导师姓名： 于昱 专业代码： 100202
性别： 女 专业名称： 儿科学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： 上海市杨浦区控江路1665号新华医院yuyu@xinhuamed.com.cn
邮编： 200092 邮箱地址： yuyu_chn@163.com

研究方向 (点击浏览详细信息)
先心病发病分子及遗传机制的研究
心血管重塑的研究

社会任职
Bentham Science出版社中国区大使
Current Medicinal Chemistry、Molecular Biology Reports、Medical Science Monitor、Experimental Physiology、Science China Life Sciences、<<生命科学>>、<<第二军医大学学报>>及<<营养学报>>等杂志审稿专家
国家自然科学基金委员会项目函评专家
上海市科学技术专家库成员
Current Topics in Medicinal Chemistry, Executive Guest Editor
中国病理生理学会、营养学会及毒理学会成员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
20ZR** DDX缺陷小鼠模型构建及扩心分子病理机制研究 上海市科学技术委员会科技创新行动计划 2020-07~2023-06 20万元 课题负责人
** 转录因子SOX7介导BMP2信号通路在房室间隔缺损中的作用及机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** ADAR1调控内皮细胞焦亡介导的免疫炎症所致肺血管损伤的机制研究 国家自然科学基金重点项目 2020-01~2024-12 297万元 课题参与人
引进-13 环境污染物二恶英(TCDD)对血管内皮细胞凋亡的影响及其分子机制探讨 上海交通大学医学院附属新华医院 2016-12~2018-11 20万元 课题负责人
** 巨噬细胞锌转运蛋白ZIP11/ SLC39A11在动脉粥样硬化形成中的作用及其分子机制研究 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
2012M511152 新基因SLC39A12/ZIP12在铁稳态代谢中的功能研究 中国博士后科学基金面上项目 2012-07~2012-12 5万元 课题负责人
2012CB945104 血管损伤及其重塑的分子机制 科技部973计划 2012-01~2016-08 520万元 课题参与人
2010KIP309 锌转运蛋白SLC39A12/ZIP12调控锌稳态代谢的分子机制的研究 中国科学院上海生命科学研究院优秀青年人才领域前沿项目 2010-08~2012-07 15万元 课题负责人
** 微量元素锌代谢稳衡调控通路中新基因SLC39A11（ZIP11）的功能研究 国家自然科学基金青年科学基金 2010-01~2012-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang L.#,X. Shi#,C. Gu#,B.Chen,M.Wang,Y.Yu* （通讯作者）,K.Sun*, and R.Zhang* Identification of cell-to-cell interactions by ligand-receptor pairs in human fetal heart BBA - Molecular Basis of Disease 2020 1866(12):165917
ZhangE.,J.Yang,Y.Liu,N.Hong,H.Xie,Q.Fu,F.Li,S.Chen,Y.Yu* （通讯作者）,and K.Sun* MESP2 variants contribute to conotruncal heart defects by inhibiting cardiac neural crest cell proliferation Journal of Molecular Medicine 2020 98(7):1035-1048
Zhang Q.,and Y.Yu （通讯作者） Epidemiological features of the 2019 novel coronavirus outbreak in China Current Topics in Medicinal Chemistry 2020 20(13):1137-1140
Jin L., N. Hong, X. Ai, J. Wang, Z. Li, Q. Zhang, Y. Yu* （通讯作者）, and K. Sun* LncRNAs as therapeutic targets for autophagy-involved cardiovascular diseases: A review of molecular mechanism and therapy strategy Current Medicinal Chemistry 2020 doi: 10.2174/35
Shi X#, L. Zhang#, K. Bai#, H. Xie, T. Shi, R. Zhang, Q. Fu, S. Chen, Y. Lu*, Y. Yu* （通讯作者）, and K. Sun* Identification of rare variants in novel candidate genes in pulmonary atresia patients by next generation sequencing Computational and Structural Biotechnology Journal 2020 381-392
Guo S, R. Zhang, Q. Liu, Q. Wan, Y. Wang, Y. Yu, G. Liu, Y. Shen, Y. Yu, and J. Zhang 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice FASEB Journal 2019 33(9):10207-10217
Xie H., N. Hong, E. Zhang, F. Li, K. Sun*, and Y. Yu* （通讯作者） Identification of rare copy number variants associated with pulmonary atresia with ventricular septal defect Frontiers in Genetics 2019 10:15
Yu Yu （通讯作者） Bioactive small molecules: promising novel therapies in cardiovascular diseases - PART II Current Topics in Medicinal Chemistry 2019 19(21): 1877
Yu Yu （通讯作者） Bioactive small molecules: promising novel therapies in cardiovascular diseases - PART I Current Topics in Medicinal Chemistry 2019 19(20): 1789
Xie H.#, E. Zhang#, N. Hong, Q. Fu, F. Li, S. Chen, Y. Yu* （通讯作者）, and K. Sun* Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing Human Genomics 2018 12:44
