导师姓名： 郑凌艳 专业代码： 100302
性别： 女 专业名称： 口腔临床医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市瞿溪路500号
邮编： 200011 邮箱地址： zhenglingyan73@163.com

研究方向 (点击浏览详细信息)
涎腺非肿瘤性疾病，颌面部感染，牙槽外科

社会任职
上海市口腔医学会第三届口腔颌面外科专业委员会委员
中华口腔医学会口腔颌面外科专业委员会专科会员
中国医师协会口腔医师分会会员
中华口腔医学会口腔颌面外科涎腺学组委员
中华口腔医学会专科会员
上海口腔医学会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 去泛素化酶Usp13在TLR9介导唾液腺上皮细胞异常抗原递呈中的作用及机制研究 国家自然基金面上项目 2020-01~2023-12 55万元 课题负责人
** 原发性舍格伦综合征中TLR9异常高表达的分子调控及发病机制研究 国家自然基金面上项目 2017-01~2020-12 58万元 课题负责人
16ZR** TLR9信号通路负反馈调节功能障碍在原发性舍格伦综合征发病机制中的作用研究 上海市科学技术委员会自然基金项目 2016-07~2019-06 20万元 课题负责人
YG2015MS03 PHA基可降解唾液腺导管专用支架的合成及应用研究 上海交通大学医工交叉研究基金项目 2016-01~2018-12 21万元 课题负责人
** TLR9依赖的p38MAPK信号通路的激活原发性舍格伦综合征发病机制中的作用 国家自然科学青年基金 2012-01~2014-12 22万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhan T, Wang B, Fu J, Shao Y, Ye L, Shi H, Zheng L. （通讯作者） Artesunate inhibits Sj?gren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-κB signaling Phytomedicine 2021 80:153381
Ye L, Shi H, Wu S, Yu C, Wang B, Zheng L. （通讯作者） Dysregulated interleukin 11 in primary Sj?gren's syndrome contributes to apoptosis of glandular epithelial cells Cell Biology International 2020 44(1):327-335
Fu J, Shi H, Zhan T, Li H, Ye L, Xie L, Wang Z, Wang B, Zheng L. （通讯作者） BST-2/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-κB signaling in neoplastic B-lymphoid cells Experimental Cell Research 2020 https://doi.org/10.1016/j.yexcr.2020.112399
Fu Jiayao, Shi Huan, Wang Baoli, Zhan Tianle, Shao Yanxiong, Ye Lei, Wu Shufeng, Yu Chuangqi, Zheng Lingyan （通讯作者） LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sjogren's syndrome-like autoimmune response Journal of Autoimmunity 2020 107:102358
Wu Shufeng, Wang Baoli, Yu Chuangqi, Wang Zhijun, Xie Lisong, Fu Jiayao, Shi Huan, Zheng Lingyan. （通讯作者） Juvenile recurrent parotitis: Soft foods contribute to the delayed development of salivary glands Journal of Oral Rehabilitation 2020 47:485–493
Ye L, Shi H, Yu C, Fu J, Chen C, Wu S, Zhan T, Wang B, Zheng L. （通讯作者） LncRNA Neat1 positively regulates MAPK signaling and is involved in the pathogenesis of Sj?gren's syndrome International Immunopharmacology 2020 88:106992.
Fu J, Shi H, Cao N, Wu S, Zhan T, Xie L, Wang Z, Ye L, Li C, Shen Y, Yu C, Zheng L. （通讯作者） Toll-like receptor 9 signaling promotes autophagy and apoptosis via divergent functions of the p38/JNK pathway in human salivary gland cells Exp Cell Res 2019 375(2):51-59.
Chen C, Shi H, Wang B, Cao N, Yu C, Zheng L. （通讯作者） Aberrant expression of the innate restriction factor bone marrow stromal antigen-2 in primary Sjogren's syndrome J Craniomaxillofac Surg 2018 46(11):1899-1904.
Wu S, Shi H, Cao N, Ye L, Yu C, Zheng L. （通讯作者） The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation Acta Oto-Laryngologica 2018 138(12):1112-1116.
