导师姓名： 王学锋 专业代码： 100208
性别： 男 专业名称： 临床检验诊断学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市瑞金二路197号瑞金医院
邮编： 200025 邮箱地址： **@139.com

研究方向 (点击浏览详细信息)
出血病与血栓病诊治，临床输血

社会任职
上海医学会检验分会副主任委员
上海医学会输血分会前任主任委员
全国临床输血委员会副主任
上海医学会检验分会候任主委
中国输血协会理事
中华医学会检验学会血液学和体液学学组副组长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 功能获得性突变Gly397Ala增强凝血因子XI凝血活性的分子机制研究 国家自然基金委面上项目 2018-01~2021-12 55万元 课题负责人
** 丝氨酸蛋白酶21作为血小板中凝血因子XI样活性蛋白的鉴定及凝血相关功能研究 国家自然基金面上项目 2016-01~2019-12 66万元 课题负责人
** 囊泡分选蛋白VPS33B在血小板α颗粒形成中的机制研究 国家自然基金委,面上项目2014.01-2017.12 2014-01~2017-12 88万元 课题负责人
** 凝血因子Ⅷ Trp1707Ser突变相关抑制物的作用机制研究 国家自然基金委,面上项目 2012.01-2015.12 2012-01~2015-12 70万元 课题负责人
** 凝血因子Ⅷ His99Arg突变蛋白的分子发病机制研究 国家自然基金委,面上项目 2009-01~2011-12 33万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Lu Y, Mehta-D'souza P, Biswas I, Villoutreix BO, Wang X, Ding Q, Rezaie AR Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis. Haematologica 2020 2019 Aug 8, Epub
Cai X, Ren M, Chen F, Li L, Lei H, Wang X. （通讯作者） Blood transfusion during the COVID-19 outbreak Blood Transfus 2020 2020;18(2):79-82
Yeling Lu,* Zhenping Chen,* Jing Dai,* Xi Wu, Hao Gu, Zekun Li, Jian Li, Qiulan Ding, Wenman Wu, Runhui Wu, Xuefeng Wang （通讯作者） Maternal microchimerism protects hemophilia A patient from inhibitor development Blood Advance 2020 2020 12;4(9):1867-1869
Wenman Wu, Lin Xiao, Xi Wu, Xiaoling Xie, Ping Li, Changming Chen, Zhaoyue Zheng,Jiangang Ai, Alexander Valencia, Birong Dong, Qiulan Ding, Biao Dong, and Xuefeng Wang （通讯作者） Factor IX alteration p.Arg338Gln (FIX Shanghai) potentiates FIX clotting activity and causes thrombosis Haematologica 2020 2020.Feb,Epub
Xi Wu,* Jing Dai,* Xiaoqian Xu, Fang Li, Lei Li, Yeling Lu, Qin Xu, Qiulan Ding, Wenman Wu, Xuefeng Wang （通讯作者） Prothrombin Arg541Trp Mutation Leads to Defective PC (Protein C) Pathway Activation and Constitutes a Novel Genetic Risk Factor for Venous Thrombosis ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2020 2020，40（2）：483-494
Yeling Lu, Hemant Giri, Bruno O. Villoutreix, Qiulan Ding, Xuefeng Wang （通讯作者）, and Alireza R.Rezaie Gly197Arg mutation in protein C causes recurrent thrombosis in a heterozygous carrier J Thromb Haemost 2020 2020 Feb 20, Epub
Yeling Lu, Xi Wu, Jing Dai, Qiulan Ding, Wenman Wu, Xuefeng Wang*. （通讯作者） The characteristics and spectrum of F9 mutations in Chinese sporadic haemophilia B pedigrees. Haemophilia 2019 25（2）:316-323
Lei Li, Xi Wu, Wenman Wu, Qiulan Ding, Xiaohong Cai, Xuefeng Wang*. （通讯作者） Clinical Manifestation and Mutation Spectrum of 53 Unrelated Pedigrees with Protein S Deficiency in China. Thromb Haemost 2019 119（3）:449-460
Y Lu, Y Xin, J Dai, X Wu, G You, Q Ding, W Wu, X Wanng （通讯作者） Spectrum and origin of mutations in sporadic cases of haemophilia A in China Haemophilia 2018 24(2):291-298
Qiulan Ding; Likui Yang; Xiaoqing Zhao; Wenman Wu; Xuefeng Wang*; Alireza R. Rezaie. Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation. Thromb Haemost 2017 117(3);479-490
Zhou J, Ding Q, Wu W, Ouyang Q, Xie Y, Wu X, Lu Y, Dai J, Liang Q, Wang H, Wang X* （通讯作者）, Hu Y Dysfibrinogenemia-associated novel heterozygous mutation, Shanghai （FGA c.169_180＋2 del）, leads to N-terminal truncation of fibrinogen Aα chain and impairs fibrin polymerization Clin Pathol 2017 70（2）:145-153
Cai X, Qian C, Wu W, Lei H, Ding Q, Zou W, Xiang D, Wang X （通讯作者） An exonic missense mutation c.28G>A is associated with weak B blood group by affecting RNA splicing of the ABO gene. Transfusion 2017 57(9):2140-2149
