导师姓名： 姚志荣 专业代码： 100206
性别： 男 专业名称： 皮肤病与性病学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： zryaoxh@sina.com
邮编： 200092 邮箱地址： zryaoxh@sina.com

研究方向 (点击浏览详细信息)
特应性皮炎的基础与临床研究
遗传性皮肤病的基因诊断与产前基因诊断

社会任职
中华医学会皮肤性病学分会“特应性皮炎研究中心” 首席专家
上海市微生物学会真菌专业委员会 主任委员
上海交通大学医学院“遗传性皮肤病诊疗中心”主任
中国医师协会皮肤科医师分会第五届委员会副会长
上海交通大学医学院皮肤病研究所所长
中华医学会皮肤性病学分会儿童皮肤病学组 顾问
国家医学继续教育教材《皮肤性病学分册》 副主编
国际特应性皮炎理事会（IEC）理事
中华医学会皮肤性病学分会副秘书长
上海市医学会皮肤性病学分会 候任主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2017ZZ02026 儿童保健与皮肤病学（与张军教授共同主持） 上海市重中之重临床医学中心和重点学科建设计划 2017-07~2020-06 50万元 课题负责人
** 炎症致特应性皮炎皮肤屏障功能破坏的机制和干预策略 国家自然科学基金 2017-01~2021-12 275万元 课题负责人
DLY201610 利多卡因静脉封闭vs环孢素治疗18-70岁重度特应性皮炎发作期的多中心、随机双盲和平行对照研究 上海交通大学医学院 2016-07~2021-05 100万元 课题负责人
** 利多卡因促进特应性皮炎调节性T细胞分化的作用及机制 国家自然科学基金 2015-01~2018-12 65万元 课题负责人
国家临床重点专科建设项目 国家卫生部 2013-01~2015-12 500万元 课题负责人
利多卡因静脉封闭治疗重度特应性皮炎的疗效与安全性 上海市科委医学重点基金 2012-10~2015-09 20万元 课题负责人
11JC** 利多卡因对中间丝相关蛋白基因表达的影响及其抗炎作用新机制 上海市科委 2012-01~2014-12 30万元 课题负责人
** 马拉色菌及其变应原致敏FLG突变小鼠的机制 国家自然科学基金 2012-01~2015-12 58万元 课题负责人
特应性皮炎的病症管理与治疗 国家卫生部 2012-01~2014-12 190万元 课题负责人
** 新生隐球菌同性、异性交配子代毒力差异和机制 国家自然科学基金 2009-01~2011-12 30万元 课题负责人
08JC** 利多卡因静脉封闭治疗特应性皮炎的机制 市科委 2008-10~2010-09 40万元 课题负责人
** 基因突变分析应用于遗传性大疱性表皮松解症的产前诊断研究 上海市卫生局,局级课题 2007-01~2009-12 3万元 课题负责人
08JC** 利多卡因静脉封闭治疗特应性皮炎的机制 上海市科委，基础重点项目 ~2010-09 40万元

学术论文 作者论文标题期刊名出版年卷期页码
Yu X, Zhang J, Xu K, Li M, Yao Z. （通讯作者） Skin involvement as the first symptom of rapidly progressive ALK-positive systemic anaplastic large cell lymphoma. Clin Exp Dermatol 2017 42(5):539-542.
Yu X, Chen F, Ni C, Zhang G, Zheng L, Zhang J, Li C, A S, Yao Z （通讯作者）, Li M. A Missense Mutation within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis. J Invest Dermatol 2017 pii:S0022-202X(17)32935-4.
Xu Q, Li C, Zhang J, Ling B, Yu H, Yao Z. （通讯作者） Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review. J Dermatol 2017 doi: 10.1111/1346-8138.
Wang Y, Cheng R, Lu Z, Guo Y, Yan M, Liang J, Huang P, Li M, Yao Z. （通讯作者） Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes. J Dermatol Sci 2017 85(3):235-240.
Zhang J, Cheng R, Yu X, Sun Z, Li M, Yao Z. （通讯作者） Expansion of the genotypic and phenotypic spectrum of xeroderma pigmentosum in Chinese population. Photodermatol Photoimmunol Photomed 2017 33(1):58-63.
Liang J, Huang P, Li H, Zhang J, Ni C, Wang Y, Shen J, Li C, Kang L, Chen J, Zhang H, Wang Z, Zhang Z, Li M （通讯作者）, Yao Z. Mutations in IL36RN are associated with geographic tongue. Hum Genet. 2017 136(2):241-252.
