导师姓名： 赵维莅 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 血液病
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： Zhao.weili@yahoo.com

研究方向 (点击浏览详细信息)
恶性血液病的基础和临床研究

社会任职
Biomarker Res编委
美国血液学会外籍委员
临床血液学杂志编委
Pathobiology编委
中华医学会血液分会血液实验诊断学组副组长
中国病理生理学会中国实验血液学分会常委
白血病淋巴瘤杂志编委
中华医学会血液学分会委员
中华血液学杂志编委
中国临床肿瘤协会抗淋巴瘤联盟副主席
中国病理生理学会中国实验血液学分会副秘书长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
YFC** 白血病分子分型精细图谱构建及新型分子标志发现 ，国家重点研发计划项目 国家重点研发计划 2016-07~2018-10 100万元 课题负责人
微小RNA/Ras信号通路在肿瘤血管介导淋巴瘤细胞免疫 国家自然科学基金 2016-01~2020-12 235万元 课题负责人
** 淋巴细胞疾病 国家****科学基金 2014-01~2016-12 200万元 课题负责人
13XD** AMPK/mTOR通路调控恶性淋巴细胞自噬的机制研究和靶向干预 上海市科委优秀学术带头人 2013-05~2015-12 40万元 课题负责人
11JC** 运用代谢组学方法研究淋巴瘤疾病进展的分子标志 上海市科委重点项目 2012-01~2014-12 30万元 课题负责人
** T细胞淋巴瘤NF-kappaB信号通路组蛋白乙酰化修饰的研究 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
09SG21 毛萼乙素抗淋巴瘤作用及其机制研究 上海市教委曙光计划 2010-01~2012-12 15万元 课题负责人
09QH** 血管内皮细胞促T细胞淋巴瘤生长的调控机制及干预治疗的研究 上海市科委青年科技启明星跟踪资助项目 2009-07~2011-06 20万元 课题负责人
凋亡相关基因在恶性淋巴瘤中的表达调控机制及其生物学作用 上海市科委国际合作项目 2008-09~2010-09 30万元 课题负责人
** PRDM1基因beta异构型在弥漫大B细胞性淋巴瘤中的表达及其生物学作用 国家自然基金委青年科学基金项目 2008-01~2010-12 17万元 课题负责人
NCET-07-0556 弥漫大B细胞淋巴瘤分子分型 国家教育部“新世纪优秀人才支持计划” 2007-10~2010-12 50万元 课题负责人
2006aa02a301 癌症的基因组重排研究 国家科技部“863”计划重大项目 2007-01~2009-12 756万元 课题负责人
05QMX1429 T细胞淋巴瘤血管内皮生长因子A表达和抗血管治疗的研究 上海市科委启明星 2005-09~2008-09 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiong J, Zhao WL （通讯作者） Targetable Metabolic Vulnerability in Diffuse Large B-Cell Lymphoma EBioMedicine 2018 28;5–6
Ji MM, Huang YH, Huang JY, Wang ZF, Fu D, Liu H, Liu F, Leboeuf C, Wang L, Ye J, Lu YM, Janin A, Cheng S, Zhao WL （通讯作者） Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified Haematologica 2018 103(4):679-687
Fang Y,Wang H,Dou HJ,Fan X,Fei XC, Cheng S,Janin A,Wang L,Zhao WL （通讯作者） Doxorubicin-loaded dextran-based nano-carriers for highly efficient inhibition of lymphoma cell growth and synchronous reduction of cardiac toxicity Int J Nanomedicine 2018 13;5673–5683
Xu PP,Sun C, Cao X, Zhao X, Dai HJ, Lu S, Guo JJ, Fu SJ, Liu YX , Li SC, Chen M, McCord R, Venstromd J, Glusman ES, Punnoose E, Kiermaier A, Cheng G, Zhao WL （通讯作者） Immune Characteristics of Chinese Diffuse Large B-Cell Lymphoma Patients: Implications for Cancer Immunotherapies EBioMedicine 2018 33;94-104
Zheng Z, Xu PP, Wang L, Zhao HJ, Weng XQ, Zhong HJ, Qu B, Xiong J, Zhao Y, Wang XF, Janin A, Zhao WL （通讯作者） MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells Journal of Experimental & Clinical Cancer Research 2017 36:82
Xiong J, Wang L, Fei XC, Jiang XF, Zheng Z, Zhao Y, Wang CF, Li B, Chen SJ, Janin A, Gale RP,Zhao WL （通讯作者） MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma Blood Cancer Journal 2017 7; e582
Xu PP, Zhong HJ, Huang YH, Gao XD, Zhao X, Shen Y, Cheng S, Huang JY, Chen SJ, Wang L, Zhao WL （通讯作者） B-cell Function Gene Mutations in Diffuse Large B-cell Lymphoma：A Restropective Cohort Study EBioMedicine 2017 16;106–114
Ji MM, Wang L, Zhan Q, Xue W, Zhao Y, Zhao X, Xu PP, Shen Y, Liu H, Janin A, Cheng S, Zhao WL （通讯作者） Induction of autophagy by valproic acid enhanced lymphoma cell chemo-sensitivity through an HDAC-independent IP3-mediated PRKAA/AMPK activation Autophagy 2015 11:10,1-12
