导师姓名： 常春康 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 血液病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： changchunkang7010@aliyun.com
邮编： 200233 邮箱地址： changchunkang7010@yahoo.cn

研究方向 (点击浏览详细信息)
MDS基础与临床，骨髓微环境

社会任职
上海市第六人民医院血液科主任
中国老年血液学会副会长
上海医学会血液学分会副主任委员
中国抗癌协会上海血液肿瘤分会副主任委员
抗癌协会上海理事
中华医学会血液学分会全国委员
CACA全国髓系学组委员
上海医师协会血液学会委员
上海血液免疫学会委员
中华血液学杂志通讯编委、中国实验血液学杂志、诊断学理论与实践编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2019LJ16 TP53突变在预测MDS去甲基化药物疗效中的作用及机制研究 上海医学领军人才计划 2019-12~2022-06 45万元 课题负责人
** MDS克隆细胞通过S100A9/TLR4信号重编程MSC的机制研究 国家自然科学基金 2018-01~2021-12 55万元 课题负责人
** MSC介导的miR-34a/JAG-1/Notch信号通路调控MDS细胞恶性生物学行为的机制研究 国家自然科学基金 2017-01~2019-12 20万元 课题参与人
** 衰老MSC通过MMP1/PAR1信号通路调控MDS克隆细胞增殖的机制研究 国家自然科学基金 2016-01~2019-12 65万元 课题负责人
** TAp73甲基化通过Dicer1调控MDS-MSC细胞衰老的机制研究 国家自然科学基金 2015-01~2017-12 23万元 课题参与人
** MSC成骨分化异常在MDS发病机制中的作用 国家自然科学基金 2012-01~2015-12 60万元 课题负责人
脐带间充质干细胞抑制小鼠物抗宿主病的作用 市科委白玉兰基金 2011-01~2012-12 8万元 主要责任人
染发与骨髓增生异常综合征 上海交大 2011-01~2012-12 3万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
2. Shi L, Zhao Y, Fei C, Guo J, Jia Y, Wu D, Wu L, Chang C （通讯作者） Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation Aging (Albany NY) 2019 11(21):9626-9642
Guo J#, Zhao Y, Fei C, Zhao S, Zheng Q, Su J, Wu D, Li X, Chang C*. （通讯作者） Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells Cell Death Dis 2018 1;9(5):512.
Fei CM#, Guo J, Zhao YS, Zhao SD, Zhen QQ, Shi L, Li X, Chang CK* （通讯作者） Clinical significance of hyaluronan levels and its pro-osteogenic effect on mesenchymal stromal cells in myelodysplastic syndromes. J Transl Med 2018 16(1): 234
Zheng Q#, Zhao Y, Guo J, Zhao S, Fei C, Xiao C, Wu D, Wu L, Li X, Chang C* （通讯作者） Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway Cell Death Dis 2018 9(5):515
Zhang Z#, He Q, Tao Y, Guo J, Xu F, Wu LY, Zhao YS, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X*, Chang CK* （通讯作者） Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes Am J Transl Res 2017 9(2):454-465
Zheng QQ#, Zhao YS, Guo J, Zhao SD, Song LX, Fei CM, Zhang Z, Li X, Chang CK* （通讯作者） Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome Leuk Res 2017 23（58）:55-6258:55-62
Chang CK#, Zhao YS#, Xu F, Guo J, Zhang Z, He Q, Wu D, Wu LY, Su JY, Song LX, Xiao C, Li X*. TP53 mutations predict decitabine-induced complete responses in patients with myelodysplastic syndromes. Br J Haematol 2017 176(4):600-608.
Gu S#, Xv Y, Fei C, Xiao C, Guo J, Zhao Y, Xv F （通讯作者）, Li X, Chang C* Labile plasma iron, more practical and more sensitive to iron overload in myelodysplastic syndromes Hematology 2017 22(1):9-15.?
Xu F#, Wu LY#, He Q, Wu D, Zhang Z, Song LX, Zhao YS, Su JY, Zhou LY, Guo J, Chang CK*, Li X* （通讯作者） Exploration of the role of gene mutations in myelodysplastic syndromes through a sequencing design involving a small number of target genes Sci Rep 2017 21（7）:43113
Zhao S#, Zhao Y#, Guo J, Fei C, Zheng Q, Li X, Chang C* （通讯作者） Downregulation of MMP1 in MDS-derived mesenchymal stromal cells reduces the capacity to restrict MDS cell proliferation Sci Rep 2017 6（7）:43849
Zhang Z#, Chang CK# （共同第一作者）, He Q, Guo J, Tao Y, Wu LY, Xu F, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X Increased PD-1/STAT1 ratio may account for the survival benefit in decitabine therapy for lower risk myelodysplastic syndrome Leuk Lymphoma. 2017 58(4):969-978
Zhao S#, Guo J, Zhao Y, Fei C, Zheng Q, Li X, Chang C* （通讯作者） Chidamide, a novel histone deacetylase inhibitor, inhibits the viability of MDS and AML cells by suppressing JAK2/STAT3 signaling. Am J Transl Res 2016 8.8(7):3169-78.
Guo J#, Su J, He Q, Li X, Zhao Y, Gu S, Fei C, Chang C*. （通讯作者） The prognostic impact of multiparameter flow cytometry immunophenotyping and cytogenetic aberrancies in patients with multiple myeloma. Hematology. 2016 21(3):152-61.
