钱峰 教授、长聘副教授

电话：
邮箱：fengqian@sjtu.edu.cn



个人简历 研究方向 发表论文 科研成果
钱峰：男，博士，教授、长聘副教授，博士生导师。2006年在南京大学生命科学院获得博士学位，2006年至2011年，在美国伊利诺伊大学药理学系从事博士后研究工作，并于2011年3月晋升为助理教授，2013年回国在上海交通大学药学院任分子药理学课题组组长。上海交通大学-浙江医药高通量筛选平台负责人。主要学术研究方向为分子药理学、免疫药理学、肿瘤药理学和抗体工程，力求阐明复杂性疾病的发病机理与分子机制。在国际著名杂志EMBO J，Nature Immunology，Journal of immunology等学术杂志上发表研究论文60余篇。中国药理学会抗炎免疫药理专业委员会委员和青年委员会常务委员，上海药学会药理专业委员会委员，上海市药物代谢研究中心理事，世中联中医药免疫专委会常务理事，美国心血管学会、美国生理学会、美国胸科学会，美国免疫学家学会等学会会员。主持国家自然科学基金面上项目4项，国家重点研发计划“精准医学研究”专项1项（分项目负责人），作为骨干参与重大专项“重大新药创制”1项。担任《人民卫生出版社中国医学教育题库》药理学学科副主编。
教育和研究工作经历：
2013年2月-现在 上海交通大学药学院 教授
2011年3月-2013年1月 美国伊利诺伊大学医学研究中心 助理教授
2006年11月-2011年2月 美国伊利诺伊大学医学研究中心 博士后
2003年9月-2006年7月 南京大学生命科学院 生理学 博士
2000年9月-2003年7月 蚌埠医学院 临床检验诊断学 硕士
1995年9月-2000年7月 蚌埠医学院 检验诊断学 学士
学术兼职情况：
1. 上海市药学会药理学专业委员会委员
2. 上海市药物代谢研究中心理事
教学情况：
1. 培养博士研究生9名，其中已经博士毕业3名。
2. 培养硕士研究生8名，其中已经硕士毕业5名。
3. 培养博士后2名。
4. 培养上海交通大学“君政****”2名。
5. 主讲研究生《药理学研究导论》和《免疫药理学》。
6. 参讲本科生《微生物学和免疫学》和《药学进展》。


1.针对急慢性炎症性疾病和肿瘤的新药靶标发现和发病机制研究
2.新型药物筛选体系的建立与高通量药物筛选
3.急慢性炎症性疾病与肿瘤的抗体药物研发

已发表SCI研究论文：
（1）Xingli Li, Chenxian Ye, Mubarak Mulati, Lei Sun*, Feng Qian*. Ellipticine blocks synergistic effects of IL-17A and TNF-alpha in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury. Biochem Pharmacol. 2020 Apr 23; 177: 113992. doi: 10.1016/j.bcp.2020.113992. PMID: **
（2）Jun Wang, Lei Sun, Yunjuan Nie, Shixin Duan, Tao Zhang, Weiwei Wang, Richard D Ye, Shangwei Hou, Feng Qian*. Protein Kinase C δ (PKCδ) Attenuates Bleomycin Induced Pulmonary Fibrosis via Inhibiting NF-κB Signaling Pathway. Front Physiol, 2020 Apr 22;11:367. doi: 10.3389/fphys.2020.00367. PMID: **
（3）Qing Liang, Wuyang Cai , Yaxue Zhao, Huanbai Xu, Huirong Tang, Daijie Chen, Feng Qian*, Lei Sun*. Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis. Pharmacol Res, 2020 May 16;104884. doi: 10.1016/j.phrs.2020.104884. PMID: **
（4）Li-Nian Huang, Lei Sun, Li-Ming Liu, Hui-Hui Zhang, Zhong-Bo Liang, Yan Rui, Jun-Feng Hu, Yong Zhang, John W Christman, Feng Qian*. p38alpha MAP kinase promotes asthmatic inflammation through modulation of alternatively activated macrophages. J Mol Cell Biol, 2019 Dec 19;11(12):1095-1097. doi: 10.1093/jmcb/mjz054. PMID: **
（5）Lei Sun, Qiong Wu, Yunjuan Nie, Ni Cheng, Rui Wang, Gang Wang, Dan Zhang, Huiqion He, Richard D. Ye and Feng Qian*, A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury. Frontiers in Immunology, 2018 Nov 13, 9: 2610，doi：10.3389/fimmu.2018.02610, PMID：**
（6）Yaxian Wu, Huiqiong He, Sirui Liu, Yunhe Ding, Depeng Zhang, Dan Zhang, Lei Sun, Richard D. Ye, Feng Qian*. MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA. American Journal of Physiology-Lung Cellular and Molecular Physiology 2018, 315(3): L371-L381, doi: 10.1152/ajplung.00019.2018. PMID: **
（7）Yunhe Ding, Yunduan Ding, Yaxian Wu, Huiqiong He, Tianhong Yu, Yudong Hu, Depeng Zhang, Kaikai Yu, Xiaozong Li, Lei Sun, Feng Qian*. Isoalantolactone suppresses lipopolysaccharide-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury. Acta Pharmacologica Sinica, 2019, 40(1): 64-74. doi: 10.1038/s41401-018-0061-3. PMID: **
