导师姓名： 李连喜 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市徐汇区宜山路600号，上海市第六人民医院内分泌代谢科
邮编： 200233 邮箱地址： lilx@sjtu.edu.cn

研究方向 (点击浏览详细信息)
糖尿病大血管病变
甲状腺疾病

社会任职
上海市医学会医疗鉴定专家库成员
国家自然科学基金一审专家
中华医学会糖尿病学分会糖尿病代谢性大血管病变学组委员
中华医学会糖尿病学分会糖尿病及相关内分泌病学组委员
中华糖尿病杂志、Cardiovascular Diabetology等杂志编委和审稿人

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** FAM172A调控脂肪发育及能量代谢在肥胖发病中的作用及机制 国家自然科学基金 2021-01~2024-12 55万元 课题负责人
2018YFC** 糖尿病防诊治协同服务模式与传播体系研究及示范应用 国家重点研发计划子课题 2018-09~2020-12 115万元 子课题负责人
** FAM172A调控血管平滑肌细胞表型转化在糖尿病动脉粥样硬化中的作用 国家自然科学基金 2018-01~2021-12 56万元 课题负责人
** 基于代谢记忆效应组蛋白甲基化标志物对糖尿病大血管病变的预警价值 上海市科学技术委员会 2015-09~2018-09 30万元 课题负责人
** FAM172A通过组蛋白H3K9甲基化致糖尿病血管损伤机制研究 国家自然科学基金 2012-01~2015-12 58万元 课题负责人
** 抑瘤素M在糖尿病大血管病变中的致病作用及早期预测研究 上海市卫生局 2009-01~2012-01 3万元 课题负责人
EYF151016 新的UBA家族蛋白TM4在糖尿病动脉粥样硬化中的致病作用研究 复旦大学 2007-01~2008-08 1.5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yan D,Xu Y,Li LX （通讯作者） The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report BMC endocrine disorders 2020 20(1):97
Xu PP,Zeng S,Xia XT,Ye ZH,Li MF,Chen MY,Xia T,Xu JJ,Jiao Q,Liu L,Li LX （通讯作者）,Guo MG FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC Endocr Relat Cancer 2020 27(11): 657-669
Li MF,Ma L,Yu TP,Zhu Y,Chen MY,Liu Y,Li LX （通讯作者） Adverse maternal and neonatal outcomes in pregnant women with abnormal glucose metabolism Diabetes Res Clin Pract 2020 161:108085
Li MF,Ma L,Feng QM,Zhu Y,Yu TP,Ke JF,Zhang ZH,Liu Y,Li LX （通讯作者） Effects of Maternal Subclinical Hypothyroidism in Early Pregnancy Diagnosed by Different Criteria on Adverse Perinatal Outcomes in Chinese Women With Negative TPOAb Frontiers in Endocrinology 2020 11:580380
Wang JW, Wang AP, Chen MY, Lu JX, Ke JF, Li LX （通讯作者）, Jia WP Prevalence and clinical characteristics of hypertension and metabolic syndrome in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study Diabetol Metab Syndr 2019 11:31
Chen MY,Wang AP,Wang JW,Ke JF,Yu TP,Li LX （通讯作者）,Jia WP Coexistence of hyperuricaemia and low urinary uric acid excretion further increases risk of chronic kidney disease in type 2 diabetes Diabetes & metabolism 2019 45(6):557-563
Wang JW, Ren Y, Lu ZG, Gao J ,Zhao CC, Li LX （通讯作者）, Wei M The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study BMC cardiovascular disorders 2019 19:50
Li TT,Wang AP,Lu JX,Chen MY,Zhao CC,Tang ZH,Li LX （通讯作者）,Jia WP Prevalence and clinical characteristics of non-alcoholic fatty liver disease in newly diagnosed patients with ketosis-onset diabetes Diabetes & metabolism 2018 44(5):437-443
Chen MY,Zhao CC,Li TT,Zhu Y,Yu TP,Bao YQ,Li LX （通讯作者）,Jia WP Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes Scientific reports 2017 7:40009
Li MF,Zhao CC,Li TT,Tu YF,Lu JX,Zhang R,Chen MY,Bao YQ,Li LX （通讯作者）,Jia WP The coexistence of carotid and lower extremity atherosclerosis further increases cardio-cerebrovascular risk in type 2 diabetes Cardiovasc Diabetol 2016 15(1):43
Li MF,Zhang R,Guo MG,Li LX （通讯作者）,Lu HK,Lu JX,Jia WP FAM172A protein promotes the proliferation of human papillary thyroid carcinoma cells via the p38 mitogen-activated protein kinase pathway Mol Med Rep 2016 13(1):353-8
Li MF,Zhang R,Li TT,Chen MY,Li LX （通讯作者）,Lu JX,Jia WP High Glucose Increases the Expression of Inflammatory Cytokine Genes in Macrophages Through H3K9 Methyltransferase Mechanism J Interferon Cytokine Res 2016 36(1):48-61
