导师姓名： 黄金艳 专业代码： 071000
性别： 男 专业名称： 生物学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： https://github.com/jhuanglab/
邮编： 200025 邮箱地址： jinyan@shsmu.edu.cn

研究方向 (点击浏览详细信息)
1, 生物信息学、医学信息学、大数据综合分析
2, 临床诊断数据分析
4, 更多请访问实验室网站: https://github.com/jhuanglab/
5, 急性淋巴细胞白血病分子分型及分子机制等
3, DNA-seq， RNA-seq数据分析

社会任职
中国病理生理学会实验血液学青年委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于全基因组测序建立病毒拷贝数和整合位点的生物信息学方法及数据分析 国家自然科学基金委员会面上基金项目 2018-01~2021-12 55万元 课题负责人
2016YFC** 基于组学特征谱的白血病分子分型研究 国家重点研发计划 2017-01~2020-01 320万元 课题参与人
** 生物信息学 上海交通大学医学院高峰高原计划 —“临床专职科研队伍” 2017-01~2019-02 100万元 课题负责人
** 成人及儿童急性淋巴细胞白血病的基因组转录组生物信息学分析方法建立及数据分析 国家自然科学基金委员会面上基金项目 2016-01~2019-01 60万元 课题负责人
052 诱导性多能干细胞形成的关键的信号网 教育部新教师基金 2010-01~2012-12 3.6万元 课题负责人
** 调控诱导性多能干细胞形成的基因和信号网络研究 国家自然科学基金委员会青年基金项目 2010-01~2012-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang S, Zhang YX, Huang T, Sui JN, Lu J, Chen XJ, Wang KK, Xi XD, Li JM, Jinyan Huang （通讯作者）, Chen B. Mutation profile and associated clinical features in Chinese patients with cytogenetically normal acute myeloid leukemia Int J Lab Hematol 2018 40(4):408-418
Merino J, Dashti HS, et al., Jinyan HUANG, et al., Chu AY, Tanaka T. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry 2018 Jul 9
Dong X, Zhang W, Wu H, Jinyan Huang （共同第一作者）, et al., Structural basis of DUX4/IGH-driven transactivation Leukemia 2018 115(9): 2180-5
Jun Chen, Ehsan Behnam, Jinyan Huang, Miriam F. Moffatt, Daniel J. Schaid Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA, BMC Genomics (2017). BMC Genomics 2017 18(1):413.
Peng-Peng Xu, Hui-Juan Zhong, Yao-Hui Huang, Xiao-Dong Gao, Xia Zhao, Yang Shen, Shu Cheng, Jin-Yan Huang, Sai-Juan Chen, Li Wang, Wei-Li Zhao B-cell Function Gene Mutations in Diffuse Large B-cell Lymphoma: A Retrospective Cohort Study Ebiomedicine 2017 16:106-114
Lindstrom S, Loomis S, Turman C, Huang H, Jinyan Huang, et.al A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts PLoS One. 2017 12(3):e**.
Bing Chen#, Lu Jiang#, Meng-Ling Zhong#, Jian-Feng Li#, Ben-Shang Li#, Li-Jun Peng, Yu-Ting Dai, Bo-Wen Cui, Tian-Qi Yan, Wei-Na Zhang, Xiang-Qin Weng, Yin-Yin Xie, Jing Lu, Rui-Bao Ren, Su-Ning Chen, Jian-Da Hu, De-Pei Wu, Zhu Chen*, Jing-Yan Tang, Jin-Yan Huang* （通讯作者）, Jian-Qing Mi*, and Sai-Juan Chen*, Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia PNAS 2017 115(2):373-378
Manning A, et al., Jin-Yan Huang, et al. A low-frequency inactivating AKT2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk Diabetes 2017 db161329.
Omer Schwartzman, et al, Jinyan Huang, et.al Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome PNAS 2017 114(20):E4030-E4039.
Jun Li, Xiaoyan Zhu,et al, Jinyan Huang,et.al Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome Circulation Research 2017 120(11):1754-1767.
Wang M, Gong Q, Zhang J, Chen L, Zhang Z, Lu L, Yu D, Han Y, Zhang D, Chen P, Zhang X, Yuan Z, Jinyan Huang （通讯作者）,Zhang X. Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis Scientific Reports 2017 7:43446.
Yong?Mei Zhu, Pan?Pan Wang, Jin-Yan Huang, et al., Sai-Juan Chen and Yang Shen Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance Journal of Translational Medicine 2017 15(1):178
Yu-Jun Dai#, Yue-Ying Wang#, Jinyan Huang# （共同第一作者）, et.al Conditional knock-in of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement PNAS 2017 114(20):5237-5242.
Berndt SI, et al, Jinyan Huang, et.al Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia Nature Communication 2016 7:10933
Wu M, Jinyan Huang, Zhang J, Benes C, Jiao B, Ren R N-Arachidonoyl Dopamine Inhibits NRAS Neoplastic Transformation by Suppressing Its Plasma Membrane Translocation Mol Cancer Ther 2016 16(1):57-67.
