导师姓名： 谢冰 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： brinkleybing@126.com

研究方向 (点击浏览详细信息)
眼视网膜新生血管性疾病的临床和基础研究

社会任职
中华医学会上海眼科分会青年委员
上海交通大学医学院附属瑞金医院科技发展处副处长
美国Johns Hopkins 大学/医院Wilmer眼科访问****，博士后（2006-2008）
瑞金-卢湾医疗联合体副秘书长，办公室主任
上海交通大学医学院青联委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** IL-17A调控巨噬细胞极化对视网膜新生血管形成的作用机 国家自然基金面上项目 2016-01~2019-12 57万元 课题负责人
** T细胞激活与巨噬细胞极化对视网膜新生血管作用的研究 国家自然基金青年项目 2012-01~2015-12 22万元 课题负责人
眼部肿瘤患病人群的流行病学调查 上海市科委慈善癌症研究中心项目 2011-10~2013-10 4万元 课题负责人
10QA** 巨噬细胞清除和极性改变抑制眼新生血管的机理研究 上海市科委启明星人才项目 2010-04~2012-03 13万元 课题负责人
09YZ86 ID1基因敲除抑制视网膜新生血管的机制研究 上海市教委 2009-01~2011-12 8万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Sha Gao, Changwei Li, Yanji Zhu, Yanuo Wang, Ailing Sui, Yisheng Zhong, Bing Xie （通讯作者）, Xi Shen PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy Scientific Reports 2017 Feb 17;7:42846
Yanji Zhu, Ling Zhang, Qing Lu, Yushuo Gao, Yujuan Cai,Ailing Sui, Ting Su, Xi Shen,Bing Xie （通讯作者） Identification of different macrophage subpopulations with distinct activities in a mouse model of oxygen-induced retinopathy INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2017 40: 281-292, 2017
Yanji Zhu, Wei Tan, Anna M. Demetriades, Yujuan Cai, Yushuo Gao, Ailing Sui, Qing Lu, Xi Shen, Chunhui Jiang, Bing Xie （通讯作者）,Xinghuai Sun. Interleukin-17A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization. Immunology 2016 147(4):414-28
Jian Yu, Ruiping Gu, Yuan Zong, Huan Xu, Xiaolei Wang, Xinghuai Sun, Chunhui Jiang, Bing Xie （通讯作者）, Yali Jia, and David Huang. Relationship Between Retinal Perfusion and Retinal Thickness in Healthy Subjects: An Optical Coherence Tomography Angiography Study. Invest Ophthalmol Vis Sci. 2016 57: 204-210
2.Yujuan Cai, Wei Tan, Xi Shen, Yanji Zhu, Yushuo Gao, Ailing Sui, Qing Lu, Yisheng Zhong, Bing Xie （通讯作者） Neutralization of IL-23 depresses experimental ocular Neovascularization. Experimental Eye Research 2016 2016(3): 242-251
1.Yanji Zhu, Qing Lu, Ling Zhang, Yu Cheng, Qin Jiao, Yushuo Gao, Xi Shen, Bing Xie. （通讯作者） Investigation and evaluation of an innovative retinal neovascularization staining- one click staining. Int J Clin Exp Med. 2016 9 (2)
Zhongjing Lin, Shouyue Huang, Bing Xie （通讯作者）, and Yisheng Zhong. Peripapillary Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis. Journal of Ophthalmology 2016 16 (5)
Wang Y, Lu Q, Gao S, Zhu Y, Gao Y, Xie B （通讯作者）, Shen X. Pigment Epithelium-derived Factor Regulates Glutamine Synthetase and l-Glutamate/l-Aspartate Transporter in Retinas with Oxygen-induced Retinopathy. Curr Eye Res. 2014 40(12):1232-44
Zhu Y, Lu Q, Shen J, Zhang L, Gao Y, Shen X, Xie B （通讯作者） Improvement and optimization of standards for a preclinical animal test model of laser induced choroidal neovascularization. PLoS One. 2014 4:94743-94743
