导师姓名： 李江 专业代码： 100302
性别： 女 专业名称： 口腔临床医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： lijiang182000@126.com
邮编： 200011 邮箱地址： lijiang182000@126.com

研究方向 (点击浏览详细信息)
口腔颌面头颈肿瘤发生机制、诊断及转化研究

社会任职
上海医师协会病理分会委员
上海市头颈肿瘤诊治和转化医学中心成员
中华口腔医学会组织委员会委员
中华口腔医学会口腔病理专业委员会副主任委员
国家医学考试中心口腔组织病理组组长
上海口腔研究所 副所长
中华医学会病理学分会头颈疾病学组副组长
中国肿瘤学会头颈组常务委员
国际牙医学院Fellow
上海市口腔医学会理事
上海医学会病理专科分会委员
中华口腔医学会口腔病理学专业委员会副主任委员
上海口腔医学会口腔基础专业委员会主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 腺样囊性癌驱动基因调控NDRG2通路介导氧化应激的化疗耐药机制研究 国家自然科学基金面上项目 2019-01~2022-12 55万元 课题负责人
** MYB-NFIB基因敲入构建唾液腺腺样囊性癌动物模型及发病机理研究 上海市科委 2016-09~2018-09 20万元 课题负责人
** 涎腺多形性腺瘤中PLAG1与不同伙伴基因的融合及相关基因表达调节在肿瘤多向分化中的作用 国家自然科学基金，面上项目 2014-01~2017-12 50万元 课题负责人
085 ?RASSF1A基因及PI3K/AKT通路、微管在涎腺腺样囊性癌侵袭、转移中的作用 教育部博士点基金 2013-01~2015-12 6万元 课题负责人
** DNA修复蛋白及其基因启动子甲基化与涎腺腺样囊性癌化疗耐药性研究 国家自然基金，面上项目 2011-01~2013-12 34万元 课题负责人
s30206 腺样囊性癌组蛋白修饰与DNA甲基化 上海市重点学科 2009-01~2011-06 30万元 课题负责人
** E-cadherin的遗传学、表遗传学改变在涎腺多形性腺瘤发生、恶变中的作用 国家自然基金委,面上项目 2009-01~2011-12 30万元 课题负责人
** DNA去甲基化抑制涎腺腺样囊性癌生长、转移的实验研究 国家自然基金委,面上项目 2006-01~2008-12 25万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Rong-Hui Xia, Chun-Ye Zhang, Jing-Jing Sun, Zhen Tian, Yu-Hua Hu, Ting Gu, Li-Zhen Wang, Jiang Li （通讯作者） Ameloblastoma with mucous cells: A clinicopathological, BRAF mutation, and MAML2 rearrangement study Oral Dis 2020 26(4):805-814
李江 （通讯作者） 口腔癌及口咽癌病理诊断规范 中华口腔医学杂志 2020 55(3):145-152
Rong-Hui Xia, Ling Zhu, Li-Zhen Wang, Zhen Tian, Chun-Ye Zhang, Yu-Hua Hu, Ting Gu, Jiang Li. （通讯作者） Primary pseudomyogenic hemangioendothelioma of right maxilla: a case with immunohistochemistry and FOSB rearrangement study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 S2212-4403(19)31639-6.