Qian Liang, Huanhuan Qin, Qiulan Ding, Xiaoling Xie, Runhui Wu, Hongli Wang, Yiqun Hu, Xuefeng Wang*. （通讯作者） Molecular and clinical profile of VWD in a large cohort of Chinese population: application of next generation sequencing and CNVplex? technique Thromb Haemost 2017 117:1543-1548
Qianlan Ding, Xi Wu, Yeling Lu, Changming Chen, Rui Shen, Xi Zhang, Zhengwen Jiang, Xuefeng Wang*. （通讯作者）, AccuCopy quantification combined with pre-amplification of long-distance PCR for fast analysis of intron 22 inversion in haemophilia A. Clinical Chimica Acta 2016 458:78-83
Jing Dai, Yeling Lu, Conghui Wang, Xue Chen, Xuemei Fan, Hao Gu, Xiaolin Wu, Kemin Wang, T Kent Gartner, Junke Zheng, Guoqiang Chen, Xuefeng Wang* （通讯作者）, Junling Liu*. Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes Journal of Pathology 2016 240: 108–119
Zhou J, Xin Y, Ding Q, Jiang L, Chen Y, Dai J, Lu Y, Wu X, Liang Q, Wang H, Wang X （通讯作者） Thromboelastography predicts risks of obstetric complication occurrence in (hypo)dysfibrinogenemia patients under non-pregnant state Clin Exp Pharmacol Physiol 2015 doi: 10.1111/1440-1681.12509
Ding Q, Yang L, Dinarvand P, Wang X （通讯作者）, Rezaie AR Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays Blood 2015 125(15):2428-34
Zhou J, Ding Q, Chen Y, Quyang Q, Jiang L, Dai J, Lu Y, Wu X, Liang Q, Wang H, Wang X （通讯作者） Clinical features and molecular basis of 102 Chinese patients with congenital dysfibrinogenemia Blood cells, molecules and diseases 2015 55(4), 308-315
Zhou J, Ding Q, Chen Z, Yang H, Lin L, Wang H, Wang X （通讯作者）, Wu R Risk factors associated with inhibitor development in Chinese Patients with haemophilia B Haemophilia 2015 21(4), e286-e293
Lu Q, Yang L, Manithody C, Wang X （通讯作者）, Rezaie AR Expression and Characterization of Gly-317 Variants of Factor IX Causing Variable Bleeding in Hemophilia B Patients Biochemistry 2015 54(24):3814-21
Qin HuanHuan, Xing ZF, Wang XF （通讯作者）, Ding QL, Xi XD,Wang HL Similarity in joint and mucous bleeding syndromes in type 2N von Willebrand disease and severe hemophilia A coexisting with type 1 von Willebrand disease in two Chinese pedigrees Blood Cells, Molecules, and Diseases 2014 52(4):181-185
Lu QiuYa, Yang L, Manithody C, Wang X （通讯作者）, Rezain AR Molecular basis of the clotting defect in a bleeding patient missing the Asp-185 codon in the factor X gene Thromb Res 2014 134(5):1103-9
You G, Chi K, Lu Y, Ding Q, Dai J, Xi X, Wang H and Wang X. . 2014; 112. Identification and characterisation of a novel aberrant pattern of intron 1 inversion with concomitant large insertion and deletion within the F8 gene Thromb Haemost 2014 112():-
Wu YT, Yue F, Wang M, Lu YL, Dai J, Ding QL, Wang HL, Chen HF, Wang XF （通讯作者） Hereditary protein C deficiency caused by compound heterozygous mutants in two independent Chinese families Pathology 2014 46(7):630-5
Wu X, Lu Y, Ding Q, You G, Dai J, Xi X, Wang H and Wang X. . 2014; 112. Characterisation of large F9 deletions in seven unrelated patients with severe haemophilia B Thromb Haemost 2014 112():-
Ding Q, Shen Y, Yang L, Wang X （通讯作者）, Rezaie AR. . . 2013 Jul 1;110(1):53-61. The missense Thr211Pro mutation in the factor X activation peptide of a bleeding patient causes molecular defect in the clotting cascade Thromb Haemost 2013 110(1):53-61
Ding Q, Shen W, Ye X, Wu Y, Wang X （通讯作者）, Wang H Clinical and genetic features of protein C deficiency in 23 unrelated Chinese patients Blood Cells Mol Dis 2013 50(1):53-8
Qiulan Ding, Min Wang, Guanqun Xu, Xu Ye, Xiaodong Xi, Tingting Yu, Xuefeng Wang （通讯作者）, and Hongli Wang.. . 2013 Sep;132(3):367-73. Molecular basis and thrombotic manifestations of antithrombin deficiency in 15 unrelated Chinese patients Thromb Res 2013 132(3):367-73