Yu X, Zhang J, Wu Z, Liu M, Chen R, Gu Y, Li M, Yao Z. （通讯作者） LUMBAR syndrome: A case manifesting as cutaneous infantile hemangiomas of the lower extremity, perineum and gluteal region, and a review of published work. J Dermatol 2017 44(7):808-812.
Zhang J, Li M, Yao Z. （通讯作者） Updated review of genetic reticulate pigmentary disorders. Br J Dermatol 2017 177(4):945-959.
Li CX, Li HG, Huang LT, Kong YW, Chen FY, Liang JY, Yu H , Yao ZR （通讯作者） H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p Cell Death Dis 2017 Nov 30;8(11)e3174
Cheng R, Guo Y, Huang L, Hao F, Gao X, Bieber T, Yao Z. （通讯作者） Current status in diagnosis of atopic dermatitis in China. Allergy 2017 72(9):1277-1278.
Li M, Wang J, Zhang J, Ni C, Li X, Liang J, Cheng R, Li Z, Yao Z. Genome-wide linkage and exome sequencing analyses identify an initiation codon mutation of KRT5 in a unique Chinese family with generalized Dowling–Degos disease Br J Dermatol 2016 Mar;174(3):663-6.
Ni C, Zhang J, Zhang H, Cheng RH, JY, Li CX, Li M, Yao ZR. （通讯作者） A novel mutation in the COL7A1 gene results in a unique phenotype of epidermolysis bullosa pruriginosa J Eur Acad Dermatol Venereol 2016 Mar;30(3):535-6.
Shen J, Zhang J, Wang Z, Ni C, Li H, Cheng R, Liang J, Li M, Yao Z. （通讯作者） Gene diagnosis and prenatal genetic diagnosis of a case of dystrophic epidermolysis bullosa family caused by gonadosomatic mosaicism for the COL7A1 mutation Gly2043Arg in the pregnant mother J Eur Acad Dermatol Venereol 2016 Sep;30(9):1627-9
Li M, Li Z, Wang J, Ni C, Sun Z, Wilson NJ, Zhang J, Chen F, Li X, Du X, Yu H, Zhang L, Smith FJ, Zhang G, Yao Z. （通讯作者） Mutations in the mevalonate pathway genes in Chinese patients with porokeratosis J Eur Acad Dermatol Venereol. 2016 Sep;30(9):1512-7.
Ni C, Yan M, Zhang J, Cheng R, Liang J, Deng D, Wang Z, Li M, Yao Z （通讯作者） A novel mutation in TRPV3 gene causes atypical familial Olmsted syndrome Sci Rep 2016 Feb 23;6:21815.
Li M, Wang J, Li Z, Zhang J, Ni C, Cheng R, Yao Z. （通讯作者） Genome-wide linkage analysis and whole-genome sequencing identify a recurrent SMARCAD1 variant in a unique Chinese family with Basan syndrome Eur J Hum Genet 2016 Aug;24(9):1367-70.
Li CX, Li HG, Zhang H, Cheng RH, Li M, Liang JY, Gu Y, Ling B, Yao ZR （通讯作者）, Yu H. andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore a23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice modelinduced atopic Drug Des Devel Ther 2016 Feb 19;10:781-91
Cheng R, Yan M, Ni C, Zhang J, Li M, Yao Z. （通讯作者） Report of Chinese family with severe dermatitis, multiple allergies and metabolic wasting syndrome caused by novel homozygous desmoglein-1 gene mutation. J Dermatol 2016 Oct;43(10):1201-1204.
Zhang J, Shen J, Cheng R, Ni C, Liang J, Li M, Yao Z. （通讯作者） Identification of a PTPN11 hot spot mutation in a child with atypical LEOPARD syndrome Mol Med Rep 2016 Sep;14(3):2639-43.
Zhang J, Wang Y, Cheng R, Ni C, Liang J, Li M, Yao Z. （通讯作者） Novel MBTPS2 missense mutation causes a keratosis follicularis spinulosa decalvans phenotype: mutation update and review of the literature Clin Exp Dermatol 2016 Oct;41(7):757-60
Zhang J, Yan M, Liang J, Li M, Yao Z. （通讯作者） A novel KRT5 mutation associated with generalized severe epidermolysis bullosa simplex in a 2?year?old Chinese boy Exp Ther Med 2016 Nov;12(5):2823-2826.
Zhang J, Li M, Yao Z. （通讯作者） Molecular screening strategies for NF1-like syndromes with café-au-lait macules Mol Med Rep 2016 Nov;14(5):4023-4029.
