王志龙 研究员

电话：
邮箱：zlwang@sjtu.edu.cn



个人简历 研究方向 发表论文 科研成果
2004年毕业于上海交通大学，获博士学位
2008年德国赫姆霍兹研究员，客座研究员（DAAD基金资助）
2008年获首届校晨星优秀青年教师奖
2009年美国伊利诺伊（香槟）大学，访问****
2011年 韩国釜山大学， 访问****
2012年 上海交通大学药学院 研究员


1.化学（药物）生物技术：生物催化是合成复杂结构药物或前体的重要手段。应用浊点系统技术解除生物催化（微生物转化与发酵）过程中存在的底物生物利用度低、底物/产物抑制、产物进一步降解等瓶颈问题。
2.微生物次级代谢：微生物次级代谢受到多种环境因素的调控。应用Pickering乳液技术创造复杂的生态位，进而调控微生物次级代谢的途径及效率。


1.Qiao Xin, Tao Pan, Wei-Min Zhang, Zhilong Wang*. Submerged culture of marine-derived Penicillium sclerotiorum FS50 to produce sclerotiorin. Process biochemistry, 2019, 79: 28-31
2.Yaolin Huang, Lujie Liu, Gaowei Zheng, Xuehong Zhang, Zhilong Wang*. Efficient production of red Monascus pigments with single non-natural amine residue by in situ chemical modification. World journal of microbiology and biotechnology, 2019, 35, doi: 10.1007/s11274-018-2585-6
3.Lujie Liu, Jixing Zhao, Yaolin Huang, Qiao Xin, Zhilong Wang*. Diversifying of chemical structure of native Monascus pigments. Frontiers in microbiology, 2018, 9:3143. doi: 10.3389/fmicb.2018.03143
4.Fengling Lv, Lujie Liu, Yaolin Huang, Xuehong Zhang, Zhilong Wang*. Production of Monascus pigments as extracellular crystals by cell suspension culture. Applied microbiology and biotechnology, 2018, 102: 677-687
5.Fengling Lv, Yaolin Huang, Xuehong Zhang, Zhilong Wang*. Biocatalytic activity of Monascus mycelia depending on physiology and high sensitivity to product concentration. AMB Express, 2017, 7: 88 (DOI: 10.1186/s13568-017-0391-4)
6.Lihong Zhao, Fengling Lu, Xuehong Zhang, Zhilong Wang*. Isolation of ionizable red Monascus pigments after extractive fermentation in nonionic surfactant micelle aqueous solution. Process biochemistry, 2017, 61: 156-162
7.Lihong Zhao, Xuehong Zhang, Zhilong Wang*. Extraction of anionic dyes with ionic liquid-nonionic surfactant aqueous two-phase system. Separation science and technology, 2017, 52(5): 804-811
8.Minglue Hu, Xuehong Zhang, Zhilong Wang*. Releasing intracellular product to prepare whole cell biocatalyst for biosynthesis of Monascus pigments in water-edible oil two-phase system. Bioprocess and biosystems engineering, 2016, 39(11):1785-1791
9.Bo Wang, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang*. Biosynthesis of Monascus pigments by resting cell submerged culture in nonionic surfactant micelle aqueous solution. Applied microbiology and biotechnology, 2016, 100 (16): 7083-7089
10.Bo Wang, Xuehong Zhang, Zhenqiang Wu*, Zhilong Wang*. Investigation of relationship between lipid and Monascus pigment accumulation by extractive fermentation. Journal of biotechnology, 2015, 212:167-173
11.Sijia Zhong, Xuehong Zhang*, Zhilong Wang*. Preparation and characterization of yellow Monascus pigments. Separation and purification technology, 2015, 150:139-144
12.Xu Xiong, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang*. Coupled aminophilic reaction and directed metabolic channeling to red Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution. Process biochemistry, 2015, 50(2): 180-187
13.Xu Xiong, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang*. Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution. Applied microbiology and biotechnology, 2015, 99 (3):1173-1180


发表SCI期刊论文50多篇
2017年、2018年、2019年分别培养了赵丽红、陆丰翎、黄瑶琳等上海市级、交大校级优秀毕业生
目前开展课题包括：
1.微生物培养红曲色素与化学改性：基本完成了实验室研究，研究成果正在积极推向产业化应用
2.应用生物Pickering流体实现疏水性化合物的界面催化与萃取发酵：正在推进中