导师姓名： 黄旲 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市江浦路1500号新华医院科教楼330室huangying@xinhuamed.com.cn
邮编： 邮箱地址： huangy@sibcb.ac.cn

研究方向 (点击浏览详细信息)
表观遗传调控的结构生物学

社会任职
ASBMB美国生物化学与分子生物学会会员
RNA society会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基因信息传递过程中非编码RNA的调控作用机制 国家自然科学基金委重大研究计划集成项目 2020-01~2022-12 100万元 课题参与人
** piRNA介导的转录沉默的结构与分子机制研究 国家自然科学基金委面上项目 2019-01~2022-12 56万元 课题负责人
** piRNA生成加工通路中重要蛋白质及复合体的结构功能研究 国家自然科学基金委重大研究计划培育项目 2017-01~2019-12 90万元 课题负责人
XDB** 生物超大分子复合体的结构、功能与调控 中国科学院B类先导专项 2014-01~2018-12 240万元 子课题负责人
** SETDB1蛋白调控ES细胞命运的结构和功能研究 国家自然科学基金委面上项目 2013-01~2016-12 100万元 课题负责人
2012CB910500 植物表观遗传机制与重要调控蛋白质的功能和结构研究 国家重大科学研究计划 2012-01~2016-12 350万元 子课题负责人
2011CB966300 干细胞编程与重编程中表观遗传调控的分子机制和结构基础 国家重大科学研究计划 2011-01~2015-12 126万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Kun Dou*, Yanchao Liu, Yingpei Zhang, Chenhui Wang, Ying Huang* （通讯作者）, Zz Zhao Zhang* Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading J Genet Genomics 2020 47(4):187-199
Yao Lu, Ying Qiu, Peng Chen, Haishuang Chang, Luqiang Guo, Fang Zhang, Li Ma, Chi Zhang, Xin Zheng, Jun Xiao, Ruiyue Zhong, Lei Han, Xiaoyan Xu, Yanbo Zhang, Dangsheng Li, Guisheng Zhong, Rosemary Boyton, Ying Huang, Yongning He, Ronggui Hu* , Bin Wei*, and Hongyan Wang ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection Nat Microbiol 2019 4(12):2331-2346
Qiyuan Yang, Ronghong Li, Qifeng Lyu, Li Hou, Zhen Liu, Qiang Sun, Miao Liu, Huijuan Shi, Beiying Xu, Mingru Yin, Zhiguang Yan, Ying Huang, Mofang Liu, Yiping Li*, Ligang Wu* Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes Nat Commun 2019 10(1):3389
Kang Zhao, Sha Cheng, Na Miao, Ping Xu, Xiaohua Lu, Yuhan Zhang, Ming Wang, Xuan Ouyang, Xun Yuan, Weiwei Liu, Xin Lu, Peng Zhou, Jiaqi Gu, Yiqun Zhang, Ding Qiu, Zhaohui Jin, Chen Su, Chao Peng, Jian-Hua Wang, Meng-Qiu Dong, Youzhong Wan, Jinbiao Ma, Hong Cheng, Ying Huang* （通讯作者）, Yang Yu* A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation Nat Cell Biology 2019 21(10):1261-1272
Ying Yang, Lu Wang, Xiao Han, Wen-Lan Yang, Mengmeng Zhang, Hai-Li Ma, Bao-Fa Sun, Ang Li, Jun Xia, Jing Chen, Jian Heng, Baixing Wu, Yu-Sheng Chen, Jia-Wei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hai-Lin Wang, Ying Huang, Ying-Pu Sun, Yong-Liang Zhao, Anming Meng, Jinbiao Ma*, Feng Liu*, Yun-Gui Yang* RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay Mol Cell 2019 75(6):1188-1202
Xiao-Juan Yang, Hong Zhu, Shi-Rong Mu, Wen-Juan Wei, Xun Yuan, Meng Wang, Yanchao Liu, Jingyi Hui*, Ying Huang* （通讯作者） Crystal structure of a Y-box binding protein 1 (YB-1)–RNA complex reveals key features and residues interacting with RNA J Biol Chem 2019 294(28):10998-11010
Xin Chen, Ang Li, Bao-Fa Sun, Ying Yang, Ya-Nan Han, Xun Yuan, Ri-Xin Chen, Wen-Su Wei, Yanchao Liu, Chun-Chun Gao, Yu-Sheng Chen, Mengmeng Zhang, Xiao-Dan Ma, Zhuo-Wei Liu, Jun-Hang Luo, Cong Lyu, Hai-Lin Wang, Jinbiao Ma, Yong-Liang Zhao, Fang-Jian Zhou, Ying Huang* （通讯作者）, Dan Xie*, Yun-Gui Yang* 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs Nat Cell Biology 2019 21(8):978-990
Ling Peng, Fengjuan Zhang, Renfu Shang, Xueyan Wang, Jiayi Chen, James J Chou, Jinbiao Ma, Ligang Wu*, Ying Huang* （通讯作者） Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain J Biol Chem 2018 293(26):9981-9994
Yuhan Zhang, Weiwei Liu, Ronghong Li, Jiaqi Gu, Ping Wu, Chao Peng, Jinbiao Ma, Ligang Wu, Yang Yu, Ying Huang* （通讯作者） Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi Proc Natl Acad Sci USA 2018 115(13):3374-3379
Bowen Yu, Yu An Lin, Swapnil S Parhad, Zhaohui Jin, Jinbiao Ma, William E Theurkauf, ZZ Zhao Zhang*, Ying Huang* （通讯作者） Structural insights into Rhino‐Deadlock complex for germline piRNA cluster specification EMBO Rep 2018 19(7):e45418
Hua Tang, Haishuang Chang, Yue Dong, Luqiang Guo, Xiangyi Shi, Yichun Wu, Ying Huang, Yongning He* Architecture of cell-cell adhesion mediated by sidekicks Proc Natl Acad Sci USA 2018 115(37):9246-9251
Zhenzheng Hu, Xiangyi Shi, Bowen Yu, Na Li, Ying Huang, Yongning He* Structural insights into the pH-dependent conformational change and collagen recognition of the human mannose receptor Structure 2018 26(1):60-71
