导师姓名： 狄文 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200127 邮箱地址： diwen163@163.com

研究方向 (点击浏览详细信息)
妇科肿瘤
妊娠合并SLE

社会任职
中华医学会妇产科学分会副主任委员
《中国实用妇科与产科杂志》副主编
《上海医学》副主编
中国医师协会妇产科医师分会副会长
上海市医师协会妇科肿瘤学医师分会副会长
《中华妇产科杂志》副总编辑
上海市母婴安全专家委员会主任委员
上海市医师协会妇产科医师分会会长
上海医学会妇科肿瘤学分会前任主任委员
上海医学会妇产科分会顾问
上海市医师协会妇科肿瘤分会副会长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** BRD4通过超级增强子促进卵巢癌化疗耐药的作用与机制 国家自然科学基金面上项目 2020-01~2024-12 55万元 课题负责人
19dz** 基于“女性全生命周期生殖健康管理”的科普教育工程 上海市科委 2019-12~2021-08 98万元 课题负责人
/ 上海市临床重点专科建设项目-女性肿瘤 上海市卫生和计划生育委员会 2019-10~2022-12 150万元 课题负责人
RJLJHZ-07 卵巢癌天然免疫识别与治疗研究 仁济医院 2019-01~2019-12 97.5万元 课题负责人
/ 上海市临床重点专科建设项目-妇产科学 上海市卫生和计划生育委员会 2018-10~2020-12 469万元 课题负责人
ZY（2018-2020）-FWTX-3006 中西医联合治疗免疫“窗口期”上皮性卵巢癌的临床研究（上海市综合医院中西医结合专项重点项目） 上海市卫生和计划生育委员会、上海市申康医药发展办公室 2018-09~2020-12 44.36万元 课题负责人
** 一种妊娠合并免疫性疾病病情监测试剂盒的开发 上海市科委 2018-04~2021-06 35万元 课题负责人
** 顺铂诱导的卵巢癌细胞自噬对TAM极化的调控作用及机制研究 国自然面上项目 2018-01~2021-12 55万元 课题负责人
/ 上海市妇科肿瘤重点实验室（地高大建设项目） 上海交通大学医学院 2018-01~2020-12 50万元 课题负责人
2017ZZ02016 上海市重中之重临床重点学科--妇产科学 上海市卫生和计划生育委员会 2017-07~2020-06 100万元 课题负责人
14DZ** 上海市妇科肿瘤重点实验室 上海市科委 2017-01~2020-12 150万元 课题负责人
16CR2001A 基于精准医学的筛选靶向药物联合治疗在晚期卵巢癌中的临床研究 上海申康医院发展中心 2016-10~2018-10 80万元 课题负责人
2016YFC** 宫颈癌筛查与干预新技术及方案的研究--基于分子的癌前病变“无创”干预的研究 国家重点研发计划 2016-09~2020-10 100万元 课题负责人
DLY201505 基于分子诊断选择复发性卵巢癌治疗方案的前瞻性、随机、多中心临床研究 上海交通大学医学院 2016-01~2020-12 100万元 课题负责人
15GWZK0701 公共卫生三年行动计划重点学科——妇产科学 上海市卫生和计划生育委员会 2016-01~2017-12 1078.6万元 课题负责人
** EGF修饰的靶向性载miR-7脂质体的构建及其抗卵巢癌作用研究 国家自然科学基金面上项目 2015-01~2018-12 80万元 课题负责人
14DZ** 上海市妇科肿瘤重点实验室 上海市科委 2014-01~2016-12 150万元 课题负责人
2013ZYJB0202 上海市卫生系统重要疾病联合攻关项目（重大项目）——建立在蛋白质组/转录组基础上的卵巢癌早期诊断和个体化综合治疗研究 上海市卫生和计划生育委员会 2014-01~2016-12 150万元 课题负责人
2013-KJ-03 基于社区的健康促进项目（更年期、老年期女性及男性） 上海市卫生和计划生育委员会 2013-03~2013-12 90万元 课题负责人
** 卵巢癌自噬现象对化疗后免疫窗口期抗肿瘤CD8+CD45R0+T细胞生成调控作用的研究 国家自然科学基金面上项目 2013-01~2016-12 75万元 课题负责人
卵巢癌综合治疗的多中心临床研究 上海市科委 2012-10~2015-09 100万元 课题负责人
12GWZX0302 上海市公共卫生重点学科——妇幼卫生和儿童保健学 上海市卫生局 2012-01~2013-12 75万元 课题负责人
11nm** 靶向EGFR的载顺铂免疫纳米海藻酸钠脂质体改善卵巢癌耐药的机制研究 上海市科委 2011-12~2014-09 30万元 课题负责人
上海市领军人才建设专项 上海市科委 2011-12~2014-09 25万元 课题负责人
11DZ** 卵巢癌物理治疗临床转化研究示范基地 上海市科委 2011-12~2013-09 60万元 课题负责人
卫生行业科研专项：生殖与生育重大疾病诊治的规范化与推广——任务单元（宫颈疾病的诊治的规范化和功能保护） 卫生部科技教育司 2011-07~2014-06 18.72万元 课题负责人
075 自噬对卵巢癌细胞耐药及侵袭转移的调控作用 教育部博士点基金 2011-01~2013-12 6万元 课题负责人
新型抗血管生成药物靶向治疗卵巢癌的研究 上海交通大学理工交叉 2011-01~2012-12 12.5万元 课题负责人
** 自噬对卵巢癌细胞耐药及失巢凋亡抵抗的调控研究 国家自然科学基金面上项目 2011-01~2013-12 34万元 课题负责人
BXJ201023 ACC活性与上皮性卵巢癌治疗的相关性研究 交大医学院研究生院博士点基金 2010-10~2011-11 2万元 课题负责人
