导师姓名： 瞿介明 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 呼吸系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200025 邮箱地址： jmqu0906@163.com

研究方向 (点击浏览详细信息)
肺部感染与炎症损伤的机制和干预研究

社会任职
中国医师协会呼吸医师分会 副会长
上海市医学会医疗技术和伦理工作委员会 主任委员
上海医院协会 副会长
中华医学会灾难医学学会 常委
中国医学教育协会感染疾病专业委员会 常务理事
上海医学会 副会长
第二届上海市医疗服务标准技术委员会 主任委员
上海医学会呼吸病学主任委员 感染学组组长
中华医学会呼吸病学会候任主任委员 感染学组组长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
SQ2018YFGH000345 耐药革兰阴性菌感染快速诊断和智能优化治疗方案的研究 国家重点研发计划 2019-07~2022-07 696万元 课题负责人
2017ZZ02014 上海市重中之重临床医学中心和 重点学科建设 上海市卫生计划委员会 2017-06~2020-06 100万元 课题负责人
** 以间充质干细胞为主的多因素干预治疗耐药铜绿假单胞菌所致肺部重 症感染及其机制研究 国家自然科学基金 2017-01~2021-12 275万元 课题负责人
** 间充质干细胞治疗铜绿假单胞菌所致肺部感染时调节PGE2表达水平的机制研究 国家自然科学基金 2016-01~2019-12 55万元 课题负责人
** Beta防御素2基因修饰的脂源性肝细胞干预铜绿假单胞菌下呼吸道感染的研究 国家自然科学基金 2013-01~2016-12 70万元 课题负责人
2007CB513000 肠道微生态与感染的基础研究 科技部973 2013-01~2017-12 75万元 子课题负责人
** 经胸腔接种MSC治疗急性肺损伤机制研究 国家自然科学基金 2010-01~2010-12 8万元 课题负责人
** 携带缺氧诱导有丝分裂因子基因的骨髓间充质干细胞治疗急性肺损伤的研究 国家自然科学基金 2008-01~2010-12 36万元 课题负责人
** NOD在树突状细胞抗曲霉菌感染免疫中的作用研究 国家自然科学基金 2006-01~2008-12 26万元 课题负责人
** 模式识别受体在内毒素耐受小鼠中的作用和意义 国家自然科学基金 2004-01~2004-12 7万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liu D, Yan Y, Chen JW, Yuan P, Wang XJ, Jiang R, Wang L, Zhao QH, Wu WH, Simonneau G, Qu JM （通讯作者）, Jing ZC Hypermethylation of BMPR2 Promoter Occurs in the Patients with Heritable Pulmonary Arterial Hypertension and Inhibits BMPR2 Expression Am J Respir Crit Care Med 2017 Feb 7. doi: 10.1164/rccm.201611-2273LE
Tang XD, Shi L, Monsel A, Li XY, Zhu HL, Zhu YG, Qu JM （通讯作者） Mesenchymal Stem Cell Microvesicles Attenuate Acute Lung Injury in Mice Partly Mediated by Ang-1 mRNA Stem Cells 2017 35(7):1849-1859
Liu D, Liu QQ, Guan LH, Jiang X, Zhou DX, Beghetti M, Qu JM （通讯作者）, Jing ZC BMPR2 mutation is a potential predisposing genetic risk factor for congenital heart disease associated pulmonary vascular disease Int J Cardiol 2016 211:132-6
Tong L, Zhou J, Rong L, Seeley EJ, Pan J, Zhu X, Liu J, Wang Q, Tang X, Qu J （通讯作者）, Bai C, Song Y Fibroblast Growth Factor-10 (FGF-10) Mobilizes Lung-resident Mesenchymal Stem Cells and Protects Against Acute Lung Injury Sci Rep 2016 6:21642
Liu D, Wu BX, Sun N, Yan Y, Yuan P, Qu JM （通讯作者）, Jing ZC Elevated Levels of Circulating Bone Morphogenetic Protein 7 Predict Mortality in Pulmonary Arterial Hypertension Chest 2016 150(2):367-73
Zhao J, Zhang J, Zhang X, Feng M, Qu J （通讯作者） High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer Oncotarget 2016 7(26):40725-40734
Liu D, Peng SH, Zhang J, Bai SH, Liu HX, Qu JM （通讯作者） Prediction of short term re-exacerbation in patients with acute exacerbation of chronic obstructive pulmonary disease International journal of chronic obstructive pulmonary disease 2015 10: 1265-73
Mao YX, Xu JF, Seeley EJ, Tang XD, Xu LL, Zhu YG, Song YL, Qu JM （通讯作者） Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Pulmonary Infection Caused by Pseudomonas aeruginosa via Inhibiting Overproduction of Prostaglandin E2 Stem cells 2015 33: 2331-42
Liu D, Zhang J, Liu HX, Zhu YG, Qu JM （通讯作者） Intravenous combined with aerosolised polymyxin versus intravenous polymyxin alone in the treatment of pneumonia caused by multidrug-resistant pathogens: a systematic review and meta-analysis Int J Antimicrob Agents 2015 46(6):603-9
Xu LL, Lu YT, Zhang J, Wu L, Merrilees MJ, Qu JM （通讯作者） Knockdown of versican 1 blocks cigarette-induced loss of insoluble elastin in human lung fibroblasts Respiratory physiology & neurobiology 2015 215:58-63
Liu D, Zhang J, Liu HX, Zhu YG, Qu JM （通讯作者） Intravenous combined with aerosolised polymyxin versus intravenous polymyxin alone in the treatment of pneumonia caused by multidrug-resistant pathogens: a systematic review and meta-analysis Int J Antimicrob Agents 2015 46(6):603-9