（8）Gufang Zhang, Jin Liu, Lehao Wu, Yu Fan, Lei Sun, Feng Qian, Daijie Chen, Richard D. Ye. Elevated expression of serum amyloid A 3 protects colon epithelium against acute injury through TLR2-dependent induction of neutrophil IL-22 expression in a mouse of colitis. Front Immunol, 2018, 29 (9): 1503. doi: 10.3389/fimmu.2018.01503 PMID: **
（9）Yu Li, Depeng Zhang, Kaikai Yu, Yudong Hu, Qiong Wu, Feng Qian*, Zishu Wang*. CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest. Biol Res, 2018, 51: 11, doi: 10.1186/s40659-018-0159-6, PMID: **
（10）Depeng Zhang, Xiaozong Li, Yudong Hu, Hongchao Jiang, Yaxian Wu, Yunhe Ding, Kaikai Yu, Huiqiong He, Jingsong Xu, Lei Sun, Feng Qian*. Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination. Biochem Pharmacol, 2018, 154: 183-192 doi: 10.1016/j.bcp.2018.05.004. PMID:**
（11）Yudong Hu, Kaikai Yu, Gang Wang, Depeng Zhang, Chaoji Shi, Yunhe Ding, Duo Hong, Dan Zhang, Huiqiong He, Lei Sun, Jun-Nian Zheng*, Shuyang Sun*, Feng Qian*, Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell. Biochem Pharmacol, 2018, 150: 280-292. doi: 10.1016/j.bcp.2018.02.023 PMID: **
（12）Yi-Gong Guo, Yun-He Ding, Guo-Jing Wu, Sheng-lan Zhu, Yuan-Fang Sun, Shi-Kai Yan, Feng Qian*, Hui-Zi Jin*, Wei-Dong Zhang*. Three new alkaloids from Xylopia vielana and their antiinflmmatory activities. Fitoterapial, 2018, S0367-326X (17): 31863. doi: 10.1016/j.fitote. 2018.02.001 PMID: **
（13）Yunduan Song, Xiaozong Li, Yaxian Wu, Yao Shen, Fangfang Liu, Peipai Gao, Lei Sun, Feng Qian*. Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model. Acta Pharmacologica Sinica, 2018, 39 (1): 85-96. doi: 10.1038/aps.2017.147 PMID: **
（14）Ya-xian Wu, Hui-qiong He, Yun-juan Nie, Yun-he Ding, Lei Sun，Feng Qian*. Protostemonine effectively attenuates lipopolysaccharide-induced acute lung injury in mice. Acta Pharmacologica Sinica, 2018, 39 (1): 85-96. doi: 10.1038/aps.2017.131. PMID: **
（15）Yunjuan Nie, Lei Sun, Yaoyao Yang, Jun Wang, Huiqiong He, Yanhua Chang, Yaxian Wu, Qing Liang, Yudong Hu, Jianwei Zhu, Richard D. Ye, John W. Christman, Feng Qian*. AKT2 regulates pulmonary inflammation and fibrosis via modulating macrophage activation. Journal of Immunology，2017, 198: 4470, doi: 10.4049/jimmunol.**, PMID: **
（16）Ziyan Zhu, Lei Sun, Rui Hao, Hongchao Jiang, Feng Qian, Richard D. Ye. Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury, American Journal of Physiology-Lung Cellular and Molecular Physiology 2017; 313: L104-L114. PMID: **
（17）Shu-Qin Li, Ning Su, Ping Gong, Hai-Bo Zhang, Jin Liu, Ding Wang, Yan-Ping Sun, Yan Zhang, Feng Qian, Bo Zhao, Yang Yu, and Richard D. Ye. Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer, Sci Rep. 2017; 7: 5918. doi: 10.1038/s4 1598-017-06368-9 PMID: **
（18）Hui-qiong He, Ya-xian Wu, Yun-juan Nie, Jun Wang, Mei Ge, Feng Qian* LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury by suppressing the TLR 4 signaling pathway, Acta Pharmacologica Sinica, 2017, 38(3): 342-350. doi: 10.1038/aps.2016.141. PMID: **
（19）Qing Liang, Ni Cheng, Gufang Zhang, Yurong Liang, Feng Qian, Dianqing Wu, Richard D. Ye. Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis. Sci Rep. 2016; 6: 25785, PMID:**, doi: 10.1038/srep25785.