CAMB022010 液基细胞学、HPV检测及hTERC、C-MYC基因检测在宫颈癌筛查中的相关性研究 中华医学会 2010-08~2012-08 8万元 课题负责人
CAMB012010 FISH术技检测自然流产或死胎死产组织中染色体及基因异常临床应用研究 中华医学会 2010-08~2012-09 6万元 课题负责人
10dz** 卵巢肿瘤标志物筛选和机制研究 上海市科委 2010-06~2012-05 50万元 课题负责人
B-0801-10-0001 2009交大优秀学科带头人培养计划 上海交通大学医学院 2009-10~2012-12 150万元 课题负责人
0952mm04100 EGF修饰的装载顺铂的PEG-PLA纳米粒靶向特异性治疗卵巢癌的研究 上海市科委 2009-07~2011-06 50万元 课题负责人
09dz** 卵巢癌早期诊断和有效治疗研究平台建设 上海市科委（重点实验室） 2009-06~2011-06 50万元 主要责任人
PKY2009-Y15 宫颈病变早期诊断、早期干预及信息平台建设 浦东新区科委 2009-01~2011-12 10万元 课题负责人
08DZ** 上海市妇科肿瘤重点实验室建设 上海市科委 2008-09~2010-09 200万元 课题负责人
08XD14027 调控ACC活性作为上皮性卵巢癌治疗标靶的可行性研究 上海市科委（学科带头人） 2008-08~2010-08 40万元 课题负责人
2008BAI57B00 妇科疾病现代治疗规范化研究：宫颈病变发病及诊治规范化研究和推广 国家科技部“十一五”科技支撑重点项目课题 2008-06~2011-12 50万元 课题负责人
** 缺氧环境下LOX和TrkB促进上皮性卵巢癌转移的相互调控机制研究 国家自然科学基金面上项目 2008-01~2010-12 29万元 课题负责人
宫颈癌及子宫内膜异位症早期诊断与多中心临床研究 上海市科委重大项目 2008-01~2010-12 90万元 课题负责人
08YZ43 上海市教委第5期重点学科 上海市教委 2007-12~2013-12 490万元 课题负责人
2006DFA32780 抑制卵巢癌腹膜转移的靶向治疗研究 科技部国际合作重点项目 2007-01~2009-12 55万元 课题负责人
07ZZ40 一线化疗对卵巢癌患者免疫功能影响的研究 上海市教委 2007-01~2009-12 10万元 课题负责人
** BRMSI转移抑制基因和缺氧诱导因子HIF-1与卵巢上皮癌转移关系的研究 国家自然科学基金面上项目 2005-01~2007-12 21万元 课题负责人
2005ZD004 宫颈癌早期诊断及有效干预的实验及临床多中心研究 上海市卫生局 2005-01~2008-12 30万元 课题负责人
2004BA720A05-01 女性生殖道感染的相关研究 国家十五攻关课题子课题 2004-01~2006-12 10万元 课题负责人
04JC14045 转移抑制基因BRMSI和缺氧诱导因子HIF-1与卵巢上皮癌转移关系的研究 上海市科委 2004-01~2007-12 30万元 课题负责人
03-07-03 细胞信号传导对卵巢癌生物学行为的影响 上海市卫生局 2003-01~2006-12 20万元 课题负责人
34002 妊娠期糖尿病与瘦素关系的研究 上海市卫生局 2003-01~2005-12 3万元 课题负责人
02JC14028 三氧化二砷抗卵巢癌细胞及耐药细胞系的机理研究 上海市科委 2003-01~2005-12 15万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wenwen Li#, Lu Lu#, Juanjuan Lu, Xinran Wang, Chao Yang, Jingsi Jin, Lingling Wu, Xiaochuan Hong, Fanlin Li, Dongqing Cao, Yuanqin Yang, Meng Wu, Bing Su, Jinke Cheng, Xuanming Yang*, Wen Di* （通讯作者）, Liufu Deng* cGAS-STING-mediated DNA sensing maintains CD8 T cell stemness and promotes antitumor T cell therapy Sci Transl Med 2020 12(eaay9013):1-14
Wan Liu, Wenjing Wang, Xinran Wang, Cong Xua, Ning Zhang*, Wen Di* （通讯作者） Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis Cancer Letters 2020 472(1):59-69
Qiaohong Wang#, Jingze Gao#, Wen Di & Xia Wu* Anti-angiogenesis therapy overcomes the innate resistance to PD-1/PD-L1 blockade in VEGFA-overexpressed mouse tumor models Cancer Immunol. Immunother. 2020 69(9):1781–1799
Chaojun Wang#, Wen Di# （通讯作者）,Zhuowei Gu* Endocrine and glycolipid metabolism characteristics of diminished ovarian reserve in Chinese women with polycystic ovary syndrome Journal of International Medical Research 2020 48(3) 1–6