Pan M, Zhang Q, Liu P, Jinyan Huang, et.al Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG Front Med 2016 10(4):410-419.
Pan MM, Zhang QY, Wang YY, Liu P, Ren RB, Jinyan Huang, et.al Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway Leukemia 2016 30(7):1590-3.
Janine F. Felix, et al, Jinyan Huang, et.al Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index Human Molecular Genetics 2016 2016 Jan 15;25(2):389-403
Fuchsberger C, et al, Jinyan Huang, et.al The genetic architecture of type 2 diabetes Nature 2016 536(7614):41-7.
Machiela MJ, et al, Jinyan Huang, et.al Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes Human Molecular Genetics 2016 25(8):1663-76.
Yuanfang Liu, et al, Jinyan Huang, et.al Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia Ebiomedicine 2016 8:173-83.
Li Man, et al, Jinyan Huang, et.al SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function, J Am Soc Nephrol J Am Soc Nephrol 2016 28(3):981-994.
Yu XJ, Yang MJ, Zhou B, Wang GZ, Huang YC, Wu LC, Cheng X, Wen ZS, Jinyan Huang, Zhang YD, Gao XH,et.al Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer EBioMedicine 2015 2(6):583-90
O'Neal WK, Gallins P, Pace RG, Dang H, Wolf WE, Jones LC, Guo X, Zhou YH, Madar V, Jinyan Huang, Liang L, Moffatt MF, Cutting GR, et.al Gene Expression in Transformed Lymphocytes Reveals Variation in Endomembrane and HLA Pathways Modifying Cystic Fibrosis Pulmonary Phenotypes Am J Hum Genet 2015 96(2):318-28
Peter K. Joshi1, Tonu Esko, HanneleMattsson, Niina Eklund, Ilaria Gandin, et al, Jinyan Huang, et.al Directional dominance on stature and cognition in diverse human populations Nature 2015 9(3), pp 271-284
Mohlke, Karen L, et al, Jinyan Huang, et.al New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015 518(7538):187-96.
Vijai J, Wang Z, Berndt SI, Skibola CF, Slager SL, de Sanjose S, Melbye M, Glimelius B, Bracci PM, Conde L, Birmann BM, Wang SS, et al,Jinyan Huang, et al A genome wide association study of marginal zone lymphoma shows association to the HLA region Nature Communication 2015 2015 Jan 8;6:5751.
Huang Tao, Jinyan Huang, Qi Q, Li Y, Bray GA, Rood J, Sacks FM, Qi L PCSK7 Genotype Modifies Effect of a Weight-Loss Diet on 2-Year Changes of Insulin Resistance: The POUNDS LOST Trial Diabetes Care 2015 2015 Mar;38(3):439-44
Wu Shuai-Lai, Fu Xing, Jinyan Huang （共同第一作者）, Jia Ting-Ting, Zong Feng-Yang, Mu Shi-Rong, Zhu Hong, et.al Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme Nucleic Acids Research 2015 2015 Sep 30;43(17):8516-28
Lu Jiang, Zhao-Hui Gu, Zi-Xun Yan, Xia Zhao, Yin-Yin Xie, Zi-Guan Zhang, Chun-Ming Pan, Yuan Hu, Chang-Ping Cai, Ying Dong, Jinyan Huang, Li Wang, Yang Shen, et.al Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma Nature Genetics 2015 doi:10.1038/ng.3358
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, et al,Jinyan Huang, et al Genetic studies of body mass index yield new insights for obesity biology Nature 2015 2015 Feb 12;518(7538):197-206
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI,et al, Jinyan Huang, Humphreys K, Hunter DJ, et.al. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair Nature Genetics 2015 47(11):1294-303
Zhang J, Jinyan Huang （共同第一作者）, Chen YN, Yuan F, Zhang H, Yan FH, Wang MJ, et.al. Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma Scientific Reports 2015 2015 Sep 2;5:13750
Jinyan Huang, Jun Chen, Jorge Esparza, Jun Ding, et.al eQTL mapping identify insertion and deletion specific eQTLs in mutipule tissues Nature Communication 2015 11(45), pp 1044-1049
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, Huffman JE, Mihailov E, Porcu E, Robino A, Rose LM, Schick UM, Stolk L, Teumer A, Thompson DJ, Traglia M, Wang CA, Yerges-Armstrong LM, Antoniou AC, Barbieri C, Coviello AD, Cucca F, Demerath EW, Dunning AM, Gandin I, Grove ML, Gudbjartsson DF, Hocking LJ, Hofman A, Jinyan Huang, et.al Rare coding variants and X-linked loci associated with age at menarche Nature Communication 2015 6:7756
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY,et al, Jinyan Huang, Jackson RD, Karasik D, Kriebel J, Lange EM,et.al. Rare coding variants and X-linked loci associated with age at menarche Nature Communication 2015 Nature Communication
