孟青青 副教授

电话：
邮箱：qqmeng@sjtu.edu.cn
主页：药学院7号楼502室


个人简历 研究方向 发表论文 科研成果
1998年9月-2002年7月，复旦大学化学系，应用化学，学士学位
2002年9月-2007年7月，复旦大学化学系，有机化学，理学博士学位
2007年8月-2018年12月，上海交通大学药学院，助理研究员
2012年5月-2013年5月，Department of Translational Imaging, The Houston Methodist Hospital Research Institute，博士后研究
2019年1月-至今，上海交通大学药学院，副教授


药物化学，分子影像学


[1]Huang, Gu.; Dong, J.; Zhang, Q.; Meng, Q.;* Zhao, H.; Zhu, B.; Li, S.* Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. Eur. J. Med. Chem., 2019, 165, 160-171.
[2]Cui, J.; Zhang, Xu.; Huang, G.; Zhang, Q.; Dong, J.; Sun G.; Meng, Q.;* Li, S.* DMAKO-20 as a New Multitarget Anticancer Prodrug Activated by the Tumor Specific CYP1B1 Enzyme. Mol. Pharmaceutics, 2019, 16, 409-420.
[3]Meng, Q.*; Wang, Z.; Cui, J.; Cui, Q.; Dong, J.; Zhang, Q.; Li, S*. Design, synthesis, and biological evaluation of cytochrome P450 1B1 targeted molecular imaging probes for colorectal tumor detection. J. Med. Chem. 2018, 61, 10901-10909.
[4]Huang, G.; Meng, Q. (共同第一作者); Zhou, W.; Zhang, Q.; Dong, J.; Li, S*. "Design and synthesis of biotinylated dimethylation of alkannin oxime derivatives." Chin. Chem. Lett. 2016, 28, 453-457.
[5]Meng,Q.; Liu, Z.; Li, S*. "Prediction and Early Evaluation of Anticancer Therapy Response: From Imaging of Drug Efflux Pumps to Targeted Therapy Response." Curr. Med. Chem., 2016, 23, 4625-4638.
[6]Cui, J.; Meng, Q.(共同第一作者); Zhang, X.; Cui, Q.; Zhou, W.*; Li, S.* “Design and Synthesis of New α-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression.” J. Med. Chem., 2015, 58, 3534-3547.
[7]Meng,Q.; Liu, Z.; Li, F.; Ma, J.; Wang, H.; Huan, Y.; Li Z.* “An HDAC-Targeted Imaging Probe LBH589?Cy5.5 for Tumor Detection and Therapy Evaluation.” Mol. Pharmaceutics, 2015, 12, 2469-2476.
[8]Wang, R.; Zhou, W.*; Meng, Q.; Zhang, X.; Ding, J.; Xu, Y.; Song, H.; Yang, K.; Cui,J.; Li, S*. “Design, Synthesis, and Biological Evaluation of Shikonin and Alkannin Derivatives as Potential Anticancer Agents via a Prodrug Approach.” ChemMedChem, 2014, 9, 2798-2808.
[9]Wu,P.; Zhang, J.; Meng Q.; Nare, B.; Jacobs ,R.; Zhou, H*. “Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei.” Eur. J. Med. Chem., 2014, 81, 59-75.
[10]Zhao, Y; Meng, Q; Bai, L; Zhou, H*. “In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors.” Int. J. Mol. Sci. 2014, 15, 1358-1373.
[11]Meng, Q.; Li, F.; Jiang,S.; Li, Z*. “Novel 64Cu-Labeled CUDC-101 for in Vivo PET Imaging of Histone Deacetylases.” ACS Med. Chem. Lett., 2013, 4, 858-862.
[12]Meng, Q.; Li, Z*. “Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer.” Int. J. Biomedical Imaging, 2013, 2013, 230487.
[13]Zhao, Y.; Wang Q.; Meng, Q.; Ding D.; Yang H.; Gao, G.; Li, D.; Zhu, W.; Zhou, H*. “ Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis.” Bioorg. Med. Chem. 2012, 20, 1240-1250.
[14]Ding, D.; Meng, Q. (共同第一作者); Gao, G.; Zhao,Y.; Wang, Q.; Nare, B.; Jacobs, R.; Rock, F.; Alley, M. R. K.; Plattner, J. J.; Chen, G.; Li, D.; Zhou, H*. “Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal Agents.” J. Med. Chem. 2011, 54, 1276-1287.
[15]Wu, M.; Meng, Q.; Ge, M.; Bai, L.; Zhou, H*. “2,3,6-Trideoxy sugar nucleotides: synthesis and stability.” Tetrahedron Lett. 2011, 52, 5799-5801.
[16]Qiao, Z.; Wang, W.; Wang, L.; Wen, D.; Zhao, Y.; Wang, Q.; Meng, Q.; Chen, G.; Wu, Y.; Zhou, H*. “Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.” Bioorg. Med. Chem. Lett. 2011, 21, 6389-6392.
[17]Wu, P.; Meng, Q.; Zhou, H*. “Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel–Crafts reaction catalyzed by anhydrous stannic chloride.” Chin. Chem. Lett. 2011, 22, 1411-1414.
[18]Ding, D.; Zhao, Y.; Meng, Q.; Xie, D.; Nare, B.; Chen, D.; Bacchi, C. J.; Yarlett, N.; Zhang, Y. K.; Hernandez, V.; Xia, Y.; Freund, Y.; Abdulla, M.; Ang, K. H.; Ratnam, J.; McKerrow, J. H.; Jacobs, R. T.; Zhou, H.; Plattner, J. J. “Discovery of novel benzoxaborole-based potent antitrypanosomal agents.” ACS Med. Chem. Lett. 2010, 1, 165-169.
[19]Ye, L.; Ding, D.; Feng, Y.; Xie, D.; Wu, P.; Guo, H.; Meng, Q.; Zhou, H. “Convenient and versatile synthesis of formyl-substituted benzoxaboroles.” Tetrahedron 2009, 65, 8738-8744.


主持科研项目：
（1）上海交通大学医工交叉项目（以CYP1B1酶为靶点的分子影像探针在乳腺癌早期诊断中的应用，在研）。
（2）上海市自然科学基金（靶向细胞色素P4501B1 (CYP1B1) 酶的分子探针的设计合成及肿瘤活体成像研究，项目编号16ZR**，已结题）。
（3）国家自然科学基金青年基金（以亮氨酰tRNA 合成酶为靶标的高效抗原虫抑制剂的设计合成及构效关系研究，批准号**，已结题）。
（4）上海交通大学医工交叉项目（利用淋巴管内皮细胞MR分子靶向探针探索克罗恩病的淋巴管改变，已结题）。
（5）上海交通大学医工交叉项目（乙型肝炎重要靶标La蛋白新型抑制剂的结构改造与活性研究，已结题）。
（6）2016年度上海交通大学“SMC-晨星青年****奖励计划”（C类计划）。