Zhang J, Zhang G, Ni C, Cheng R, Liang J, Li M, Yao Z. （通讯作者） Nagashima-type palmoplantar keratosis in a Chinese Han population Mol Med Rep 2016 Nov;14(5):4049-4054
Guo Y, Li P, Tang J, Han X, Zou X, Xu G, Xu Z, Wei F, Liu Q, Wang M, Xiao F, Zong W, Shen C, Li J, Liu J, Luo Y, Chang J, Sheng N, Dong C, Zhang D, Dai X, Zhou J, Meng C, Niu H, Shi X, Zhang X, Xiang J, Xu H, Ran Q, Zhou Y, Li M, Zhang H, Cheng R, Gao X, Wang H, Gu H, Ma L, Yao Z. （通讯作者） Prevalence of Atopic Dermatitis in Chinese Children aged 1–7 ys Sci Rep 2016 Jul 19;6:29751
Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, Yan M, Gu Y, Feng X, Liang J, Yu X, Wang H, Yao Z. （通讯作者） Effects of lidocaine on regulatory T cells in atopic dermatitis J Allergy Clin Immunol 2016 Feb;137(2):613-617.e5.
Zhang J, Cheng R, Liang J, Ni C, Li M, Yao Z. （通讯作者） Lentiginous phenotypes caused by diverse pathogenic genes (SASH1 and PTPN11):clinical and molecular discrimination Clin Genet 2016 Oct;90(4):372-7.
Zhang J, Cheng R, Ni C, Liang J, Li M, Yao Z. （通讯作者） First Mal de Meleda report in Chinese Mainland: two families with a recurrent homozygous missense mutation in SLURP-1 J Eur Acad Dermatol Venereol. 2016 May;30(5):871-3.
Zhang J, Cheng R, Liang J, Ni C, Li M, Yao Z. （通讯作者） Report of a child with sporadic familial progressive hyper- and hypopigmentation caused by a novel KITLG mutation Br J Dermatol 2016 Dec;175(6):1369-1371.
Zhang J, Yan M, Cheng R, Ni C, Liang J, Li M, Yao Z （通讯作者） A rare RECQL4 indel mutation in a Chinese patient with Rothmund–Thomson syndrome J Eur Acad Dermatol Venereol 2016 Nov;30(11):e159-e161
Zhang J, Tong H, Fu X, Zhang Y, Liu J, Cheng R, Liang J, Peng J, Sun Z, Liu H, Zhang F, Lu W, Li M, Yao Z （通讯作者） Molecular Characterization of NF1 and Neurofibromatosis Type 1 Genotype-Phenotype Correlations in a Chinese Population. Sci Rep. 2015 2015 Jun 9;5:11291
Sun Z, Zhang J, Guo Y, Ni C, Liang J, Cheng R, Li M, Yao Z. （通讯作者） Genotype-phenotype correlation of xeroderma pigmentosum in a Chinese Han population. Br J Dermatol. 2015 2015 Apr;172(4):1096-102
Feng X, Ling B, Yang X, Liao W, Pan W, Yao Z. （通讯作者） Molecular Identification of Candida Species Isolated from Onychomycosis in Shanghai, China. Mycopathologia. 2015 2015 Dec;180(5-6):365-71
Feng X, Guan W, Guo Y, Yu H, Zhang X, Cheng R, Wang Z, Zhang Z, Zhang J, Li H, Zhuang Y, Zhang H, Lu Z, Li M, Yu H, Bao Y, Hu Y, Yao Z. （通讯作者） Genome sequence of a novel recombinant coxsackievirus a6 strain from shanghai, china, 2013. Genome Announc. 2015 2015 Jan 8;3(1). pii: e01347-14
Feng X, Guan W, Guo Y, Yu H, Zhang X, Cheng R, Wang Z, Zhang Z, Zhang J, Li H, Zhuang Y, Zhang H, Lu Z, Li M, Yu H, Bao Y, Hu Y, Yao Z. （通讯作者） A novel recombinant lineage's contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013. Sci Rep 2015 2015 Jun 30;5:11700
Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, Yan M, Gu Y, Feng X, Liang J, Yu X, Wang H, Yao Z. （通讯作者） Effects of lidocaine on regulatory T cells in atopic dermatitis. J Allergy Clin Immunol 2015 pii: S0091-6749(15)01102-1.
