导师姓名： 陈子江 专业代码： 100211
性别： 女 专业名称： 妇产科学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： chenzijiang@vip.163.com
邮编： 邮箱地址： chenzijiang@vip.163.com

研究方向 (点击浏览详细信息)
妇科内分泌学、生殖医学、生殖遗传学

社会任职
Asian Journal of Andrology 编委
国际奥委会（IOC）医学委员会External专家组成员
中国医师协会生殖医学分会副主任委员
中华医学会妇产科学分会妇科内分泌学组组长
国际生殖学会联盟（IFFS）常务理事兼秘书长
Human Reproduction Update 副主编
亚太地区生殖医学学会（ASPIRE）常务理事
世界卫生组织（WHO）合作咨询专家
国务院学位委员会第七届学科评议组成员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 卵子发生与胚胎发育的调控 国自然基础科学中心 2020-01~2024-12 1600万元 课题负责人
** 长链非编码RNA GRIFIN-L在原发性卵巢功能不全发病中的作用及机制研究 国家自然科学基金面上项目 2017-01~2019-12 60万元 课题负责人
** 复发流产和子痫前期的遗传和表观遗传标记挖掘及鉴定 国家自然基金重大项目 2015-01~2019-12 240万元 课题负责人
辅助生殖与优生新技术建立协同创新中心 上海高等学校创新能力提升计划竞争性引导项目 2014-01~2014-12 300万元 主要责任人
上海市高校“一流学科” 上海交大医学院“一流学科” 2013-01~2015-12 1000万元 主要责任人
上海交通大学医学院生殖医学重点资助学科 上海交通大学医学院 2013-01~2015-12 500万元 主要责任人
12DZ** 上海市辅助生殖与优生重点实验室建设项目 上海市科委 2012-10~2014-10 200万元 主要责任人
2012CB944700 排卵障碍相关疾病发生机制研究 国家重大科学研究计划（973项目） 2012-01~2016-08 2563万元 主要责任人
生殖与生育重大疾病诊治的规范化与推广 卫生公益性行业科研专项（重大） 2011-07~2014-06 1677万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
Daimin Wei, Heping Zhang, Richard S Legro, Zi-Jiang Chen*. （通讯作者） Fresh versus frozen blastocyst transfer - Authors' reply. Lancet 2019 2019 Oct 5;394(10205):1228.
34.Xuepeng Chen△, Yuwen Ke△, Keliang Wu(Co-first authors) △, Han Zhao△, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu* & Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryo. Nature. 2019 2019; 576(7786): 306-310.
Daimin Wei, Jia-Yin Liu, Yun Sun, Yuhua Shi, Bo Zhang, Jian-Qiao Liu, Jichun Tan, Xiaoyan Liang, Yunxia Cao, Ze Wang, Yingying Qin, Han Zhao, Yi Zhou, Haiqin Ren, Guimin Hao, Xiufeng Ling, Junzhao Zhao, Yunshan Zhang, Xiujuan Qi, Lin Zhang, Xiaohui Deng, Xiaoli Chen,Yimin Zhu, Xiaohong Wang, Li-Feng Tian, Qun Lv, Xiang Ma, Heping Zhang, Richard S Legro （通讯作者）, Zi-Jiang Chen*. Frozen versus fresh single blastocyst transfer in ovulatory women: a multicenter, randomized controlled trial. Lancet 2019 2019 Mar 30;393(10178):1310-1318.
Yuhua Shi, Yun Sun, Cuifang Hao, Heping Zhang, Daimin Wei, Yunshan Zhang, Yimin Zhu, Xiaohui Deng, Xiujuan Qi, Hong Li, Xiang Ma, Haiqin Ren, Yaqin Wang, Dan Zhang, Bo Wang, Fenghua Liu, Qiongfang Wu, Ze Wang, Haiyan Bai, Yuan Li, Yi Zhou, Mei Sun, Hong Liu, Jing Li, Lin Zhang, Xiaoli Chen, Songying Zhang, Xiaoxi Sun, Richard S. Legro, and Zi-Jiang Chen*. （通讯作者） Transfer of Fresh versus Frozen Embryos in Ovulatory Women N Engl J Med 2018 378(2):126-136.