Zhao CC,Wang AP,Li LX （通讯作者）,Li TT,Chen MY,Zhu Y,Yu TP,Bao YQ,Jia WP Urine uric acid excretion is associated with nonalcoholic fatty liver disease in patients with type 2 diabetes J Diabetes Complications 2016 30(6):1074-1080
Li LX, Wang AP, Zhang R, Li TT, Wang JW, Bao YQ, Jia WP Decreased urine uric acid excretion is an independent risk factor for chronic kidney disease but not for carotid atherosclerosis in hospital-based patients with type 2 diabetes: a cross-sectional study Cardiovasc Diabetol 2015 14:36
Li LX, Dong XH, Li MF, Zhang R, Li TT, Shen J, Shen J, Bao YQ, Jia WP Serum uric acid levels are associated with hypertension and metabolic syndrome but not atherosclerosis in Chinese inpatients with type 2 diabetes J Hypertens 2015 33(3):482-490
Li MF, Feng QM, Li LX （通讯作者）, Tu YF, Zhang R, Dong XH, Lu JX, Bao YQ, Jia WP, Hu RM High-normal Urinary Albumin Creatinine Ratio is independently associated with Metabolic Syndrome in Chinese patients with Type 2 diabetes mellitus J Diabetes Investig 2015 6:354–359
Li LX （通讯作者）,Lu JX,Shuai HP,Xia HF,Zhang R,Wang JW,Chen MY,Li TT,Bao YQ,Jia WP Decreased urine uric acid excretion is associated with diabetic retinopathy but not with lower limb atherosclerosis in hospitalized patients with type 2 diabetes Atherosclerosis 2015 242(1):13-18
Li LX,Wu X,Lu JX,Tu YF,Yu LB,Li MF,Zhang WX,Zhu JA,Yuan GY,Bao YQ,Jia WP Comparison of carotid and lower limb atherosclerotic lesions in both previously known and newly diagnosed type 2 diabetes mellitus J Diabetes Investig 2014 5(6):734-742
Li LX （通讯作者）, Wu X, Hu B, Zhang HZ, Lu HK Localized subacute thyroiditis presenting as a painful hot nodule BMC Endocr Disord 2014 14(1):4.
Dong X, Wu D, Jia C, Ruan Y, Feng X, Wang G, Liu J, Shen Y, Li H, Li L （通讯作者） Low ankle-brachial index is associated with early-stage chronic kidney disease in type 2 diabetic patients independent of albuminuria PLOS ONE 2014 9(10):109-641
Li MF,Ren Y,Zhao CC,Zhang R,Li LX （通讯作者）,Liu F,Lu JX,Tu YF,Zhao WJ,Bao YQ,Jia WP Prevalence and clinical characteristics of lower limb atherosclerotic lesions in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study Diabetology & Metabolic Syndrome 2014 6:71
Li LX,Li MF,Lu JX,Jia LL,Zhang R,Zhao CC,Ren Y,Tu YF,Shen Y,Liu F,Bao YQ,Jia WP Retinal microvascular abnormalities are associated with early carotid atherosclerotic lesions in hospitalized Chinese patients with type 2 diabetes mellitus J Diabetes Complications 2014 28(3):378-385
Li MF, Tu YF, Li LX （通讯作者）, Lu JX, Dong XH, Yu LB, Zhang R, Bao YQ, Jia WP, Hu RM Low-grade albuminuria is associated with early but not late carotid atherosclerotic lesions in community-based patients with type 2 diabetes Cardiovasc Diabetol 2013 12(1):110.
Li LX （通讯作者）, Zhao CC, Ren Y, Tu YF, Lu JX, Wu X, Zhang WX, Zhu JA, Li MF, Yu LB, Bao YQ, Jia WP Prevalence and clinical characteristics of carotid atherosclerosis in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study Cardiovasc Diabetol 2013 12(1):18.
Li L,Chen L,Yang Y,Han J,Wu S,Bao Y,Jia W Giant anterior mediastinal parathyroid adenoma Clin Nucl Med 2012 37(9):889-891
Li L,Yu H,Zhu J,Wu X,Liu F,Zhang F,Li Q,Wu S,Bao Y,Jia W The combination of carotid and lower extremity ultrasonography increases the detection of atherosclerosis in type 2 diabetes patients J Diabetes Complications 2012 26(1): 23-28.
Li L,Dong X,Leong MC,Zhou W,Yang Z,Chen F,Bao Y,Jia W,Hu R Identification of the novel protein FAM172A, and its up-regulation by high glucose in human aortic smooth muscle cells Int J Mol Med 2010 26(4):483-490.