导师姓名： 刘振国 专业代码： 100204
性别： 男 专业名称： 神经病学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： zhenguoliu2004@aliyun.com

研究方向 (点击浏览详细信息)
帕金森病运动并发症基础与临床研究

社会任职
上海医学会神经内科分会副主任委员
上海医师学会神经内科分会副会长
中国医师协会神经内科专业委员会帕金森病及运动障碍疾病学组委员
中华医学会神经内科专业委员会帕金森病及运动障碍疾病学组委员
上海市中西医结合学会脑心同治专业委员会名誉主任委员
中华神经科杂志编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** M1型小胶质细胞极化通过NR2B受体参与帕金森病异动症的机制研究 国家自然科学基金 2020-01~2023-12 55万元 课题负责人
2019SY024 帕金森病患者血压监测及干预方案实施与推广 上海市卫生健康委先进适宜技术推广项目 2019-07~2022-06 30万元 课题负责人
** 帕金森病异动症发生中mBDNF-TrKB/proBDNF-p75NTR通路参与皮质-纹状体突触功能调控 国家自然基金 2018-01~2021-12 54万元 课题负责人
2017 YFC ** 中西医结合预防和缓解帕金森病的新型治疗策略研究 国家重点研发计划 2017-09~2020-12 726万元 课题负责人
** 治疗帕金森病新药--天芪平颤颗粒的临床前研究 上海市科委生物医药领域科技支撑项目 2017-03~2020-09 70万元 课题负责人
SHDC** 脑血管病双向转诊及二级预防的早期识别及规范化诊疗体系建立 上海申康医院发展中心临床科技创新项目 2015-12~2018-12 15万元 课题负责人
** mGluR5通过PKC/ERK/c-Rel信号通路参与帕金森病异动症发生及治疗机制研究 国家自然科学基金 2015-01~2018-12 80万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xie CL, Lin JY, Wang MH, Zhang Y, Zhang SF, Wang XJ, Liu ZG. （通讯作者） Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats Sci Rep 2016 21;6:23527. 1.7.
Song L, Zhang Z, Hu R, Cheng J, Li L, Fan Q, Wu N, Gan J, Zhou M, Liu Z. （通讯作者） Targeting the D1-N-methyl-D-aspartate receptor complex reduces L-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats. Drug Des Devel Ther 2016 2016 3;10:547-55.
Lou ZY, Yu WB, Chen J, Li L, Jiang LS, Xiao BG, Liu ZG （通讯作者） Neuroprotective Effect Is Driven Through the Upregulation of CB1 Receptor in Experimental Autoimmune Encephalomyelitis. J Mol Neurosci. 2016 2016 ;58(2):193-200
Zhang Y, Gan J, Pu Z, Xu Mm, Wang Lf, Li Yh, Liu Zg. （通讯作者） TSC1 R509X Mutation in a Chinese Family with Tuberous Sclerosis Complex Neuromolecular Med 2015 17(2):202-8
Gan J, Qi C,Liu Z （通讯作者） Roles of Ca2+/calmodulin-dependent protein kinase IIin subcellular expression of striatal N-Methyl-D-aspartate receptors in l-3, 4-dihydroxyphenylalanine-induced dyskinetic rats. Drug Design, Development and Therapy 2015 9 :2119–2128
Qi C, Xu M, Gan J, Yang X, Wu N, Song L, Yuan W, Liu Z. （通讯作者） Erythropoietin improves neurobehavior by reducing dopaminergic neuron loss in a 6 hydroxydopamine induced rat model. Int J Mol Med 2014 34(2):440-50
Gan J, Qi C, Mao L, Liu Z （通讯作者） Changes in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson’s disease Drug Design, Drug Design, Development and Therapy 2014 8:165-173
Xie CL, Wang WW, Zhang SF, Yuan ML, Che JY, Gan J, Song L, Yuan W, Liu Z. （通讯作者） Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson’s rats. Scientific Reports 2014 16(4):7506
Xie CL,Wang WW, Zhang SF, Gan J, Liu ZG. （通讯作者） Continuous dopaminergic stimulation (CDS)-based treatment in Parkinson’s disease patients with motor complications: A systematic review and meta-analysis. Scientific Reports 2014 12(4):6027-6035
Zhou MZ, Gan J, Wei YR, Ren XY, Chen W, Liu ZG （通讯作者） The association between non-motor symptoms in Parkinson's disease and age at onset Clinical Neurology and Neurosurgery 2013 115(10):2103-2107
Ma L,Wei L,Wu F,Hu Z,Liu Z （通讯作者）,Yuan W Advance with microRANs in Parkinson’s diease research Drug Design, Development and Therapy 2013 7:1103-1113
Wu N, Song L, Yang X, Yuan W, Liu Z （通讯作者） NMDA receptor regulation of levodopa-induced behavior andchangs in striatal G protein-coupled receptor kinase 6 and β-arrestin-1 expression in parkinsonian rats. Clinical Interventions in Aging 2013 8:347-352
