导师姓名： 陈丰原 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属新华医院 三级学科/
专业领域： 心血管病
导师类型： 博士生导师 专业学位导师：
联系方式： chenfengyuan@xinhuamed.com.cn。教育部“****”讲座教授、国家自然科学基金****基金获得者，科技部973项目首席科学家. 上海交通大学“致远荣誉计划”直博生导师，新华医院心内科教授，心血管发育与再生医学研究所所长。兼任上海交通大学医学院临床药学创新研究院名誉院长，上海交通大学药学院兼职讲席教授。 。
邮编： 200092 邮箱地址： afychen@yahoo.com

研究方向 (点击浏览详细信息)
心血管疾病损伤，修复与再生的机制研究

社会任职
第七届国务院药学学科专家评议组成员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** RNA编辑/修饰关键酶ADAR1调控内皮细胞焦亡介导的免疫炎症所致肺血管损伤 国家自然科学基金重点项目 2020-01~2024-12 297万元 课题负责人
** 组织蛋白酶Cathepsin L/V促进血管内膜新生的机制研究 国家自然科学基金重点项目 2018-01~2022-12 294万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Li L, Tang L, Yang X, Chen R, Zhang Z, Leng Y, Chen AF. （通讯作者） Gene Regulatory Effect of Pyruvate Kinase M2 is Involved in Renal Inflammation in Type 2 Diabetic Nephropathy Exp Clin Endocrinol Diabetes 2020 2020 Jan 20. doi: 10.1055/a-1069-7290. [Epub ahead of print]
Ma Y, Zhang Z, Chen R, Shi R, Zeng P, Chen R, Leng Y, Chen AF （通讯作者） NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition Am J Physiol Heart Circ Physiol 2019 316(5):H1039-H1046
Peng C, Dong XH, Liu JL, Tao YL, Xu CF, Wang LP, Liu CL, Su DF, Tao X, Zhang C, Chen AF （通讯作者）, Xie HH. A Preventive Injection of Endothelial Progenitor Cells Prolongs Lifespan in Stroke-prone Spontaneously Hypertensive Rats. Clin Sci (Lond). 2018 Jul 13
Leng YP, Ma YS, Li XG, Chen RF, Zeng PY, Li XH, Qiu CF, Li YP, Zhang Z, Chen AF. （通讯作者） l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. British journal of pharmacology. 2018 175(8):1157-1172.
Dong XH, Peng C, Zhang YY, Tao YL, Tao X, Zhang C, Chen AF （通讯作者）, Xie HH. Chronic Exposure to Subtherapeutic Antibiotics Aggravates Ischemic Stroke Outcome in Mice. EBioMedicine. 2017 24:116-126.
Cai J, Wen J, Bauer E, Zhong H, Yuan H, Chen AF. （通讯作者） The Role of HMGB1 in Cardiovascular Biology: Danger Signals. Antioxidants & redox signaling. 2015 23(17):1351-69.
Dong XH, Sun X, Jiang GJ, Chen AF （通讯作者）, Xie HH. Dietary intake of sugar substitutes aggravates cerebral ischemic injury and impairs endothelial progenitor cells in mice. Stroke. 2015 46(6):1714-8.
Cai J, Yuan H, Wang Q, Yang H, Al-Abed Y, Hua Z, Wang J, Chen D, Wu J, Lu B, Pribis JP, Jiang W, Yang K, Hackam DJ, Tracey KJ, Billiar TR, Chen AF. （通讯作者） HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4. Arteriosclerosis, thrombosis, and vascular biology. 2015 35(12):2579-93.
Jiang R, Cai J, Zhu Z, Chen D, Wang J, Wang Q, Teng Y, Huang Y, Tao M, Xia A, Xue M, Zhou S, Chen AF. （通讯作者） Hypoxic trophoblast HMGB1 induces endothelial cell hyperpermeability via the TRL-4/caveolin-1 pathway. Journal of immunology (Baltimore, Md. : 1950). 2014 193(10):5000-12.
Wang JM, Tao J, Chen DD, Cai JJ, Irani K, Wang Q, Yuan H, Chen AF. （通讯作者） MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arteriosclerosis, thrombosis, and vascular biology. 2014 34(1):99-109.
Liu F, Chen DD, Sun X, Xie HH, Yuan H, Jia W, Chen AF. （通讯作者） Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes. Diabetes. 2014 63(5):1763-78.
Chen AF, Li H. Editorial: therapeutic strategies to target endothelial nitric-oxide synthase (eNOS). Current pharmaceutical design. 2014 20(22):3501-2.
Bae ON, Wang JM, Baek SH, Wang Q, Yuan H, Chen AF. （通讯作者） Oxidative stress-mediated thrombospondin-2 upregulation impairs bone marrow-derived angiogenic cell function in diabetes mellitus. Arteriosclerosis, thrombosis, and vascular biology. Arteriosclerosis, thrombosis, and vascular biology. 2013 33(8):1920-7.
