导师姓名： 杜艳芝 专业代码： 100211
性别： 女 专业名称： 妇产科学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 200135 邮箱地址： yanzhidu@hotmail.com

研究方向 (点击浏览详细信息)
女性生殖障碍疾病相关分子机制、肠道菌群和生殖系统肿瘤药物治疗机制研究

社会任职
中国医师协会生殖医学专业委员会精准辅助生殖研究学组 委员
上海市医学会分子诊断专科分会第一届委员会遗传疾病学组副组长
上海市微生物学会微生物组专委会委员
中华医学会生殖医学分会第四届委员会精子库管理学组委员
中国生理学会微生态专业委员会委员
上海市医学会生殖医学分会第三届委员会委员兼秘书

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** EPHA7通过调节下丘脑-垂体-卵巢轴在多囊卵巢综合征排卵障碍中的分子机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
2018YFC** 排卵障碍性疾病的遗传易感和环境互作的研究 国家重点研发计划 2018-12~2021-12 272万元 课题负责人
** 多囊卵巢综合征（PCOS）患者肠道菌群谱及药物治疗对肠道菌群结构的影响 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题负责人
16CR3003A 植入前遗传学筛查新技术对改善严重男性不育患者辅助生殖结局与出生缺陷的疗效评估 上海申康医院发展中心 2016-12~2019-06 7.94万元 课题参与人
2016YFC** 人类配子发生、成熟障碍与胚胎停育的分子机制 国家重点研发计划 2016-07~2020-12 41万元 子课题负责人
** 运用宏基因组技术研究肠道菌群在PCOS发病机制中的作用 上海市教育委员会高峰高原学科建设计划 2015-01~2017-12 100万元 课题负责人
2013CB966802 重编程造血细胞的基础与临床应用研究 国家重大科学研究计划 2013-01~2017-12 108.75万元 子课题负责人
** 从遗传学及表观遗传学水平筛选慢性粒细胞白血病病程急变的标识物及潜在特异性药物 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
** 从遗传学及表观遗传学水平筛选慢性粒细胞白血病病程急变的标识物及潜在特异性药物 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
整合多层面高通量生物技术从遗传学及表观遗传学水平筛选慢性粒细胞白血病病程急变的标识物及潜在特异性药物 上海市人才发展基金 2011-01~2013-12 10万元 课题负责人
KSCX2-EW-Q-1-08 整合多层面高通量生物技术从遗传学及表观遗传学水平筛选慢性粒细胞白血病病程急变的标识物及潜在特异性药物 中国科学院生命科学领域优秀青年科技专项 2011-01~2013-12 80万元 课题负责人
KSCX1-YW-22-01 癌症重大科学问题及防治新策略的研究 中国科学院知识创新工程重大项目 2009-06~2011-05 80万元 课题参与人
** AMN107联合砷剂治疗慢性粒细胞白血病分子机制的研究 国家自然科学基金 2007-01~2009-12 23万元 课题负责人
2006AA02Z332 全面、准确、系统性地挖掘转录组数据的方法研究 科技部863计划项目 2006-12~2008-12 90万元 课题负责人
06QA14059 AMN107联合砷剂治疗慢性粒细胞白血病分子机制的研究 上海市科技启明星计划 2006-10~2008-10 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Luan X, Li S, Zhao J, Zhai J, Liu X, Chen ZJ, Li W, Du Y. （通讯作者） Down-regulation of CCR7 via AKT pathway and GATA2 inactivation suppressed trophoblast migration and invasion in recurrent spontaneous abortion. Biol Reprod. 2020 102(2):424-433.
Chu WW, Zhai JY, Xu JY, Li S, Li WP, Chen ZJ, Du Y. （通讯作者） Continuous Light-Induced PCOS-like Changes in Reproduction, Metabolism, and Intestinal Microbiota in Sprague-Dawley Rats. Front Microbiol. 2020 10:3145
Li S, Zhai J, Xu B, Liu JS, Chu W, Wang DS, Geng XY, Geng X, Chen ZJ, Du Y. （通讯作者） Erythropoietin-producing hepatocellular A7 inhibits estrogen-negative feedback of luteinizing hormone via ephrin A5 in the hypothalamus of female rats. Am J Physiol Endocrinol Metab 2020 319(1):E81-E90.
Xu J, Bian G, Zheng M, Lu G, Chan WY, Li W, Yang K, Chen ZJ, Du Y. （通讯作者） Fertility factors affect the vaginal microbiome in women of reproductive age. Am J Reprod Immunol. 2020 83(4):e13220.
