导师姓名： 于布为 专业代码： 100217
性别： 男 专业名称： 麻醉学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： yubuwei_2013@126.com
邮编： 200025 邮箱地址： yubuwei_2013@126.com

研究方向 (点击浏览详细信息)
麻醉与记忆的神经机制疼痛中枢机制容量治疗策略

社会任职
中华医学会麻醉学分会第十届委员会全国主任委员，中国医师协会麻醉学医师分会副会长，上海医师协会麻醉科医师分会会长，上海市麻醉学分会名誉主任委员《中华麻醉学杂志》副主编《麻醉与监护论坛》主编

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
320.6750.14192 结合珠蛋白对体外循环术后溶血病的早期诊断和治疗价值的应用研究 吴阶平医学基金会临床科研专项基金 2015-06~2016-12 20万元 课题负责人
2014年适宜技术项目 有效血容量监测及理想麻醉状态的建立 上海市卫生计划委员会适宜技术项目 2014-01~2016-12 15万元 课题负责人
** 运用分子探针技术寻找异丙酚分子靶点及功能鉴定 国家自然科学基金 2014-01~2017-12 80万元 课题负责人
目标指导个体化液体治疗策略对于心脏手术和非心脏重大手术患者麻醉管理和术后转归影响的临床多中心研究 中华医学会 2011-08~2014-04 30万元 课题负责人
临床有效输血及血液风险控制技术应用研究与推广（围术期合理用血技术应用研究与推广） 2010年度卫生公益性行业科研专项 2011-02~2014-02 99.26万元 子课题负责人
** SUMO化修饰在全身麻醉药物调节谷氨酸释放中的作用 国家自然科学基金委面上项目 2011-01~2013-12 35万元 课题负责人
** 脊髓背角神经细胞钾氯共转运体和碳酸酐酶在阿片类药物痛觉过敏机制中作用的研究 国家自然基金委,面上项目 2007-01~2009-12 28万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yu B, Ouyang B, Ge S, Luo Y, Li J, Ni D, Hu S, Xu H, Liu J, Min S, Li L, Ma Z, Xie K, Miao C, Wu X Incidence of postoperative residual neuromuscular blockade after general anesthesia: a prospective, multicenter, anesthetist-blind, observational study Current Medical Research and Opinion 2016 32(1):1-9
Zhang Y, Yu T, Yuan J, Yu BW （通讯作者） The ventrolateral preoptic nucleus is required for propofol-induced inhibition of locus coeruleus neuronal activity Neurological Sciences 2015 36(12):2177-84
Jia L, Dong R, Zhang F, Wang W, Lu H, Luo Y, Xue Q, Yu B. （通讯作者） Propofol Provides More Effective Protection for Circulating Lymphocytes Than Sevoflurane in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery Journal of Cardiothoracic and Vascular Anesthesia 2015 29(5):1172-9
Wang S, Zhuang L, Yang X, Li Q, Xue Q, Luo Y, Zhang F, Yu B （通讯作者） Impaired acquisition of conditioned taste aversion memory induced by isoflurane is accompanied with calcineurin activation and Egr-1 down-regulation in amygdala in rats Neuroscience Letters 2015 21;607:114-9
Song XX,Yu BW （通讯作者） Anesthetic effects of propofol in the healthy human brain: functional imaging evidence Journal of Anesthesia 2015 29(2):279-88
Tu Y, Wei Y, Sun K, Zhao W, Yu B. （通讯作者） Altered spontaneous brain activity in patients with hemifacial spasm: a resting-state functional MRI study PLoS One 2015 10: e**
Li G, Xue Q, Luo Y, Hu X, Yu B. （通讯作者） S6 inhibition contributes to isoflurane neurotoxicity in the developing brain Toxicility Letters 2015 233: 102-113
Tu Y, Yu T, Wei Y, Sun K, Zhao W, Yu B （通讯作者） Structural brain alterations in hemifacial spasm: A voxel-based morphometry and diffusion tensor imaging study Clinical Neurophysiology 2015 S1388-2457(15)00754-3
Zhang Y, Yu T, Liu Y, Qian K, Yu BW. （通讯作者） Muscarinic M1 receptors regulate propofol modulation of GABAergic transmission in rat ventrolateral preoptic neurons Journal of Molecular Neuroscience 2015 55: 830-835
Cheung H, Dong Q, Dong R, Yu B （通讯作者） Correlation of cardiac output measured by non-invasive continuous cardiac output monitoring (NICOM) and thermodilution in patients undergoing off-pump coronary artery bypass surgery Journal of Anesthesia 2015 29(3):416-20