Xiao-ru Wang1,Yong-pu Li, Shui Gao, Wei Xia,Kun Gao, Qing-hua Kong, Hui Qi, Ling Wu, Jing Zhang, Jie-ming Qu （通讯作者）, Chun-xue Bai Increased serum levels of lipocalin-1 and -2 in patients with stable chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014 9():543-9
Xu JF, Shen L, Zhang Y, Zhang P, Qu JM （通讯作者）, Li HP Lung biopsy-proved hypersensitivity pneumonitis without known offending antigen: characteristics and follow-up. Clin Respir J. 2014 8(3):297-304
Kai-Xiong Liu, Bing Xu, Jie Wang, Jing Zhang, Hai-Bo Ding, Felinda Ariani, Jie-Ming Qu （通讯作者）, Qi-Chang Lin Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis and COPD: a systematic review and meta-analysis J Thorac Dis. 2014 6(3):221-9
Jing Zhang,Yue-Li Zhang,Kai-Xiang Ma,Jie-Ming Qu （通讯作者） Efficacy and safety of adjunctive anticoagulation in patients with lung cancer without indication for anticoagulants: a systematic review and meta-analysis. Thorax 2013 68(5):442-50
Summah H1, Zhu YG, Falagas ME, Vouloumanou EK, Qu JM （通讯作者） Use of real-time polymerase chain reaction for the diagnosis of Pneumocystis pneumonia in immunocompromised patients: a meta-analysis Chin Med J (Engl) 2013 126(10):1965-73
Lili Tao,Wenhan Zhu,Bi-Jie Hu,Jie-Ming Qu （通讯作者）,Zhao-Qing Luob Induction of rapid cell death by an environmental isolate of Legionella pneumophila in mouse macrophages. Infect Immun. 2013 81(9):3077-88
Jin Yang,Kai-xiong Liu,Jie-ming Qu （通讯作者）,Xiao-dan Wang The changes induced by cyclophosphamide in intestinal barrier and microflora in mice. Eur J Pharmacol. 2013 714(13):120-4
Jie Wang,Kai-xiong Liu,Felinda Ariani1,Li-li Tao,Jing Zhang,Jie-Ming Qu （通讯作者） Probiotics for preventing ventilator-associated pneumonia: a systematic review and meta-analysis of high-quality randomized controlled trials. PLoS One. 2013 8(12):-
Hong-Ni Jiang,Bo Zeng,Yi Zhang,Nikoleta Daskoulidou,Hong Fan,Jie-Ming Qu （通讯作者）,Shang-Zhong Xu Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. PLoS One. 2013 8(6):-
Zi-li Wang,Zhi-qiang Fan,Han-dong Jiang,Jie-ming Qu （通讯作者） Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling Carcinogenesis 2013 34(3):638-46
Zhao-hui Qin,Jin-fu,Jie-ming Qu （通讯作者）,Jing Zhang,Yin Sai,Chun-mei Chen,Lian Wu,Long Yu Intrapleural delivery of MSCs attenuates acute lung injury by paracrine/endocrine mechanism. J Cell Mol Med. 2012 16(11):2745-53
Kai-xiong Liu,Ying-gang Zhu,Jing Zhang,Li-li Tao,Jae-Woo Lee,Xiao-dan Wang,Jie-ming Qu （通讯作者） Probiotics' effects on the incidence of nosocomial pneumonia in critically ill patients: a systematic review and meta-analysis. Crit Care. 2012 16():-
Lin Song,Jinfu Xu,Jieming Qu （通讯作者）,Yin Sai,Chunmei Chen,Long Yu,Dechun Li5,Xuejun Guo A therapeutic role for mesenchymal stem cells in acute lung injury independent of hypoxia-induced mitogenic factor. J Cell Mol Med. 2012 16(2):376-85
Jing Zhang,Ming-xiang Feng,Jie-ming Qu （通讯作者） Low dose theophylline showed an inhibitory effect on the production of IL-6 and IL-8 in primary lung fibroblast from patients with COPD. Mediators Inflamm. 2012 2012():-
Zhuo-zhe Li, Li-li Tao, Jing Zhang, Hui-jun Zhang, Jie-ming Qu （通讯作者） Role of NOD2 in regulating the immune response to Aspergillus fumigatus. Inflamm Res. 2012 61(6):643-8
Jing Zhang, Hanssa Summah, Ying-gang Zhu, Jie-Ming Qu （通讯作者） Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis Respir Res. 2011 12(158):-
Hanssa Summah, Li-li Tao, Ying-gang Zhu, Hong-ni Jiang, Jie-ming Qu （通讯作者） Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis BMC Infect Dis 2011 11(280):-
