明专利：
[1]周选围，孔应予，丛蔚然. 黑灵芝真菌免疫调节蛋白的制备方法及其应用。专利号：7.2. （授权日：2016-08-30）
[2]周选围，丛蔚然. 一种属内重组真菌免疫调节蛋白的制备方法及其应用.专利号：3.5. （授权日：2015-05-27）
[3] 汪新，周选围. 基于灵芝菌丝分泌酶的灵芝孢子粉优化破壁方法. 专利号：ZL 9.8(授权日：2019-07-23)
[4]汪新，周选围. 青稞胚芽米的制备方法. 专利号：ZL4.6. (授权日：2015-06-19)
[5] 周选围，王雪飞，李奇璋，苏恺奇，丛蔚然. 灵芝属间的重组真菌免疫调节蛋白基因、该基因编码的蛋白及其应用。专利号: ZL 2011 1 **.7 （授权日：2013-05-1）
[6] 周选围，王雪飞，李奇璋，苏恺奇，丛蔚然. 灵芝属内重组的真菌免疫调节蛋白基因、该基因编码的蛋白及其应用。专利号: ZL 2011 1 **.0 （授权日：2013-05-01）
[7]李奇璋，周选围. 真菌免疫调节蛋白基因启动子、重组载体及宿主细胞. 专利号：ZL 2009 1 **.9 （授权日：2012-07-04）
[8]周选围，龚振华，唐克轩. 北冬虫夏草甘油醛-3-磷酸脱氢酶基因启动子.专利号：ZL 2009 1 **.1 （授权日：2012-06-13）
[9] 汪新, 周选围. 虫草多糖含片及其制备方法.专利号ZL2008 1 **.7（授权日：2011-09-21）
[10]周选围, 林娟, 李奇璋, 尹燡周, 唐克轩.利用特异基因序列鉴别药用灵芝的检测方法.专利号: ZL2007 1 **.X. （授权日：2010-06-30）
代表性专著或译著：
[1] 主编：《生物技术概论》（高等教育出版社，2019年（第2版）。(国家“十二五”规划教材)
[2] 主编：《天然抗癌植物资源与开发利用》（西北大学出版社，1999）。
[3] 编著：《学业评价的原理与技术》（陕西师范大学出版社，2002）。
[4]参编：《Edible and Medicinal Mushrooms: Technology and Application》（John Wiley & Sons Ltd, 2017）。
[5]参编：《中草药生物技术》(复旦大学出版社，2005)。
[6]参编：《体外培养的原理和技术》（科学出版社，2001）。