Jia Qi, Wangsheng Wang, Qinling Zhu, Yaqiong He, Yao Lu, Yuan Wang, Xiaoxue Li, Zi-jiang Chen* （通讯作者）, Yun Sun* Local Cortisol Elevation Contributes to Endometrial Insulin Resistance in Polycystic Ovary Syndrome J Clin Endocrinol Metab 2018 103(7):2457-2467.
Xuan Yao*, Meiling Zhang, Xing Wang, Wenqin Ying, Xinde Hu, Pengfei Dai, Feilong Meng, Linyu Shi, Yun Sun, Ning Yao, Wanxia Zhong, Yun Li, Keliang Wu, Weiping Li*, Zi-jiang Chen* （通讯作者）, Hui Yang*. Tild-CRISPR Allows for Efficient and Precise Gene Knockin in Mouse and Human Cells Dev Cell 2018 45(4):526-536.e5.
Hong Lv, Jing Tong, Jieqiong Yang, Shijian Lv, Wei-Ping Li*, Cong Zhang*, Zi-Jiang Chen*. （通讯作者） Dysregulated Pseudogene HK2P1 May Contribute to Preeclampsia as a Competing Endogenous RNA for Hexokinase 2 by Impairing Decidualization Hypertension 2018 71(4):648-658.
Xue Jiao, Hanni Ke, Yingying Qin* （通讯作者）, Zi-Jiang Chen*. Molecular Genetics of Premature Ovarian Insufficiency. Trends Endocrinol Metab Trends Endocrinol Metab 2018 EPUB
Xuan Yao*, Meilign Zhang, Xing Wang, Wenqin Ying, Xinde Hu, Pengfei Dai, Feilong Meng, Linyu Shi, Yun Sun, Ning Yao, Wanxia Zhong, Yun Li, Keling Wu, Weiping Li*, Zi-jiang Chen* （通讯作者）, Hui Yang*. Efficient precise targeted integration using Tild-CRISPR Developmental Cell 2018 45(4):526-536.e5.
Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Han Zhao, Jianqiao Liu*, Zi-Jiang Chen* （通讯作者）, Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and its Association with Evolution Cell 2018 173(1):248-259.e15.
Keliang Wu, Tailai Chen, Sexin Huang, Cuiqing Zhong, Junhao Yan, Xiaoyu Zhang, Jinsong Li, Yuan Gao*, Han Zhao*, Zi-Jiang Chen （通讯作者） Pre-pronuclear transfer in human embryos Cell Research 2017 1-4
Keliang Wu, Cuiqing Zhong, Tailai Chen, Xiaoyu Zhang, Wenrong Tao, Jingye Zhang, Hongchang Li, Han Zhao*, Jinsong Li* and Zi-Jiang Chen Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy Cell Research 2017 epub
Xue Jiao, Huihui Zhang, Hanni Ke, Jiangtao Zhang, Lei Cheng, Yixun Liu, Yingying Qin*, Zi-Jiang Chen* （通讯作者） Premature Ovarian Insufficiency: Phenotypic Characterization within Different Etiologies J Clin Endocrinol Metab 2017 epub
Xiaofei Xu, Xinxia Chen, Xiruo Zhang, Yixun Liu, Zhao Wang, Peng Wang, Yanzhi Du, Yingying Qin,and Zi-Jiang Chen （通讯作者） Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency Hum Reprod 2017 32(1):201-207
Ting Guo, Shidou Zhao, Shigang Zhao, Min Chen, Guangyu Li, Xue Jiao, Zhao Wang, Yueran Zhao Yingying Qin*, Fei Gao*, Zi-Jiang Chen*. . . Mutations in MSH5 in Primary Ovarian Insufficiency Hum Mol Genet 2017 epub