Guo YF, Pan WH, Cheng RH, Yu H, Liao WQ, Yao ZR. （通讯作者） Successful treatment of neurological malignant atrophic papulosis in child by corticosteroid combined with intravenous immunoglobulin. CNS Neurosci Ther. 2014 2014 Jan;20(1):88-91
Feng X, Wu Z, Ling B, Pan S, Liao W, Pan W, Yao Z. （通讯作者） Identification and differentiation of Candida parapsilosis complex species by use of exon-primed intron-crossing PCR. J Clin Microbiol. 2014 2014 May;52(5):1758-61
Feng X, Wu J, Ling B, Yang X, Liao W, Pan W, Yao Z. （通讯作者） differentiation of clinically relevant yeast species closely related to Candida guilliermondii and Candida famata. J Clin Microbiol. 2014 2014 Sep;52(9):3190-5
Li M, Han J, Lu Z, Li H, Zhu K, Cheng R, Jiao Q, Zhang C, Zhu C, Zhuang Y, Wang Y, Shi J, Guo Y, Wu R, Yao Z. （通讯作者） Prevalent and Rare Mutations in IL-36RN Gene in Chinese Patients with Generalized Pustular Psoriasis and Psoriasis Vulgaris. J Invest Dermatol 2013 133(11):2637-9.
Feng X, Fu X, Ling B, Wang L, Liao W, Yao Z （通讯作者） Development of a singleplex PCR assay for rapid identification and differentiation of Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. neoformans, Cryptococcus gattii, and hybrids. J Clin Microbiol 2013 2013 Jun;51(6):1920-3
Li M, Cheng R, Liang J, Yan H, Zhang H, Yang L, Li C, Jiao Q, Lu Z, He J, Ji J, Shen Z, Li C, Hao F, Yu H, Yao Z （通讯作者） Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease. Am J Hum Genet 2013 2013 Jun 6;92(6):895-903
Li M, Cheng R, Shi M, Liu J, Zhang G, Liu Q, Yu H, Yao Z （通讯作者） Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris (IV) and atopic dermatitis-associated IV Br J Dermatol 2013 2013 Jun;168(6):1335-8
Cheng R, Li M, Guo Y, Yao Y, Gao C, Yao Z. （通讯作者） Three novel mutations in the SLCO2A1 gene in two Chinese families with primary hypertrophic osteoarthropathy. Eur J Dermatol. 2013 2013 Sep-Oct;23(5):636-9
Jiao Q, Wang H, Hu Z, Zhuang Y, Yang W, Li M, Yu X, Liang J, Guo Y, Zhang H, Chen X, Cheng R, Yao Z （通讯作者） Lidocaine inhibits staphylococcal enterotoxin-stimulated activation of peripheral blood mononuclear cells from patients with atopic dermatitis Arch Dermatol Res 2013 2013 Sep;305(7):629-36
Zhang H, Chen X, Guo Y, Liang J, Tang L, Yu H, Yao Z. （通讯作者） Hutchinson-Gilford progeria syndrome: report of 2 cases and a novel LMNA mutation of HGPS in China. J Am Acad Dermatol. 2013 2013 Oct;69(4):e175-6
Li M, Han J, Lu Z, Li H, Zhu K, Cheng R, Jiao Q, Zhang C, Zhu C, Zhuang Y, Wang Y, Shi J, Guo Y, Wu R, Yao Z. （通讯作者） Prevalent and rare mutations in IL-36RN gene in Chinese patients with generalized pustular psoriasis and psoriasis vulgaris. J Invest Dermatol. 2013 2013 Nov;133(11):2637-9
Feng X, Fu X, Ling B, Wang L, Liao W, Pan W, Yao Z （通讯作者） Rapid differentiation of cryptic species within Cryptococcus gattii by a duplex PCR assay. J Clin Microbiol 2013 2013 Sep;51(9):3110-2
Li M, Liu Q, Liu J, Cheng R, Zhang H, Xue H, Bao Y, Yao Z （通讯作者） Mutations analysis in filaggrin gene in northern China patients with atopic dermatitis J Eur Acad Dermatol Venereol 2012 27(2):169-74
Cheng R, Li M, Zhang H, Guo Y, Chen X, Tao J, Jiang A, Gan J, Qi H, Yu H, Liao W, Yao Z （通讯作者） Common FLG Mutation K4671X Not Associated with Atopic Dermatitis in Han Chinese in a Family Association Study PLoS One 2012 7(11):e49158
Feng X, Ling B, Yang G, Yu X, Ren D, Yao Z （通讯作者） Prevalence and distribution profiles of Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis responsible for superficial candidiasis in a Chinese university hospital Mycopathologia 2012 173(4):229-34
Li M, Liang JY, Sun ZH, Zhang H, Yao ZR （通讯作者） Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis (CIPA) Genetics and Molecular Research 2012 11(3):2156-62
Li M, Lu Z, Cheng R, Li H, Guo Y, Yao Z （通讯作者） IL36RN gene mutations are not associated with sporadic generalized pustular psoriasis in Chinese Patients Bri J Dermatol 2012 doi: 10.1111/j.1365-2133. 2012.11195.x.