Wang J, Xu J, Han Q, Chu W, Lu G, Chan WY, Qin Y, Du Y. （通讯作者） Changes in the vaginal microbiota associated with primary ovarian failure. BMC Microbiology 2020 20(1):230.
Zhai J, Li S, Cheng X, Chen ZJ, Li W, Du Y. （通讯作者） A candidate pathogenic gene, zinc finger gene 217 (ZNF217) may contribute to polycystic ovary syndrome through prostaglandin E2. Acta Obstetricia et Gynecologica Scandinavica 2020 99(1):119-126.
Han QX,Du Y. （通讯作者） Advances in the application of biomimetic endometrium interfaces for uterine bioengineering in female infertility. Front Bioeng Biotechnol. 2020 8:153.
Zhou R, Li S, Liu J, Wu H, Yao G, Sun Y, Chen ZJ, Li W, Du Y. （通讯作者） Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome. EBioMedicine 2020 52:102635.
Chu WW, Han QX, Xu JY, Wang J, Sun Y, Li W, Chen ZJ, Du Y. （通讯作者） Metagenomic analysis identified microbiome alterations and pathological association between intestinal microbiota and polycystic ovary syndrome. Fertil Steril. 2020 113(6):1286-1298.
Zhai J, Li S, Hu M, Di F, Liu J, Du Y. （通讯作者） Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome. Reprod Biol Endocrinol. 2020 18(1):32.
Li S, Zhai J, Chu W, Geng X, Chen ZJ, Du Y. （通讯作者） Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome. Transl Res. 2020 219:13-29.
Zhao J, Huang J, Geng X, Chu W , Li S, Chen ZJ, Du Y. （通讯作者） Polycystic Ovary Syndrome: Novel and Hub lncRNAs in the Insulin Resistance-Associated lncRNA– mRNA Network. Front. Genet. 2019 22;10:772.
Liu X, Zhao J, Luan X, Li S, Zhai J, Liu J, Du Y. （通讯作者） SPARCL1 impedes trophoblast migration and invasion by down-regulating ERK phosphorylation and AP-1 production and altering EMT-related molecule expression. Placenta 2019 18;89:33-41.
Wei Y, Lang J, Zhang Q, Yang CR, Zhao ZA, Du Y （通讯作者）, Sun Y. DNA methylation analysis and editing in single mammalian oocytes. Proc Natl Acad Sci U S A. 2019 116(20):9883-9892
Luan X, Li S, Zhao J, Zhai J, Liu X, Chen ZJ, Li W, Du Y. （通讯作者） Down-regulation of CCR7 via AKT pathway and GATA2 inactivation suppressed trophoblast migration and invasion in recurrent spontaneous abortion. Biology of Reproduction 2019 Doi: 10.1093/biolre/ioz172
Zhu Y, Yin Q, Wei D, Yang Z, Du Y （通讯作者）, Ma Y. Autophagy in male reproduction. Syst Biol Reprod Med. 2019 24:1-8.
Di F, Liu J, Li S, Hong Y, Chen ZJ, Du Y. （通讯作者） Activating transcriptional factor 4 correlated with obesity and insulin resistance in polycystic ovary syndrome. Gynecol Endocrinol. 2019 35(4):351-355
Li S, Zhai J, Liu J, Di F, Sun Y, Li W, Chen ZJ, Du Y. （通讯作者） Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome. EBioMedicine 2018 36:539-552
Di F, Liu J, Li S, Yao G, Hong Y, Chen ZJ, Li W, Du Y. （通讯作者） ATF4 contributes to ovulation via regulating COX2/PGE2 expression: a potential role of ATF4 in PCOS. Front Endocrinol (Lausanne). 2018 9:669
Liu L, Liu J, Wang H, Zhao H, Du Y. （通讯作者） Fenretinide targeting of human colon cancer sphere cells through cell cycle regulation and tress responsive activities. Oncol Lett. 2018 16(4):5339-5348
Wang Y, Zhang M, Chen ZJ, Du Y. （通讯作者） Resveratrol promotes the embryonic development of vitrified mouse oocytes after in vitrofertilization. In Vitro Cell Dev Biol Anim. 2018 54(6):430-438
Zhao J, Xu J, Wang W, Zhao H, Liu H, Liu X, Liu J, Sun Y, Dunaif A, Du Y （通讯作者）, Chen ZJ. Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome. EBioMedicine 2018 36:526-538.
