导师姓名： 许大康 专业代码： 100208
性别： 男 专业名称： 临床检验诊断学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： dakang_xu@163.com

研究方向 (点击浏览详细信息)
肿瘤、炎症与免疫调控的基础研究和临床转化，精准诊断，精准医疗

社会任职
许大康，医学博士，研究员，博士生导师，曾获得澳大利亚国家卫生研究项目及健康研究基金的项目资助(NHMRC grant)多项。国家自然科学基金面上项目四项（12，14，16，18年）。担任国际著名期刊: Clinical and Experimental Pharmacology and Physiology (CEPP) 的副主编，入选为中国免疫学会临床免疫分会委员，获得浙江省****（创新人才）。已发表论文50余篇，其中第一及通讯作者占20篇以上，多篇论文发表在国际重要核心刊物如 Immunity, EMBO J和Nature Immunology , Nature communication , Proc. NatI. Acad. Sci（PNAS）, Cancer Res等学术期刊上。作为主编，于2017年在Springer Nature 出版社出版了免疫学专著《Regulation of Inflammatory Signaling in Health and Disease》。

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 探讨锌指家族转录因子对系统性红斑狼疮患者I型干扰素基因特征的调控和疾病的影响 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
** 感染性疾病中炎症信号通路的选择性调控 国家自然科学基金面上项目 2017-01~2020-12 60万元 课题负责人
** ATF3负向调控炎症和肿瘤进展的机制及其抗肿瘤治疗作用研究 国家自然科学基金面上项目 2015-01~2018-12 72万元 课题负责人
** 转录因子PLZF在干扰素IFN调控抗病毒感染中的作用 国家自然科学基金面上项目 2013-01~2016-12 70万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ying L, Yan F, Meng Q, Yu L, Yuan X, Gantier MP, Williams BRG, Chan DW, Shi L,Tu Y, Ni P, Wang X, Chen W, Zang X, Xu D* and Hu Y*. （通讯作者） PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers. Oncoimmunology. 2018 20;7(6):e**
Vasanthakumar A#, Xu D# （共同第一作者）, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS. A non-canonical function of Ezh2 preserves immune homeostasis. EMBO Rep. 2017 18(4):619-631.
Ying L, Yan F, Meng Q, Yuan X, Yu L, Williams BRG, Chan DW, Shi L, Tu Y, Ni P,Wang X, Xu D* and Hu Y*. （通讯作者） Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry. J Transl Med 2017 12;15(1):206.
DAKANG XU （通讯作者） Regulation of Inflammatory Signalling in Health and Disease Advances in Experimental Medicine and Biology 2017 Book series
Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, and Xu D* （通讯作者） BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs Proc Natl Acad Sci U S A 2015 112(5):1535-40
Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST,Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR, and Xu D*. （通讯作者） The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF Nat Commun. 2015 Apr 13;6:6795. doi:10.1038/ncomms7795.
De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S,Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W,Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, R?cken M, Lütjohann D, Wright SD, Schultze JL, Latz E. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol 2014 15(2):152-60
Li Y, Song W, Wu J, Zhang Q, He J, Li A, Qian J, Zhai A, Hu Y, Kao W, Wei L, Zhang F*, and Xu D* （通讯作者） MAVS-mediated host cell defense is inhibited by Borna disease virus. Int J Biochem Cell Biol 2013 45:1546-55.
Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, Chen J, Meng Q, Irving A, Wang D, Williams ED, Liu JP, Sadler AJ, Williams BR, Shen L*, and Xu D* （通讯作者） ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodelling of the actin cytoskeleton. Cancer Res. 2013 73:3625-37
Yuan X, Zhou Y, Wang W, Li J, Xie G, ZhaoY, Xu D* （通讯作者）, and Shen L* Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production Cell Death & Disease 2013 12;4:e794
Ma Y, Yuan X, Deng L, Xu W, Zheng Y, Yue C, Zhang G, Xie F, Yang YH, Gantier MP, Liu J, Xu D* and Shen L* （通讯作者） Imbalanced Frequencies of Th17 and Treg cells in Acute Coronary Syndromes Are Mediated by IL-6-STAT3 Signaling PLoS One. 2013 26;8(8):e72804.
Zheng Y, Wang Z, Deng L, Yuan X, Ma Y, Zhang G, Gantier MP, Liu JP, Shen L* ,and Xu D*. （通讯作者） Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells. Eur J Immunol. 2012 42:2803-14
Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H, Xu D, Williams BR, Sadler AJ. Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity 2012 25;36(5):795-806
Pan X, Yuan X, Zheng Y, Wang W, Shan J, Lin F, Jiang G, Yang Y, Liu JP, Xu D* and Shen L* （通讯作者） Increased CD45RA+ FoxP3(low) regulatory T cells with impaired suppressive function in patients with systemic lupus erythematosus PLoS ONE 2012 7(4):e34662.
Yuan X, Chen L, Li M., Dong P, Xue J, Wang J., Zhang T, Wang X., Zhang F, Ge H, Shen L* and Xu, D* （通讯作者） Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner Clin Immunol 2010 134(3), 277-88
Shen L,Wang J,Shen D,Yuan X,Dong P,Li M,Xue J,Zhang F,Ge H*,and Xu D*. （通讯作者） CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression Clin Immunol 2009 131(1):109-18
Xu D （共同第一作者）, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD and Williams BR Promyelocytic leukemia zincfinger protein regulates interferon-mediated innate immunity. Immunity 2009 19;30(6):802-16.
Xu D* （通讯作者）, Dwyer J, Li H, Duan W and Liu JP*. Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. J Biol Chem. 2008 29;283(35):23567-80.
Li H#, Xu D# （共同第一作者）, Li J, Berndt MC, Liu JP. Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene. J Biol Chem. 2006 1;281(35):25588-600
Xu D, Wilson TJ, Chan D, De Luca E, Zhou J, Hertzog PJ and Kola I. Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells EMBO J 2002 1;21(15):4081-93