导师姓名： 黄莺 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海重庆南路280号2号楼907室 ***776403
邮编： 200025 邮箱地址： huangying@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤发生发展相关的细胞分子生物学机制研究

社会任职
中国病理生理学会会员
Current Molecular Pharmacology评委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** FAM122A抑制PP2A磷酸酶活性在肿瘤发生中的作用 国家自然基金面上项目 2016-01~2019-12 72万元 课题负责人
** FAM122A调控DNA损伤反应的分子机制及其意义 国家自然基金面上项目 2014-01~2017-12 73万元 课题负责人
** 早幼粒细胞白血病蛋白与自噬分子LC3 的相互作用及其意义 国家自然基金面上项目 2013-01~2013-12 16万元 课题负责人
** 早幼粒白血病相关融合蛋白 PML-RARa 增强自噬活性及其意义 国家自然基金面上项目 2011-01~2013-12 34万元 课题负责人
** 低氧诱导因子1a 介导白血病细胞分化的分子机制研究 国家自然基金面上项目 2004-01~2006-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Fan L, Liu MH, Guo M, Hu CX, Yan ZW, Chen J, Chen GQ, Huang Y. （通讯作者） FAM122A, a new endogenous inhibitor of protein phosphatase 2A. Oncotarget 2016 7(39):63887-63900
Hou JK, Huang Y* （通讯作者）, He W, Yan ZW, Fan L, Liu MH, Xiao WL, Sun HD, Chen GQ. Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells. Cell Death Dis. 2014 5:e1400. doi: 10.1038/cddis.2014.345.
He W, Hu CX, Hou JK, Fan L, Xu YW, Liu MH, Yan SY, Chen GQ, Huang Y*. （通讯作者） Microtubule-associated protein 1 light chain 3 interacts with and contributes to growth inhibiting effect of PML. PLOS ONE 2014 9(11): e113089. doi:10.1371/journal.pone.**.
Yan ZW, Hou JK, He W, Fan L, Huang Y*. （通讯作者） Chloroquine enhances cobalt chloride-induced leukemic cell differentiation via the suppression of autophagy at the late phase. Biochem Biophys Res Commun. 2013 430(3):926-32.
Ying Huang, Jia-Kai Hou, Ting-Ting Chen, Xu-Yun Zhao, Zhao-Wen Yan, Jing Zhang, Jie Yang, Scott C. Koganand Guo-Qiang Chen PML-RARα enhances constitutiveautophagic activity through inhibiting the Akt/mTOR pathway Autophagy 2011 7(10):1132-44
Wu SF, Huang Y （共同第一作者）, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ. The downregulationof onzin expression by PKCepsilon-ERK2 signaling and its potential role in AMLcell differentiation. Leukemia 2010 24(3):544-551
Yuan TT, Huang Y （共同第一作者）, Zhou CX, Yu Y, Wang LS, Zhuang HY, Chen GQ. Nucleartranslocation of dihydrofolate reductase is not a pre-requisite for DNA damageinduced apoptosis. Apoptosis. 2009 14(5):699-710.
Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S, Chen GQ. Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha. Oncogene. 2008 27(6):839-847
Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ. Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene. 2008 27(4):519-527
Huang Y, Qiu J, Chen GQ, Dong S. Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARalpha, resulting in sequestration and decreased mobility of SMRT. Biochem Biophys Res Commun. 2008 365(2):258-265.
Qiu J, Huang Y, Chen GQ, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell. 2007 18(10):3941-3951.
Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 Isoforms ? and ?, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3 mapping to its unique C-terminal end. J Biol Chem. 2007 282(48):34958-34967
Han YH, Xia L, Song LP, Zheng Y, Chen WL, Zhang L, Huang Y, Chen GQ, Wang LS. Comparative proteomic analysis of hypoxia-treated and untreated human leukemicU937 cells. Proteomics. 2006 6(11):3262-3274.
Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica. 2005 90(12):1607-1616.
Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lübbert M, Chen GQ. Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha. Leukemia. 2005 19(7):1239-1247.