Xiong J, Bian J, Wang L, Zhou JY, Wang Y, Zhao Y, Wu LL, Hu JJ, Li B, Chen SJ, Yan C, Zhao WL （通讯作者） Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting Blood Cancer J. 2015 13;5:287. doi: 10.1038/
Jiang L, Gu ZH, Yan ZX, Zhao X, Xie YY, Zhang ZG, Pan CM, Hu Y, Cai CP, Dong Y, Huang JY, Wang L, Shen Y, Meng GY, Zhou JF, Hu JD, Wang JF, Liu YH, Yang LH, Zhang F, Wang JM, Wang Z, Peng ZG, Chen FY, Sun ZM, Ding H, Shi JM, Hou J, Yan JS, Shi JY, Xu L, Li Y, Lu J, Zheng Z, Xue W, Zhao WL （通讯作者）, Chen Z, Chen SJ Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma Nature Genetics 2015 47(9):1061-6
Zhang L, Chen QS, Xu PP, Qian Y, Wang AH, Xiao D, Zhao Y, Sheng Y, Wen XQ, Zhao WL （通讯作者） Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RARα oncoprotein degradation J Hematol Oncol. 2014 7(1):75
Xu PP, Yu D, Wang L, Shen Y, Shen ZX, Zhao WL （通讯作者） Analysis of prognostic factors and comparison of prognostic scores in peripheral T cell lymphoma, not otherwise specified: a single-institution study of 105 Chinese patients Ann Hematol. 2014 94(2):239-47
Yan ZX, Wu LL, Xue K, Zhang QL, Guo Y, Romero M, Leboeuf C, Janin A, Chen SJ, Wang L, Zhao WL （通讯作者） MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma LEUKEMIA 2014 28(4):880-887
Zheng Z, Cheng S, Wu W, Wang L, Zhao Y, Shen Y, Zhao WL （通讯作者） c-FLIP is involved in tumor progression of peripheral T-cell lymphoma and targeted by histone deacetylase inhibitors J Hematol Oncol. 2014 7(1):88
Yang F, Xiong J, Jia XE, Gu ZH, Shi JY, Zhao Y, Li JM, Chen SJ, Zhao WL （通讯作者） GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression PLoS One 2014 9(2):e89302. doi: 10.1371/journal.pone.**
Dong LH, Cheng S, Zheng Z, Wang L, Shen Y, Shen ZX, Chen SJ, Zhao WL （通讯作者） Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma J Hematol Oncol. 2013 6:53. doi: 10.1186/1756-8722-6-53
Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX, Chen SJ, Chen Y, Zhao WL （通讯作者） Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibitionof mTOR pathway and induction of autophagy Cell Death Dis 2012 1;3:e275
Xu PP, Wang Y, Shen Y, Wang L, Shen ZX, Zhao WL （通讯作者） Bevacizumab potentiates chemotherapeutic effect on T-leukemia/lymphoma cells by direct action on tumor endothelial cells. Prognostic factors of Chinese patients with T/NK-cell lymphoma: a single institution study of 170 patients Med Oncol 2012 29(3):2176-82
Wang L, Shi WY, Yang F, Tang W, Gapihan G, Varna M, Shen ZX, Chen SJ, Leboeuf C, Janin A, Zhao WL （通讯作者） Bevacizumab potentiates chemotherapeutic effect on T-leukemia/lymphoma cells by direct action on tumor endothelial cells Haematologica. 2011 96(6):927-31
Shi WY, Wang L, Xiao D, Yao Y, Yang F, Jiang XX, Leboeuf C, Janin A, Chen SJ, Zhao WL （通讯作者） Proteasome inhibitor bortezomib targeted tumor-endothelial cell interaction in T-cell leukemia/lymphoma Ann Hematol 2011 90(1): 53-56
Tang W, Wang L, Zhao WL, Chen YB, Shen ZX, Hu J Inttravenous busulfan-cyclophosphamide as a preparative regimen before allogeneic hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia Biol Blood Marrow Transplant 2011 17(10):1555-61
Zhang YW, Jiang XX, Chen QS, Shi WY, Wang L, Sun HD, Shen ZX, Chen Z, Chen SJ, Zhao WL （通讯作者） Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways Exp Hematol. 2010 38(3):191-201
