王哲
职称：长聘教轨副教授，独立课题组长，博士生导师
所属学科：动物科学系
研究方向：人畜共患病原微生物学和系统生物学
电话/传真：
电子信箱：wangz@sjtu.edu.cn
联系地址：上海交通大学农业与生物学院0-310室
邮编:200240

个人和课题组简介：
2002年本科毕业于西安交通大学生命科学与技术学院，获工学学士学位。2008年博士毕业于北京大学生命科学学院。2008至2013年，分别在复旦大学生物医学研究院和美国康奈尔大学人类生态学院接受博士后训练。2013年起任美国康奈尔大学医学院传染病科学系任助理研究员。至2020年回国加入上海交通大学农业与生物学院动物科学系。
分枝杆菌是对人类和动物危害较大的一类致病性细菌。其中，结核分枝杆菌与非结核分枝杆菌感染病例在我们国家仍居高不下。与此同时，现有抗生素耐药性的普遍出现，以及缺乏新型抗生素的问题日趋严重。我们课题组将综合运用病原微生物学、免疫学、群体遗传学、基因组学、代谢组学和药物化学等手段，重点关注以下几个方向：
1. 致病性分枝杆菌能量代谢通路关键基因的进化与功能分析。
2. 病原体-宿主之间互作的分子机制解析。
3. 新型抗细菌药物的开发以及耐药性机理的研究。
4. 新型快速精准疾病诊断技术的开发。
科研项目：
目前主持国家自然科学基金面上项目1项，曾经主持青年基金等国家级和省部级项目4项。
论文论著：
完整论文发表记录请参考https://www.researchgate.net/profile/Zhe-Wang-3
Zhe Wang, Vijay Soni, Gwendolyn Marriner, Takushi Kaneko, Helena I. M. Boshoff, Clifton E. Barry III, Kyu Rhee. Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M.tuberculosis to bedaquiline. 2019, 16 (39), Proceedings of the National Academy of Sciences (PNAS)
Zhe Wang^*#, Xuepeng Sun^*, Josephine Wee, Xiaoxian Guo, Zhenglong Gu#. Novel Insights into Global Translational Regulation through Puf3p Revealed by Ribosomal Profiling, 2018, 1-12, Current Genetics
Zhe Wang^#and Zhenglong Gu. Chapter 12: Novel insights of the gene translational dynamic and complex revealed by Ribosome Profiling. Editor: Jan Barciszewski. Springer publishing, 2018, 239-256, In Book: Systems Biology
Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi…, Zhe Wang…Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland. Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA, 2018, 9(6). mBio
Xavier Carette, John Platig, David C. Young, Michael Helmel, Albert T. Young, Zhe Wang,…Kyu Y. Rhee, D. Branch Moody, Hanno Steen, Robert N. Husson. Multi-systems analysis of Mycobacterium tuberculosis reveals kinase-dependent remodeling of the pathogen-environment interface, 2018, 9 (2), mBio
Zhe Wang^#.Plant-derived antifungal compounds trigger a common transcriptional response, 2017, 54, 1-3, Infection, Genetics and Evolution
Hyungjin Eoh, Zhe Wang, Emilie Layre, Poonam Rath, Roxanne Morris, D. Branch Moody, Kyu Rhee. Metabolic anticipation in Mycobacterium tuberculosis, 2017, 2, 17084, 1-7, Nature Microbiology
Irnov Irnov, Zhe Wang, Nicholas D. Jannetty, Julian A. Bustamante, Kyu Y. Rhee, Christine Jacobs-Wagner. Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate, 2017, 13 (8), PLoS Genetics
Susan Puckett, Carolina Trujillo, Zhe Wang, Hyungjin Eoh, Thomas R. Ioerger, Inna Krieger, James Sacchettini, Dirk Schnappinger, Kyu Y Rhee, Sabine Ehrt. Glyoxylate detoxification: An essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis, 2017, 114（11）2225-2232, Proceedings of theNational Academy of Sciences (PNAS)
Kerry E. Boyle, Hilary T. Monaco, Maxime Deforet, Jinyuan Yan, Zhe Wang, Kyu Rhee and Joao Xavier. Metabolism and the evolution of social behavior, 2017, 34(9):2367-2379, Molecular Biology and Evolution
Joanna C. Evans, Carolina Trujillo, Zhe Wang, Hyungjin Eoh, Sabine Ehrt, Dirk Schnappinger, Helena I.M. Boshoff, Kyu Y. Rhee, Clifton E. Barry 3rd, Valerie Mizrahi. Validation of CoaBC as a bactericidal target in the coenzyme A pathway of Mycobacterium tuberculosis. 2016, 2 (12), 958–968, ACS Infectious Diseases
Zhe Wang^#and Yan Shen. Antifungal compound honokiol triggers oxidative stress responsive signaling pathway and modulates central carbon metabolism. 2016, 7 (3), 124-133, Mycology
Zhe Wang*, Xuepeng Sun*, Xiaoxian Guo, Huifeng Jiang, Zhenglong Gu. Evolution of gene regulation during transcription and translation. 2015, 7 (4), 1155-1167, Genome Biology and Evolution
Wenxia Sun*, Zhe Wang*, Hengyi Jiang, Jing Zhang, Jurg Bahler, Dongrong Chen, Alastair I. H. Murchie. A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1. 2011, 39(7), 2690-700, Nucleic Acids Research
Hengyi Jiang*, Wenxia Sun*, Zhe Wang*,Jing Zhang, Dongrong Chen, Alastair I. H. Murchie. Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe. 2011, 39(12) 5119-30, Nucleic Acids Research
Huirong Yang*, Zhe Wang*, Yan Shen*, Ping Wang*, Xu Jia, Liang Zhao, Pei Zhou, Rui Gong, Ze Li, Ying Yang, Dongrong Chen, Alastair I. H. Murchie Yanhui Xu. Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus. 2010, 49(30), 6440-50, Biochemistry
*=共同第一作者， #=通讯作者