Shi X.#, T. Huang#, J. Wang#, Y. Liang, C. Gu, Y. Xu, J. Sun, Y. Lu, K. Sun*, S. Chen*, and Y. Yu* （通讯作者） Next generation sequencing identifies novel genes with rare variants in total anomalous pulmonary venous connection EBioMedicine 2018 38:217-227
Jin L., and Y. Yu （通讯作者） Bioactive small molecules in the pathogenesis and pharmacology of cardiovascular diseases: from bench to bedside Current Topics in Medicinal Chemistry 2018 18(16): 1351 - 1353
Wang Y.,S. Yan, B. Xiao, S. Zuo, Q. Zhang, G. Chen, Y. Yu, D. Chen, Q. Liu, Y. Liu, Y. Shen*, and Y. Yu* Prostaglandin F2α facilitates hepatic glucose production through CaMKIIγ/p38/FoxO1-signaling pathway in fasting and obesity Diabetes 2018 67(9):1748-1760
Liu G, Q.Liu, Y. Shen, D. Kong, Y. Gong, B. Tao, G. Chen, S. Guo, J. Li, S. Zuo, Y. Yu, H. Yin, L. Zhang, B.Zhou, C.D.Funk, J. Zhang*, and Y. Yu* Early treatment with resolvin E1 facilitates myocardial recovery from ischaemia in mice British Journal of Pharmacology 2018 175(8):1205-1216
Zhang E.#, N. Hong#, S. Chen, Q. Fu, F. Li, Y. Yu* （通讯作者）, and K.Sun* Targeted sequencing identifies novel GATA6 variants in a large cohort of patients with conotruncal heart defects Gene 2018 30;641:341-348
Hong N, E. Zhang, Q. Wang, X. Zhang, F. Li, Q. Fu, R. Xu, Y. Yu, S. Chen, Y. Xu*, and K. Sun* A loss-of-function mutation p.T52S in RIPPLY3 is a potential predisposing genetic risk factor for Chinese Han conotruncal heart defect patients without the 22q11.2 deletion/duplication Journal of Translational Medicine 2018 16(1):260
Yan S.#, J. Tang#, Y. Zhang, Y. Wang, S. Zuo, Y. Shen, Q. Zhang, D. Chen, Y. Yu, K. Wang, S. Duan*, and Y. Yu* PGE2 promotes hepatic biliary cholesterol excretion by EP3-mediated HNF4a/CYP7A1 pathway in mice Hepatology 2017 65(3):999-1014
Tang J.,Y.Shen, G.Chen, Q.Wan, K.Wang, J.Zhang, J.Qin, G.Liu, S.Zuo, B.Tao, Y.Yu, J.Wang, M.Lazarus, and Y.Yu* Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction Nature Communication 2017 8:14656
Yu Y.#, Q.Liu #,S.Guo, Q.Zhang,J.Tang,G.Liu, D.Kong, J.Li, S.Yan, R.Wang, P.Wang*, X.Su*, and Y.Yu* 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin promotes endothelial cell apoptosis through activation of EP3/p38MAPK/Bcl-2 pathway Journal of Cellular and Molecular Medicine 2017 21(12):3540-3551
Yu Y., L.Lu, S.Li, L.Zhang, and X.Luo* Organic zinc absorption by the intestine of broilers in vivo British Journal of Nutrition 2017 117(8):1086-1094
LiJ.,D.Kong,Q.Wang,W.Wu,Y.Tang,T.Bai,...Y.Yu,...L.Wang* and Y.Yu* Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation EMBO Molecular Medicine 2017 9(5):571-588
Liu Q., B. Tao, G. Liu, G. Chen, Q. Zhu, Y. Yu, Y. Yu* （通讯作者）, and H. Xiong* Thromboxane A2 receptor inhibition suppresses multiple myeloma cell proliferation by inducing P38/JNK MAP kinase mediated-G2/M progression delay and cell apoptosis Journal of Biological Chemistry 2016 291(9): 4779-4792
Shen Y. #, S. Zuo# , Y. Wang , H. Shi , S. Yan ,D. Chen , B. Xiao , J. Zhang , Y. Gong, M. Shi, J .Tang, D. Kong, L. Lu, Y. Yu , B. Zhou , S. Duan, C. Schneider ,C. D. Funk , and Y. Yu* Thromboxane governs the differentiation of adipose-derived stromal cells toward endothelial cells in vitro and in vivo Circulation Research 2016 118(8):1194-207