Lin Qiu, Abraham Morse, Wen Di, Lei Song, Beihua Kong, Zehua Wang, Jinghe Lang, Wenzhao Chai, Lan Zhu*, and Experts from the Chinese Obstetricians and Gynecologists Association Management of gynecology patients during the coronavirus disease 2019 pandemic: Chinese expert consensus American Journal of Obstetrics & Gynecology 2020 223(1)：3-8
Cong Xu, Wan Liu, Yuan Hu, Weiping L*, Wen Di* （通讯作者） Bioinspired tumor-homing nanoplatform for co-delivery of paclitaxel and siRNA-E7 to HPV-related cervical malignancies for synergistic therapy Theranostics 2020 10(7): 3325-3339
Jie Cheng*, Jiaxin Niu, You Wang, Chuan Wang, Qiong Zhou, Yunyan Chen, Yu Zhang, Jianhua Lin,Wen Di* （通讯作者） Hemophagocytic lymphohistiocytosis in pregnancy: a case report and review of the literature journal of obstetrics and gynaecology 2020 40(2):153‐159
Xiaoyan Wan, Zubei Hong, Yuhong Mao, Wen Di* （通讯作者） Correlations of AKIP1, CXCL1 and CXCL2 expressions with clinicopathological features and survival profiles in cervical cancer patients Translational Cancer Research 2020 9(2):726-734
Yuan Hu, Huaimin Wang, Chenge Li, Jinyao Liu*, Bing Xu*, Wen Di* （通讯作者） Enzyme-instructed assembly of a cholesterol conjugate promotes pro-inflammatory macrophages and induces apoptosis of cancer cells Biomaterials Science 2020 8, 2007–2017
Yanling Chang#, Yunyan Chen#, Qiong Zhou, Chuan Wang, Lei Chen, Wen Di* （通讯作者）, Yu Zhang* Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia Clinical Science 2020 134 (2): 289–302
Li LY#, Yin KM#,Bai YH, Zhang ZG, Di W* （通讯作者）, Zhang S* CTHRC1 promotes M2-like macrophage recruitment and myometrial invasion in endometrial carcinoma by integrin-Akt signaling pathway clinical & experimental metastasis 2019 Aug;36(4):351-363
Yifeng He#*, Zhuowei Gu#, Qiujing Zhu, Mo Chen, Chenghui He, Yuting Huang, Qing Li, Wen Di* （通讯作者） CA125 over-release behavior following a 75-gram oral glucose test as a predictive biomarker of multidrug resistance in patients with ovarian cancer international journal of cancer 2019 145(6):1690-1700
Keqi Song#, Lan Dai#*, Xiaoran Long, Xiaojuan Cui, Yixuan Liu, Wen Di* （通讯作者） Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo OncoTargets and Therapy 2019 12 4437–4449
Liying Gu#, Zubei Hong#, Hua Gao,Lihua Qiu*,Wen Di* （通讯作者） Incidence of cervical high‐grade squamous intraepithelial lesions and squamous cell carcinoma in women with highrisk human papillomavirus and normal cervical cytology A retrospective analysis of 1858 cases stratified by age and human papillomavirus genotype Cytopathology 2019 30:419–425.
