导师姓名： 贾伟平 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： wpjia@sjtu.edu.cn

研究方向 (点击浏览详细信息)
糖尿病、肥胖病的发病机制、诊断及治疗

社会任职
上海市医学会内科专科分会主任委员
The Lancet Diabetes Endocrinology编委
中华医学会糖尿病学分会前任主任委员
国际糖尿病联盟西太区执委
亚洲糖尿病协会理事
《中华内科杂志》总编辑

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 数字医学在慢病防控网络建设中的应用研究 上海市科委 2019-11~2020-10 100万元 课题负责人
** 基于人工智能的糖尿病并发症筛查与风险预警技术研究及跨国临床实践 上海市科委 2018-10~2021-09 150万元 课题负责人
** 基于深度神经网络的糖尿病视网膜病变辅助诊断技术研究与应用 上海市科委 2017-10~2020-09 50万元 课题负责人
17DZ** 上海市糖尿病重点实验室 上海市科委 2017-04~2020-04 240万元 课题负责人
2016YFC** 基于组学特征谱的2型糖尿病分子分型及分类体系的研究 国家重点研发计划精准医学专项 2016-07~2019-06 320万元 课题负责人
采用生物标志物对2型糖尿病进行风险预测和转归评价的中澳联合转化研究 国家自然基金委 2016-01~2019-12 350万元 课题负责人
14DZ** 上海市糖尿病重点实验室 上海市科委 2014-01~2016-12 240万元 课题负责人
** 基诺族人群血糖调控适应环境与进化的多基因作用机制 国家自然科学基金重大项目 2014-01~2016-12 100万元 课题负责人
膳食纤维调节肝脏脂质代谢的分子机制研究及临床研究 国家自然科学基金国际（地区）合作与交流项目 2013-01~2017-02 290万元 课题负责人
2012AA02A509 2型糖尿病分子分型和个体化诊疗技术 国家科技部，863计划 2012-01~2015-12 189万元 课题负责人
2011ZX09307-001-02 代谢性疾病临床标本资源库建设 国家科技部，重大新药创制 2011-01~2013-12 420.6万元 子课题负责人
2011CB504000 2型糖尿病病理生理变化的分子机理研究 国家科技部，973计划 2011-01~2015-08 2715万元 课题负责人
** 2型糖尿病遗传家系的收集以及染色体1q区域易感基因的识别和鉴定 国家自然基金委,重点项目 2007-01~2010-12 155万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Hu C, Jia W*. （通讯作者） Diabetes in China: Epidemiology and Genetic Risk Factors and Their Clinical Utility in Personalized Medication. Diabetes. 2018 67(1):3-11.
Li H, Wu G, Fang Q, Zhang M, Hui X, Sheng B, Wu L, Bao Y, Li P, Xu A*, Jia W*. （通讯作者） Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat Commun. 2018 9(1):272
Lu J, Ma X, Zhou J*, Zhang L, Mo Y, Ying L, Lu W, Zhu W, Bao Y, Vigersky RA, Jia W*. （通讯作者） Association of Time in Range, as Assessed by Continuous Glucose Monitoring, With Diabetic Retinopathy in Type 2 Diabetes. Diabetes Care. 2018 41(11):2370-2376.
Hu C, Jia W （通讯作者） Linking MTNR1B Variants to Diabetes: The Role of Circadian Rhythms. Diabetes 2016 65:1490- 1492
Zhang L, Guo KF, Lu JX, Zhao FY, Yu HY, Han JF, Bao YQ, Chen HB, Jia WP （通讯作者） Nonalcoholic Fatty Liver Disease is Associated with Increased Carotid Intima-Media Thickness in Type 1 Diabetic Patients Sci Rep 2016 6:26805
Yan J, Peng DF, Jiang F, Zhang R, Chen M, Wang T, Yan DD, Wang SY, Hou XH, Bao YQ, Hu C, Jia W （通讯作者） Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9 year prospective cohort study in the Chinese population Diabetologia 2016 59( 7): 1458- 1462
Wang T, Ma XJ, Peng DF, Zhang R, Sun X, Chen M, Yan J, Wang SY, Yan DD, He Z, Jiang F, Bao YQ, Hu C, Jia W （通讯作者） Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population. Sci Rep 2016 6:20691
Chen M, Zhang R, Jiang F, Wang J, Peng DF, Yan J, Wang SY, Wang T, Bao YQ, Hu C *, Jia WP （通讯作者） Joint effects of diabetic-related genomic loci on the therapeutic efficacy of oral anti-diabetic drugs in Chinese type 2 diabetes patients Sci Rep 2016 6:23266.
Miao Chen, Cheng Hu*, Rong Zhang, Feng Jiang, Jie Wang, Danfeng Peng, Shanshan Tang, Xue Sun, Jing Yan, Shiyun Wang, Tao Wang, Yuqian Bao, Weiping Jia* （通讯作者） A variant of the PSMD6 gene is associated with the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes Sci Rep 2015 5:10701
Haoyong Yu, Yan Ni, Yuqian Bao, Pin Zhang, Aihua Zhao, Tianlu Chen, Guoxiang Xie, Yinfang Tu, Lei Zhang, Mingming Su, Li Wei, Wei Jia, Weiping Jia* （通讯作者） Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients J Clin Endocrinol Metab 2015 100(11): 4222-4230
Danfeng Peng, Jie Wang, Rong Zhang, Feng Jiang, Shanshan Tang, Miao Chen, Jing Yan, Xue Sun, Shiyun Wang, Tao Wang , Dandan Yan, Yuqian Bao, Cheng Hu*, Weiping Jia* （通讯作者） Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes. Diabetologia 2015 58(6): 1231-1238
