导师姓名： 王阳 专业代码： 100202
性别： 男 专业名称： 儿科学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 200092 邮箱地址： wangyang@xinhuamed.com.cn

研究方向 (点击浏览详细信息)
先天性巨结肠分子遗传机制
肠神经系统分子调控机制

社会任职
上海交通大学“SMC-晨星优秀青年教师” （2013年度、2017年度两次入选）
Frontiers in Genetics 杂志（IF=4.151）国际编委会委员
上海市科学技术专家库成员
美国哈佛大学医学院博士后
上海高校优秀青年教师（2012年度）

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
MicroRNA表达谱在先天性巨结肠临床早期诊断中的应用研究 上海市卫计委临床研究专项（面上项目） 2019-01~2021-12 10万元 课题负责人
** MiR-132介导巯基亚硝基化修饰在先天性巨结肠发生中的作用及其调控机制研究 国家自然科学基金面上项目 2017-01~2020-12 58万元 课题负责人
** 肠道菌群失调对早产儿肠外营养相关肝损害作用及机制研究 国家自然科学基金（重点项目） 2017-01~2021-12 275万元 课题参与人
14X 顺-反式调控效应在先天性巨结肠发生中的作用及其分子机制研究 上海交通大学“晨星优秀青年教师奖励计划” 2013-12~2016-12 8万元 课题负责人
YG2012MS04 基因表达顺式调控机制在先天性巨结肠发生中的作用及其临床应用研究 上海交通大学医工交叉研究基金（面上项目） 2013-01~2015-12 15万元 课题负责人
** 先天性巨结肠相关Hedgehog及Notch信号通路的分子遗传机制研究 国家自然科学基金青年项目 2013-01~2015-12 23万元 课题负责人
ZZjdyx12094 等位基因特异性表达诱导先天性巨结肠发生的机制研究 上海高校优秀青年教师培养资助计划 2012-10~2014-09 5万元 课题负责人
12XJ30067 顺式调控网络相关先天性巨结肠的机制研究 上海交通大学医学院科技基金 2012-06~2014-06 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang Y, Jiang Q, Cai H, Xu Z, Wu W, Gu B, Li L, Cai W. Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease. Aging 2020 12(5):4379-4393
Wang Y, Jiang Q, Chakravarti A, Cai H, Xu Z, Wu W, Gu B, Li L, Cai W. MicroRNA-4516-mediated regulation of MAPK10 relies on 3' UTR cis-acting variants and contributes to the altered risk of Hirschsprung disease. J Med Genet 2020 Epub ahead of print
Jiang Q, Wang Y （共同第一作者）, Li Q, Zhang Z, Xiao P, Wang H, Liu N, Wu J, Zhang F, Chakravarti A, Cai W, Li L. Sequence characterization of RET in 117 Chinese Hirschsprung disease families identifies a large burden of de novo and parental mosaic mutations. Orphanet J Rare Dis 2019 14(1):237
Wang Y, Yan W, Wang J, Zhou Y, Chen J, Gu B, Cai W. Common genetic variants in GAL, GAP43 and NRSN1 and interaction networks confer susceptibility to Hirschsprung disease. J Cell Mol Med 2018 22(7):3377-3387
Dai LN, Yan JK, Xiao YT, Wen J, Zhang T, Zhou KJ, Wang Y, Cai W. Butyrate stimulates the growth of human intestinal smooth muscle cells by activation of yes-associated protein. J Cell Physiol 2018 233(4):3119-3128
Cheng S, Wang J, Pan W, Yan W, Shi J, Guan W, Wang Y, Cai W. Pathologically assessed grade of Hirschsprung-associated enterocolitis in resected colon in children with Hirschsprung's disease predicts postoperative bowel function. J Pediatr Surg 2017 52(11):1776-1781
Wang Y, Veremeyko T, Wong AH, El Fatimy R, Wei Z, Cai W, Krichevsky AM. Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. Neurobiol Aging 2017 51:156-166
Wang Y, Cao Y, Huang X, Yu T, Wei Z, McGrath J, Xu F, Bi Y, Li X, Yang F, Li W, Zou X, Peng Z, Xiao Y, Zhang Y, He L, He G. Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia. Sci Rep 2016 6:26688
Teplyuk NM, Uhlmann EJ, Gabriely G, Volfovsky N, Wang Y, Teng J, Karmali P, Marcusson E, Peter M, Mohan A, Kraytsberg Y, Cialic R, Chiocca EA, Godlewski J, Tannous B, Krichevsky AM. Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med 2016 8(3):268-87
Wang Y, Wang J, Zhou Y, Wei Z, Xiao Y, Zhou K, Wen J, Yan J, Cai W. Contribution of Common Variants in GABRG2, RELN and NRG3 and Interaction Networks to the Risk of Hirschsprung Disease. Cell Physiol Biochem 2016 40(3-4):509-526
Xiao Y, Wang J, Yan W, Zhou Y, Chen Y, Zhou K, Wen J, Wang Y, Cai W. Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling. J Hepatol 2015 62(4):889-96
Chen Y1, Xiao Y, Ge W, Zhou K, Wen J, Yan W, Wang Y, Wang B, Qu C, Wu J, Xu L, Cai W. miR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells. Cell Death Dis 2013 4:e541
Wang Y, Wang J, Pan W, Zhou Y, Xiao Y, Zhou K, Wen J, Yu T, Cai W. Common genetic variations in Patched1 (PTCH1) gene and risk of hirschsprung disease in the Han Chinese population. PLoS One 2013 20;8(9):e75407
Huang X, Wang Y （共同第一作者）, Yu T, Liu B, Li X, Li W, Chen S, Zhao Q, Li X, Yang F, Wang Q, Wang J, Xiao Y, Xu Y, Feng G, Peng Z, He L, He G Association study of APC polymorphisms with colorectal cancer in Han Chinese. Clin Biochem 2012 45(18):1669-72
Wang Y, He G, He L, McGrath J. Do shared mechanisms underlying cell cycle regulation and synaptic plasticity underlie the reduced incidence of cancer in schizophrenia? Schizophr Res 2011 130(1-3):282-4
Li J, Zhou G, Ji W, Feng G, Zhao Q, Liu J, Li T, Li Y, Chen P, Zeng Z, Wang T, Hu Z, Zheng L, Wang Y, Shen Y, He L, Shi Y. Common variants in the BCL9 gene conferring risk of schizophrenia. Arch Gen Psychiatry 2011 68(3):232-40
Wang Y, Wang L, Li X, Liu B, Zhao Q, Chen P, Wang T, Li T, Ji J, Yang F, Wang Q, Wang J, Xiao Y, Xu Y, Feng G, Peng Z, He L, He G. Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients. BMC Cancer 2010 10:523.
Wang Y, Zhang J, Liu B, Shao L, Wei Z, Li X, Ji J, Yang F, Wang T, Liu J, Wan C, Li B, Xu Y, Feng G, He L, He G. Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population. World J Biol Psychiatry 2010 11(8):956-63
Wang Y, Zhang J, Li X, Ji J, Yang F, Wan C, Feng G, Wan P, He L, He G. SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population Prog Neuropsychopharmacol Biol Psychiatry 2008 32(8):1902-4