wenting ji, weihua lou, zubei hong, lihua qiu, wen di* （通讯作者） Genomic amplification of HPV, h-TERC and c-MYC in liquid-based cytological specimens for screening of cervical intraepithelial neoplasia and cancer oncology letters 2019 17: 2099-2106
Chen Y#,Hong Z#,Wang W,Gu L,Gao H,Qiu L*,Di W* （通讯作者） Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women BMC infectious diseases 2019 Aug 1/19(1):677-
Jun Shi, Rongfen Huo,Ningli Li, Haichuan Li,Tianhang Zhai, Huidan Li, Baihua Shen, Jing Ye, Ruojin Fu, Wen Di* （通讯作者） CYR61, a Potential Biomarker of Tumor Inflammatory Response in Epithelial Ovarian Cancer Microenvironment of Tumor Progress BMC Cancer 2019 19/1/1140
Qi Wang#, Xiangyu Zhang#, Ying Sun, Liting Wang, Li Ding, Wei-Hong Zhu* , Wen Di* （通讯作者）, You-Rong Duan* Gold-caged copolymer nanoparticles as multimodal synergistic photodynamic/photothermal/chemotherapy platform against lethality androgen-resistant prostate cancer Biomaterials 2019 Volume 212, August 2019, Pages 73-86
Xia Yin#, RuiBi#, PengfeiMa#, Shengzhe Zhang#,Yang Zhang, Yunheng Sun,Yi Zhang, Ying Jing, Minhua Yu, Wenjing Wang, Li Tan, Wen Di* （通讯作者）, Guanglei Zhuang*, Mei-Chun Cai* Multiregion whole-genome sequencing depicts intratumor heterogeneity and punctuated evolution in ovarian clear cell carcinoma Journal of Medical Genetics 2019 jmedgenet-2019-106418
shanshan Zhong#, Yi Zhang#, Xia Yin, Wen Di* （通讯作者） cDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the Gg2/M phase and inhibiting transcriptional activity in cervical cancer OncoTargets and Therapy 2019 12 2137–2147
Chen Y#,Hong Z#,Wang W,Gu L,Gao H,Qiu L*,Di W* （通讯作者） Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women BMC infectious diseases 2019 Aug 1/19(1):677-
Keqi Song#, Lan Dai#*, Xiaoran Long, Xiaojuan Cui, Yixuan Liu, Wen Di* （通讯作者） Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo OncoTargets and Therapy 2019 12 4437–4449
Qi Tian#, He-FenSun, Wen-Jing Wang, Qing Li, JieDing, Wen Di* （通讯作者） miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB Future Oncol. 2019 15(17), 2019–2028
Xiaoran Long#, Keqi Song#, Hao Hu#, Qi Tian, Wenjing Wang, Qian Dong, Xia Yin, Wen Di* （通讯作者） Long non-coding RNA GAS5 inhibits DDPresistance and tumor progression of epithelial ovarian cancer via GAS5-E2F4-PARP1-MAPK axis Journal of Experimental & Clinical Cancer Research 2019 38:345
Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang*, Wen Di* （通讯作者）, Guanglei Zhuang* PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors eLife 2019 8:e44306.
Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang*, Wen Di* （通讯作者）, Guanglei Zhuang* PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors eLife 2019 8:e44306.
Zhuo-wei GU, Yi-feng HE, Wen-jing WANG, Qi TIAN, Wen DI （通讯作者） MiR-1180 from bone marrow-derived mesenchymal stem cells induces glycolysis and chemoresistance in ovarian cancer cells by upregulating the Wnt signaling pathway* Zhejiang Univ-Sci B (Biomed & Biotechnol) 2019 20(3):219-237
Jiayue WU, Wei-Hong ZHANG, Jinghang MA, Chunde BAO ,Jinlin LIU,Wen DI （通讯作者） Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study BMJ-Open 2019 Feb 11;9(2):e023849
Jiayue Wu, Wen Di （通讯作者） Pregnancy outcome in Chinese women with systemic lupus erythematosus: a retrospective study of 255 cases in a single center Int J Clin Exp Med 2018 11(2):966-974
Zhouzhou Bao,Yuqing Zhang,Ziyang Tan,Xia Yin,Wen Di （通讯作者）,Jian Ye Gap-enhanced Raman tags for high-contrast sentinel lymph node imaging Biomaterials 2018 163:105-115
Zhuowei Gu,Yifeng He,Yue Zhang,Mo Chen,Keqi Song,Yuting Huang,Qing Li,Wen Di （通讯作者） Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer Journal of Translational Medicine 2018 16: 114