Xu X, Qin L, Tian Y, Wang M, Li G, Du Y, Chen ZJ, Li W. Family-based analysis of GGT1 and HNF1A gene polymorphisms in patients with polycystic ovary syndrome. Reprod Biomed Online. 2018 36(1):115-119
Zhu K, Li S, Liu J, Hong Y, Chen ZJ, Du Y. （通讯作者） The role of RAB5A in FSHR mediated signal transduction in human granulosa cells. Reproduction 2018 155(6):505-514
Zhai J, Liu J, Zhao S, Zhao H, Chen ZJ, Du Y （通讯作者）, Li W. Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion. Reproduction. 2017 pii: REP-17-0268. doi: 10.1530/REP-17-0268.
Wei D, Shi Y, Li J, Wang Z, Zhang L, Sun Y, Zhou H, Xu Y, Wu C, Liu L, Wu Q, Zhuang L, Du Y, Li W, Zhang H, Legro RS, Chen ZJ. Effect of pretreatment with oral contraceptives and progestins on IVF outcomes in women with polycystic ovary syndrome. Hum Reprod. 2017 32(2):354-361.
Li S, Zhai JY, Liu JS, Hong Y, Zhao WX, Zhao AM, Sun K, Du YZ （通讯作者）, Chen ZJ. BMAL1 Facilitates Trophoblast Migration and Invasion via SP1-DNMT1/DAB2IP Pathway in Recurrent Spontaneous Abortion. Oncotarget 2017 8(52):89451-89464.
Xu X, Chen X, Zhang X, Liu Y, Wang Z, Wang P, Du Y, Qin Y, Chen ZJ. Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency. Hum Reprod. 2017 32(1):201-207.
Wei D, Zhang B, Shi Y, Zhang L, Zhao S, Du Y, Xu L, Legro RS, Zhang H, Chen ZJ. Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2017 102(10):3822-3829
Zhai J, Liu J, Cheng X, Li S, Hong Y, Sun K, Chen ZJ, Du Y （通讯作者）, Li W. Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E2 Synthesis and Inhibiting Thrombospondin-1 (TSP-1). Sci Rep. 2017 12;7(1):3245.
狄芳芳,刘建胜,李尚,杜艳芝. （通讯作者） 转录因子C/EBPβ在子宫蜕膜化中的作用及机制研究进展 狄芳芳，刘建胜，李尚，杜艳芝*. 转录因子C/EBPβ在子宫蜕膜化中的作用及机制研究进展上海交通大学学报（医学版）. 2017 37（6）：865-869.
Yan W, Du J, Du Y, Pu H, Liu S, He J, Zhang J, Hou J. Fenretinide targets the side population in myeloma cell line NCI-H929 and potentiates the efficacy of antimyeloma with bortezomib and dexamethasone regimen. Leuk Res. 2016 51:32-40.
徐洁颖,陈子江,杜艳芝. （通讯作者） 肠道菌群与多囊卵巢综合征发病关系的研究进展. 上海交通大学学报（医学版） 2016 36（8）：112-117
Zhou W, Fang F, Zhu W, Chen ZJ, Du Y, Zhang J. Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome. Int J Environ Res Public Health. 2016 Dec 27;14(1). pii: E18.
李尚,杜艳芝 （通讯作者）,陈子江. 玻璃化冷冻对卵母细胞和胚胎DNA甲基化的影响. 中华妇产科杂志 2016 7:551-554.
Tian Y, Zhang W, Zhao S, Sun Y, Bian Y, Chen T, Du Y, Zhang J, Wang Z, Huang T, Peng Y, Yang P, Zhao H, Chen ZJ. FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome. Sci Rep. 2016 16;6:21195.
Zhang J, Liu J, Zhu K, Hong Y, Sun Y, Zhao X, Du Y （通讯作者）, Chen ZJ. Effects of BMAL1–SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS. Endocrine. 2016 53(2):574-84.
Zhang Q, Liu D, Zhang M, Li N, Lu S, Du Y （通讯作者）, Chen ZJ. Effects of brain-derived neurotrophic factor on oocyte maturation and embryonic development in a rat model of polycystic ovary syndrome. Reprod Fertil Dev. 2015 Jun 25. doi: 10.1071/RD15131.
刘建胜,张善镇,姚志洪,杜艳芝． （通讯作者） 不同表达谱芯片分析方法在药效机制研究中的应用 计算机应用与软件 2015 32(6)：57 – 61
Wang C, Kam RK, Shi W, Xia Y, Chen X, Cao Y, Sun J, Du Y, Lu G, Chen Z, Chan WY, Chan SO, Deng Y, Zhao H. The proto-oncogene transcription factor Ets1 regulates neural crest development through Histone Deacetylase 1 to mediate output of bone morphogenetic protein signaling. J Biol Chem. 2015 2015 Jul 20. pii: jbc.M115.644864.