（20）Sangwoon Chung, Tae Jin Lee, Brenda F. Reader, Ji Young Kim, Yong Gyu Lee, Gye Young Park, Manjula Karpurapu, Megan N. Ballinger, Feng Qian, Luiza Rusu, Hae Young Chung, Terry G. Unterman, Carlo M. Croce and John W. Christman. FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype. Oncotarget, 2016, 7: 17532-46, PMID: **, DOI: 10.18632/oncotarget.8162.
（21）Feng Qian*, Jing Deng, Yong Gyu Lee, Jimmy Zhu, Manjula Karpurapu, Sangwoon Chung, Jun-Nian Zheng, Lei Xiao, Gye Young Park, and John W. Christman. The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammation. Journal of Molecular Cell Biology, 2015，7: 557. 封面文章 PMID: **, DOI: 10.1093/jmcb/mjv042.
（22）Feng Qian*, Jing Deng, Gang Wang, Richard D. Ye, John W. Christman. Pivotal role of mitogen-activated protein kinase-activated protein kinase 2 in inflammatory pulmonary diseases. Current Protein and Peptide Science, 2016, 17: 332. PMID: **
（23）Yao-yao Yang, Hui-qiong He, Jia-hua Cui, Yun-juan Nie, Ya-xian Wu, Rui Wang, Richard D. Ye, Qiong Wu, Shao-shun Li and Feng Qian*. Shikonin derivative DMAKO-05 inhibits Akt signal activation and melanoma proliferation. Chemical Biology & Drug Design, 2016, 87: 895 PMID: **
（24）Yong Gyu Lee, Jong Jin Jeong, Sharmilee Nyenhuis, Evgeny Berdyshev, Sangwoon Chung, Ravi Ranjan, Manjula Karpurapu, Jing Deng, Feng Qian, Elizabeth A.B. Kelly, Nizar N. Jarjour, Steven J. Ackerman, Viswanathan Natarajan, John W Christman, and Gye Young Park. Recruited alveolar macrophages, in response to airway epithelial-derived MCP-1/ CCL2, regulate airway inflammation and remodeling in allergic asthma, Am J Respir Cell Mol Biol, 2015; 52: 772-784 PMID: **
（25）Xiaowen Liu, Tao Yang, Koya Suzuki, Sachiko Tsukita, Masaru Ishii, Shuping Zhou, Gang Wang, Luyang Cao, Feng Qian, Shalina Taylor, Myung-jin Oh, Irena Levitan, Richard D. Y, Graeme K. Carnegie, Yong Zhao, Asrar Malik, Jingsong Xu. Moesin and Myosin phosphatase confine neutrophil orientation in a chemotactic gradient, J Exp Med, 2015; 212: 267-280 PMID: **
（26）Shu-Qin Li, Yang Yu, Jin-Zhao Han, Ding Wang, Jin Liu, Feng Qian, Guo-Huang Fan, Richard Bucala, Richard D. Ye. Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer’s disease. Journal of Neuroinflammation, 2015, 12: 177. PMID: **, DOI: 10.1186/s12974-015-0396-3.
（27）Bo Shen, Brian Estevez, Zheng Xu, Barry Kreutz, Andrei Karginov, Yanyan Bai, Feng Qian, Urao Norifumi, Deane Mosher, Xiaoping Du. The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA. Mol Biol Cell, 2015, 26: 3658-3670. PMID: **
（28）Mingjie Chen, Huibing Zhou, Ni Cheng, Feng Qian, Richard D. Ye. Serum amyloid A1 isoforms display different efficacy at Toll-like receptor 2 and formyl peptide receptor 2. Immunobiolgy, 2014; 219: 916-923. PMID: **
（29）Hong Yin, Alesander Zakharov, Weidong Xu, Adam Corken, Alexander Zakharov, Feng Qian, Sasha Pavlovic, Alekasandar Krbanjevic, Alexander Lyubimov, Zaijie J. Wang, Xiaoping Du. Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality. Arterioscler Thromb Vasc Biol, 2013; 33: 2529-2537. PMID: **
（30）Feng Qian, Guy C. Le Breton, Jia Chen, Jing Deng, John W. Christman, Dianqing Wu, Richard D. Ye. A critical role for the guanine nucleotide exchange factor P-Rex1 in platelet secretion and aggregation. Arterioscler Thromb Vasc Biol 2012; 32: 768-777. PMID: **