Weiping Jia* （通讯作者）, Xinhua Xiao, Qiuhe Ji, Kyu-Jeung Ahn, Lee-Ming Chuang, Yuqian Bao, Can Pang, Lei Chen, Fei Gao, Yinfang Tu, Pengfei Li, Jun Yang Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin:an open-label, randomised, controlled trial Lancet Diabetes & Endocrinology 2015 Apr;3(4):254-262
Fang Q, Yang W, Li H, Hu W, Chen L,Jiang S, DongK, Song Q,Wang C, Chen S, Liu F, Jia W （通讯作者） Negative regulation of DsbA-L gene expression by the transcription factor Sp1 Diabetes 2014 63(12):4165-4171
ChenM, Hu C,ZhangR, Jiang F, WangJ,PengD,TangS,SunX, YanJ,LuoY, BaoY and JiaW （通讯作者） Association of PAX4 genetic variants with oral antidiabetic drugs efficacy in Chinese type 2 diabetes patients Pharmacogenomics J 2014 14(5):488-92
Wu G, Li H, Fang Q, Jiang S, Zhang L, Zhang J, Hou X, Lu J, Bao Y, Xu A, Jia W （通讯作者） Elevated Circulating Lipocalin-2 Levels Independently Predict Incident Cardiovascular Events in Men in a Population-Based Cohort Arterioscler Thromb Vasc Biol 2014 34:2457-2464
Jiang S, Yan C, Fang Q, Shao M, Zhang Y, Liu Y, Deng Y, Shan B, Liu J,Li H, Yang L, Zhou J, Dai Z,Liu Y, Jia W （通讯作者） Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts ER stress-induced hepatic steatosis J Biol Chem 2014 289(43): 29751-29765
Li H, Dong K, Fang Q, Hou X, Zhou M, Bao Y, Xiang K, Xu A, Jia W （通讯作者） High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease:A 3-year prospective study in China J of Hepatology 2013 58(3):557-63
Wang C, Li X, Mu K, Li L, Wang S, Zhu Y, Zhang M, Ryu J, Xie Z, Shi D, Zhang WJ, Dong LQ, Jia W. （通讯作者） Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function. Diabetologia 2013 56(9): 1999-2009
Li H, Gao Z, Zhang J, Ye X, Xu A, Ye J, Jia W （通讯作者） Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3 Diabetes 2012 61(4):797-806
Hu C, Zhang R, Wang C, Wang J, Pang C, Ma X, Bao Y, Xiang K, Jia W （通讯作者） CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetes patients Diabetes 2011 60(11):3085-3089
Yu W, Hu C, Zhang R, Wang C, Qin W, Lu J, Jiang F, Tang S, Bao Y, Xiang K, Jia W （通讯作者） Effects of KCNQ1 Polymorphisms on the Therapeutic Efficacy of Oral Antidiabetic Drugs in Chinese Patients With Type 2 Diabetes Clin Pharmacol Ther 2011 Mar;89(3):437-42
Zhou M, Bao Y, Lu J, Zhou J, Jia W （通讯作者） Serum A-FABP Is Increased and Closely Associated with Elevated NT-proBNP Levels in Type 2 Diabetic Patients Treated with Rosiglitazone PLoS One 2011 6(10):e27032
Bao Y, Ma X, Li H, Zhou M, Hu C, Wu H, Tang J, Hou X, Xiang K, Jia W （通讯作者） Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey British Medical Journal 2010 340:2249-2257
Li H, Fang Q, Gao F, Fan J, Zhou J, Wang X, Zhang H, Pan X, Bao Y, Xiang K, Xu A, Jia W （通讯作者） Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride J Hepatol 2010 53(5):934-940
Li H, Bao Y, Xu A, Pan X, Lu J, Wu H, Lu H, Xiang K, Jia W （通讯作者） Serum Fibroblast Growth Factor 21 is Associated with Adverse Lipid Profiles and {gamma}-glutamyltransferase but not Insulin Sensitivity in Chinese Subjects J Clin Endocrinol Metab 2009 Jun;94(6):2151-6.
Wang C, Hu C, Zhang R, Bao Y, Ma X, Lu J, Qin W, Shao X, Lu J, Xu J, Lu H, Xiang K, Jia W （通讯作者） Common Variants of Hepatocyte Nuclear Factor 1B are Associated with Type 2 Diabetes in a Chinese Population Diabetes 2009 Apr;58(4):1023-7
Zhou J, Li H, Ran X, Yang W, Li Q, Peng Y, Li Y, Gao X, Luan X, Wang W, Jia W （通讯作者） Reference values for continuous glucose monitoring in Chinese subjects Diabetes Care 2009 Jul;32(7):1188-93.
Jia W （通讯作者）, Wu H, Bao Y, Wang C, Lu J, Zhu J, Xiang K Association of serum retinol binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. J Clin Endocr Metab 2007 Aug;92(8):3224-3229.