Wang J, Liu XH, Yang ZJ, Xie B （通讯作者）, Zhong YS The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells. BMC Cancer 2014 Feb 14:14-89
Lu Qing, Ling Zhang, Xi Shen,Yanji Zhu, Qing wei Zhou, Renbao Gan, Hui Zhang, Jiaqi Gu, Yisheng Zhong, Bing Xie. （通讯作者） A novel and effective human hepatocyte growth factor kringle 1 domain inhibits ocular neovascularization. Exe Eye Res. 2012 105: 15-20
Ping Huang, Jing Wang, Xi Shen, Qin Jiao, Yu Cheng, Bing Xie （通讯作者）,Yisheng Zhong. The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate. MOL MED REP. 2012 6: 662-666
Xie B, Jiao Q, Cheng Y, Zhong Y, Shen X Effect of pigment epithelium derived factor on the glutamate uptake in retinal Muller cells under high glucose conditions. Invest Ophthalmol Vis Sci. 2012 Feb 27; 53(2):1023-32
Ling Zhang, Xi Shen, Qing Lu, Qingwei Zhou, Jiaqi Gu, Renbao Gan, Hui Zhang, Xiaodong Sun, Bing Xie. （通讯作者） A potential therapeutic strategy for inhibition of ocular neovascularization with a new endogenous protein: rhEDI-8t. Graefes Arch Clin Exp Ophthalmol. 2012 May;250(5):731-9
Xi Shen, Yisheng Zhong, Bing Xie （通讯作者）, Yu Cheng, Qin Jiao Pigment epithelium derived factor as an anti-inflammatory factor against decrease of glutamine synthetase expression in retinal Müller cells under high glucose conditions. Graefes Arch Clin Exp Ophthalmol127–1136 2010 248:1127–1136
Aling Dong, Bing Xie* （共同第一作者）, Jikui Shen, Yoshida T, Yokoi K, Hackett SF, Campochiaro PA. Oxidative Stress Promotes Ocular Neovascularization. J. Cell. Physiol. 2009 219 (3): 544-552
Bing Xie, Jikui Shen, Aling Dong, Aymen Rashid, Glenn Stoller, Peter Campochiaro. Blockade of Sphingosine-1-Phosphate Reduces Macrophage Influx and Retinal and Choroidal Neovascularization. J. Cell. Physiol. 2009 218 (1): 192-198.
Xie B, Shen J, Dong A, Swaim M, Hackett SF, Wyder L, Worpenberg S, Barbieri S, Campochiaro PA. An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization. FASEB J. 2008 22(8): 2775-83.
Shen J, Yang X, Xie B, Chen Y, Swaim M, Hackett SF, Campochiaro PA MicroRNAs regulate ocular neovascularization. Mol Ther. 2008 16(7):1208-16
Shen J, Xie B* （共同第一作者）, Dong A, Swaim M, Hackett SF, Campochiaro PA. In vivo immunostaining demonstrates macrophages associate with growing and regressing vessels. Invest Ophthalmol Vis Sci. 2007 48(9): 4335-41
Shen J, Xie B, Hatara CM, Hackett SF, Campochiaro PA. Vegf or EphA2 antisense polyamide-nucleic acids; vascular localization and suppression of retinal neovascularization. Mol Ther. 2007 15 (11): 1924-1930
谢冰,叶纹,沈玺,钟一声 转化生长因子-β1对人Tenon囊成纤维细胞表型转化的作用 眼科新进展 2006 Vol.26: No.5
谢冰, 叶纹, 钟一声, 沈玺 转化生长因子-β1对人Tenon囊成纤维细胞表型转化的作用 上海交通大学学报（医学版）. 2006 3: 263-265
谢冰, 叶纹, 钟一声, 沈玺 bFGF不能调节人结膜下Tenon's囊成纤维细胞表型改变 细胞生物学 2005 2005; 8: 549-553