You Wang, Zhicheng Zhou, Xinran Wang, Xuping Zhang, Yansu Chen, Jin Bai?, Wen Di （通讯作者） TRIM59 Is a Novel Marker of Poor Prognosis and Promotes Malignant Progression of Ovarian Cancer by Inducing Annexin A2 Expression International Journal of Biological Sciences 2018 14(14): 2073-2082
Yuqing Zhang,Zhiyang Liu,Benjamin D. Thackray,Zhouzhou Bao,Xia Yin,Fenglei Shi,Jianbo Wu,Jian Ye,Wen Di （通讯作者） Intraoperative Raman‐Guided Chemo‐Photothermal Synergistic Therapy of Advanced Disseminated Ovarian Cancers Small 2018 2018 Jul 4:e**
Zhang Shengzhe,Zhang Meiying, Jin Ying, Yin Xia, Ma Pengfei, Zhang zhenfeng, Wang Xiaojie, Di Wen （通讯作者）, Zhuang Guanglei Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhititors Nature communications 2018 9:215
Jiayue Wu,Jinghang Ma,Wei-Hong Zhang,Wen Di （通讯作者） Management and outcomes of pregnancy with or without lupus nephritis: a systematic review and meta-analysis Therapeutics and Clinical Risk Management 2018 14: 885–901
Jiayue Wu,Jinghang Ma,Chunde Bao,Wen Di,Wei-Hong Zhang （通讯作者） Pregnancy outcomes among Chinese women with and without systemic lupus erythematosus: a retrospective cohort study BMJ OPEN 2018 13;8(4):e020909
Cui X,Sun Y,Shen M,Song K,Yin X,Di W （通讯作者）,Duan Y Enhanced Chemotherapeutic Efficacy of Paclitaxel Nanoparticles Co-delivered with MicroRNA-7 by Inhibiting Paclitaxel-Induced EGFR/ERK pathway Activation for Ovarian Cancer Therapy ACS applied materials & interfaces 2018 10(9):7821-7831
Huifen Yin#, Jing Ye#, Hua Gao, Qing Li, Qi tian, Wenjing Wang, Wen Di* （通讯作者） Knowledge, attitude and practice about reproductive health of perimenpausal and postmenopausal Women in Shanghai:a cross-sectional and intervention study Int J Clin Exp Med 2017 10(7)10944-10951
Xia Yin#, Ying Jing#, Mei-Chun Cai#, Pengfei Ma, Yi Zhang, Cong Xu, Meiying Zhang, Wen Di* （通讯作者）, Guanglei Zhuang* Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer cancer research 2017 Dec 1;77(23):6551-6561
Lan Dai#*, Yixuan Liu#, Lei Xie#, Xia Wu, Lihua Qiu, Wen Di* （通讯作者） Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis Oncotarget 2017 Aug 24;8(43):74947-74961
Yun-Yan Chen#, Li-Ying Gu#, Wen Di* （通讯作者）, Jian-Hua Lin* Acute fatty liver of pregnancy: a retrospective analysis of 13 cases International Journal of Clinical and Experimental Pathology 2017 10(6):7075-7081
Lan Dai, Lei Xie, Yixuan Liu, Lihua Qiu, Wen Di （通讯作者） Clinicopathological and prognostic significance of serum interleukin-8 in ovarian cancer: a meta-analysis Int J Clin Exp Med 2017 10(1):97-105
Zhang N#, Lou WH#, Zhang XB, Lin JH, Di W* （通讯作者） Antepartum hemorrhage from previous-cesarean-sectioned uterus as a potential sign of uterine artery pseudoaneurysm J Zhejiang Univ Sci B 2017 May;18(5):441-444
Wenting Ji#, Jiayue Wu#, Jiejun Cheng, Wen Di* （通讯作者） Serous adenocarcinoma arising from endometriosis in cesarean section abdominal wall scar: a case report and literature review Int J Clin Exp Med 2017 10(7):7534-7541
Meiying Zhang, Guanglei Zhuang, Xiangjun Sun, Yanying Shen, Wenjing Wang, Qing Li, Wen Di （通讯作者） TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer Diagnostic Pathology 2017 Feb 2;12(1):16
Xia Yin, Xiaojie Wang, Boqiang Shen, Ying Jing, Qing Li, Mei-Chun Cai, Zhuowei Gu, Qi Yang, Zhenfeng Zhang, Jin Liu, Hongxia Li, Wen Di （通讯作者）, Guanglei Zhuang A VEGF-dependent gene signature enriched in mesenchymal ovarian cancer predicts patient prognosis Scientific Reports 2016 Aug 8;6:31079
Ning Zhang, Weihua Lou, Fang Ji, Lihua Qiu, Benjamin K. Tsang, Wen Di （通讯作者） Low molecular weight heparin and cancer survival: clinical trials and experimental mechanisms J Cancer Res Clin Oncol 2016 142(8):1807-16
Yifeng He, Qiujing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Qing Li, Yuting Huang, Wen Di （通讯作者） The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer Oncotarget 2016 Oct 25;7(43):70803-70821