Xiao B.#, S. Gu # , M. Li , J. Li , B. Tao , Y. Wang , Y. Wang , S. Zuo , Y. Shen , Y. Yu , D. Chen , G. Chen , D. Kong, J. Tang, Q. Liu, D. Chen, Y. Liu, S. Alberti, M. Dovizio, R. Landolfi, L. Mucci, P. Miao, P. Gao, D. Zhu, J. Wang, B. Li, P. Patrignani, and Y. Yu* Rare SNP rs** in the miR-590-3p target site of the prostaglandin F2α receptor gene confers risk for essential hypertension in the Han Chinese population Arteriosclerosis, Thrombosis and Vascular Biology 2015 35(7):1687-1695
Lu A. #, C. Zuo # , Y. He # , G. Chen , L. Piao, J. Zhang, B. Xiao , Y. Shen , J. Tang, D. Kong , S. Alberti , D. Chen , S. Zuo , Q. Zhang, S. Yan, X. Fei, F. Yuan, B. Zhou, S. Duan , Y. Yu , M. Lazarus, Y. Su, R. Breyer , C. Funk, and Y. Yu* EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling Journal of Clinical Investigation 2015 125 (3):1228-1242
Yu Y., J. Qin, D. Chen, H. Wang, J. Wang*, and Y. Yu*. Chronic cardiovascular disease-associated gene network analysis in human umbilical vein endothelial cells exposed to 2, 3, 7, 8-Tetrachlorodibenzo -p-dioxin Cardiovascular Toxicology 2015 15(2):157-171
Liu Z. # , Y. Yu# （共同第一作者）, X. Li, A. Wu, M. Mu, N. Li, Y. Deng, X. Jin, S. Li, Y. Lin, X. Chen, F. Wang*, and J. Zhu* Maternal lead exposure and risk of congenital heart defects occurrence in offspring Reproductive Toxicology 2015 51:1-6
Guan Y. #, P. An #, Z. Zhang, F. Zhang, Y. Yu, Q. Wu, Y. Shi, X. Guo, Y. Tao, and F. Wang* Screening identifies the Chinese medicinal plant Caulis Spatholobi as an effective HAMP expression inhibitor Journal of Nutrition 2013 143(7):1061-1066
Yu Y. #, A. Wu#, Z. Zhang, G. Yan, F. Zhang, L. Zhang, X. Shen, R. Hu, Y. Zhang*, K. Zhang*, and F. Wang* Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter Journal of Nutritional Biochemistry 2013 24(10):1697-1708
Zhang F., Y. Tao, Z. Zhang, X. Guo, P. An, Y. Shen, Q. Wu, Y. Yu, and F. Wang* Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses Haematologica 2012 97（12）:1826-1835
Yan G. #, Y. Zhang#, J. Yu#, Y. Yu, F. Zhang, Z. Zhang, A. Wu, X. Yan, Y. Zhou, and F. Wang* ZIP7, plays a critical role in development and zinc homeostasis in zebrafish PLoS One 2012 7（8）：e42939
Sun L. #, Y. Yu# （共同第一作者）, T. Huang#, P. An, D. Yu, Z. Yu, H. Li, H. Sheng, L. Cai, J. Xue, M. Jing, Y. Li*, X. Lin*, and F. Wang* The associations between ionomic profile and metabolic abnormalities in human population PLoS One 2012 7(6):e38845
Gan W. #, Y. Guan#, Q. Wu, P. An, J. Zhu, L. Lu, L. Jing, Y. Yu, S. Ruan, D. Xie, M. Makrides, R. Gibson, G. Anderson, H. Li, X. Lin*, and F. Wang* Association of TMPRSS6 polymorphisms with ferritin, hemoglobin and type 2 diabetes American Journal of Clinical Nutrition 2012 95(3):626-632
Zhang Z., F. Zhang, P. An, X. Guo, Y. Shen, Y. Tao, Q. Wu, Y. Zhang, Y. Yu, B. Ning, G. Nie, M. D. Knutson, G. J. Anderson, and F. Wang* Ferroportin 1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses Blood 2011 118(7):1912-1922
Yu Y., L. Lu, R. Wang, L. Xi, X. Luo*, and B. Liu Effects of zinc source and phytate on zinc absorption by in situ ligated intestinal loops of broilers Poultry Science 2010 89(10):2157-2165
Yu Y., L. Lu, X. Luo*, and B. Liu Kinetics of zinc absorption by in situ ligated intestinal loops of broilers involved in zinc transporters Poultry Science 2008 87 (6): 1146-1155
王静,金理辉,张琪,孙锟,于昱 （通讯作者） 完全性肺静脉异位引流患儿的ARHGEF16 基因突变筛查及突变功能分析 上海交通大学学报（医学版） 1901 2020, （1）：26-30
王静,石鑫,陈笋,孙锟,于昱 （通讯作者） 完全性肺静脉异位引流基因学研究进展 中国循环杂志 1900 2019，34（10）:1034-1037