导师姓名： 钟一声 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： yszhong68@126.com
邮编： 200025 邮箱地址： yszhong68@126.com

研究方向 (点击浏览详细信息)
青光眼、神经眼科学、葡萄膜病

社会任职
《中华眼底病杂志》特邀审稿人
《眼科新进展杂志》编委
《Acta Ophthalmol》(SCI) 特邀审稿人
《Clin Exp Ophthalmology》 (SCI)特邀审稿人
《中华实验眼科杂志》通信编委
上海市中西医结合学会眼科分会常委
上海市眼科学会青光眼学组副组长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** IL-17A对实验性青光眼视网膜小胶质细胞激活的调控作用研究 国家自然科学基金，面上项目 2021-01~2024-12 55万元 课题负责人
** 骨桥蛋白调控实验性青光眼视网膜小胶质细胞的激活及其机制研究 国家自然科学基金，面上项目 2019-01~2022-12 57万元 课题负责人
** 前房单次注射交联水凝胶建立大鼠慢性高眼压模型及其性能评估 上海市科委“科技创新行动计划”实验动物研究项目 2017-07~2019-06 30万元 课题负责人
** 血浆中硫化氢的水平与青光眼视神经损害程度的关系研究 上海市科委,西医引导 2016-07~2019-06 20万元 课题负责人
** 腺苷对实验性青光眼视网膜Müller细胞钾离子通道调控的研究 国家自然科学基金，面上项目 2014-01~2017-12 70万元 课题负责人
11JC** 腺苷对实验性青光眼视网膜Müller细胞钾离子通道的调控 上海市科委基础研究重点项目 2012-01~2014-12 30万元 课题负责人
** RhoA/ROCK通路在EPO促视网膜神经细胞轴突生长中的作用 国家自然科学基金，面上项目 2011-01~2013-12 32万元 课题负责人
1330 ROCK蛋白表达和活性改变对视网膜母细胞瘤细胞运动表型的影响研究 上海市科委慈善癌症研究中心项目 2010-10~2012-09 4万元 课题负责人
08ZR** RhoA/ROCK通路在EPO促视网膜神经细胞轴突生长中的作用 上海市科委，自然科学基金 2008-09~2011-12 10万元 课题负责人
06BZ040 小胶质细胞在青光眼视神经损害中的抗原呈递性研究 上海市教委 2006-12~2009-12 8万元 课题负责人
034075 蓝/黄刺激检测青光眼视神经损害的实验和临床研究 上海市卫生局 2004-01~2006-12 3万元 课题负责人
04JC14023 青光眼术后滤过道组织重塑及促红细胞生成素保护视神经的基础研究 上海市科委基础研究重点项目 2004-01~2006-12 15万元 子课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yu H, Zhong H, Chen J, Sun J, Huang P, Xu X, Huang S, Zhong Y （通讯作者） Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber Med Sci Monit 2020 26:e925852
Lin ZJ, Chen ZH, Huang SY, Sun J, Shen X, Zhong YS （通讯作者） Clinical efficacy of Ahmed glaucoma valve implantation combined with 23-gauge vitrectomy for medically uncontrolled neovascular glaucoma with proliferative diabetic retinopathy Int J Ophthalmol 2020 13(5):832-836
Lin Z, Huang S, Yu H, Sun J, Huang P, Zhong Y （通讯作者） Analysis of Plasma Hydrogen Sulfide, Homocysteine, and L-Cysteine in Open-Angle Glaucoma Patients J Ocul Pharmacol Ther. 2020 36(8):649-657
Huang S, Huang P, Yu H, Lin Z, Liu X, Shen X, Guo L, Zhong Y （通讯作者） Extracellular signal-regulated kinase 1/2 pathway is insufficiently involved in the neuroprotective effect by hydrogen sulfide supplement in experimental glaucoma Invest Ophthalmol Vis Sci 2019 2019;60(13):4346-4359
Lin Z, Huang S, Huang P, Li C, Chen Z, Zhong Y （通讯作者） Concordance of 24-h intraocular pressure curve in patients with untreated unilateral primary open-angle glaucoma Exp Ther Med 2018 16(2):1461-1469
Lin Z, Huang S, Huang P, Guo L, Bian H, Zhong Y （通讯作者） Analysis of choroidal thickness in ocular hypertensive patients using enhanced depth imaging optical coherence tomography Lasers Med Sci 2018 33(1):111-121
Lin Z, Huang P, Huang S, Guo L, Xu X, Shen X, Xie B, Zhong Y （通讯作者） Effect of adenosine and adenosine receptor antagonists on retinal müller cell inwardly rectifying potassium channels under exogenous glutamate stimulation Biomed Res Int 2018 2018:**
Huang S, Huang P, Lin Z, Liu X, Xu X, Guo L, Shen X, Li C, Zhong Y （通讯作者） Hydrogen sulfide supplement attenuates the apoptosis of retinal ganglion cells in experimental glaucoma Exp Eye Res 2018 168:33-48
Huang S, Huang P, Liu X, Lin Z, Wang J, Xu S, Guo L, Leung CK, Zhong Y （通讯作者） Relevant variations and neuroprotecive effect of hydrogen sulfide in a rat glaucoma model Neuroscience 2017 341:27-41