Meiying Zhang, Guanglei Zhuang, Xiangjun Sun, Yanying Shen, Aimin Zhao, Wen Di （通讯作者） Risk prediction model for epithelial ovarian cancer using molecular markers and clinical characteristics Journal of Ovarian Research 2015 2015, 8 :67
Yijie chen*, Xinran Wang*, Ting liu, Ding sheng-zi Zhang, Yunfei Wang, hongchen gu, Wen Di （通讯作者） highly effective antiangiogenesis via magnetic mesoporous silica-based sirNavehicle targeting the VegF gene for orthotopic ovarian cancer therapy International Journal of Nanomedicine 2015 Mar 31;10:2579-94
Lan Dai, Weihua Lou, Jie Zhu, Xingchen Zhou, Wen Di （通讯作者） MiR-199a inhibits the angiogenic potential of endometrial stromal cells under hypoxia by targeting HIF-1α/VEGF pathway Int J Clin Exp Pathol 2015 May;8(5):4735-44
Zhang Y, Zhu HP, Fan JX, Yu H, Sun LZ, Chen L, Chang Q, Zhao NQ, Di W （通讯作者） Intravaginal Misoprostol for Cervical Ripening and Labor Induction in Nulliparous Women: A Double-blinded, Prospective Randomized Controlled Study Chin Med J 2015 128(20):2736-2742
Dai L, Qi Y, Chen J, Kaczorowski D, Di W （通讯作者）, Wang W, Xia P Sphingosine Kinase (SphK) 1 and SphK2 Play Equivalent Roles in Mediating Insulin's Mitogenic Action. Molecular endocrinology 2014 28(2):197-207
You Wang, Yingying Wang, Jingying Xiang, Fang Ji, Yan Deng, Chunhui Tang, Shuyun Yang, Qinghua Xi, Rong Liu, Wen Di （通讯作者） Knockdown of CRM1 inhibits the nuclear export of p27Kip1 phosphorylated at serine 10 and plays a role in the pathogenesis of epithelial ovarian cancer Cancer Letters 2014 343: 6–13
Lilan Chen, Ting Liu, Jinhua Zhou, Yunfei Wang, Xinran Wang,Wen Di （通讯作者）, Shu Zhang Citrate Synthase Expression Affects Tumor Phenotype and Drug Resistance in Human Ovarian Carcinoma PLOS One 2014 2014 Dec 29;9(12):e115708.
Yunfei Wang, Jinhua Zhou, Lihua Qiu, Xinran Wang, Lilan Chen, Ting Liu, Wen Di （通讯作者） Cisplatin–alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells Biomaterials 2014 35(14): 4297-4309
Lan Dai, Pu Xia, Wen Di （通讯作者） Sphingosine 1-phosphate: A Potential Molecular Target for Ovarian Cancer Therapy? Cancer Investigation 2014 32(3): 71-80
Lilan Chen, Ting Liu, Shu Zhang, Jinhua Zhou, Yunfei Wang, Wen Di （通讯作者） Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1αpathway in human ovarian cancer in vitro International Journal of Nanomedicine 2014 7:115
Yifeng He*, Xin Wu*, Qiujing Zhu, Xuezhe Wu, Lingda Feng, Xia Wu, Aimin Zhao,Wen Di （通讯作者） Combined laparoscopy and hysteroscopy vs. uterine curettage in the uterine artery embolization-based management of cesarean scar pregnancy: a retrospective cohort study BMC Womens Health 2014 Sep 24;14:116
Yunfei Wang, Peifeng Liu, Yourong Duan, Xia Yin, Qi Wang, Xiaofei Liu, Xinran Wang, Jinhua Zhou, Wenwen Wang, Lihua Qiu, Wen Di （通讯作者） Specific cell targeting with APRPG conjugated PEG-PLGA nanoparticles for treating ovarian cancer Biomaterials 2014 Jan;35(3):983-92
Ting Liu*, Lilan Chen*, Xiangjun Sun, You Wang, Shu Li, Xia Yin, Xinran Wang, Chenhuan Ding, He Li, Wen Di （通讯作者） Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies. Tumor Biology 2014 35, 2427-36
YaoWang,Osamu Okitsu,Xiao-Ming Zhao,Yun Sun,Wen Di （通讯作者）,Ri-Cheng Chian The effect of minimal concentration of ethylene glycol (EG) combined with polyvinylpyrrolidone (PVP) on mouse oocyte survival and subsequent embryonic development following vitrification Journal of assisted reproduction and genetics 2014 31:55–63
Jinhua Zhou*, Yunfei Wang*, You Wang, Xia Yin, Yifeng He, Lilan Chen, Wenwen Wang, Ting Liu, Wen Di （通讯作者） FOXM1 Modulates Cisplatin Sensitivity by Regulating EXO1 in Ovarian Cancer PLoS One 2014 9(5): e96989
Zhang M, He Y, Sun X, Wen Di （通讯作者） A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients Journal of Ovarian Research 2014 7(1): 19