You GL, Ding QL, Lu YL, Dai J, Xi XD, Wang XF, Wang HL Characterization of large deletions in the F8 gene using multiple competitive amplification and the genome walking technique J Thromb Haemost 2013 11(6):1113-10
Ding Q, Yang L, Hassanian SM, Rezaie AR, （通讯作者） Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population Thromb Haemost 2013 109(4):614-24
Dai J, Lu Y, Ding Q, Wang H, Xi X, Wang X. （通讯作者） The status of carrier and prenatal diagnosis of haemophilia in China Haemophilia 2012 18(2):235-240
Ding QL, Lu YL, Dai J, Xi XD, Wang XF （通讯作者）, Wang HL. Characterisation and validation of a novel panel of the six short tandem repeats for genetic counselling in Chinese haemophilia A pedigrees Haemophilia 2012 18(4):621-5
Y. L. LU, X. F. WANG （通讯作者）, Q. L. DING, J. DAI, X. D. XI, H. L. WANG Prevalence of the factor 8 gene intron 1 inversion in Chinese haemophiliacs and its application to carrier detection and prenatal diagnosis in haemophilia A families Haemophilia 2011 17(3):541-2
Wang XF, Zhao YQ, Yang RC, Wu JS, Sun J, Zhang XS, Ding QL, Ge HL, Wang HL The prevalence of factor VIII inhibitors and genetic aspects of inhibitor development in Chinese patients with haemophilia A Haemophilia 2010 16(4):632-9
Xue-Feng Wang （共同第一作者）, Pei-Pei Jin, Tong Zhou, Ya-Peng Zhao, Qiu-Lan Ding, Deng-Bin Wang,Guang-Ming Zhao,Jing-Dai,Hong-Li Wang, and Hai-Liang MR Molecular Imaging of Thrombus:Development and Application of a Gd-based Novel Contrast Agent Targeting to P-selectin Clinical and Applied Thrombosis/Hemostasis 2010 16(2):177-183
Yeling Lu, Bingshou Xie, Qiulan Ding, et al. Occurence of hemophilia A and B in a Chinese family with mosaicism of the F9 gene mutation in the HB index’s maternal grandfather Thromb Haemost 2010 103(5):1106-8
H. CHEN, X. WANG （共同第一作者）, X. SU, F. YANG, Y. LU, G. XU, J. DAI, Q. DING, X. XI and H. WANG Identification of a novel splicing mutation in the fibrinogen Aa chain gene leading to in a Chinese pedigree HAEMOPHILIA 2009 15：394-397
PEI-PEI JIN, XUE-FENG WANG.QIU-LAN DING （共同第一作者）,QI-HUA FU, XIAO-HONG CAI, LI-SONG SHEN AND HONG-LI WANGWANG,LISONG SHEN and DAO LI Ser234Leu missense mutation in the A 1 domain of factor V causing moderate faxtor V deficiency in a Chinese family mutation Pathology 2009 41(6):566-571
T. YU,X. WANG （共同第一作者）, Q. DING, Q. FU, J. DAI,Y. LU, X. XI and H. WANG Using a minigene approach to characterize a novel splice site mutation in human F7 gene causing inherited factor VII deficiency in a Chinese pedigree HAEMOPHILIA 2009 15, 1262–1266
H. CHEN, X. WANG （共同第一作者）, X. SU, F. YANG, Y. LU, G. XU, J. DAI, Q. DING, X. XI and H. WANG Identification of a novel splicing mutation in the fibrinogen Aa chain gene leading to in a Chinese pedigree HAEMOPHILIA 2009 15：394-397
JING WANG, XUEFENG WANG （共同第一作者）, JING DAI, QIULAN DING, QIHUA FU, HONGLI WANG,LISONG SHEN and DAO LI A case of factor XI deficiency caused by compound heterozygous F11 gene mutation HAEMOPHILIA 2009 15, 603–606
Wang X （共同第一作者）, Lu Y,Ding Q,Dai J,Xi X,Wang H Haemophilia A in two unrelated females due to F8 gene inversions combined with skewed inactivation of X chromosome THROMBOSIS AND HAEMOSTASIS 2009 101: 775-778
Yeling Lu,Xuefeng Wang （共同第一作者）, Qiulan Ding,Jing Dai,Xiaodong Xi,Hongli Wang Recombination in a Chinese haemophilia A familywith skewed inactivation of X chromosome PATHOLOGY 2008 40: 635-638
Xiaohong Cai,Xuefeng Wang （共同第一作者）,Qiulan Ding,Qihua Fu,Hongli Wang Factor V C1149G and 5609-10INSCGTGGTT causing factor V deficiency: Molecular characterization by in-vitro expression THROMBOSIS AND HAEMOSTASIS 2007 98: 683-685