Yang X,Wu N, Song L, Yuan W, Liu Z （通讯作者） Intrastriatal injections of KN-93 ameliorates levodopa-induced dyskinesia in a rat model of Parkinson’s disease Neuropsychiatric Disease and Treatment 2013 9:1213-1220
Wu N,Yang X,Song L,Wei J,Liu Z （通讯作者） Effect of Tianqi antitremor granules on behavioral manifestations and expression of g protein-coupled receptor kinase 6 and β-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson’s disease Drug Design, Development and Therapy 2013 7:1481-1489
Yang X, Zheng R, Cai Y, Liao M, Yuan W, Liu Z. （通讯作者） Control released levodopa methyl ester/benserazide-loaded nanoparticles ameliorated levodopa-induced dyskinesia in rats. Int J Nanomedicine 2012 7:2077-2086
Yuan W,Liu Z. （通讯作者） Controlled-release and preserved bioactivity of proteins from (self-assembled)core-shell double-walled microspheres. Int J Nanomedicine 2012 7:257-270
Ren TT, Yang XX, Wu N, Cai YP, Liu Z （通讯作者）, Yuan W. Sustained-release formulation of levodopa methl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-lesioned rats. International Neurosicence Letters. 2011 502:117-122
Guan-Shui Bao , Wen-An Wang , Tian-Zhe Wang , Jian-Kang Huang ,Hua He , Zhenguo Liu （通讯作者）, Fu-De Huang Overexpression of Human MRP1 in Neurons causes resistance to Antiepileptic Drugs in Drosophila Seizure Mutants. J. Neurogenetics 2011 25(4):201-206
Yuan W,Liu Z. （通讯作者） Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor. International Journal of Nanomedicine 2011 6:3139-3149
Yuan W,Liu Z. （通讯作者） Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor. International Journal of Nanomedicine 2011 6:3139-3149
Yang X, Song L, Liu Z. （通讯作者） The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease. Neuroreport 2010 21(4):268-272
Yang X, Yuan W, Ren T, Song L, Wu N, Liu Z. （通讯作者） Levodopa/benserazide-loaded biodegradable mocrospheres reduce dyskinesia in rats. Neuroreport 2010 21(12):837-40
Yang XX, Song Lu L, Wu N, Liu ZG （通讯作者） Value of embolization of brain arteriovenous malformations with ethylene vinyl alcohol copolymer. Chinese Medical Journal 2010 123:1466-1469
Min Kong, Maowen Ba, Lu Song, Guozhao Ma, Zhenguo Liu. （通讯作者） Comparative effects of acute or chronic administration of levodopa to 6-OHDA-lesioned rats on the expression and phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in the striatum. Neurochem Res 2009 34:1513–1521
Lu Song, Yaping Ma, Min Kong, Zhenguo Liu. （通讯作者） Inhibitory Effect of 8-(3-chlorostryryl) Caffeine on Levodopa-induced Motor Complications is Associated with Adenosine A2A Receptor-DARPP-32-ERK1/2 Signaling Pathway in Parkinson's Disease. Brain Res 2009 18;1276:171-179
Maowen Ba, Min Zhenguo Liu. Cellular and behavioural effects of 5-HT1A receptor agonist 8-OH-DPAT in a rat model of levodopa-induced motor complications. Brain Research 2007 1127(1):177-184
Maowen Ba, Min Kong, Hongqi Yang, Guozhao Ma, Guoqiang Lu,Shengdi Chen, Zhenguo Liu （通讯作者） Changes in Subcellular Distribution and Phosphorylation of GluR1 in Lesioned Striatum of 6-OHDA-Lesioned and L-dopa-Treated Rats. Neurochem Res, 2006 31(11):1337-1347
Zhenguo Liu （共同第一作者）, Limin Mao, Nikhil K. parelkar, Qingsong Tang, Shazia Samdani and John Q. Wang. Distinct expression of phosphorylation NMDA receptor NR1 subunits by projection neurons and interneurons in the striatum of normal and amphetamine-treated rats J. Comp. Neurol. 2004 474(3):393-406
Yang X, Chen Y, Hong X, Wu N, Song L,Yuan W, Liu Z （通讯作者） Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats Drug Des Dev Ther. 6:341-7.