Zhao WL （通讯作者） Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways Leukemia 2010 24(1):13-21
Xia ZG, Xu ZZ, Zhao WL, Zhao SQ, Ding F, Chen Y, Chen QS, Zheng Y, Zhu Q, Hu JP, Shen ZX, Li JM The prognostic value of immunohistochemical subtyping in Chinese patients with de novo diffuse large B-cell lymphoma undergoing CHOP or R-CHOP treatment Ann Hematol. 2010 89(2):171-7
Zhang QL, Wang L, Zhang YW, Jiang XX, Yang F, Wu WL, Janin A, Chen Z, Shen ZX, Chen SJ, Zhao WL （通讯作者） The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis Leukemia 2009 23(8):1507-1514
Shen Y, Yao Y, Li JM, Mi JQ, Chen QS, Chen Y, Zhao WL （通讯作者）, You JH, Zhao HJ, Wang Y, Wang L, Cheng S, Shen ZX Reassessment of the prognostic factors of international prognostic index (IPI) in the patients with diffuse large B-cell lymphoma in an era of R-CHOP in Chinese population Ann Hematol. 2009 88(9):863-869
Soltani-Arabshahi R, Leboeuf C, Rivet J, Pisonero H, Zhao WL （通讯作者）, Bachelez H,Ameisen JC, Janin A Bcl-xL gene expression correlated with lower apoptotic cell numbers and shorter progression-free survival in PCFCL J Invest Dermatol. 2009 129(7):1703-9
Fu JF, Shi JY, Zhao WL （共同第一作者）, Li G, Pan Q, Li JM, Hu J, Shen ZX, Jin J, Chen FY, Chen SJ MassARRAY assay: a more accurate method for JAK2V617F mutation detection in Chinese patients with myeloproliferative disorders Leukemia 2008 22(3):660-663
Zhao WL （共同第一作者）, Liu YY, Zhang QL, Wang L, Leboeuf C, Zhang YW, Ma J, Garcia JF, Song YP, Li JM, Shen ZX, Chen Z, Janin A, Chen SJ PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor Blood 2008 111(7):3867-3871
Wang L, Zhao WL （共同第一作者）, Yan JS, Liu P, Sun HP, Zhou GB, Weng ZY, Wu WL, Weng XQ, Sun XJ, Chen Z, Sun HD, Chen SJ Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner Cell Death Differ 2007 14(2): 306-317
Liu YY, Leboeuf C, Shi JY, Li JM, Wang L, Shen Y, Garcia JF, Shen ZX, Chen Z, Janin A, Chen SJ, Zhao WL （通讯作者） Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma Blood 2007 110(1): 339-344
Zhao WL （共同第一作者）, Wang L, Liu YH, Yan JS, Leboeuf C, Liu YY, Wu WL, Janin A, Chen Z, Chen SJ Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin's B-lymphoma cells apoptosis Exp Hematol 2007 35(12):1801-11
Zhu YM, Zhao WL （共同第一作者）, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis Clin Cancer Res. 2006 12(10):3043-3049
Chen B, Zhao WL （共同第一作者）, Jin J, Xue YQ, Cheng X, Chen XT, Cui J, Chen ZM, Cao Q, Yang G, Yao Y, Xia HL, Tong JH, Li JM, Chen J, Xiong SM, Shen ZX, Waxman S, Chen Z, Chen SJ Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries Leukemia 2005 19(5):767-775
Zhao WL （共同第一作者）, Daneshpouy ME, Mounier N, Brière J, Leboeuf C, Plassa LF, Turpin E, Cayuela JM, Ameisen JC, Gisselbrecht C, Janin A Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma Blood 2004 103(2):695-697
Zhao WL （共同第一作者）, Mourah S, Mounier N, Leboeuf C, Daneshpouy ME, Legrès L, Meignin V, Oksenhendler E, Maignin CL, Calvo F, Brière J, Gisselbrecht C, Janin A Vascular endothelial growth factor-A is expressed both on lymphoma cells and endothelial cells in angioimmunoblastic T-cell lymphoma and related to lymphoma progression Lab Invest 2004 84(11):1512-1519