Li M, Liu JB, Liu Q, Yao M, Cheng R, Xue H, Zhou H, Yao Z （通讯作者） Interactions between FLG Mutations and Allergens in Atopic Dermatitis Arch Dermatol Res 2012 304(10):787-93
Li M, Cheng RH, Zhuang Y, Yao ZR A recurrent mutation in the APCDD1 gene responsible for hereditary hypotrichosis simplex in a large Chinese family Bri J Dermatol 2012 167(4):952-4
Li M, Jin C, Yang L, Lai M, Yao Z （通讯作者） A novel complex insertion-deletion mutation in ADAR1 gene in a Chinese family with dyschromatosis symmetrica hereditaria J Eur Acad Dermatol Venereol 2011 25(6):743-6
Sun LD, Xiao FL, Li Y, Zhou WM, Tang HY, Tang XF, Zhang H, Schaarschmidt H, Zuo XB, Foelster-Holst R, He SM, Shi M, Liu Q, Lv YM, Chen XL, Zhu KJ, Guo YF, Hu DY, Li M, Li M, Zhang YH, Zhang X, Tang JP, Guo BR, Wang H, Liu Y, Zou XY, Zhou FS, Liu XY, Chen Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population Nat Genet 2011 43:690-4
Feng X, Yao Z （通讯作者）, Ling B, Ren D, Liao W Perilla frutescens seed agar, a new medium for identification of the Cryptococcus species complex: evaluation for all major molecular types J Microbiol Methods 2011 84:359-61
Shi M, Zhang H, Chen X, Guo Y, Tao J, Qi H, Gan J, Jiang A （通讯作者）, Yu H, Liang J, Chen J, Yang L, Zhuang Y, Yan M, Gu Y, Yu X, Feng X, Yao Z Clinical features of atopic dermatitis in a hospital-based setting in China J Eur Acad Dermatol Venereol 2011 25(10):1206-12
Tang L, Liang J, Wang W, Yu L, Yao Z （通讯作者） A novel mutation in MBTPS2 causes a broad phenotypic spectrum of ichthyosis follicularis, atrichia, and photophobia syndrome in a large Chinese family J Am Acad Dermatol 2011 64(4):716-22
Zhang H, Guo Y, Wang W, Shi M, Chen X, Yao Z （通讯作者） Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis Allergy 2011 66(3):420-7
Li M, Chen X, Chen R, Bao Y, Yao Z （通讯作者） Filaggrin gene mutations are associated with independent atopic asthma in Chinese patients Allergy 2011 66(12):1616-7
Zhang H, Guo Y, Wang W, Yu X, Yao Z （通讯作者） Associations of FLG mutations between ichthyosis vulgaris and atopic dermatitis in Han Chinese Allergy 2011 66(9):1253-4
Feng X, Yao Z （通讯作者）, Ren D, Liao W Rapid differentiation of VGII/AFLP6 genotype within Cryptococcus gattii by polymerase chain reaction Diagn Microbiol Infect Dis 2010 68: 471-473
Yu H, Kong J, Gu Y, Ling B, Xi Z, Yao Z （通讯作者） A child with coexistent juvenile xanthogranuloma and Langerhans cell histiocytosis J Am Acad Dermatol 2010 62(2):329-32
Li M, Yang L, Li C, Jin C, Lai M, Zhang G, Hu Y, Ji J, Yao Z （通讯作者） Mutational spectrum of the ADAR1 gene in dyschromatosis symmetrica hereditaria Arch Dermatol Res 2010 302(6):469-76
Feng X, Yao Z （通讯作者）, Ren D, Liao W Simultaneous identification of molecular and mating types within the Cryptococcus species complex by PCR-RFLP analysis J Med Microbiol 2008 57:1481-90
Feng X, Yao Z （通讯作者）, Ren D, Liao W, Wu J Genotype and mating type analysis of Cryptococcus neoformans and Cryptococcus gattii isolates from China that mainly originated from non-HIV-infected patients FEMS Yeast Res 2008 8:930-8