Xiaoxue Yuan, Tao Hu, Han Zhao, Yuanyuan Huang, Rongcai Ye, Jun Lin, Chuanhai Zhang, Hanlin Zhang, Gang Wei, Huiqiao Zhou, Meng Dong, Jun Zhao, Haibin Wang, Qingsong Liu, Hyuek Jong Lee, Wanzhu Jin*, and Zi-Jiang Chen* （通讯作者） Brown adipose tissue transplantation ameliorates polycystic ovary syndrome Proc Natl Acad Sci U S A 2016 113(10):2708-13
Cuiqing Zhong, Meiling Zhang, Qi Yin, Han Zhao, Yang Wang, Sexin Huang, Wenrong Tao, Keliang Wu*, Zi-Jiang Chen* （通讯作者）, and Jinsong Li* Generation of human haploid embryonic stem cells from parthenogenetic embryos obtained by microsurgical removal of male pronucleus Cell Research 2016 26(6):743-6
Ye Tian, Han Zhao, Haitao Chen,Yingqian Peng, Linlin Cui, Yanzhi Du, Zhao Wang, Jianfeng Xu, and Zi-Jiang Chen* （通讯作者） Variants in FSHB are associated with polycystic ovary syndrome and luteinizing hormone level in Han Chinese women J Clin Endocrinol Metab 2016 101(5):2178-84
Zi-Jiang Chen* （通讯作者）, Yuhua Shi, Yun Sun, Bo Zhang, Xiaoyan Liang, Yunxia Cao, Jing Yang, Jiayin Liu, Daimin Wei, Ning Weng, Lifeng Tian, Cuifang Hao, Dongzi Yang, Feng Zhou, Juanzi Shi, Yongle Xu, Jing Li, Junhao Yan, Yingying Qin, Han Zhao, Heping Zhang, Richard S. Legro Fresh versus Frozen Embryos for Infertility in Polycystic Ovary Syndrome N Engl J Med 2016 375(6):523-33
Yimei Zhang, Guangyu Li, Yuanyuan Fan, Yuqian Cui, SexinHuang, JinlongMa, JunhaoYan*, and Zi-JiangChen*. （通讯作者） Novel missense mutation in WNT6 in 100 couples with unexplained recurrent miscarriage. Hum Reprod. 2015 30(4):994-9.
Yujie Dang, Shidou Zhao, Yingying Qin, Ting Han, Weiping Li, Zi-Jiang Chen*. （通讯作者） MicroRNA-22-3p is down-regulated in the plasma of Han Chinese patients with premature ovarian failure. Fertil Steril. 2015 103(3): 802-7.e1.
Yingying Qin, Xue Jiao, Joe Leigh Simpson, Zi-Jiang Chen （通讯作者） Genetics of primary ovarian insufficiency: new developments and opportunities Hum Reprod Update 2015 21(6):787-808
Huidan Wang, Haitao Chen, Yingying Qin, Zhuqing Shi, Xiaoming Zhao, Jianfeng Xu, Bowen Ma, Zi-Jiang Chen （通讯作者） Risks associated with premature ovarian failure in Han Chinese women Reprod Biomed Online 2015 30(4):401-7
Shan Liu, Xuan Gao, Yingying Qin, Wen Liu, Tao Huang, Jinlong Ma, Joe Leigh Simpson, Zi-Jiang Chen （通讯作者） Nonsense mutation of EMX2 is potential causative for uterus didelphysis: first molecular explanation for isolated incomplete müllerian fusion Fertil Steril 2015 103(3):769-774.e2
X. Song, X. Sun c, G. M, Y. Sun d, Y. Shi, Y. Dud, Zi-Jiang Chen （通讯作者） Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese Eur J Obstet Gynecol Reprod Biol 2015 195:108-112.