Parul Khare , Jiang Li （通讯作者）, Luz Andrea Velandia Palacio , Ivan Gali? , Luigi Ferrante , Roberto Cameriere Validation of the Third Molar Maturity Index Cut-Off Value of <0.08 for Indicating Legal Age of 18 Years in Eastern Chinese Region. Leg Med (Tokyo) 2020 42,101645-101645
Ke Xu, You Fu, Yong Han, Ronghui Xia, Shengming Xu, Shengzhong Duan, Zhiyuan Zhang, Jiang Li （通讯作者） Fewer tumour-specific PD-1 + CD8 + TILs in high-risk "Infiltrating" HPV – HNSCC. Br J Cancer 2020 s41416-020-0966-8
Shengming Xu, Bao Sun, Rong Zhou, Chaoji Shi, Yong Han, Jiayi Li, Jingjing Sun, Zhen Tian, Zhiyuan Zhang, Jiang Li. （通讯作者） Evaluation of p16 as a surrogate marker for transcriptionally active human papillomavirus status of oropharyngeal squamous cell carcinoma in an eastern Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol 2020 129(3):236-45
Han J, Zhang C, Gu T, Yang X, Hu L, Tian Z, Li J （通讯作者）, Zhang C. Analysis of clinicopathological characteristics, MYB rearrangement and prognostic factors in salivary adenoid cystic carcinoma. Oncol Lett. 2019 17(3):2915-2922.
Sun J, Wang L, Tian Z, Hu Y, Xia R, Li J. （通讯作者） Higher Ki67 Index, Nodal Involvement, and Invasive Growth Were High Risk Factors for Worse Prognosis in Conventional Mammary Analogue Secretory Carcinoma. J Oral Maxillofac Surg. 2019 77(6):1187-1202.
Zhou R, Shi C, Tao W, Li J, Wu J, Han Y, Yang G, Gu Z, Xu S, Wang Y, Wang L, Wang Y, Zhou G, Zhang C, Zhang Z, Sun S. Analysis of Mucosal Melanoma Whole-Genome Landscapes Reveals Clinically Relevant GenomicAberrations. Clin Cancer Res. 2019 25(12):3548-3560
Wang Y, Zhang CY, Xia RH, Han J, Sun B, Sun SY, Li J. （通讯作者） The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivaryadenoid cystic carcinoma. Cell Death Dis. 2018 9(9):917-923.
Zhang C, Hu Y, Tian Z, Zhu L, Zhang C, Li J. （通讯作者） Oral carcinoma cuniculatum presenting with moth-eaten destruction of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 125(4):e86-e93.
Liu L, Wang H, Cui J, Zhang Q, Zhang W, Xu W, Lu H, Liu S, Shen S, Fang F, Li L, Yang W, Zhuang Z, Li J. （通讯作者） Inhibition of Protein Phosphatase 2A Sensitizes Mucoepidermoid Carcinoma to Chemotherapy via the PI3K-AKT Pathway in Response to Insulin Stimulus. Cell Physiol Biochem. 2018 50(1):317-331.
Yu-Hua Hu, Wei Li, Chun-Ye Zhang, Rong-Hui Xia, Zhen Tian, Li-Zhen Wang, Lu Xie, Jiang Li. （通讯作者） Prognostic Nomogram for disease specific survival of carcinoma ex pleomorphic adenoma of the salivary gland. Head & Neck. 2017 ;39(12):2416-2424.
Liang Xia, Yuhua Hu, Jiang Li* （通讯作者）, Ting Gu, Chunye Zhang, Lizhen Wang, Zhen Tian*. A low percentage of HER-2 amplification whereas indicates poor prognosis in salivary carcinoma ex pleomorphic adenoma: a study of 140 cases. J Oral Pathol Med. 2017 46(3):167-174.
Chunye Zhang, Ling Zhu, Lizhen Wang, Yuhua Hu, Jiang Li* （通讯作者）, Zhen Tian*. Diffuse tenosynovial giant cell tumor in the temporomandibular joint area in a Chinese population: a clinicopathological analysis of 32 cases. Int J Clin Exp Pathol. 2016 9(2):1105-1115
Wang Z, Xia RH, Ye DX, Li J. （通讯作者） Human Papillomavirus 16 Infection and TP53 Mutation: Two Distinct Pathogeneses for Oropharyngeal Squamous Cell Carcinoma in an Eastern Chinese Population. PLoS One. 2016 11(10):e**.