He M, Xu M, Zhang B, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Jinyan Huang, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, et al Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci Human Molecular Genetics 2014 22(45), pp 1268-1277
Tao Huang, Jianqin Sunc, Yanqiu Chenc, Hua Xiec, Danfeng Xuc, Jinyan Huang, Duo Li Genetic variants in desaturase gene, erythrocyte fatty acids, and risk of type 2 diabetes in Chinese Hans Nutrition 2014 2014 Jul-Aug;30(7-8):897-902
van der Valk RJ, Kreiner-Moller E, Kooijman MN, Guxens M, Stergiakouli E, Saaf A, Bradfield JP, Geller F, et al, Jinyan Huang, et al A Novel Common Variant in DCST2 is associated with Length in Early Life and Height in Adulthood Human Molecular Genetics 2014 2015 Feb 15;24(4):1155-68
Qi Q, Kilpellinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renstr?m F, Lin X, ?ngquist LH, Jinyan Huang, et al FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals Human Molecular Genetics 2014 55(78), pp 5457-5467
Chen P, Takeuchi F, Lee JY, Wu JY, et.al, Jinyan Huang, Huang T, Yuan J, et.al Multiple Non-glycemic Genomic Loci Are Newly Associated with Blood Level of Glycated Hemoglobin in East Asians Diabetes 2014 2014 Jul;63(7):2551-62
Qi Q, Chu AY, Kang JH, Jinyan Huang, Rose LM, et.al Fried food consumption and genetic predisposition to obesity BMJ 2014 2014 Mar 19;348:g1610
Cerhan JR, Berndt SI, Vijai J, Ghesquières H, McKay J, Wang SS, Wang Z, Yeager M, Conde L, et al , Jinyan Huang, et al Genome-wide association study identifies multiple susceptibility loci for diffuse large B-cell lymphoma Nature Genetics 2014 46(11):1233-8.
Wang Qixuan#,Jinyan Huang# （共同第一作者）, Sun Hanfei, Liu Jing, Wang Juan, Wang Qian, Qin Qian, Mei et.al CR Cistrome: a ChIP-Seq database for chromatin regulators and histone modification linkages in human and mouse Nucleic Acids Research 2014 42(Database issue), pp D450-D458
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, M?gi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, et al, Jinyan Huang, Kanoni S, et al New genetic loci link adipose and insulin biology to body fat distribution Nature 2014 12(4), pp 1254-1262
Baoshan Ma, Jinyan Huang （共同第一作者）, Liming Liang Real-time online engine for expression quantitative trait loci analyses Database 2014 Published by Oxford University Press
Skibola CF, Berndt SI, Vijai J, Conde L, Wang Z, Yeager M, de Bakker PI, Birmann BM, Vajdic CM, Foo JN, Bracci PM, et al, Jinyan Huang, et al Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region Am J Hum Genet 2014 2014 Oct 2;95(4):462-71
Juan Wang,Xueqiu Lin,Su Wang,Chenfei Wang,Qixuan Wang,Xikun Duan,Peng Lu,Qian Wang,Chengyang Wang,X. Shirley Liu,Jinyan Huang （通讯作者） PHF8 associating with NRSF at gene promoter regions genome-wide regulating genes expression Scientific Reports 2014 doi:10.1038/srep05008
Jinyan Huang, Chen Jun, Lathrop Mark, Liang Liming A tool for RNA sequencing sample identity check Bioinformatics 2013 2013 Jun 1;29(11):1463-4
Huang T, Ren J, Jinyan Huang, Li D Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach BMC Genomics 2013 2013 Dec 10;14:867
Jinyan Huang, Renault V, Sengenes J, Touleimat N, Michel S, Lathrop M, Tost J MeQA: a pipeline for MeDIP-seq data quality assessment and analysis Bioinformatics 2012 28(4), pp 587-588
Shen L, Gao G, Zhang Y, Zhang H, Ye Z, Huang S, Jinyan Huang, Kang J. A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA Nucleic Acids Res 2010 2010 Oct;38(18):6054-64
Liu G, Ding M, Wang H, Jinyan Huang, Jing Q, Shen B. Pathway analysis of microRNAs in mouse heart development Int J Bioinform Res Appl 2010 2010;6(1):12-20.
Jinyan Huang, Chen Taotao, Liu Xiaosong, Jiang Jing, Li Jinsong, Li Dangsheng, Liu X. Shirley, Li Wei, Kang Jiuhong, Pei Gang More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells Cell Research 2009 19(10), pp 1127-1138
Xiaosong Liu, Jinyan Huang, Taotao Chen, Ying Wang, Shunmei Xin, Jian Li, Gang Pei, Jiuhong Kang Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells Cell Research 2008 114(477), pp 1200-1204