导师姓名： 孙刚 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： sungangrenji@sjtu.edu.cn; **
邮编： 200135 邮箱地址： sungangrenji@qq.com

研究方向 (点击浏览详细信息)
胎盘与妊娠疾病
多囊卵巢综合症

社会任职
《PLoS》学术编委
中国动物学会生殖生物学会理事
《生理学报》编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 胎膜表达的血清淀粉样蛋白A1在无菌性炎症和分娩启动中的作用 国家自然科学基金重点项目 2019-01~2023-12 291万元 课题负责人
2017YFC** 人类胚胎着床调控及相关重大妊娠疾病发生机制 国家重点研发计划 2017-07~2021-06 79万元 子课题负责人
** H3K27甲基化修饰在胎盘糖皮质激素屏障建立中的关键作用研究 国家自然科学基金 2017-01~2020-12 60万元 课题负责人
2014CB943302 环境内分泌干扰物致卵母细胞、胚胎植入、胚胎发育异常的分子机制 国家科技部重大科学研究计划子课题 2014-01~2018-12 456万元 子课题负责人
** 胎膜皮质醇再生正反馈环路在新生儿早产中的作用及转化医学研究 国家自然科学基金重点项目 2014-01~2018-12 290万元 课题负责人
** 人胎膜皮质醇再生对赖氨酰氧化酶表达影响的研究 国家然科学基金面上项目 2013-01~2016-12 72万元 课题负责人
2011CB944400 妊娠建立和维持的分子机制 国家科技部重大科学研究计划子课题 2011-01~2015-12 156万元 子课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiao-Wen Gan, Wang-Sheng Wang, Jiang-Wen Lu, Li-Jun Ling, Qiong Zhou, Hui-Juan Zhang, Hao Ying, Kang Sun* （通讯作者） De novo synthesis of SAA1 in the placenta participates in parturition. Frontiers in Immunology 2020 accepted
Wang-Sheng Wang, Chun-Ming Guo, Kang Sun*. （通讯作者） Cortisol regeneration in the fetal membranes, a coincidental or requisite event in human parturition? Frontiers in Physiology 2020 11:462. doi: 10.3389/fphys.2020.00462.
Chuyue Zhang, Jingwen Hu, Wangsheng Wang, Yun Sun*, and Kang Sun* （通讯作者） HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS. FASEB J 2020 accepted
Zhu P, Wang WS, Zuo RJ, Sun K. （通讯作者） Mechanisms for establishment of the placental glucocorticoid barrier, a guard for life Cell Mol Life Sci 2019 76(1):13–26.
Wang YW, Wang WS*, Wang LY, Bao YR, Lu JW, Lu Y, Zhang CY, Li WJ, Sun K* （通讯作者）, Ying H* Extracellular matrix remodeling effects of serum amyloid A1 in the human amnion: implications for fetal membrane rupture Am J Reprod Immunol 2019 81(1): e13053
Lu Y, Wang WS, Lin YK, Lu JW, Li WJ, Zhang CY, Sun K* （通讯作者） Enhancement of cortisol-induced SAA1 transcription by SAA1 in human amnion. 33(2):2770-2781. J Mol Endocrinol 2019 62:149-158.
Lu JW, Wang WS, Myatt L, Sun K （通讯作者） Activation of prostaglandin EP4 receptor attenuates the induction of cyclooxygenase-2 expression by EP2 receptor activation in human amnion fibroblasts: implications for parturition. FASEB J 2019 accepted
Wang WS*, Li WJ, Wang YW, Wang LY, Mi YB, Lu JW, Lu Y, Zhang CY, Sun K* （通讯作者） Involvement of serum amyloid A1 in the rupture of fetal membranes through induction of collagen I degradation Clin Sci 2019 133: 515-530.
Wang LY, Wang WS, Wang YW, Lu JW, Lu Y, Zhang CY, Li WJ, Sun K* （通讯作者）, Ying H Drastic induction of MMP-7 by cortisol in the human amnion: implications for membrane rupture at parturition. FASEB J 2019 33(2):2770-2781.
Wang WS, Chen ZJ, Myatt L, Sun K （通讯作者） 11β-HSD1 in human fetal membranes as a potential therapeutic target for preterm birth. Endocrine Reviews 2018 39:241-260
Zhang CY, Ma J, WangWS, Sun Y, Sun K （通讯作者） Lysyl oxidase blockade ameliorates anovulation in polycystic ovary syndrome Hum Reprod 2018 33(11):2096-2106
Mi YB, Wang WS, Lu JW, Ying H, Sun K （通讯作者） Proteasome-mediated degradation of collagen III by cortisol in human amnion fibroblasts: implications for membrane rupture J Mol Endocrinol 2018 60 (2): 45-54.
Li WJ, Wang WS, Zuo RJ, Liu C, Shu Q, Ying H, Sun K （通讯作者） Induction of pro-inflammatory genes by serum amyloid A1 in human amnion fibroblasts Sci Rep 2017 7: 693. DOI:10.1038/s41598-017-00782-9
Lu JW, Wang WS, Mi YB, Zhang CY, Ying H, Wang LY, Wang YW, Myatt L, Sun K （通讯作者） AKAP95-mediated nuclear anchoring of PKA mediates cortisol-induced PTGS2 expression in human amnion fibroblasts. Sci Signal 2017 10(506). pii: eaac6160.
