导师姓名： 余韵 专业代码： 100208
性别： 女 专业名称： 临床检验诊断学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： yy@shsmu.edu.cn
邮编： 200025 邮箱地址： yunyu6@hotmail.com

研究方向 (点击浏览详细信息)
肿瘤相关基因的功能及分子机制研究

社会任职
中国病理生理学会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** FBXO22泛素化降解AIF的分子机制及其在肿瘤发病中的意义 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
15ZR** ANP32B表达对乳腺癌干细胞的影响及其分子机制 上海市自然科学基金 2015-01~2017-12 10万元 课题负责人
2013CB910903 赖氨酸残基多种翻译后修饰对蛋白质功能的调控作用 国家重大科技973项目 2013-01~2017-12 75万元 课题参与人
** ANP32B蛋白调控凋亡诱导因子表达的分子机制及其意义 国家自然科学基金面上项目 2010-01~2012-12 31万元 课题负责人
** 酸性富亮氨酸核磷酸蛋白32B在细胞凋亡中的作用机制 国家自然科学基金面上项目 2009-01~2011-12 32万元 课题参与人
** 新喜树碱衍生物诱导白血病细胞凋亡的体内外研究 国家自然科学基金青年基金 2006-01~2008-12 24万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhu XN, He P, Zhang L, Yang S, Zhang HL, Zhu D, Liu MD, Yu Y* （通讯作者） FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth Cell Death & Disease 2019 10 (7):486
Shen SM, Ji Y, Zhang C, Dong SS, Yang S, Xiong Z, Ge MK, Yu Y, Xia L, Guo M, Cheng JK, Liu JL, Yu JX, Chen GQ Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role Nat Commun 2018 19;9(1):2392
Gao YH, Wu ZX, Xie LQ, Li CX, Mao YQ, Duan YT, Han B, Han SF, Yu Y, Lu HJ, Yang PY, Xu TR, Xia JL, Chen GQ, Wang LS. VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2. Nat Commun 2017 15;8:15337
Xiong Z, Guo M, Yu Y, Zhang FF, Ge MK, Chen GQ, Shen SM Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer Carcinogenesis 2016 37(11):1079-1088
Yang S, Zhou L, Reilly PT, Shen SM, He P, Zhu XN, Li CX, Wang LS, Mak TW, Chen GQ, Yu Y*. （通讯作者） ANP32B deficiency impairs proliferation and suppresses tumor progression by regulating AKT phosphorylation. Cell Death & Disease 2016 2016 Feb 4;7:e2082.
Li CX, Shen SM, Wang LS, Yu Y* （通讯作者） Caspase-3-Resistant Uncleavable Form of ANP32B Potentiates Leukemic Cell Apoptosis. Molecular Medicine Reports 2015 11(4):2813-18
Han B, Wang TD, Shen SM, Yu Y, Mao C, Yao ZJ, Wang LS Annonaceous acetogenin mimic AA005 inducescancer cell death via apoptosis inducing factor through caspase-3-independent mechanism BMC Cancer. 2015 18;15:139
Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ. AIF inhibits tumor metastasis by protecting PTEN from oxidation EMBO Rep. 2015 16(11):1563-80
Reilly PT, Yu Y, Hamiche A, Wang L Cracking the ANP32 whips: Important functions, unequal requirement, and hints at disease implications Bioessays 2014 36 (11):1062-71
Yun Yu , Shao-Ming Shen , Fei-Fei Zhang, Zhao-Xia Wu, Bin Han, Li-Shun Wang. Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) contributes to retinoic acid-induced differentiation of leukemic cells. Biochem Biophys Res Commun. 2012 423(4):721-25
Shen SM, Yu Y* （共同第一作者）, Wu ZX, Zheng Y, Chen GQ, Wang LS. Apoptosis-inducing factor is a target gene of C/EBPα and participates in adipocyte differentiation. FEBS Lett 2011 585(14):2307-12.
Shen SM, Yu Y* （共同第一作者）, Wu YL, Cheng JK, Wang LS, Chen GQ. Down-regulation of ANP32B, a novel substrate of caspase-3, enhances caspaspe-3 activation and apoptosis induction in myeloid leukemic cells. Carcinogenesis 2010 31(3): 419-26
Yuan TT, Huang Y, Zhou CX, Yu Y, Wang LS, Zhuang HY, Chen GQ. Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis Apoptosis 2009 14(5):699-710
Zhang N, Zhang HW, Xia L, Zheng Y, Yu Y, Zhu YS, Chen GQ, Di W NSC606985 induces apoptosis, exerts synergistic effects with cisplatin and inhibits hypoxia-stabilized HIF-1a protein in human ovarian cancer cells. Cancer Letters 2009 278(2):139-44
Liu W, Zhu YS, Guo M, Yu Y, Chen GQ Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia Leuk Res. 2007 31 (11):1565-74.
Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ. Subcellular proteome analysis of camptothecin analog NSC606985-treated acute myeloid leukemic cells. J Proteome Res 2007 6(9):3808-18
Guo M, Song LP, Jiang Y, Liu W, Yu Y, Chen GQ Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms. Apoptosis 2006 11(1):67-77
Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells Haematologica 2005 90(12):1607-16.
Jiang Y, Xue ZH, Shen WZ, Du KM, Yan H, Yu Y, Peng ZG, Song MG, Tong JH, Chen Z, Huang Y, Lubbert M, Chen GQ. Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha Leukemia 2005 19(7):1239-47
Yu Y, Chen S, Wang LS, Chen WL, Guo WJ, Yan H, Zhang WH, Peng CH, Zhang SD, Li HW, Chen GQ. Prediction of pancreatic cancer by serum biomarkers using surface-enhanced laser desorption/ionization-based decision tree classification. Oncology 2005 68(1):79-86
Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH, Wang Q, Chen Z, Zhu YS, Chen GQ. Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH, Wang Q, Chen Z, Zhu YS, Chen GQ. Blood 2005 105(9):3714-21
Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ, Zhao Q Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1alpha protein Biochem Biophys Res Commun 2005 332(4):1140-45
Cai X, Yu Y* （共同第一作者）, Huang Y, Zhang L, Jia PM, Zhao Q, Chen Z, Tong JH, Dai W, Chen GQ. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. Leukemia. 2003 17(7):1333-37
Zhu Q, Zhang JW, Zhu HQ, Shen YL, Flexor M, Jia PM, Yu Y, Cai X, Waxman S, Lanotte M, Chen SJ, Chen Z, Tong JH. Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Blood 2002 99(3):1014-22
Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L, Huang Y, Zhang JW, Xiong SM, Chen SJ, Wang ZY, Chen Z, Chen GQ Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia Leukemia 2000 14(2):262-70