Chen DD, Dong YG, Yuan H, Chen AF. （通讯作者） Endothelin 1 activation of endothelin A receptor/NADPH oxidase pathway and diminished antioxidants critically contribute to endothelial progenitor cell reduction and dysfunction in salt-sensitive hypertension. Hypertension (Dallas, Tex. : 1979). 2012 59(5):1037-43.
Chen AF, Chen DD, Daiber A, Faraci FM, Li H, Rembold CM, Laher I. Free radical biology of the cardiovascular system. Clinical science (London, England : 1979). 2012 123(2):73-91.
Marrotte EJ, Chen DD, Hakim JS, Chen AF. （通讯作者） Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice. The Journal of clinical investigation. 2010 120(12):4207-19.
Xie HH, Zhou S, Chen DD, Channon KM, Su DF, Chen AF. （通讯作者） GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. Hypertension (Dallas, Tex. : 1979). 2010 56(6):1137-44.
Ceylan-Isik AF, Guo KK, Carlson EC, Privratsky JR, Liao SJ, Cai L, Chen AF, Ren J. Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. Hypertension (Dallas, Tex. : 1979). 2009 53(6):1023-31.
Du YH, Chen AF. （通讯作者） A new role for caveolin-1: regulation of guanosine triphosphate cyclohydrolase I and tetrahydrobiopterin in endothelial cells. Hypertension (Dallas, Tex. : 1979). 2009 53(2):115-7.
Du YH, Guan YY, Alp NJ, Channon KM, Chen AF. （通讯作者） Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension. Circulation. 2008 117(8):1045-54.
Lin HW, Liu CZ, Cao D, Chen PY, Chen MF, Lin SZ, Mozayan M, Chen AF, Premkumar LS, Torry DS, Lee TJ. Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion. Proceedings of the National Academy of Sciences of the United States of America. 2008 105(49):19526-31.
Chen DD, Chen AF. （通讯作者） CuZn superoxide dismutase deficiency: culprit of accelerated vascular aging process. Hypertension (Dallas, Tex. : 1979). 2006 48(6):1026-8.
Kidd GA, Hong H, Majid A, Kaufman DI, Chen AF. （通讯作者） Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke. Stroke. 2005 36(12):2705-11.
Luo JD, Wang YY, Fu WL, Wu J, Chen AF. （通讯作者） Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation. 2004 110(16):2484-93.
Xu FP, Chen MS, Wang YZ, Yi Q, Lin SB, Chen AF, Luo JD. Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes. Circulation. 2004 110(10):1269-75.
Li L, Watts SW, Banes AK, Galligan JJ, Fink GD, Chen AF. （通讯作者） NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension. Hypertension (Dallas, Tex. : 1979). 2003 42(3):316-21.
Li L, Chu Y, Fink GD, Engelhardt JF, Heistad DD, Chen AF. （通讯作者） Endothelin-1 stimulates arterial VCAM-1 expression via NADPH oxidase-derived superoxide in mineralocorticoid hypertension. Hypertension (Dallas, Tex. : 1979). 2003 42(5):997-1003.
Zheng JS, Yang XQ, Lookingland KJ, Fink GD, Hesslinger C, Kapatos G, Kovesdi I, Chen AF. （通讯作者） Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation. 2003 108(10):1238-45.
Li L, Fink GD, Watts SW, Northcott CA, Galligan JJ, Pagano PJ, Chen AF. （通讯作者） Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension. Circulation. 2003 107(7):1053-8.
Li L, Galligan JJ, Fink GD, Chen AF. （通讯作者） Vasopressin induces vascular superoxide via endothelin-1 in mineralocorticoid hypertension. Hypertension (Dallas, Tex. : 1979). 2003 41(3 Pt 2):663-8.
Li L, Crockett E, Wang DH, Galligan JJ, Fink GD, Chen AF. （通讯作者） Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesion molecule-1 expression and superoxide production in deoxycorticosterone acetate-salt hypertension. Arteriosclerosis, thrombosis, and vascular biology. 2002 22(2):249-55.
Chen AF, O'Brien T, Katusic ZS. Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system. Trends in pharmacological sciences. 1998 19(7):276-86.
Chen AF, Jiang SW, Crotty TB, Tsutsui M, Smith LA, O'Brien T, Katusic ZS. Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. Proc Natl Acad Sci USA 1997 94(23):12568-73
Chen AF, O'Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ,Katusic ZS. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery. Circulation research. 1997 80(3):327-35.
Lee TJ, Sarwinski S, Ishine T, Lai CC, Chen FY Inhibition of cerebral neurogenic vasodilation by L-glutamine and nitric oxide synthase inhibitors and its reversal by L-citrulline. J Pharmacol Exp Ther 1996 276(2):353-8
Chen FY, Lee TJ. Arginine synthesis from citrulline in perivascular nerves of cerebral artery. J Pharmacol Exp Ther 1995 273(2):895-901
Chen FY, Lee TJ. Role of nitric oxide in neurogenic vasodilation of porcine cerebral artery. J Pharmacol Exp Ther 1993 265(1):339-45.