Shi H, Cao N, Pu Y, Xie L, Zheng L （通讯作者）, Yu C. Long non-coding RNA expression profile in minor salivary gland of primary Sjogren’s syndrome. Arthritis Res Ther 2016 18(1):109-122.
Gao Q, Yang C, Zheng L （通讯作者）, Hu Y. Removal of Long-Term Broken Roots Displaced Into the Maxillary Sinus by Endoscopic Assistant. J Craniofac Surg 2016 27(1), e77-e80.
Zheng L, Yang C, Zhang W, Cai X, Jiang B, Wang B, Pu Y, Jin J, Guan X. Comparison of multi-space infection of the head and neck in the elderly and non-elderly people PartⅡ: the influencing factors of the outcomes. J Craniofac Surg 2015 26(2):581-584.
Zheng L, Xie L, Wang Z, Shi H, Cao N, Yu C. Endoscopic-assisted gland preserving therapy for the management of parotid gland sialolithiasis: Our preliminary experience. J Craniomaxillofac Surg 2015 43(8):1650-1654.
Xie L, Zheng L （通讯作者）, Yu C, Yang C, Chen Z, Yun B, Kim E. Foreign body induced sialolithiasis treated by sialoendoscopic intervention. J Craniofac Surg 2014 25(4):1372-1375.
Shi H, Yu CQ, Xie LS, Wang ZJ, Zhang P, Zheng LY. （通讯作者） Activation of TLR9-dependent p38MAPK pathway in the pathogenesis of primary Sjogren’s syndrome in NOD/Ltj mouse. J Oral Pathol Med 2014 43(10):785-791.
Zheng LY, Yu CQ, Yang C, Xie LS, Shi H, Wang ZJ. The serological profiles of subgroup of primary Sjogren’s syndrome correlation with the clinical features of parotid glands. J Craniomaxillofac Surg 2014 42(7):1260-1264.
Xie L, Yu CQ, Zheng LY. （通讯作者） Bilateral aplasia of the major salivary glands and unilateral atresia of lacrimal duct. J Craniofac Surg 2013 24(2) :177-179.
Zheng, L. Y., Kim, E., Yu, C. Q., Yang, C., Park, J., Chen, Z. Z. A retrospective case series illustrating a possible association between a widened hilum and sialolith formation in the submandibular gland. J Craniomaxillofac Surg 2013 41(7):648-651.
Zheng L, Yang C, Zhang W, Cai X, Jiang B, Wang B, Pu Y, Jin J, Kim E, Wang J, Zhang Z, Zhou L, Zhou J, Guan X. Comparison of multi-space infections of the head and neck in the elderly and non-elderly: Part I the descriptive data. J Craniomaxillofac Surg 2013 41（8）, e208-e212.
Zheng Lingyan, Chuangqi Yu, Chi Yang. Different Lymphoproliferative Disorders in Different Salivary Glands of Primary Sj?gren Syndrome. J Craniofac Surg 2013 24(5): e462-e465.
Zheng, L, Yang, C, Zhang, W, Cai, X, Kim, E, Jiang, B, Guan, X. Is there association between severe multispace infections of the oral maxillofacial region and diabetes mellitus? J Oral Maxillofac Surg 2012 70(7)： 1565-1572.
Zheng L, Yang C, Kim E, Zhang W, Cai X, Jiang B, Wang B, Pu Y, Jin J, Wang J, Zhang Z, Zhou L, Zhou J, Guan X. The clinical features of severe multi-space infections of the head and neck in patients with diabetes mellitus compared to non-diabetic patients. Br J Oral Maxillofac Surg 2012 50（8）: 757–761.
Zheng L, Zhang Z, Yu C, Yang C. Expression of Toll-like receptors 7, 8, and 9 in primary Sj?gren's syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 109(6)：844-850.
Zheng L, Yu C, Zhang Z, Yang C, Cai, X. Expression of interferon regulatory factor 1, 3, and 7 in primary Sj?gren syndrome. Oral Surgry, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2009 107(5)：661-668.
Zheng L, Zhang Z, Yu C, Tu L, Zhong L, Yang C. Association between IFN-α and primary Sjogren's syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 107(1), e12-e18.