导师姓名： 胡镜宙 专业代码： 100302
性别： 男 专业名称： 口腔临床医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海交通大学医学院附属第九人民医院上海市制造局路639号 第九人民医院1号楼12楼-5160
邮编： 200011 邮箱地址： huyayi@163.com

研究方向 (点击浏览详细信息)
口腔颌面头颈肿瘤的基础与临床研究；口腔颌面部组织工程学

社会任职
上海市口腔医学会口腔颌面外科学术委员会青年委员
上海市口腔医学会口腔颌面头颈肿瘤专业委员会委员
上海市抗癌协会青年理事
中国医药教育协会头颈肿瘤专业委员会副主任委员
中国抗癌协会头颈肿瘤专业委员会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SIRT3诱导肿瘤相关巨噬细胞M2型极化促进口腔鳞癌免疫抑制性微环境形成的机制研究 国家自然科学基金 2019-01~2022-12 54万元 课题负责人
** RIG-I调节自噬促进口腔鳞状细胞癌转移的效应与分子机制研究 国家自然科学基金 2015-01~2018-12 72万元 课题负责人
14ZR** TLR4促进口腔颌面-头颈鳞癌对西妥昔单抗耐药的效应与机制研究 上海市自然科学基金 2014-07~2017-06 10万元 课题负责人
** EGFR 和TLR4 信号通路交叉调控对头颈部鳞癌的效应与机制研究 国家自然科学基金 2012-01~2012-12 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ma H, Chang H, Yang W, Lu Y, Hu J （通讯作者）, Jin S A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma Mol Cancer 2020 19(1):4
Hailong Ma, Wenyi Yang, Liming Zhang, Shuli Liu, Mei Zhao, Ge Zhou, Lizhen Wang, Shufang Jin, Zhiyuan Zhang, Jingzhou Hu （通讯作者） Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signaling in head and neck squamous cell carcinoma Br J Cancer 2019 120(3):317-330
Ren ZH, Wu K, Wang Y, Tian ZW, Hu JZ （通讯作者） Role of a two-step suture in the prevention of postoperative transoral salivary fistulas during reconstruction of the oral cavity Br J Oral Maxillofac Surg 2019 57(2):164-168
Wenyi Yang, Chunlan Jiang, Weiya Xia, Houyu Ju, Shufang Jin, huli Liu, Liming Zhang, Guoxin Ren, Hailong Ma, Min Ruan, Jingzhou Hu （通讯作者） Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma Cancer Letters 2019 451:34–47
Zhou W, Hu Z, Wang T, Yang G, Xi W, Gan Y, Lu W, Hu J （通讯作者） Enhanced corrosion resistance and bioactivity of Mg alloy modified by Zn-doped nanowhisker hydroxyapatite coatings Colloids Surf B Biointerfaces 2019 186:110710
Li-Ming Zhang, Hou-Yu Ju, Yun-Teng Wu, Wei Guo, Lu Mao, Hai-Long Ma, Wei-Ya Xia, Jing-Zhou Hu （通讯作者）, Guo-Xin Ren Long non-coding RNA ANRIL promotes tumorgenesis through regulation of FGFR1 expression by sponging miR-125a-3p in head and neck squamous cell carcinoma Am J Cancer Res 2018 8(11):2296-2310
Ma H, Jin S, Yang W, Zhou G, Zhao M, Fang S, Zhang Z, Hu J （通讯作者） Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma Br J Cancer 2018 118(4):509-521
Ju H, Mao L, Zhang L, Liu S, Wu Y, Ruan M, Hu J （通讯作者）, Ren G Ultrasound hyperthermia enhances chemo-sensitivity in oral squamous cell carcinoma by TRIF mediated pathway J Oral Pathol Med 2018 47(10):964-971
Ju H, Zhang L, Mao L, Wu Y, Liu S, Ruan M, Hu J （通讯作者）, Ren G A comprehensive genome-wide analysis of the long noncoding RNA expression profile in metastatic lymph nodes of oral mucosal melanoma gene 2018 675: 44-53
Houyu Ju, Liming Zhang, Lu Mao, Shuli Liu, Weiya Xia, Jingzhou Hu （通讯作者）, Min Ruan, Guoxin Ren Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma Am J Cancer Res 2018 8(9): 1788-1800
