导师姓名： 沈成兴 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 心血管病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： shenchienx2@hotmail.com,shencx@sjtu.edu.cn
邮编： 200233 邮箱地址： Shenchienx2@hotmail.com

研究方向 (点击浏览详细信息)
急性心肌梗死后心肌修复与再生的机制研究

社会任职
FESC，中国医师学会委员，中华医学会上海心血管病分会常务委员，中国微循环学会常务理事，海峡心血管重症学会常委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 几丁质酶3样蛋白1（CHI3L1）调控巨噬细胞极化及其影响心肌纤维化与老年心功能的机制研究 资助类别： 国家自然科学基金面上项目 2019-01~2022-12 56万元 课题负责人
** 调节单核/巨噬细胞自噬抑制急性心肌梗死后心肌过度纤维化的研究 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题负责人
15ZH1004 冠心病PCI术后尿PDG-BB与支架内血栓以及再狭窄关系的前瞻性研究 上海交通大学医学院 2015-06~2016-05 20万元 课题负责人
** 凋亡MSCs刺激单核-巨噬细胞分泌外泌体对急性心肌梗死心肌修复的新机制 国家自然科学基金面上项目 2015-01~2018-12 73万元 课题负责人
** 葆至能与单纯他汀强化调脂治疗对ACS患者血浆辅酶Q10水平的影响及肌肉相关不良反应的临床观察及机制研究 中华医学会 2014-06~2016-05 14万元 课题负责人
** MSCs刺激巨噬细胞分泌细胞因子促进心肌细胞存活和心肌干细胞分化的机制研究 国家自然科学基金面上项目 2012-01~2015-12 57万元 课题负责人
** 巨噬细胞吞噬干细胞后的旁分泌在细胞移植治疗急性心肌梗死的心肌修复中的作用及机制 国家自然科学基金面上项目 2011-01~2011-12 10万元 课题负责人
** 磁探针标记的HO-1基因修饰的骨髓间充质干细胞移植治疗急性心肌梗死的研究 国家自然科学基金面上项目 2006-01~2009-12 27万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liu Liang, Jin Xian, Hu Cui-Fen, Zhang Ya-Ping, Zhou Zhong'e, Li Rong, Shen Cheng-Xing* （通讯作者） Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway Basic Research in Cardiology 2018 113(2)
Beibei Han, Yongguang Li, Zhifeng Dong, Qing Wan, Hong Shen, Jingbo Li, Meng Wei, Chengxing Shen* （通讯作者） Diastolic dysfunction predicts the risk of contrast-induced nephropathy and outcome post-emergency percutaneous coronary intervention in AMI patients with preserved ejection fraction Heart and Vessels 2018 33(10):1149-1158
Jin Xian, Liu Liang, Zhang Yaping, Xiang Yin, Yin Guizhi, Lu Yi, Shi Ludong, Dong Jian, Shen Chengxing* （通讯作者） Advanced Glycation End Products Enhance Murine Monocyte Proliferation in Bone Marrow and Prime Them into an Inflammatory Phenotype through MAPK Signaling Journal of Diabetes Research 2018 2018: **~**
Shen, CX, Ge, JB Epidemic of Cardiovascular Disease in China: Current Perspective and Prospects for the Future Circulation 2018 138:342-344
Liang Liu, Xian Jin, Cui-Fen Hu, Rong Li, Zhong’e Zhou, Cheng-Xing Shen* （通讯作者） Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways Cellular Physiology and Biochemistry 2017 43(1):52-68
Xian Jin, Liang Liu, Zhong’e Zhou, Junhua Ge, Tongqing Yao, Chengxing Shen* （通讯作者） Pioglitazone alleviates inflammation in diabetic mice fed a high-fat diet via inhibiting advanced glycation end-product-induced classical macrophage activation FEBS Journal 2016 283(12):2295-308
Liang Liu, Xian Jin, Zhong’e Zhou, Chengxing Shen* （通讯作者） Enhancement of Anti-Hypoxic Activity and Differentiation of Cardiac Stem Cells by Supernatant Fluids from Cultured Macrophages that Phagocytized Dead Mesenchymal Stem Cells International Journal of Molecular Sciences 2016 17(7)
Zhong’e Zhou, Yong Tang, Xian Jin, Chengjun Chen, Yi Lu, Liang Liu, Chengxing Shen* （通讯作者） Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression Journal of Diabetes Research 2016 2016;2016:**
Jin X, Yao T, Zhou Z, Zhu J, Zhang S, Hu W, #Shen C. （通讯作者） Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway Biomed Res Int. 2015 2015:732450.
Yao T, Lu W, Zhu J, Jin X, Ma G, Wang Y, Meng S, Zhang Y, Li Y, #Shen C （通讯作者） Role of CD11b+Gr-1+ myeloid cells in AGEs-induced myocardial injury in a mice model of acute myocardial infarction. Int J Clin Exp Pathol. 2015 2015;8(3):3238-49.
Lu W, Fu C, Song L, Yao Y, Zhang X, Chen Z, Li Y, #Ma G, #Shen C. 2013； （通讯作者） Exposure to supernatants of macrophages that phagocytized dead mesenchymal stem cells improves hypoxic cardiomyocytes survival. Int J Cardiol. 2013 165(2):333-40.
Lu W, Fu C, Chen Y, Lu J, Yao Y, #Shen C （通讯作者）, #Gu Z. Multiplex detection of B-typenatriuretic peptide, cardiac troponin I and C-reactive protein with photonicsuspension array. PLoS One. 2012 7(7):e41448.
Jiang YB, Zhang XL, Tang YL, Ma GS, #Shen CX （通讯作者）, Wei Q, Zhu Q, Yao YY , Liu NF Effects of heme oxygenase-1 gene modulated mesenchymal stem cells on vasculogenesis in ischemic swine hearts. Chinese Medical Journal 2011 124(3):401-407.
*Feng Y, *Shen C （共同第一作者）, Ma G, Wang J, Chen Z, Dai Q, Zhi H, Yang C, Fu Q, Shang G, Guan Y. Prolonged pain to hospital time is associated with increased plasma advanced oxidation protein products and poor prognosis in patients with percutaneous coronary intervention for ST-elevation myocardial infarction. Heart Vessels. 2010 25(5):374-8.
Jiang Y, Chen L, Tang Y, #Ma G, #Shen C （通讯作者）, Qi C, Zhu Q, Yao Y, Liu N. HO-1 gene overexpression enhances the beneficial effects of superparamagnetic iron oxide labeled bone marrow stromal cells transplantation in swine hearts underwent ischemia/reperfusion: A MRI study. Basic research in cardiology 2010 105:431-442.
*Shen C （共同第一作者）, *Li Q, Zhang YC, Ma G, Feng Y, Zhu Q, Dai Q, Chen Z, Yao Y, Chen L, Jiang Y, Liu N. Advanced glycation endproducts increase EPC apoptosis and decrease nitric oxide release via MAPK pathways. Biomed Pharmacother. 2010 64:35- 43.
Qi CM, Ma GS, Liu NF, Shen CX （共同第一作者）, Chen Z, Liu XJ, Hu YP, Zhang XL, Chen JY, Ju SH, Tang YL. Identification and differentiation of magnetically labeled mesenchymal stem cells in vivo in swines with myocardial infarction. Int J Cardiol. 2009 131(3):417- 419.