导师姓名： 张浩 专业代码： 100213
性别： 男 专业名称： 耳鼻咽喉科学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： zhanghaoent@163.com

研究方向 (点击浏览详细信息)
鼻窦炎，鼾症，头颈肿瘤的基础和临床研究

社会任职
中国中西医结合耳鼻咽喉科专业委员会头颈肿瘤专家委员会委员
上海医学会耳鼻咽喉头颈外科分会咽喉组委员
上海市耳鼻咽喉科临床质量控制中心督查专家

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
SHDC** 喉癌、喉咽癌治疗的规范化及其推广应用 上海申康医院发展中心临床科技创新项目 2016-01~2018-12 100万元 子课题负责人
BMSCs介导的钠碘转运体和HSV-tk应用于喉咽癌分子成像和双基因靶向治疗的可行性研究 上海市卫生和计划生育委员会 2016-01~2018-12 15万元 课题参与人
** 肿瘤微环境中成纤维细胞高表达GORAB促进胃癌发展的分子机制研究 国家自然科学基金面上项目 2014-01~2017-12 73万元 课题参与人
12ZR** AURKA经FAK介导在头颈肿瘤复发转移中的作用研究 上海市科学技术委员会 2012-07~2015-06 10万元 课题负责人
AURKA在喉鳞状细胞癌中的作用研究 上海市生物医药领域重点科技项目 2009-07~2012-06 35万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Yang Liyun, Shan Yamin, Zhang Yi, Zhou Enhui, Chen Xiaopin, Zhang Hao （通讯作者） Aurora kinase A induces chemotherapy resistance through revival of dormant cells in laryngeal squamous cell carcinoma HEAD NECK 2019 41(7):2239-2248
Gong S-Q, Xu M, Xiang M-L, Shan Y-M and Zhang Hao The Expression and Effection of MicroRNA-499a in High-Tobacco Exposed Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis Front. Oncol 2019 9:678. doi: 10.3389/fonc.2019.00678
张钰涵,陈雪华,张浩 （通讯作者） 下调极光激酶A活性抑制Hep2细胞的促血管生成作用和迁移、侵袭能力 上海交通大学学报（医学版） 2018 38（10）：1181-1185
Yang Liyun, He Changyu, Chen Xuehua, Su Liping, Liu Bingya, Zhang Hao （通讯作者） Aurora kinase A revives dormant laryngeal squamous cell carcinoma cells via FAK/PI3K/Akt pathway activation Oncotarget 2016 DOI:10.18632/oncotarget.10233
Yang Liyun, Zhou Quan, Chen Xuehua, Su Liping, Liu Bingya, Zhang Hao （通讯作者） Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer Oncology Reports 2016 36(2): 819-826
Wu Jichang, Yang Liyun, Shang Yamin, Cai Changping, Wang Shili and Zhang Hao AURKA promotes cell migration and invasion of head and neck squamous cell carcinoma through regulation of the AURKA/Akt/FAK signaling pathway Oncology Letters 2016 11(3)1889-1894
胡伟琦,单雅敏,郝立娜,许伟民,张浩 （通讯作者） 功能性鼻内镜鼻窦手术后纳吸棉鼻腔填塞效果评估 临床耳鼻咽喉头颈外科杂志 2016 30（18）：1438:1443
Yang Liyun, Shan Yamin, Wang Shili, Cai Changping, Zhang Hao （通讯作者） Endoscopic assisted adenoidectomy versus conventional curettage adenoidectomy: a meta-analysis of randomized controlled trials SpringerPlus 2016 DOI:10.1186/s40064-016-2072-1
Shan Yamin, Xu Jing, Cai Changping, Wang Shili and Zhang Hao Novel Modified Surgical Treatment of Auricular Pseudocyst Using Plastic Sheet Compression Otolaryngology–Head and Neck Surgery 2014 151(6):934-948
单雅敏,蔡昌枰,王士礼,张浩 （通讯作者） 前壁切除及塑料片 贯穿缝合治疗耳廓假性囊肿 临床耳鼻咽喉头颈外科杂志 2014 28（16）:1254-1256
Zhang Hao, Chen Xuehua, Yuesheng Jin, Liu Bingya, Zhou Liang Overexpression of Aurora-A promotes laryngeal cancer progression by enhancing invasive ability and chromosomal instability European Archives of Oto-Rhino-Laryngology 2012 269（2）:607-614
张浩,陈雪华,蔡昌枰,王士礼,刘炳亚,周梁 RNA干扰沉默Aurora-A基因抑制喉癌Hep-2细胞生长的实验研究 中华耳鼻咽喉头颈外科杂志 2012 47(1):58-63
Zhang Hao, Chen Xuehua, Liu Bingya, Zhou Liang Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells Molecular and cellular biochemistry 2011 357(1-2):95-106
Zhang Hao （通讯作者）, Cai Changping, Wang Shili, Liu Huiru, Ye Yanfen, Chen Xueming Extracranial Head and Neck Schwannomas: A Clinical Analysis of 33 Patients Laryngoscope 2007 117(2):278-281
Zhang Hao, Jin Yuesheng, Chen Xuehua, Jin Charlotte, Law Simon, Tsao Saiwah, Kwong Yoklam Extracranial Head and Neck Papillomavirus type 16 E6/E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation Cancer Letter 2007 245:184-194
Zhang Hao, Jin Yuesheng, Chen Xuehua, Jin Charlotte, Law Simon, Tsao Saiwah, Kwong Yoklam Cytogenetic aberrations in immortalization of esophageal epithelial cells Cancer Genetics and Cytogenetics 2006 165(1):25-35
Jin Yuesheng, Feng Huichen, Deng Wen, Zhang Hao, Lv Mei, Jin Charlotte, Tsao Saiwah, Kwong Yoklam Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization Cancer Genetics and Cytogenetics 2005 163(1):30-7
Zhang Hao, Tsao Sai Wah, Jin Charlotte, Bodil Str?mbeck, Yuen Po Wing, Kwong Yok-Lam, Jin Yuesheng Sequential cytogenetic and molecular cytogenetic characterization of an SV40T-immortalized nasopharyngeal cell line transformed by Epstein-Barr virus latent membrane protein-1 gene Cancer Genetics and Cytogenetics 2004 150:144-152
Jin Yuesheng, Zhang Hao, Wah Tsao Sai, Jin Charlotte, Lv Mei, Str?mbeck Bodil, Wiegant Joop, Wan Thomas Shek Kong, Yuen Po Wing, and Kwong Yok-Lam Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20 Gynecologic Oncology 2004 92:183–191
Jin Yuesheng, Jin Charlotte, Law Simon, Chu Kent-Man, Zhang Hao, Strombeck Bodil, Yuen Anthony P.W., Kwong Yok-LamBodil, Wiegant Joop, Wan Thomas Shek Kong, Yuen Po Wing, and Kwong Yok-Lam Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas Cancer Genetics and Cytogenetics 2004 148:21-28
张浩,陈学明,王士礼,肖宽林,何士方 双氯芬酸乳胶剂颈部涂抹辅助治疗急性咽部炎症 中国新药与临床 2001 20(6):484-486
张浩,陈学明,李朝晖 声带粘膜白斑32例临床分析 临床耳鼻咽喉科杂志 2000 14:22-23