导师姓名： 汪纯 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： chunwang66@gmail.com
邮编： 邮箱地址： chunwang66@gmail.com

研究方向 (点击浏览详细信息)
骨质疏松和单基因骨病遗传机制

社会任职
上海市医学会骨质疏松专科分会第七届委员会副主任委员
中华医学会骨质疏松和骨矿盐疾病分会社区学组成员
上海市医学会骨质疏松专科分会第五和第六届委员会委员兼秘书
《中华骨质疏松和骨矿盐疾病杂志》第二届编委会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 利用Clcn7基因G763R条件性敲入小鼠进行骨硬化症发病机 制及IFNγ干预研究 国家自然科学基金 2018-01~2021-12 54万元 课题负责人
** CLCN7基因R767W突变导致常染色体显性遗传骨硬化症2型外显不全修饰基因的鉴定和功能研究 国家自然科学基金 2013-01~2016-12 80万元 课题负责人
11ZR** 阿仑膦酸钠甲羟戊酸通路7个基因30个标签SNP 和单倍型与骨质疏松疗效关系的研究 上海市自然科学基金 2011-04~2014-03 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yu WJ, He JW, Fu WZ, Wang C （通讯作者）, Zhang ZL. Reports of 17 Chinese patients with tumor-induced osteomalacia J Bone Miner Metab. 2017 35(3):298-307
Zhang XY, He JW, Fu WZ, Wang C （通讯作者）, Zhang ZL Novel mutations of TCIRG1 cause a malignant and mild phenotype of autosomal recessive osteopetrosis (ARO) in four Chinese families. Acta Pharmacol Sin. 2017 38(11):1456-1465.
Yu WJ, Zhang Z, He JW, Fu WZ, Wang C （通讯作者）, Zhang ZL. Identification of two novel mutations in the COMP gene in six families with pseudoachondroplasia. Mol Med Rep. 2016 14(3):2180-6
Wang C, Zheng H, He JW, Zhang H, Yue H, Hu WW, Gu JM, Shao C, Fu WZ, Hu YQ, Li M, Liu YJ, Zhang ZL. Genetic polymorphisms in the mevalonate pathway affect the therapeutic response to alendronate treatment in postmenopausal Chinese women with low bone mineral density. Pharmacogenomics J. 2015 15(2):158-64.
Wang C, Zhang BH, Liu YJ, Hu YQ, He JW, Zhang ZL. Transforming growth factor-β1 gene mutations and phenotypes in pediatric patients with Camurati?Engelmann disease. Mol Med Rep. 2013 7(5):1695-9.
Wang C, Zhang BH, Zhang H, He JW, Hu YQ, Li M, Yue H, Hu WW, Gu JM, Liu YJ, Fu WZ, Zhang ZL. The A242T mutation in the low-density lipoprotein receptor-related protein 5 gene in one Chinese family with osteosclerosis. Intern Med. 2013 52(2):187-92.
Wang C, Zhang H, He JW, Gu JM, Hu WW, Hu YQ, Li M, Liu YJ, Fu WZ, Yue H, Ke YH,?Zhang ZL. The virulence gene and clinical phenotypes of osteopetrosis in the Chinese population: six novel mutations of the CLCN7 gene in twelve osteopetrosis families. J Bone Miner Metab 2012 30(3):338-48
Wang C, Zhang Z, Zhang H, He JW, Gu JM, Hu WW, Hu YQ, Li M, Liu YJ, Fu WZ, Yue H, Ke YH,Zhang ZL Susceptibility genes for osteoporotic fracture in postmenopausal Chinese women. J Bone Miner Res. 2012 27(12):2582-91.
Wang C, Li H, Chen SG, He JW, Sheng CJ, Cheng XY, Qu S, Wang KS, Lu ML, Yu YC. The virulence gene and clinical phenotypes of osteopetrosis in the The skeletal effects of thiazolidinedione and metformin on insulin-resistant mice. J Bone Miner Metab 2012 30(6):630-7
Wang C, Hu YM, He JW, Gu JM, Zhang H, Hu WW, Yue H, Gao G, Xiao WJ, Yu JB, Ke YH, Hu YQ, Li M, Liu YJ, Fu WZ, Ren Y,?Zhang ZL. Association between low density lipoprotein receptor-related protein 2 gene polymorphisms and bone mineral density variation in Chinese population. PLoS One 2011 6(12):e28874.
Wang C, Heim A, Schlaphoff V, Suneetha PV, Stegmann KA, Jiang H, Krueger M, Fytili P, Schulz T, Cornberg M, Kandolf R, Manns MP, Bock CT, Wedemeyer H Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis. J medical virology 2009 81(12):2079-2088