Shidou Zhao, Guangyu Li, Raymond Dalgleish, Svetlana Vujovic, Xue Jiao, Jin Li, Joe Leigh Simpson, Yingying Qin, Maja Ivanisevic, Miomira Ivovic, Milina Tancic, Farook Al-Azzawi*, Zi-Jiang Chen*. （通讯作者） Transcription factor SOHLH1 potentially associated with primary ovarian insufficiency. Fertil Steril. 2015 103(2):548-553.e5.
Shigang Zhao, Ye Tian, Xuan Gao, Xiuqing Zhang, Hongbin Liu, Li You, Yongzhi Cao, Shizhen Su, Wai-Yee Chan, Yun Sun, Han Zhao* & Zi-Jiang Chen*. （通讯作者） Family-based analysis of eight susceptibility loci in polycystic ovary syndrome. Sci Rep. 2015 5:12619.
Xinghua Xu, Chigang Du, Huihui Li, Jing Du, Xue Yan, Lina Peng, Guangyao Li, Zi-Jiang Chen （通讯作者） Association of VEGF Genetic Polymorphisms with Recurrent Spontaneous Abortion Risk: A Systematic Review and Meta-Analysis PLoS One 2015 10(4):e**
Huidan Wang, Guangyu Li, Jun Zhang, Fei Gao, Weiping Li, Yingying Qin,Zi-Jiang Chen （通讯作者） Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure Sci Rep 2015 5:13983
Lingxia Ha, Yuhua Shi, Junli Zhao, Tao Li, Zi-Jiang Chen （通讯作者） Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women PLoS One 2015 10(5):e**
Yingying Qin, Ting Guo, Guangyu Li, Tie-Shan Tang, Shidou Zhao, Xue Jiao, Juanjuan Gong, Fei Gao, Caixia Guo, Joe Leigh Simpson, Zi-Jiang Chen （通讯作者） CSB-PGBD3 Mutations Cause Premature Ovarian Failure PLoS Genet 2015 11(7):e**
Shigang Zhao, Ye Tian, Wei Zhang, Xiuye Xing, Tao Li, Hongbin Liu, Tao Huang, Yunna Ning, Han Zhao* and Zi-Jiang Chen. An association study between USP34 and polycystic ovary syndrome. J Ovarian Res. 2015 8(1):30.
Linlin Cui, Guangyu Li, Wanxia Zhong, Yuehong Bian, Shizhen Su, Yan Sheng, Yuhua Shi, Daimin Wei, Wei Zhang, Han Zhao*, and Zi-Jiang Chen*. （通讯作者） Polycystic ovary syndrome susceptibility single nucleotide polymorphisms in women with a single PCOS clinical feature. Hum Reprod. 2015 30(3):732-6.
Yuqian Cui, Shigang Zhao, Han Zhao, Yue Lv, Mengru Yu, Yu Wang, Zi-Jiang Chen （通讯作者） Mutational analysis of TOX3 in Chinese Han women with polycystic ovary syndrome Reprod Biomed Online 2014 29(6):752-5
Yuqian Cui, Yuhua Shi, Linlin Cui, Ting Han, Xuan Gao,Zi-Jiang Chen*. （通讯作者） Age-specific serum antimüllerian hormone levels in women with and without polycystic ovary syndrome. Fertil Steril. 2014 102(1):230-236.e2
Yingying Qin, Xue Jiao, Raymond Dalgleish, Svetlana Vujovic, Jin Li, Joe Leigh Simpson, Farook Al-Azzawi, Zi-Jiang Chen （通讯作者） Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure Fertil Steril 2014 101(4): 1104-1109.e6
15.Yingying Qin, Svetlana Vujovi, Guangyu Li, Jin Li, Raymond Dalgleish, Joe Leigh Simpson, Maja Ivanisevic （通讯作者）, Miomira Ivovic, Milina Tancic, Farook Al-Azzawi, Zi-Jiang Chen Ethnic Specificity of Variants of the ESR1, HK3, BRSK1 Genes and the 8q22.3 Locus: No Association with Premature Ovarian Failure (POF) in Serbian Women Maturitas 2014 77(1): 64-7