Zhao-hui Qin, Jie-ming Qu （通讯作者）, Jin-fu Xu, Jing Zhang, Hanssa Summah, He-xi Ge Sai-Yin, Chun-mei Chen, Long Yu Intrapleural delivery of mesenchymal stem cells: a novel potential treatment for pleural diseases Acta Pharmacol Sin. 2011 32(5):581-90
Xu JF, Qu JM （通讯作者）, Li HP N-Acetylcysteine modulates acute lung injury induced by Pseudomonas aeruginosa in rats Clin Exp Pharmacol Physiol. 2011 38(5):345-51
Lin-yun Zhu, Hanssa Summah, Hong-ni Jiang, Jie-ming Qu Plasma orexin-a levels in COPD patients with hypercapnic respiratory failure Mediators Inflamm. 2011 2011():-
Jing Zhang, Lian Wu, Jie-Ming Qu （通讯作者） Inhibited proliferation of human lung fibroblasts by LPS is through IL-6 and IL-8 release. Cytokine 2011 54(3):289-95
Dong-wei Shi, Jing Zhang, Hong-ni Jiang, Chao-yang Tong, Guo-rong Gu, Yuan Ji, Hanssa Summah, Jie-ming Qu LPS pretreatment ameliorates multiple organ injuries and improves survival in a murine model of polymicrobial sepsis Inflamm Res 2011 60(9):841-9
Jin Yang, Jie-ming Qu （通讯作者）, Hanssa Summah, Jin Zhang, Ying-gang Zhu, Hong-ni Jiang Protective effects of imipramine in murine endotoxin-induced acute lung injury Eur J Pharmacol. 2010 638(13):128-33
Min-fang Zhu, Jing Zhang, Jie-ming Qu （通讯作者）, Hui-jun Zhang, Shuang-cheng Zhou, Sheng-fu Dong, Hong-ni Jiang, Hanssa Summah Up-regulation of growth factor independence 1 in endotoxin tolerant macrophages with low secretion of TNF-alpha and IL-6 Inflamm Res 2010 59(10):855-60
Zhang J, Qu JM （通讯作者）, He LX IL-12 suppression, enhanced endocytosis and up-regulation of MHC-II and CD80 in dendritic cells during experimental endotoxin tolerance Acta Pharmacol Sin 2009 30(5):582-8
Xu P, Qu JM （通讯作者）, Xu JF, Zhang J, Jiang HN, Zhang HJ NAC is associated with additional alleviation of lung injury induced by invasive pulmonary aspergillosis in a neutropenic model Acta Pharmacol Sin 2009 30(7):980-6
Zhang HJ, Qu JM （通讯作者）, Shao CZ, Zhang J, He LX, Yuan ZH Aspergillus fumigatus conidia upregulates NOD2 protein expression both in vitro and in vivo Acta Pharmacol Sin 2008 29(10):1202-8
Xu J, Qu J （通讯作者）, Cao L, Sai Y, Chen C, He L, Yu L Mesenchymal stem cell based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysacharride in mice J Pathol 2008 214(4):472-81
Jiang HN, Qu JM （通讯作者）, He LX, Chen XH, Pan J, Li L, Zhu DN, Cao YX, Shen LL Effect of N(omega)-nitro-L-arginine methyl ester and aminoguanidine on lipopolysaccharide-induced airway hyperresponsiveness in guinea pigs Chin Med J (Engl) 2008 121(17):1693-7
Zhu YG, Qu JM （通讯作者） Toll like receptors and inflammatory factors in sepsis and differential expression related to age Chin Med J (Engl) 2007 120(1):56-61
Jiang H, Qu J （通讯作者）, He L, Pan J, Chen X, Li L, Zhu D, Cao Y Airway hyperresponsiveness induced by repetitive intraperitoneal injection of lipopolysacharide and the involvement of inflammation and nitric oxide in guinea pigs Inflamm Res 2006 55(7):286-92
Xu JF, Qu JM （通讯作者）, He LX, Ou ZL Impaired upregulation of keratinocyte growth factor in injured lungs induced by Pseudomonas aeruginosa in immunosuppressed rats Chin Med J (Engl) 2006 119(17):1421-1429
Shao C, Qu J （通讯作者）, He L, Zhang Y, Wang J, Wang Y, Zhou H, Liu X Transient overexpression of gamma interferon promotes Aspergillus clearance in invasive pulmonary aspergillosis Clin Exp Immunol 2005 142(2):233-41
Shao C, Qu J （通讯作者）, He L, Zhang Y, Wang J, Zhou H, Wang Y, Liu X Dendritic cells transduced with an adenovirus vector encoding interleukin-12 are a potent vaccine for invasive pulmonary aspergillosis Genes Immun 2005 6(2):103-14
Qu J （通讯作者）, Zhang J, Pan J, He L, Ou Z, Zhang X, Chen X Endotoxin tlerance inhibits lipopolysaccharide-initiated acute pulmonary inflammation and lung injury in rats Scand J Immunol 2003 58(6):613-9