Lin Z, Huang S, Huang P, Guo L, Shen X, Zhong Y （通讯作者） The diagnostic use of choroidal thickness analysis and its correlation with visual field indices in glaucoma using spectral domain optical coherence tomography PLoS One 2017 12(12):e**
Shen X, Chen Y, Wang Y, Yang L, Zhong Y （通讯作者） Intravitreal ranibizumab injection as an adjuvant in the treatment of neovascular glaucoma accompanied by vitreous hemorrhage after diabetic vitrectomy J Ophthalmol 2016 2016: **
Liu X, Huang P, Wang J, Yang Z, Huang S, Luo X, Qi J, Shen X, Zhong Y. （通讯作者） The effect of A2A receptor antagonist on microglial activation in experimental glaucoma Invest Ophthalmol Vis Sci 2016 57(3):776-786.
Cai Y, Tan W, Shen X, Zhu Y,Gao Y, Sui A, Lu Q, Zhong Y （通讯作者）, Xie B Neutralization of IL-23 depresses experimental ocular neovascularization Exp Eye Res 2016 146: 242-251
Yang Z, Huang P, Liu X, Huang S, Deng L, Jin Z, Xu S, Shen X, Luo X, Zhong Y （通讯作者） Effect of adenosine and adenosine receptor antagonist on Müller cell potassium channel in rat chronic ocular hypertension models Sci Rep 2015 5: 11294
Li Y, Liu X, Huang S, Huang P, Zhong Y （通讯作者） Effect of SCH442416 on glutamate uptake in retinal Müller cells at increased hydrostatic pressure Mol Med Rep 2015 12(3):3993-3997
Xu S, Jiao Q, Cheng Y, Sun J, Lu Q, Zhong Y （通讯作者） Short-term reproducibility of twenty-four-hour intraocular pressure curves in untreated patients with primary open-angle glaucoma and ocular hypertension PLoS One 2015 10(10):e**
Yang ZJ, Zhong YS （通讯作者） Effect of adenosine on GLAST expression in the retina of a chronic ocular hypertension rat model Exp Ther Med 2015 10(3): 991-994
Wang J, Liu XH, Yang ZJ, Xie B, Zhong YS （通讯作者） The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells BMC Cancer 2014 14(1):89
Yang Z, Wang J, Liu X, Cheng Y, Deng L, Zhong Y （通讯作者） Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration Oncol Rep 2013 29(3):1140-1146
Feng PL, Wang J, Yang ZJ, Liu XH, Zhong YS （通讯作者） Effect of Y-27632 on the cultured retinal neurocytes of rats Int J Ophthalmol 2013 2013;6(1):15-18
Zhong Y （通讯作者）, Chen L, Cheng Y, Yu F GDx VCC measurements and blue-on-yellow perimetry in ocular hypertension Lasers Med Sci 2013 28(2): 361-365
Cheng Y, Liu XH, Shen X, Zhong YS （通讯作者） Ahmed valve implantation for neovascular glaucoma after 23-gauge vitrectomy in eyes with proliferative diabetic retinopathy Int J Ophthalmol 2013 6(3):316-320
Yu J, Zhong Y(CA) （通讯作者）, Shen X, Cheng Y, Qi J, Wang J In vitro effect of adenosine A2A receptor antagonist SCH 442416 on the expression of glutamine synthetase and glutamate aspartate transporter in rat retinal Müller cells at elevated hydrostatic pressure Oncology Reports 2012 27(3):748-752
Tan H, Zhong Y （通讯作者）, Shen X, Cheng Y, Jiao Q, Deng L Erythropoietin promotes axonal regeneration after optic nerve crush in vivo by inhibition of RhoA/ROCK signaling pathway Neuropharmacology 2012 63(6):1182-1190
Tan HB, Shen X, Cheng Y, Jiao Q, Yang ZJ, Zhong YS （通讯作者） Evaluation of a partial optic nerve crush model in rats Exp Ther Med 2012 4(3):401-404
Huang P, Wang J, Shen X, Jiao Q, Cheng Y, Xie B, Zhong Y （通讯作者） The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate Mol Med Rep 2012 6(3):662-666
Tan H, Kang X, Zhong Y （通讯作者）, Shen X, Cheng Y, Jiao Q, Deng L Erythropoietin upregulates growth associated protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush Neural Regen Res 2012 7(4):295-301
