导师姓名： 吴瑾 专业代码： 100202
性别： 女 专业名称： 儿科学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
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邮编： 邮箱地址： wujin51@yahoo.com

研究方向 (点击浏览详细信息)
肠道炎症的免疫调节；自身免疫病

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 高脂饮食导致的肠道高脱氧胆酸促进M1型巨噬细胞极化诱发肠道炎症的作用及机制研究 上海市卫生健康委员会 2020-01~2022-12 10万元 课题负责人
18YJ02 高脂饮食所致高脱氧胆酸调节巨噬细胞极化诱导炎症肠病的机制研究 上海交通大学医学院附属新华医院 2019-01~2020-12 10万元 课题负责人
16ZR** 鹅脱氧胆酸诱导NLRP3炎性小体活化在胆汁淤积性肝纤维化中的作用及机制研究 上海市自然科学基金 2016-07~2019-06 20万元 课题负责人
N/A 紫杉醇影响肿瘤单核细胞样髓源性抑制细胞极化状态的作用研究 教育部留学归国人员科研启动基金 2014-01~2016-12 3万元 课题负责人
** 多巴胺“解除”肿瘤MDSC 抑制作用的新功能及其对肿瘤生长的影响 国家自然科学基金 2013-01~2015-12 23万元 课题负责人
12PJ** 神经递质多巴胺负调肿瘤MDSC一氧化氮的产生及其抗肿瘤作用研究 上海市科委浦江人才计划 2012-10~2014-09 20万元 课题负责人
** 髓系抑制性细胞在神经母细胞瘤免疫逃逸中的作用 上海市卫生局 2012-01~2014-12 3万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhou M, Xu W, Wang J, Yan J, Shi Y, Zhang C, Ge W, Wu J, Du P, Chen Y Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury. EBioMedicine 2018 35:345-360
Gong Z, Zhao S, Zhou J, Yan J, Wang L, Du X, Li H, Chen Y, Cai W, Wu J （通讯作者） Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1b production. Molecular Immunology 2018 104:11-19
Shengnan Zhao, Zizhen Gong, Xixi Du, Chunyan Tian, Lingyu Wang, Jiefei Zhou, Congfeng Xu, Yingwei Chen, Wei Cai, Jin Wu （通讯作者） Deoxycholic acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-induced Colitis through Promoting Cathepsin B Release. Journal of Immunology Research 2018 **
Chen X, Zhang S, Chen X, Hu Y, Wu J, Chen S, Chang J, Wang G, Gao Y. Emodin promotes the osteogenesis of MC3T3-E1 cells via BMP-9/Smad pathway and exerts a preventive effect in ovariectomized rats. Acta Biochim Biophys Sin. 2017 49(10):867-878
Wen J, Zhou Y, Wang J, Chen J, Yan W, Wu J, Yan J, Zhou K, Xiao Y, Wang Y, Xia Q, Cai W Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway. Cell Death Differ. 2017 24(6): 997-1006
Shengnan Zhao,Zizhen Gong,Jiefei Zhou,Chunyan Tian,Yanhong Gao,Congfeng Xu,Yingwei Chen,Wei Cai,Jin Wu （通讯作者） Deoxycholic acid triggers NLRP3 inflammasome activation and aggravates DSS-induced colitis in mice Front Immunol 2016 7: 536
Zhang S, Chen X, Hu Y, Wu J, Cao Q, Chen S, Gao Y. All-trans retinoic acid modulates Wnt3A-induced osteogenic differentiation of mesenchymal stem cells via activating the PI3K/AKT/GSK3β signalling pathway. Mol Cell Endocrinol. 2016 422:243-53
Zizhen Gong,Jiefei Zhou,Shengnan Zhao,Chunyan Tian,PanliangWang,Congfeng Xu,Yingwei Chen,Wei Cai,Jin Wu （通讯作者） Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis. Oncotarget 2016 7(51): 83951-83963
Jin Wu （通讯作者）, Ruihua Zhang, Ning Tang, Zizhen Gong, Jiefei Zhou,Yingwei Chen,Kang Chen, Wei Cai Dopamine inhibits the function of Gr-1+CD115+ myeloid-derived suppressor cells through D1-like receptors and enhances anti-tumor immunity J Leuk Biol 2015 97(1):191-200
Gong Z, Zhou J, Li H, Gao Y, Xu C, Zhao S, Chen Y, Cai W, Wu J （通讯作者） Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Mol Nutr & Food Res 2015 59(11):2132-2142
Jin Wu, Tian-jun Guan, Shirong Zheng, Grosjean F, Liu W, Xiong H,Gordon R, Vlassara H, Striker GE, Zheng F. Inhibition of Inflammation by Pentosan Polysulfate Impedes the Development and Progression of Severe Diabetic Nephropathy in Aging C57B6 Mice. Lab Invest. 2011 91(10):1459-71
Zhang W, Wu J （共同第一作者）, Qiao B, Xu W, Xiong S. Amelioration of lupus nephritis by serum amyloid p component gene therapy with distinct mechanisms varied from different stage of the disease. PLoS One. 2011 6(7): e22659
Huang L, Zhang R, Wu J, Chen J, Grosjean F, Satlin LH, Klein JD, Sands JM, Striker GE, Tan J, Zheng F. Increased Susceptibility to Acute ER Stress Kidney Injury in Mice Lacking TNFa and its receoptor 1. Kidney Int. 2011 79(6):613-623
Jin Wu, Ruihua Zhang, Massimo Torreggiani, Adrian Ting, Huabao Xiong, Gary E. Striker, Helen Vlassara, and Feng Zheng. Induction of Diabetes in Aged C57B6 Mice Results in Severe Nephropathy: Contribution of Oxidative Stress, ER Stress, and Inflammation. Am J Pathology. 2010 176(5):2163-76
Jin Wu, Changlin Mei, Helen Vlassara, Gary E. Striker and Feng Zheng. Oxidative Stress Induced JNK Activation Contributes to Proinflammatory Phenotype of Aging Diabetic Mesangial Cells. Am J Physiol Renal Physiol 2009 297(6):F1622-31
Torreggiani M, Liu H, Wu J, Zheng F, Cai W, Striker G, Vlassara H. Advanced glycation end product receptor-1 transgenic mice are resistant to inflammation, oxidative stress, and post-injury intimal hyperplasia. Am J Pathol 2009 175(4):1722-32