Zhou L#, Xu F, Chang C* （通讯作者）, Tao Y, Song L, Li X nterleukin-17-producing CD4+ T lymphocytes are increased in patients with primary immune thrombocytopenia Blood Coagul Fibrinolysis 2016 9.27(3):301-7.
Qi H, Qingxia Z, Xiao L, Lingyun W, Feng X, Zheng Z, Chunkang C （通讯作者） Recurrent Abnormal Clones in Myelodysplastic Syndrome Marrow Originate from Cells at a Pluripotent Stem Level and Maintain Their Early Differentiation Potency Cancer Invest. 2015 33(8):369-77.
Xu F, Wu LY, Chang CK （共同第一作者）, He Q, Zhang Z, Liu L, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes Nat Commun 2015 26;6:8806
Zhao Y, Wu D, Fei C, Guo J, Gu S, Zhu Y, Xu F, Zhang Z, Wu L, Li X, Chang C （通讯作者） Down-regulation of Dicer1 promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome Haematologica 2015 100(2):194-204
Fei C, Guo J, Zhao Y, Gu S, Zhao S, Li X, Chang C （通讯作者） Notch-Hes pathway mediates the impaired osteogenic differentiation of bone marrow mesenchymal stromal cells from myelodysplastic syndromes patients through the down-regulation of Runx2 Am J Transl Res 2015 7(10):1939-51
Shucheng G, Chunkang C （通讯作者）, Youshan Z, Juan G, Chengming F, Xi Z, Chao X, Xiao L Decitabine treatment could ameliorate primary iron-overload in myelodysplastic syndrome patients Cancer Invest 2015 33(4):98-106
Song LX, Lu HY, Chang CK （通讯作者）, Li X, Zhang Z Cerebral venous and sinus thrombosis in a patient with acute promyelocytic leukemia during all-trans retinoic acid induction treatment Blood Coagul Fibrinolysis 2014 25(7):773-6
Xu L, Gu ZH, Li Y, Zhang JL, Chang CK* （共同第一作者）, Pan CM, Shi JY, Shen Y, Chen B, Wang YY, Jiang L, Lu J, Xu X, Tan JL, Chen Y, Wang SY, Li X, Chen Z, Chen SJ Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers PNAS 2014 111(23):8589-94
Fei C, Zhao Y, Guo J, Gu S, Li X, Chang C （通讯作者） Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes Eur J Haematol 2014 93(6):476-486
Li X, Xu F, Chang C, Byon J, Papayannopoulou T, Deeg HJ, Marcondes AM Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes. Haematologica 2013 98(3):414-9
Zhao Y, Guo J, Zhang X, Zhang Z, Gu S, Fei C, Li X, Chang C. （通讯作者） Downregulation of p21 in myelodysplastic syndrome is associated with p73 promoter hypermethylation and indicates poor prognosis. Am J Clin Pathol. 2013 140(6):819-27
Gu S, Song X, Zhao Y, Guo J, Fei C, Xu F, Wu L, Zhang X, Zhao J, Chang C# （通讯作者）, Li X. The evaluation of iron overload through hepcidin level and its related factors in myelodysplastic syndromes. Hematology 2013 18(5):286-94
Zhao Y, Guo J, Gu S, Zhang X, Li X, Chang C （通讯作者） SDF-1/CXCR4 signal is involved in decreased expression of p57kip2 in de novo MDS patients Hematology 2012 17(4):220-8
Zhao Y, Gu S, Guo J, Zhang Z, Zhang X, Li X, Chang C （通讯作者） Aberration of p73 promoter methylation in de novo myelodysplastic syndrome Hematology 2012 17(5):275-282
Song LX, Guo J, He Q, Yang LP, Gu SC, Zhang X, Wu LY, Li X, Chang CK （通讯作者） Bone Marrow Mesenchymal StemCells in Myelodysplastic Syndromes:Cytogenetic Characterization Acta Haematol 2012 128(3):170-7
Guo J, Yang J, Cao G, Fan H, Guo C, Ma YE, Qian Y, Chen L, Li X, Chang C （通讯作者） Xenogeneic immunosuppression of human umbilical cord mesenchymal stem cells in a major histocompatibility complex-mismatched allogeneic acute graft-versus-host disease murine model. Eur J Haematol 2011 87(3):235-243
Ren WN, Chang CK （通讯作者）, Fan HH, Guo F, Ren YN, Yang J, Guo J, Li X A combination of exosomes carrying TSA derived from HLA-A2-positive human white buffy coat and PolyI:C for use as a subcellular antitumor vaccination. Journal of Immunoassay and Immunochemistry. 2011 32(3):207-18
Guo F, Chang CK （通讯作者）, Fan HH, Nie XX, Ren YN, Liu YY, Zhao LH Tumour Effects of Exosomes in Combination with Cyclophosphamide and Polyinosinic Polycytidylic Acid The Journal of International Medical Research. 2008 37(1):280-280
Chang C, Storer BE, Scott BL, Bryant EM, Shulman HM, Flowers ME, Sandmaier BM, Witherspoon RP, Nash RA, Sanders JE, Bedalov A, Hansen JA, Clurman BE, Storb R, Appelbaum FR, Deeg HJ Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome:similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic di Blood 2007 110(4):1379-87