Du YZ, Xia Y, Pan XL, Chen Z, Wang AH, Wang KK, Li JM and Zhang J. Fenretinide targets chronic myeloid leukemia stem/progenitor cells by regulation of redox signaling. Antioxid Redox Signal. 2014 20(12):1866-80.
Wang H, Zhang Y, Du Y. （通讯作者） Ovarian and breast cancer spheres are similar in transcriptomic features and sensitive to fenretinide. Biomed Res Int. 2013 2013:510905-
Qian M, Jin W, Zhu X, Jia X, Yang X, Du Y, Wang K, Zhang J. Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013
Xia Y, Fang H,Zhang J, Du YZ. （通讯作者） Endoplasmic reticulum stress-mediated apoptosis in imatinib-resistant leukemic K562-r cells triggered by AMN107combined with arsenic trioxide. Exp Biol Med (Maywood). 2013 238(8):932-42.
Feng YJ, Dai X, Li XL, Wang HW, Liu JS, Du YZ, Xia L. EGF Signaling Pathway Regulates Colon Cancer Stem Cell Proliferation and Apoptosis. Cell Prolif. 2012 45(5):413-9.
Wu K., Dong D., Fang H., Levillain F., Jin W., Mei J., Gicquel B., Du Y., Wang K., Gao Q.,*Neyrolles O., *Zhang J. An interferon-related signature in the transcriptional core response of humanmacrophages to mycobacterium tuberculosis infection Plos One 2012 7(6) : e38367
Zhang YX, Wang C, Wang HW, Wang KK, Du YZ （通讯作者）, Zhang J. Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo Cancer Letters 2011 304(1):21-32
Zhang Y, Du Y （共同第一作者）, Le W, Wang K, Kieffer N, Zhang J. Redox Control of the Survival of Healthy and Diseased Cells Antioxid Redox Signal 2011 15(11):2867-908.
Fang H, Du Y, Xia L, Li J, Zhang J, Wang K. A Topology-Preserving Selection and Clustering Approach to Multi-Dimensional Biological Data OMICS 2011 15(7-8):483-94
Jiang L, Pan X, Chen Y, Wang K, Du Y （通讯作者）, Zhang J Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells Biochem Biophys Res Commun. 2011 405(2):314-8.
Wang K, Wang P, Shi J, Zhu X, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi J, Yang X, Xiao H, Minden M, Du Y, Chen Z, Zhang J. PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia Cancer Cell 2010 17(2):186-97
Yang S, Dong Q, Yao M, Shi M, Ye J, Zhao L, Su J, Gu W, Xie W, Wang K, Du Y, Li Y, Huang Y. Establishment of an experimental human lung adenocarcinoma cell line SPC-A-1BM with high bone metastases potency by (99m)Tc-MDP bone scintigraphy Nucl Med Biol. 2009 36(3):313-21
Wang K, Fang H, Xiao D, Zhu X, He M, Pan X, Shi J, Zhang H, Jia X, Du Y, Zhang J. Converting Redox Signaling to Apoptotic Activities by Stress-responsive Regulators HSF1 and NRF2 in Fenretinide Treated Cancer Cells PLoS ONE 2009 4(10):e7538
Fu S, Zhao H, Shi J, Abzhanov A, Crawford K, Ohno-Machado L, Zhou J, Du Y, Kuo WP, Zhang J, Jiang M, Jin JG. Peripheral arterial occlusive disease: global gene expression analyses suggest a major role for immune and inflammatory responses BMC Genomics 2008 9:369-369
Du YZ, Wang KK, Fang H, Li JM, Xiao DK, Zheng PZ, Chen YL, Fan HY, Pan XL, Zhao CJ, Zhang QH, IMBEAUD S, GRAUDENS E, EVENO E, AUFFRAY C, Chen SJ, Chen Z and Zhang J. Coordination of Intrinsic, Extrinsic and Endoplasmic Reticulum-Mediated Apoptosis by Imatinib Mesylate Combined with Arsenic Trioxide in Chronic Myeloid Leukemia Blood 2006 107(4):1582-1590
Zheng PZ, Wang KK, Zhang QY, Huang QH, Du YZ, Zhang QH, Xiao DK, Shen SH, Imbeaud S, Eveno E, Zhao CJ, Chen YL, Fan HY, Waxman S, Auffray C, Jin G, Chen SJ, Chen Z, Zhang J. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide combination-Induced cell differentiation/apoptosis of acute promyelocytic leukemia PNAS 2005 102:7653-7658
Yin T, Wu YL, Sun HP, Sun GL, Du YZ, Wang KK, Zhang J, Chen GQ, Chen SJ, Chen Z. Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein BLOOD 2004 104(13):4219-25