Yu J, Chen C, Wang J, Cheng Y, Wu Q, Zhong Y （通讯作者）, Shen X In vitro effect of adenosine on the mRNA expression of Kir 2.1 and Kir 4.1 channels in rat retinal Müller cells at elevated hydrostatic pressure Exp Ther Med 2012 3(4):617-620
Yu J, Zhong Y (CA) （通讯作者）, Cheng Y, Shen X, Wang J, Wei Y Effect of high hydrostatic pressure on the expression of glutamine synthetase in rat retinal Müller cells cultured in vitro Exp Ther Med 2011 2(3):513-516
Zhong YS （通讯作者）, Chen LP, Cheng Y Blue-on-yellow perimetry and corneal thickness in patients with ocular hypertension Int J Ophthalmol. 2011 4(6):623-626
Tan HB, Zhong YS （通讯作者）, Cheng Y, Shen X Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage Int J Ophthalmol. 2011 4(6):652-657
Zhong Y （通讯作者）, Shen X, Yu J, Tan H, Cheng Y The comparison of the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness Cornea 2011 30(8):861-864
Zhong YS （通讯作者）, Xiang MH, Ye W, Huang P, Cheng Y, Jiang YQ Neuroprotective effect of Erigeron Breviscapus (vant) Hand-mazz extract on retinal ganglion cells in rabbits with chronic elevated intraocular pressure Asian Biomed 2011 5(2):195-203.
Zhong Y （通讯作者）, Zhou X, Cheng Y, Xie L Relationship between blue-on-yellow perimetry and optical coherence tomography in normal tension glaucoma Can J Ophthalmol 2010 45(5):494-500
Zhong YS （通讯作者）, Yao HP, Deng LF, Cheng Y, Min YJ Effect of erythropoietin on the survival of retinal neurocytes in culture upon serum withdrawal Neurosciences 2010 15 (3):152-158
Zhong Y （通讯作者）, Shen X, Liu X, Cheng Y The early effect of nerve growth factor in the management of serious optic nerve contusion Clin Exp Optom 2010 93(6):466-470
Yisheng Zhong （通讯作者）, Yu Cheng, Xiaohong Liu, Peili Feng Trabeculectomy in the management of glaucomatocyclitic crisis with visual field defect Ocular Immunology and Inflammation 2010 18(3):233-236
Zhong Y （通讯作者）, Min Y, Jiang Y, Cheng Y, Jiao Q, Shen X Color doppler imaging and pattern visual evoked potential in normal tension glaucoma and hypertension glaucoma Doc Ophthalmol 2009 119 (3):171-180
Zhong Y （通讯作者）, Chen L, Cheng Y, Huang P Correlation between blue-on-yellow perimetry and GDx VCC measurements in primary open angle glaucoma Jpn J Ophthalmol 2009 53(6):574-579
Zhong Y （通讯作者）, Shen X, Zhou X, Cheng Y, Min Y Blue-on-yellow perimetry and optical coherence tomography in patients with preperimetric glaucoma Clin Exp Ophthalmol 2009 37(3):262-269
Zhong Y （通讯作者）, Shen X, Min Y, Cheng Y, Jiao Q The role of blue-on-yellow perimetry in patients with pituitary tumor Ann Ophthalmol (Skokie) 2009 41(1):40-43
Zhong Y （通讯作者）, Chen L, Cheng Y, Huang P Influence of learning effect on blue-on-yellow perimetry Eur J Ophthalmol 2008 18(3):392-399
Zhong YS （通讯作者）, Liu XH, Cheng Y, Min YJ Erythropoietin with retrobulbar administration protects retinal ganglion cells from acute elevated intraocular pressure in rats J Ocular Pharmacol Ther 2008 24(5):453-459
Zhong YS （通讯作者）, Leung CKS, Pang CP Glial cells and glaucomatous neuropathy Chin Med J 2007 120 (4):326-335
Zhong Y （通讯作者）, Gao J, Ye W, Huang P, Cheng Y, Jiao Q Effect of latanoprost acid and pilocarpine on cultured rabbit ciliary muscle cells Ophthalmic Res 2007 39(4):232-240
Zhong Y （通讯作者）, Yao H, Deng L, Cheng Y, Zhou X Promotion of neurite outgrowth and protective effect of erythropoietin on the retinal neurons of rats Graefes Arch Clin Exp Ophthalmol 2007 245(12):1859-1867