Liang Zhou, Zhu Jing, Wang Yunfei, Wang You, Lin Jianhua, Di wen （通讯作者） Three transcription factors and the way immune cells affected by different plasma change in opposite ways in the development of the syndrome of pre-eclampsia chinese medical journal 2014 12(20):2252-2258
Yin X, Zhang N, Di W （通讯作者） Regulation of LC3-dependent protective autophagy in ovarian cancer cells by protein phosphatase 2A. Int J Gynecol Cancer 2013 23(4): 630-641
Brum G, Carbone T, Still E, Correia V, Szulak K, Calianese D, Best C, Cammarata G, Higgins K, Ji F, Di W （通讯作者）, Wan Y N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells Int J Oncol 2013 42(1): 211-218
Yi-feng He、Mei-ying Zhang、Xin Wu、Xiang-jun Sun、 Ting Xu、Qi-zhi He、Wen Di High MUC2 Expression in Ovarian Cancer Is Inversely Associated with the M1/M2 Ratio of Tumor-Associated Macrophages and Patient Survival Time PLoS One 2013 8(12): e79769
Gu L, Dai L, Cao C, Zhu J, Ding C, Xu HB, Qiu L, Di W （通讯作者） Functional expression of TWEAK and the receptor Fn14 in human malignant ovarian tumors: possible implication for ovarian tumor intervention PLoS One 2013 8(3): e57436
Ning Zhang,Lan Dai,Yanfei Qi, Wen Di （通讯作者）, Pu Xia Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy International Journal of Oncology 2013 42(6): 2053
Hanwen Zhang, Qiuyu Wang, Qian Zhao, Wen Di （通讯作者） MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1 Journal of ovarian research 2013 6(1): 84
Charles Best, David Calianese, Kevin Szulak, Garret Cammarata,Gabriella Brum, Thomas Carbone, Eric Still, Katelyn Higgins,Fang Ji, Wen Di （通讯作者）, Harold Wanebo, Yinsheng Wan Paclitaxel disrupts polarized entry of membrane?permeable C6 ceramide into ovarian cancer cells resulting in synchronous induction of cell death Oncology Letters 2013 5(6): 1854-1858
Li S, Qiu L, Wu B, Shen H, Zhu J, Zhou L, Gu L, Di W （通讯作者） TOFA suppresses ovarian cancer cell growth in vitro and in vivo Molecular medicine reports 2013 8(2): 373-378
Shen HR, Qiu LH, Zhang ZQ, Qin YY, Cao C#, Di W#. （通讯作者） Genome-wide methylated DNA immunoprecipitation analysis of patients with polycystic ovary syndrome. PLoS One. 2013 8(5): e64801
Fang Ji, You Wang, Lihua Qiu, Shu Li, Jing Zhu, Zhou Liang, Yinsheng Wan#, Wen Di#. （通讯作者） Hypoxia inducible factor 1α-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer International Journal of Oncology 2013 42(5): 1578-1588
Yunfei Wang, Peifeng Liu, Lihua Qiu, Ying Sun, Mingjie Zhu, Liying Gu, Wen Di# （通讯作者）, Yourong Duan Toxicity and therapy of cisplatin-loaded EGF modified mPEG-PLGA-PLL nanoparticles for SKOV3 cancer in mice Biomaterials 2013 34(16): 4068-4077
Buchu Wu, Ke Hu, Shu Li, Jing Zhu, Liying Gu, Haoran Shen, Brett D. Hambly, Shisan Bao, Wen Di （通讯作者） Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer ONCOLOGY REPORTS 2012 27:101-108
Zhu J, Zhang S, Gu L, Di W （通讯作者） Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma. Carcinogenesis 2012 33(12):2334-43
Dai L, Gu L, Di W （通讯作者） MiR-199a attenuates endometrial stromal cell invasiveness through Mol Hum Reprod 2012 18(3):136-45
Li H, Wen XS, Di W. （通讯作者） A simple LC-MS/MS method for determination of magnolol in rat blood and its application in a pharmacokinetic study. Arzneimittelforschung 2012 62(2):83-7
Buchu Wu, Shu Li, Lili Sheng, Jing Zhu, Liying Gu, Haoran Shen, Duanduan La, Brett D. Hambly, Shisan Bao, Wen Di （通讯作者） Metformin inhibits the development and metastasis of ovarian cancer ONCOLOGY REPORTS 2012 27:101-108
Xia Wu, Xuebin Zhang, Jie Zhu, Wen Di （通讯作者） Caesarean scar pregnancy comparative efficacy and safety of treatment by uterine artery chemoembolization and systemic methotrexate inject Eur J Obstet Gynecol Reprod Biol. 2012 161(1):75-9
Li H, Wen XS, Di W. （通讯作者） In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles. Arzneimittelforschung 2012 62(7):340-4.