Xiao-xing Songa, Yong-juan Yua, Xin-feng Lia, Zu-de Liua, Bu-wei Yu （通讯作者）, Zhen Guo Estrogen receptor expression in lumbar intervertebral disc of the elderly: Gender- and degeneration degree-related variations Joint Bone Spine 2014 81:250-253
Shao H, Xue Q, Zhang F, Luo Y, Zhu H, Zhang X, Zhang H, Ding W, Yu B （通讯作者） Spinal SIRT1 activation attenuates neuropathic pain in mice PLOS One 2014 9(6):e100938
Han Lu, Bing Liu, Fujun Zhang, Rong Dong, Lei Chen, Dong-Mei Qu, Yan Lu, Bu-Wei Yu （通讯作者） The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation Cell Cycle 2014 13(24):3892-3902
Wang WY, Luo Y, Jia LJ, Hu SF, Lou XK, Shen SL, Lu H, Zhang HH, Yang R, Wang H, Ma ZW, Xue QS, Yu BW （通讯作者） Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain Neuropharmacology 2014 77:90-99
Zhang F, Feng X, Zeng Q, Wang B, Wilhelmsen K, Li Q, Cao X, Yu B. （通讯作者） Sevoflurane induced amnesia inhibits hippocampal Arc expression partially through 5-hydroxytryptamine-7 receptors in the bilateral basolateral amygdala in rats. Neuroscience Letters 2014 562:13-8
Li G, Yu B. （通讯作者） Elevation of protective autophagy as a potential way for preventing developmental neurotoxicity of general anesthetics Medical Hypotheses 2014 82: 177-180
Zhang HH, Zhang XQ, Xue QS, Yan-Luo, Huang JL, Zhang S, Shao HJ, Lu H, Wang WY, Yu BW （通讯作者） The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats PLOS One 2014 9(1):e85536
Zhang X, Zhang H, Shao H, Xue Q, Yu B. （通讯作者） ERK MAP kinase activation in spinal cord regulates phosphorylation of CDK5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity PLoS One 2014 9(1): e 87788
Lin R, Zhang F, Xue Q, Yu B. （通讯作者） Accuracy of regional cerebral oxygen saturation in predicting postoperative cognitive dysfunction after total hip arthroplasty regional cerebral oxygen saturation predicts POCD Journal of Arthroplasty 2013 28: 494-497
Zhang F, Zhu Q, Xue Q, Luo Y, Yu B. （通讯作者） Extra-cellular signal-regulated kinase (ERK) is inactivated associating hippocampal ARC protein up-regulation in sevoflurane induced bidirectional regulation of memory Neurochemistry Research 2013 38: 1341-1347
Han Lu, Bin Liu, Shengwu You, Lei Chen, Qu Dongmei, Minjie Gu, Yan Lu, Yinyi Chen, Fujun Zhang, Buwei Yu （通讯作者） SENP2 regulates MEF2A de-SUMOylation in an activity dependent manner Molecular Biology Report 2013 40(3):2485-90
Wang WY, Wang H, Luo Y, Jiao LJ, Zhao JN, Zheng HH, Ma ZW, Xue QS, Yu BW （通讯作者） Bone mesenchymal stromal cells stimulate neurite outgrowth of spinal neurons by secreting neurotrophic factors Neurol Res 2012 34(2): 172-180
Peng Z, Zhu Y, Zhang Y, Wilhelmsen K, Jia C, Jin J, Xue Q, Feng X, Zhang F, Yu B Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-kB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture Int Immunopharmacol 2012 13 (4): 440-445
Gu W, Zhang F, Xue Q, Ma Z, Lu P, Yu B. Bone mesenchymal stromal cells stimulate neurite outgrowth of spinal neurons by secreting neurotrophic factors Neurol Res 2012 34(2): 172-180