（31）Feng Qian*, Jing Deng, Benjamin N. Gantner, Chen Dong, John W. Christman, Richard D Ye. MAP Kinase Phosphatase 5 protests against sepsis-induced acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 2012; 302: L866-874. PMID: **
（32）Benjamin N Gantner, Huali Jin, Feng Qian, Nissim Hay, Bin He, Richard D Ye. The Akt1 isoform is required for optimal IFN-b transcription through direct phosphorylation of b-catenin. J Immunol 2012; 189: 3104-3111. PMID: **
（33）Jing Deng, Xuerong Wang, Feng Qian, Stephen M. Vogel, Lei Xiao, Ravi Ranjan, Hyesuk Park, Manjula Karpurapu, Richard D. Ye, Gye Young Park, John W. Christman. Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression. J Immunol 2012; 188: 5734-5740. PMID: **
（34）Ram Naikawadi, Ni Cheng, Stephen M. Vogel, Feng Qian, Dianqing Wu, Asrar B. Malik, Richard D Ye. A critical role for P-Rex1 in endothelial junction disruption and vascular hyper-permeability. Circulation Research 2012; 111: 1517-1527. PMID: **
（35）Anke Di, Xiao-Pei Gao, Feng Qian, Takeshi Kawamura, Jin Han, Claudie Hecquet, Richard D. Ye, Stephen M. Vogel, Asrar B. Malik. TRPM2 regulation of membrane potential modulates NADPH oxidase-derived ROS production in phagocytes. Nature Immunology 2011; 13: 29-34. PMID: **
（36）Yuqing Chen, Dianming Li, Hongli Liu, Huanbai Xu, Honghua Zheng, Feng Qian, Wei Li, Chengling Zhao, Zhenhua Wang, Xiaojing Wang. Notch-1 signaling facilitates surviving expression in human non-small cell lung cancer cells. Cancer Biol Ther. 2011; 11: 14-21. PMID: **
（37）Min Ren, Qing Guo, Liang Guo, Martin Lenz, Feng Qian, Rory R. Koenen, Hua Xu, Alexander B. Schilling, Christian Weber, Richard D. Ye, Aaron R. Dinner, Wei-Jen Tang. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J. 2010; 29: 3952-3966. PMID: **
（38）Feng Qian, Jing Deng, Ni Cheng, Emily J. Welch, Yongliang Zhang, Asrar B. Malik, Richard A. Flavell, Chen Dong, Richard D. Ye. A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 2009; 28: 2896-2907. PMID: **
（39）Ran Song, Feng Qian, Yu-Pei Li, Xia Sheng, Shao-Xian Cao, Qiang Xu. Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivo. PLoS ONE. 2009; 4: e4450. PMID: **
（40）Jianming Guo, Feng Qian, Jianxin Li, Qiang Xu, Ting Chen. Identification of a new metabolite of Astilbin, 3’-O-Methylastilbin, and its immunosuppressive activity against contact dermatitis. Chinical Chemistry. 2007; 53: 465-471. PMID: **
（41）Feng Qian, Yu-Pei Li, Xia Sheng, Zi-Chao Zhang, Ran Song, Wei Dong, Shao-Xian Cao, Zi-Chun Hua, Qiang Xu. PRL-3 siRNA inhibits the metastasis of B16-BL6 mouse melanoma cells in vitro and in vivo. Mol. Med. 2007; 13: 151-159. PMID: **
（42）Yang Sun, Jianli Liu, Feng Qian, Qiang Xu. Nitric oxide inhibits T cell adhesion and migration through down-regulating β1 integrin expression in immunological liver injured mice. Intl. Immunopharmacol. 2006; 6(4): 616-626. PMID:**
（43）Feng Qian, Zi-Chao Zhang, Xue-Feng Wu, Yu-Pei Li, Qiang Xu. Interaction between integrin α5 and fibronectin is required for metastasis of B16F10 melanoma cells. Biochem. Biophys. Res. Commun. 2005; 333: 1269–1275. PMID: **


纵向基金资助情况：
1.国家自然科学基金面上项目（55 万），主持，2020年（**）：E3泛素连接酶AMFR调控巨噬细胞极化介导哮喘的作用机制及潜在靶标研究。
2.国家自然科学基金面上项目（55 万），主持，2018年（**）：蛋白激酶Akt2调控巨噬细胞介导特发性肺纤维化的机制研究与新型药物靶标鉴定。
3.国家重点研发计划“精准医学研究”（210万），分项目负责人，2018年，搭建中国人群头颈部恶性肿瘤个性化PDX平台（2017YFC**）。
4.国家自然科学基金面上项目（72 万），主持，2016年（**）：蛋白激酶p38 MAPK调控巨噬细胞极化在特发性肺纤维化中的作用机制研究。
5.国家自然科学基金面上项目（80 万），主持，2014年（**）：蛋白激酶MK2调控嗜中性粒细胞活化介导肝脏缺血再灌注损伤机制与新型药物靶标。
6.高等学校博士学科点专项科研基金（4 万），主持，2014年：MK2促进肝脏缺血再灌注损伤病理机制的研究。