Wu J, Ji F, DI W （通讯作者）, Chen H, Wan Y Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death Oncol Lett 2011 2(3):543-547.
Findlay JY, Wen D, Mandell MS Cardiac risk evaluation for abdominal transplantation Curr Opin Organ Transplant 2010 15(3):363-7.
Wu X, Feng QM, Wang Y, Shi J, Ge HL, Di W. （通讯作者） The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy. Cancer Immunol Immunother. 2010 59(2):279-291
Wang X, Zhang H, Di W （通讯作者）, Li W Clinical factors affecting the diagnostic accuracy of assessing dilation and curettage vs frozen section specimens for histologic grade and depth of myometrial invasion in endometrial carcinoma. Am J Obstet Gynecol 2009 201(2):194.e1-194
Lan Dai, Liying Gu, Chuanwei Ding, Lihua Qiu , Wen Di （通讯作者） TWEAK promotes ovarian cancer cell metastasis via NF-jB pathway activation and VEGF expression Cancer Letters 2009 283（2） ：159-167
Zhang N, Wu ZM, McGowan E, Shi J, Hong ZB, Ding CW, Xia P, Di W （通讯作者） Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 100(12):2459-64
Ning Zhang ,Hanwen Zhang ,Li Xia ,Ying Zheng ,Yun Yu,Yuanshan Zhu ,Guoqiang Chen,Wen Di （通讯作者） NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1a protein in human ovarian cancer cells Cancer Letters 2009 278：139-144
Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, Yang H, Chu W, Bi Z, Di W （通讯作者）, Wan Y. Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients. Fertil Steril. 2009 Jul;92(1):301-5.
Wei Pan, Hui Yang ,Cong Cao, Xiuzu Song,Brittany Wallin, Rebecca Kivlin, Shan Lu, Gang Hu , Wen Di, Yinsheng Wan AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells Oncology Reports 2008 20：1553-1559
Bao SH, Wang XP, Lin QD, Di W （通讯作者）, Xu L, Ding CW The investigation on the value of repeat and combination test of ACA and anti-beta2-GPI antibody in women with recurrent spontaneous abortion. Am J Reprod Immunol 2008 60(4):372-8
Cong Cao , Shan Lu , Alex Sowa , Rebecca Kivlin , Ashley Amaral ,Wenming Chu , Hui Yang , Wen Di （通讯作者）, Yinsheng Wan Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs Cancer Letter 2008 266（2）：249-262
Chao Ji, Cong Cao, Shan Lu, Rebecca Kivlin, Ashley Amaral, Nicola Kouttab, Hui Yang, Wenming Chu, Zhigang Bi, Wen Di （通讯作者）, Yinsheng Wan Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother Pharmacol 2008 62：857-865
Shi J, Wan Y, Di W （通讯作者） Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells. Oncol Rep 2008 20(4):803-807
Shi J, Wan Y, Di W （通讯作者） Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells. Oncol Rep 2008 20(4):803-807
WU Zhen-ming , Di Wen （通讯作者） Clinical Diagnosis And Treatment Of Small Ovarian Tumor In Postmenopausal Women Chinese Journal of Cancer Research 2006 18(3):229-234
Qiu L, Zhou C, Sun Y, Di W （通讯作者）, Scheffler E, Healey S, Kouttab N, Chu W, Wan Y Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation Int J Oncol. 2006 29(4):1003-11
WU Zhen-ming , DI Wen （通讯作者） Clinical Diagnosis And Treatment Of Small Ovarian Tumor In Postmenopausal Women Chinese Journal of Cancer Research 2006 18(3):229-234
Changlin Zhou,Lihua Qiu,Yun Sun,Sarah Healey,Harold Wanebo,Nicola Kouttab,Wen Di （通讯作者）,Bingfang Yan and Yinsheng Wan Inhibition of EGFR/PI13/AKT cell survival pathway promotes TSA’s effect on cell death and migration in human ovarian cancer cells. International Journal of Oncology 2006 29(1):269-78
Qiu L, Zhou C, Sun Y, Di W （通讯作者）, Scheffler E, Healey S, Wanebo H, Kouttab N, Chu W, Wan Y. Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. Oncology Reports 2006 16(4):907-13.