Li Q, Liu XS, Zeng QW, Xue QS, Cao XH, Liu J, Ren Y, Yu BW （通讯作者） Post-training intra-basolateral amygdala infusions of norepinephrine block sevoflurane-induced impairment of memory consolidation and activity-regulated cytoskeletal protein expression inhibition in rat hippocampus Neurobiology of Learning and Memory 2011 96：492-497
Liu J, Zhao X, Cao J, Xue Q, Feng X, Liu X, Zhang F, Yu B. （通讯作者） Differential Roles of PKA and Epac on the Production of Cytokines in the Endotoxin-Stimulated Primary Cultured Microglia Journal of Molecular Neuroscience 2011 45(2):186-93
Feng X, Zhang F, Dong R, Wang H, Liu J, Liu X, Li W, Yao J, Xu J, Yu B （通讯作者） Effects of hydroxyethyl starch(130D) on brain inflammatory response and outcome during normotensive sepsis International Immunopharmacology 2010 10(8):859-64
Xue Q, Wu X, Jin J, Yu B （通讯作者）, Zheng M Transcutaneous carbon dioxide monitoring accurately predicts arterial carbon dioxide partial pressure in patients Anesthesia Analgesia 2010 111: 417-20
Huang D, Yu B （通讯作者） The mirror-image pain: an unclered phenomenon and its possible mechanism Biobehavioral Reviews 2010 34(4): 528-532
Zhang F, Gu, W, Dong R, Dong Q （通讯作者）, Yu B Anesthetic management of phenchromocytoma resection in patient with F4 and a complete endocardial cushion defect Acta Anaesthesiologica Scandinavica 2010 54(6):785-6
Liu XS, Xue QS, Zeng QW, Li Q, Liu J, Feng XM, Yu BW （通讯作者） Sevoflurane impairs memeory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3beta in the hippocampus Neurobiology of Learning and Memory 2010 94(4): 461-7
Zhu, Qianlin; Mao, Zhihai; Jin, Jue; Deng, Yunxin; Zheng, Minhua; Yu Buwei （通讯作者） The Safety of CO2 Pneumoperitoneum for Elderly Patients During Laparoscopic Colorectal Surgery Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 2010 20: 54-57
Shan-liang JIN, Bu-wei YU （通讯作者） Effects of acute hypervolemic fluid infusion of hydroxyethyl starch and gelatin on hemostasis and possible mechanisms Clinical Applied Thrombosis Hemostasis 2010 16: 91-8
Zhang X, Chen G, Xue Q, Yu B （通讯作者） Early changes of beta-catenins and menins in spinal cord dorsal horn after peripheral nerve injury. Cell Molecular Neurobiology 2010 30(6):885-90
Gu W, Zhang F, Xue Q, Ma Z, Lu P, Yu B （通讯作者） Transplantation of bone marrow mesenchymal stem cells reduces lesion volume and induces axonal regrowth of injured spinal cord Neuropathology 2010 30(3):205-17
Shan-liang JIN, Bu-wei YU （通讯作者） Effects of artificial colloids on haemostasis British Journal of Hospital Medicine 2009 70:101-3
Feng X, Zhang F, Dong R, Li W, Liu J, Zhao X, Xue Q, Yu B （通讯作者）, Xu J Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia European Journal of Pharmacology 2009 614: 38-43
Han Lu, Bin Liu, Shengwu You, Qingsheng Xue, Fujin Zhang, Jinke Cheng, Buwei Yu （通讯作者） The activity-dependent stimuli increase SUMO modification in SHSY5Y cells Biochemical and Biopphysical Research Communications 2009 390: 872-876
Ren Y, Fu-Jun Zhang, Qing-Sheng Xue, Xin Zhao, Bu-Wei Yu （通讯作者） Bilateral Inhibition of Gamma-aminobutyric Acid Type A Receptor Function within the Basolateral Amygdala-blocked Propofol-induced Amnesia and Activity-regulated Cytoskeletal Protein Expression Inhibition in the Hippocampus Anesthesiology 2008 109: 775-781