Tian Z, Li L, Zhang CY, Gu T, Li J*. （通讯作者） Differences in MYB expression and gene abnormalities further confirm that salivary cribriform basal cell tumors and adenoid cystic carcinoma are two distinct tumor entities. J Oral Pathol Med 2016 2015 Dec 29. doi: 10.1111/jop.12414.
Hu YH, Zhang CY, Xia RH, Tian Z, Wang LZ, Li J. （通讯作者） Prognostic factors of carcinoma ex pleomorphic adenoma of the salivary glands, with emphasis on the widely invasive carcinoma: a clinicopathologic analysis of 361 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol 2016 122(5):598-608.
Xia RH（夏荣辉）, Wang Z, Zhang CY, Hu YH, Zhou RR, Wang LZ, Tian Z, Li J. （通讯作者） Low expression of endothelin receptor B (EDNRB) is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 2015 120(2):258-68.
Zhang Chun-Ye（张春叶）,Zhao Yang-Xing, Xia Rong-Hui,Han Jing, Wang Bing-Shun, Tian Zhen,Wang Li-Zhen,Hu Yu-Hua, Li Jiang* （通讯作者） RASSF1A Promoter Hypermethylation Is a Strong Biomarker of Poor Survival in Patients with Salivary Adenoid Cystic Carcinoma in a Chinese Population. PloS ONE 2014 9(10): e110159
Xia Ronghui（夏荣辉） , Zhou Rongrui , Tian Zhen,Zhang Chunye, Wang Lizhen, Hu Yuhua, Han Jing, Li Jiang * （通讯作者） High expression of H3K9me3 is a strong predictor of poor survival in patients with salivary adenoid cystic carcinoma. Archives of Pathology & Laboratory Medicine 2013 137(12):1761–1769
Xia R-H（夏荣辉）, Song X-M, Wang X-J, Li J （通讯作者）, Mao L The Combination of SMAD4 Expression and Histological Grade of Dysplasia Is a Better Predictor for the Malignant Transformation of Oral Leukoplakia. PLoS ONE 2013 8(6): e66794
Zhang CY（张春叶）, Xia RH, Han J, Wang BS, Tian WD, Zhong LP, Tian Z, Wang LZ, Hu YH, Li J*. （通讯作者） Adenoid cystic carcinoma of the head and neck: Clinicopathologic analysis of 218 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 115(3):368-75.
Zhen Tian, Yuhua Hu, Lizhen Wang, Lei Li, Chunye Zhang, Jiang Li*. （通讯作者） An unusual cribriform variant of salivary basal tumors: a clinicopathological study of 22 cases. Histopathology 2012 61:921-929
Wei Liu, Zheng-Yu Shen, Yu-Hua Hu, Xue-Min Shen, Zeng-Tong Zhou*, Jiang Li* （通讯作者） Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathologic study of 87 cases. Histopathology 2011 59(2):292-8
Yu-Hua Hu, Chun-Ye Zhang, Zhen Tian, Li-Zhen Wang, Jiang Li （通讯作者） Aberrant protein expression and promoter methylation of p16 gene are correlated with malignant transformation of salivary pleomorphic adenoma. Archives of Pathology & Laboratory Medicine 2011 135 (7):882-889
Tian Z, Li L, Wang L, Hu Y, Li J. （通讯作者） Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg, 2010 39:235-242
Zhang CY, Mao L, Li L, Tian Z, Zhou XJ, Zhang ZY, Li J （通讯作者） Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. Cancer 2007 110:87-95
Li J （共同第一作者）, El-Naggar Adel, Mao L. Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma. Cancer, 2005;104:771-6. Cancer 2005 104:771-776
Jiang Li （共同第一作者）, Beverly Yiyao Wang, Magalie Nelson, Lei Li, Yuhua Hu, Mark L Urken, and Margaret Brandwein-Gensler. Salivary adenocarcinoma, not otherwise specified: a collection of orphans. Arch Patholo Lab Med 2004 128:1385-1394