Guangzheng Yang, Huawei Yang, Lei Shi, Taolei Wang, Wuchao Zhou, Tian Zhou, Wei Han, Zhiyuan Zhang, Wei Lu, Jingzhou Hu （通讯作者） Enhancing Corrosion Resistance, Osteoinduction and Antibacterial Properties by Zn/Sr Additional Surface Modification of Magnesium Alloy Acs Biomater Sci Eng 2018 4: 4289?4298
Han N, Zhang Z, Jv H, Hu J （通讯作者）, Ruan M, Zhang C Culture supernatants of oral cancer cells induce impaired IFN-α productionof pDCs partly through the down-regulation of TLR-9 expression Arch Oral Biol 2018 93(5):141-148
Ma H, Jin S, Yang W, Tian Z, Liu S, Wang Y, Zhou G, Zhao M, Gvetadze S, Zhang Z, Hu J （通讯作者） Interferon-α Promotes the Expression of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma J Cancer 2017 8(12):2384-2393
Liu S, Shi L, Yang X, Ye D, Wang T, Dong C, Guo W, Liao Y, Song H, Xu D, Hu J （通讯作者）, Zhang Z, Deng J Nuclear survivin promoted by acetylation is associated with the aggressive phenotype of oral squamous cell carcinoma Cell Cycle 2017 16(9):894-902
Ren G, Jv H, Tian Z, Gvetadze SR, Hu J （通讯作者）, Zhao M, Zhou G, Zhang C, Zhang Z. Ultrasound hyperthermia induces apoptosis in head and neck squamous cell carcinoma: An in vitro study Med Oral Patol Oral Cir Bucal 2017 22(3):e289-e296
GUOXIN REN, JINGZHOU HU （通讯作者）, RUNXIANG WANG, WEI HAN,MEI ZHAO, GE ZHOU, CHENPING ZHANG, ZHIYUAN ZHANG Rapamycin inhibits Toll-like Receptor 4-induced Pro-oncogenic Function in Head and Neck Squamous Cell Carcinoma Oncol Rep 2014 31:2804-10
Weimin Ye, Jingzhou Hu （通讯作者）, Hanguang Zhu, Chenping Zhang, Zhiyuan Zhang Application of Modified Karapandzic Flaps in Large Lower Lip Defects Reconstruction J Oral Maxillofac Surg 2014 72:2077-82
Weimin Ye, Yipeng Song, BinbinYing, Jingzhou Hu （通讯作者）, Chenping Zhang, Zhiyuan Zhang Use of the Buccal Fat Pad in the Immediate Reconstruction of Palatal Defects Related to Cancer Surgery with Postoperative Radiation Therapy J Oral Maxillofac Surg 2014 72:2613-20
Weimin Ye, Jingzhou Hu （通讯作者）, Hanguang Zhu, Zhiyuan Zhang Tongue Reconstruction with Tongue Base Island Advancement Flap J Craniofac Surg 2013 24(3):996-8
Jingzhou Hu,Yue He, Ming Yan, Chao Zhu, Weimin Ye, Hanguang Zhu, Wantao Chen, Chenping Zhang, Zhiyuan Zhang Dose Dependent Activation of Retinoic Acid-Inducible Gene-I Promotes Both Proliferation and Apoptosis Signals in Human Head and Neck Squamous Cell Carcinoma Plos One 2013 8(3):e25873
Jingzhou Hu, Zhiyuan Zhang, Jiawei Zheng, Weimin Ye, Zhen Tian, Hanguang Zhu Unilateral Parotid Gland Involvement with Synchronous Multiple Basal Cell Adenocarcinomas: Report of One Case and Review of the Literature J Oral Maxillofac Surg 2010 68:2579-82
J. Hu, W. Ye, J. Zheng, H. Zhu,Z. Zhang The Feasibility and Significance of Preservation of the Lobular Branch of the Great Auricular Nerve in Parotidectomy Inter J Oral Maxillo Surg 2010 39(7):684-689
HU Jing-zhou, ZHANG Zhi-yuan, ZHAO Jun, ZHANG Xiu-li, LIU Gen-tao and JIANG Xin-quan An Ectopic Study of Tissue-Engineered Bone with Nell-1 Gene Modified Rat Bone Marrow Stromal Cells in Nude Mice Chin Med J 2009 122(8):972-979