Ting Guo, Yingying Qin, Xue Jiao, Guangyu Li, Joe Leigh Simpson, Zi-Jiang Chen （通讯作者） FMR1 Premutation Is an Uncommon Explanation for Premature Ovarian Failure in Han Chinese PLoS One 2014 9(7):e103316
Rong Tang, Yujie Dang, Yingying Qin, Shuhua Zou, Guangyu Li, Yu Wang, Zi-Jiang Chen （通讯作者） WNT9B in 542 Chinese women with Müllerian duct abnormalities: mutation analysis Reprod Biomed Online 2014 28(4): 503-7
Xinxia Chen, Yulan Mu, Chunyan Li, Guangyu Li, Hui Zhao, Yingying Qin, Zi-Jiang Chen （通讯作者） Mutation screening of HOXA7 and HOXA9 genes in Chinese women with Müllerian duct abnormalities Reprod Biomed Online 2014 29(5):595-9
Shi Y, Cui Y, Sun X, Ma G, Ma Z, Gao Q, Chen ZJ （通讯作者） Hypertension in women with polycystic ovary syndrome: prevalence and associated cardiovascular risk factors European Journal of Obstetrics & Gynecology and Reproductive Biology 2014 173:66-70
Peng Wang, Han Zhao, Tao Li, Wei Zhang, Keliang Wu, Mei Li, YuehongBian, Hongbin Liu, YunnaNing, Guangyu Li and Zi-Jiang Chen*. Hypomethylation of the LH/Choriogonadotropin Receptor Promoter Region Is a Potential Mechanism Underlying Susceptibility to Polycystic Ovary Syndrome. Endocrinology. 2014 155(4):1445-52
Xinxia Chen, Guangyu Li, Yingying Qin, Yuqian Cui, Li You, Zi-Jiang Chen （通讯作者） Mutations in HOXA11 are not responsible for Müllerian duct anomalies in Chinese patients Reprod Biomed Online 2014 28(6):739-42
Linlin Cui, Han Zhao, Bo Zhang, ZhongyuQu, JiayinLiu,Xiaoyan Liang, Xiaoming Zhao, Junli Zhao, YingpuSun,Peng Wang, Tao Li, Yuhua Shi, and Zi-Jiang Chen*. （通讯作者） Genotype–phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women. Human Reproduction. 2013 28(2):538-44
Han Zhao, Jianfeng Xu, Haobo Zhang, Yingpu Sun, Jielin Sun, Zhong Wang, Jiayin Liu, Qiang Ding, Shaoming Lu, Rong Shi, Li You, ...Zi-Jiang Chen A Genome-wide Association Study Reveals Variants within the HLA Region Are Associated with Risk for NonobstructiveAzoospermia. Am J Hum Genet. 2012 90(5):900-906
Yongyong Shi, Han Zhao, Yuhua Shi, Yunxia Cao, Dongzi Yang, ZhiqiangLi,Bo Zhang, Xiaoyan Liang, Tao L, Jianhua Chen, Jiawei Shen, JunzhaoZhao,Li You, Xuan Gao, Dongyi Zhu, ...Zi-Jiang Chen Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nature Genetics 2012 44(9):1020-5
Zi-Jiang Chen* （通讯作者）, Han Zhao, Lin He, Yuhua Shi, Yingying Qin, Yongyong Shi*, Zhiqiang Li, Li You, Junli Zhao, Jiayin Liu, Xiaoyan Liang, Xiaoming Zhao, Junzhao Zhao, Yingpu Sun, Bo Zhang, Hong Jiang, Dongni Zhao, YuehongBian, Xuan Gao, Ling Geng, Yiran Li, D Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nature Genetics 2011 43(1):55-59