Ling Peng, Longlong Wang, Yingpei Zhang, Aiwu Dong, Wen-Hui Shen, Ying Huang* （通讯作者） Structural analysis of the Arabidopsis AL2-PAL and PRC1 complex provides mechanistic insight into active-to-repressive chromatin state switch J Mol Biol 2018 430(21):4245-4259
Yanchao Liu, Ying Huang* （通讯作者） Uncovering the mechanistic basis for specific recognition of monomethylated H3K4 by the CW domain of Arabidopsis histone methyltransferase SDG8 J Biol Chem 2018 293(17):6470-6481
Jiayi Chen, Li Liu, Chenjiang You, Jiaqi Gu, Wenjie Ruan, Lu Zhang, Jianhua Gan, Chunyang Cao, Ying Huang* （通讯作者）, Xuemei Chen*, Jinbiao Ma* Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1 Nat Commun 2018 9(1):1-13
Hong Peng, Jiao Yang, Guangyi Li, Qing You, Wen Han, Tianrang Li, Daming Gao, Xiaoduo Xie, Byung-Hoon Lee, Juan Du, Jian Hou, Tao Zhang, Hai Rao, Ying Huang, Qinrun Li, Rong Zeng, Lijian Hui, Hongyan Wang, Qin Xia, Xuemin Zhang, Yongning He, Masaaki Komatsu, Ivan Dikic, Daniel Finley and Ronggui Hu* Ubiquitylation of p62/sequestosome1 activates its autophage receptor function and controls selective autophagy upon ubiquitin stress Cell Res 2017 27(5):657-674
Baixing Wu, Li Li, Ying Huang* （通讯作者）, Jinbiao Ma*, Jinrong Min* Readers, writers and erasers of N6-methylated adenosine modification Curr Opin Struct Biol 2017 47:67-76
Yanchao Liu, Hong Wu, Yu Yu, Ying Huang* （通讯作者） Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants Protein & Cell 2016 7(11):792-803
Zhongfei Li, Bin Li, Jian Liu, Zhihao Guo, Yuhao Liu, Yan Li, Wen-Hui Shen, Ying Huang, Hai Huang, Yijing Zhang*, Aiwu Dong* Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis J Integr Plant Biol 2016 58(12):959-970
Bowen Yu, Madeline Cassani, Min Wang, Mofang Liu, Jinbiao Ma, Guohong Li, Zhao Zhang*, Ying Huang* （通讯作者） Structural insights into Rhino-mediated germline piRNA cluster formation Cell Res 2015 25(4):525-528
Jing Jin, Jinlei Shi, Bing Liu, Yanchao Li, Ying Huang, Yu Yu*, Aiwu Dong* MORF-RELATED GENE702, a reader protein of trimethylated histone H3 lysine 4 and histone H3 lysine 36, is involved in Brassinosteroid-regulated growth and flowering time control in rice Plant Physiol 2015 168(4):1275-85
Guan-Nan Gao, Mingzhu Wang, Na Yang, Ying Huang, Rui-Ming Xu* Structure of Zeste-DNA complex reveals a new modality of DNA recognition by homeodomain-like proteins J Mol Biol 2015 427(24):3824-33
Zhongyuan Bu, Yu Yu, Zepeng Li, Yanchao Liu, Wen Jiang, Ying Huang, Ai-Wu Dong* Regulation of Arabidopsis flowering by the histone mark reader MRG1/2 via interaction with CONSTANS to modulate FT expression PLoS Genet 2014 10(9):e**
Qi Liu, Qingqing Yan, Yin Liu, Fang Hong, Zhenfei Sun, Leilei Shi, Ying Huang, Yuda Fang* Complementation of HYPONASTIC LEAVES1 by double-strand RNA-binding domains of DICER-LIKE1 in nuclear dicing bodies Plant Physiol 2013 163(1):108-17
Fan Zhu, Heidi Erlandsen, Lei Ding, Jingzhi Li, Ying Huang, Meixian Zhou, Xiaobo Liang, Jinbiao Ma, Hui Wu* Structural and Functional Analysis of a New Subfamily of Glycosyltransferases Required for Glycosylation of Serine-rich Streptococcal Adhesins J Biol Chem 2011 286(30):27048-57
Haiping Liu, Ju-Yu S Wang, Ying Huang （共同第一作者）, Zhizhong Li, Weimin Gong, Ruth Lehmann*, Rui-Ming Xu* Structural basis for methylarginine-dependent recognition of Aubergine by Tudor Genes & Develop 2010 24(17):1876-1881
Ying Huang, Lijuan Ji, Qichen Huang, Dmitry G Vassylyev, Xuemei Chen, Jin-Biao Ma* Structural insights into mechanisms of the small RNA methyltransferase HEN1 Nature 2009 461(7265):823-827
Ying Huang, Jia Fang, Mark T Bedford, Yi Zhang, Rui-Ming Xu* Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A Science 2006 312(5774):748-751
Ying Huang, Michael P Myers, Rui-Ming Xu* Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding Structure 2006 14(4):703-712
Ying Huang, Qichen Huang*, Haibao Chen, Youqi Tang, Hideo Miyake, Masami Kusunoki Crystallization and preliminary crystallographic study of rBmKαIT1, a recombinant α-insect toxin from the scorpion Buthus martensii Karsch Acta Crystallographica Section D 2003 59(9):1635-1636