Liu XH, Zuo RJ*, Bao YR, Qu XX, Sun K* （通讯作者）, Ying H* Down-regulation of PDK4 is critical for the switch of carbohydrate catabolism during syncytialization of human placental trophoblasts. Sci Rep. 2017 7: 8474
Mi YB, Wang WS, Zhang CY, Liu C, Lu JW, Li WJ, Zuo RJ, Myatt L, Sun K （通讯作者） Autophagic degradation of collagen 1A1 by cortisol in human amnion fibroblasts Endocrinology 2017 158:1005–1014.
Zhang CY, Wang WS, Liu C, Lu JW, Sun K （通讯作者） Role of NF-kB/GATA3 in the inhibition of lysyl oxidase by IL-1β in human amnion fibroblasts Immunol Cell Biol 2017 95:943-952
Zuo RJ, Liu XH, Wang WS, Li WJ, Ying H, Sun K （通讯作者） A repressive role of enhancer of zeste homolog 2 in 11β-hydroxysteroid dehydrogenase type 2 expression in human placenta J Biol Chem 2017 292 (18):7578–7587
Liu C, Zhu P, Wang WS, Li WJ, Shu Q, Chen ZJ, Myatt L, Sun K （通讯作者） Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition Mol Cell Endocrinol 2016 424:118-127
Wang WS, Liu C, Sun K （通讯作者） Induction of amnion epithelial apoptosis by cortisol via tPA/Plasmin System Endocrinology 2016 157: 4487-4498
Yang QL, Wang WS, Liu C, Wang Y, Sun K （通讯作者） Compartmentalized localization of 11β-HSD 1 and 2 at the feto-maternal interface in the first trimester of human pregnancy Placenta 2016 46:63-71
Liu C, Guo C, Wang W, Zhu P, Li W, Mi Y, Myatt L, Sun K （通讯作者） Inhibition of lysyl oxidase by cortisol regeneration in human amnion: Implications for rupture of fetal membranes Endocrinology 2016 157(10):4055-4065
Zhu QL, Zuo RJ, He YQ, Wang Y, Chen ZJ, Sun Y, Sun K （通讯作者） Local regeneration of cortisol by 11β-HSD1 contributes to insulin resistance of the granulosa cells in PCOS J Clin Endocrinol Metab 2016 101:2168-77
Yang QL, Wang WS, Liu C, Wang Y, Sun K （通讯作者） Effect of PFOS on glucocorticoid-induced changes in human first trimester decidua Reprod Toxicol 2016 63:142-50
Zhang N, Wang WS, Li WJ, Liu C, Wang Y, Sun K （通讯作者） Impairment of the endocrine function of human placental syncytiotrophoblasts by perfluorooctane sulfonate via induction of apoptosis. Placenta 2015 36: 575-580
Zhang N, Wang WS, Li WJ, Liu C, Chen Y, Yang QL, Wang Y, Sun K. （通讯作者） Inhibition of 11β-HSD2 expression by triclosan via induction of apoptosis in human placental syncytiotrophoblasts. J Clin Endocrinol Metab 2015 100: E542–E549
Wangsheng Wang, Chunming Guo, Ping Zhu, Jiangwen Lu, Wenjiao Li, Chao Liu, Huiliang Xie, Leslie Myatt, Zi-jiang Chen, Kang Sun （通讯作者） Phosphorylation of STAT3 is required for the paradoxical induction of cyclooxygenase-2 by cortisol in human amnion at parturition. Science Signaling 2015 ra106-114
Li XQ, Zhu P, Myatt L*, Sun K*. （通讯作者） Roles of Glucocorticoids in Human Parturition: A Controversial Fact? Placenta 2014 35:291-296.(invited review).
Wang WS, Liu C, Li WJ, Zhu P, Li JN, Sun K*. （通讯作者） Involvement of CRH and hCG in the induction of aromatase by cortisol in human placental syncytiotrophoblasts. Placenta 2014 35(1):30-36.
Shu Q, Li WJ, Li JN, Wang WS, Liu C, Sun K*. （通讯作者） Cross-talk between cAMP and MAPK pathways in 11beta-HSD2 induction by hCG in placental trophoblasts. PLoS ONE 2014 17;9(9):e107938.
Guo CM, Wang WS, Liu C, Myatt L, Sun K （通讯作者） Induction of PGF2α synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts. Endocrinology 2014 2014;155(8):3017-3024.
Guo CM, Li C, Myatt L, Nathanielsz PW, Sun K （通讯作者） Sexually dimorphic effects of maternal nutrient reduction on expression of genes regulating cortisol metabolism in fetal baboon adipose and liver tissues Diabetes 2013 2013, 62(4):1175-1185
Li JN, Wang WS, Liu C, Wang WH, Li WJ, Shu Q, Chen ZJ,Sun K （通讯作者） Critical role of histone acetylation by p300 in human placental 11β-HSD2 Expression. J Clin Endocrinol Metab 2013 2013,98:E1189-E1197.
Wang WH, Guo CM, Li WJ, Li JN, Wang WS, Myatt L, Sun K. （通讯作者） Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts. Endocrinology . 2012 153:5993-6002
Wang WS, Li JN, Ge YC, Li WJ, Shu Q, Guan H, Yang K, Myatt L, Sun K. （通讯作者） Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP/Sp1 pathway. Endocrinology 2012 153:2012-2022.
Guo CM, Kasaraneni N, Sun K* （通讯作者）, Myatt L*. Cross Talk between PKC and CREB in the Induction of COX-2 by PGF2α in Human Amnion Fibroblasts. Endocrinology. 2012 153:4938-4945.
Li JN, Ge YC, Yang Z, Guo CM, Duan T, Myatt L, Guan H, Yang K, Sun K*. （通讯作者） The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts. J Clin Endocrinol Metab 2011 86: E899-907